Microbes and Oxytocin: Benefits for Host Physiology and Behavior

International Review of Neurobiology

Volumn 131, Issue , 2016, Pages 91-126

  Erdman, S E ^a,b   Poutahidis, T ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Behavior; Lactobacillus reuteri; Neuropsychiatric disorders; Obesity; Oxytocin; Probiotics

Indexed keywords

OXYTOCIN; PROBIOTIC AGENT;

BEHAVIOR CHANGE; BRAIN REGION; DRUG EFFECT; DRUG RESPONSE; HOMEOSTASIS; HOST PATHOGEN INTERACTION; HUMAN; INFLAMMATION; INTESTINE FLORA; LACTOBACILLUS REUTERI; MOLECULAR DYNAMICS; MUSCLE ATROPHY; NONHUMAN; OBESITY; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUORUM SENSING; SIGNAL TRANSDUCTION; WOUND HEALING; ANIMAL; DRUG EFFECTS; GASTROINTESTINAL TRACT; MENTAL DISORDERS; METABOLISM; MICROBIOLOGY;

ANIMALS; GASTROINTESTINAL TRACT; HUMANS; MENTAL DISORDERS; OBESITY; OXYTOCIN; PROBIOTICS;

EID: 84994802243     PISSN: 00747742     EISSN: 21625514     Source Type: Book Series    
DOI: 10.1016/bs.irn.2016.07.004     Document Type: Chapter

References (229)

1. Ahl, D., Liu, H., Schreiber, O., Roos, S., Phillipson, M., Holm, L., Lactobacillus reuteri increases mucus thickness and ameliorates DSS-induced colitis in mice. Acta Physiologica (Oxford, England) 217:4 (2016), 300–310.
2. Al-Amran, F., Shahkolahi, M., Oxytocin ameliorates the immediate myocardial injury in rat heart transplant through downregulation of neutrophil-dependent myocardial apoptosis. Transplantation Proceedings 45 (2013), 2506–2512.
3. Albenberg, L.G., Wu, G.D., Diet and the intestinal microbiome: Associations, functions, and implications for health and disease. Gastroenterology 146 (2014), 1564–1572.
4. Altirriba, J., Poher, A.L., Caillon, A., Arsenijevic, D., Veyrat-Durebex, C., Lyautey, J., et al. Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes. Endocrinology 155 (2014), 4189–4201.
5. Amico, J.A., Mantella, R.C., Vollmer, R.R., Li, X., Anxiety and stress responses in female oxytocin deficient mice. Journal of Neuroendocrinology 16 (2004), 319–324.
6. Arletti, R., Benelli, A., Bertolini, A., Oxytocin inhibits food and fluid intake in rats. Physiology & Behavior 48 (1990), 825–830.
7. Balzola, F., Bernstein, C., Ho, G.T., Lees, C., Combined administration of secretin and oxytocin inhibits chronic colitis and associated activation of forebrain neurons: Commentary. Inflammatory Bowel Disease Monitoring, 22(6), 2010 654-e202.
8. Barengolts, E., Oxytocin—An emerging treatment for obesity and dysglycemia: Review of randomized controlled trials and cohort studies. Endocrine Practice 22:7 (2016), 885–894.
9. Baribeau, D.A., Anagnostou, E., Oxytocin and vasopressin: Linking pituitary neuropeptides and their receptors to social neurocircuits. Frontiers in Neuroscience, 9, 2015, 335.
10. Belkaid, Y., Hand, T.W., Role of the microbiota in immunity and inflammation. Cell 157 (2014), 121–141.
11. Beranger, G.E., Pisani, D.F., Castel, J., Djedaini, M., Battaglia, S., Amiaud, J., et al. Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. Endocrinology 155 (2014), 1340–1352.
12. Biyikli, N.K., Tugtepe, H., Sener, G., Velioglu-Ogunc, A., Cetinel, S., Midillioglu, S., et al. Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism. Peptides 27 (2006), 2249–2257.
13. Blevins, J.E., Baskin, D.G., Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. Physiology & Behavior 152 (2015), 438–449.
14. Blevins, J.E., Eakin, T.J., Murphy, J.A., Schwartz, M.W., Baskin, D.G., Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin. Brain Research 993 (2003), 30–41.
15. Blevins, J.E., Graham, J.L., Morton, G.J., Bales, K.L., Schwartz, M.W., Baskin, D.G., et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 308 (2015), R431–R438.
16. Blevins, J.E., Ho, J.M., Role of oxytocin signaling in the regulation of body weight. Reviews in Endocrine & Metabolic Disorders 14 (2013), 311–329.
17. Blevins, J.E., Thompson, B.W., Anekonda, V.T., Ho, J.M., Graham, J.L., Roberts, Z.S., et al. Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 310 (2016), R640–R658.
18. Boulange, C.L., Neves, A.L., Chilloux, J., Nicholson, J.K., Dumas, M.E., Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Medicine, 8, 2016, 42.
19. Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E., Savignac, H.M., Dinan, T.G., et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences of the United States of America 108 (2011), 16050–16055.
20. Britton, R.A., Irwin, R., Quach, D., Schaefer, L., Zhang, J., Lee, T., et al. Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. Journal of Cellular Physiology 229 (2014), 1822–1830.
21. Buffington, S.A., Di Prisco, G.V., Auchtung, T.A., Ajami, N.J., Petrosino, J.F., Costa-Mattioli, M., Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell 165 (2016), 1762–1775.
22. Bull, M.J., Plummer, N.T., Part 1: The human gut microbiome in health and disease. Integrative Medicine (Encinitas) 13 (2014), 17–22.
23. Bull, M.J., Plummer, N.T., Part 2: Treatments for chronic gastrointestinal disease and gut dysbiosis. Integrative Medicine (Encinitas) 14 (2015), 25–33.
24. Camerino, C., Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity (Silver Spring) 17 (2009), 980–984.
25. Carter, C.S., Oxytocin pathways and the evolution of human behavior. Annual Review of Psychology 65 (2014), 17–39.
26. Chang, C., Lin, H., Dysbiosis in gastrointestinal disorders. Best Practice and Research in Clinical Gastroenterology 30 (2016), 3–15.
27. Chassaing, B., Koren, O., Goodrich, J.K., Poole, A.C., Srinivasan, S., Ley, R.E., et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519 (2015), 92–96.
28. Chung, H.J., Yu, J.G., Lee, I.A., Liu, M.J., Shen, Y.F., Sharma, S.P., et al. Intestinal removal of free fatty acids from hosts by Lactobacilli for the treatment of obesity. FEBS Open Bio 6 (2016), 64–76.
29. Clemente, J.C., Ursell, L.K., Parfrey, L.W., Knight, R., The impact of the gut microbiota on human health: An integrative view. Cell 148 (2012), 1258–1270.
30. Clodi, M., Vila, G., Geyeregger, R., Riedl, M., Stulnig, T.M., Struck, J., et al. Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. American Journal of Physiology. Endocrinology and Metabolism 295 (2008), E686–E691.
31. Colaianni, G., Sun, L., Zaidi, M., Zallone, A., The “love hormone” oxytocin regulates the loss and gain of the fat-bone relationship. Frontiers in Endocrinology (Lausanne), 6, 2015, 79.
32. Collado, M.C., Cernada, M., Bauerl, C., Vento, M., Perez-Martinez, G., Microbial ecology and host-microbiota interactions during early life stages. Gut Microbes 3 (2012), 352–365.
33. Collins, F.L., Irwin, R., Bierhalter, H., Schepper, J., Britton, R.A., Parameswaran, N., et al. Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting. PloS One, 11, 2016, e0153180.
34. Conlon, M.A., Bird, A.R., The impact of diet and lifestyle on gut microbiota and human health. Nutrients 7 (2015), 17–44.
35. Costa, A., Rossi, E., Scicchitano, B.M., Coletti, D., Moresi, V., Adamo, S., Neurohypophyseal hormones: Novel actors of striated muscle development and homeostasis. European Journal of Translational Myology, 24, 2014, 3790.
36. Cotillard, A., Kennedy, S.P., Kong, L.C., Prifti, E., Pons, N., Le Chatelier, E., et al. Dietary intervention impact on gut microbial gene richness. Nature 500 (2013), 585–588.
37. Cryan, J.F., Dinan, T.G., Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews. Neuroscience 13 (2012), 701–712.
38. Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.L., Petrosino, S., et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PloS One, 6, 2011, e25565.
39. Dept. of Reproductive Health and Research, W., WHO recommendations for the prevention and treatment of postpartum haemorrhage. 2012, World Health Organization, Geneva Accessed June 2016.
40. Dethlefsen, L., Mcfall-Ngai, M., Relman, D.A., An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 449 (2007), 811–818.
41. Dinan, T.G., Stanton, C., Cryan, J.F., Psychobiotics: A novel class of psychotropic. Biological Psychiatry 74 (2013), 720–726.
42. Donaldson, Z.R., Young, L.J., Oxytocin, vasopressin, and the neurogenetics of sociality. Science 322 (2008), 900–904.
43. Douglas, A.J., Johnstone, L.E., Leng, G., Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin. Physiology & Behavior 91 (2007), 352–365.
44. Drissi, F., Raoult, D., Merhej, V., Metabolic role of lactobacilli in weight modification in humans and animals. Microbial Pathogenesis, 2016, 10.1016/j.micpath.2016.03.006 pii: S0882-4010(15)30152-2. [Epub ahead of print].
45. Ducatelle, R., Eeckhaut, V., Haesebrouck, F., Van Immerseel, F., A review on prebiotics and probiotics for the control of dysbiosis: Present status and future perspectives. Animal 9 (2015), 43–48.
46. Eaton, K.A., Honkala, A., Auchtung, T.A., Britton, R.A., Probiotic Lactobacillus reuteri ameliorates disease due to enterohemorrhagic Escherichia coli in germfree mice. Infection and Immunity 79 (2011), 185–191.
47. Elabd, C., Basillais, A., Beaupied, H., Breuil, V., Wagner, N., Scheideler, M., et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 26:9 (2008), 2399–2407.
48. Elabd, C., Cousin, W., Upadhyayula, P., Chen, R.Y., Chooljian, M.S., Li, J., et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nature Communications, 5, 2014, 4082.
49. Elands, J., Resink, A., De Kloet, E.R., Neurohypophyseal hormone receptors in the rat thymus, spleen, and lymphocytes. Endocrinology 126 (1990), 2703–2710.
50. Eming, S.A., Martin, P., Tomic-Canic, M., Wound repair and regeneration: Mechanisms, signaling, and translation. Science Translational Medicine, 6, 2014, 265sr6.
51. Erdman, S.E., Poutahidis, T., Cancer inflammation and regulatory T cells. International Journal of Cancer 127 (2010), 768–779.
52. Erdman, S.E., Poutahidis, T., The microbiome modulates the tumor macroenvironment. Oncoimmunology, 3, 2014, e28271.
53. Erdman, S.E., Poutahidis, T., Probiotic ‘glow of health’: It's more than skin deep. Beneficial Microbes 5 (2014), 109–119.
54. Erdman, S.E., Poutahidis, T., Gut bacteria and cancer. Biochimica et Biophysica Acta 1856 (2015), 86–90.
55. Erkanli Senturk, G., Erkanli, K., Aydin, U., Yucel, D., Isiksacan, N., Ercan, F., et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 40 (2013), 82–88.
56. Fabia, R., Ar'rajab, A., Johansson, M.L., Willen, R., Andersson, R., Molin, G., et al. The effect of exogenous administration of Lactobacillus reuteri R2LC and oat fiber on acetic acid-induced colitis in the rat. Scandinavian Journal of Gastroenterology 28 (1993), 155–162.
57. Fak, F., Backhed, F., Lactobacillus reuteri prevents diet-induced obesity, but not atherosclerosis, in a strain dependent fashion in Apoe −/− Mice. PloS One, 7, 2012, e46837.
58. Farshim, P., Walton, G., Chakrabarti, B., Givens, I., Saddy, D., Kitchen, I., et al. Maternal weaning modulates emotional behavior and regulates the gut-brain axis. Scientific Reports, 6, 2016, 21958.
59. Feldman, R., Monakhov, M., Pratt, M., Ebstein, R.P., Oxytocin pathway genes: Evolutionary ancient system impacting on human affiliation, sociality, and psychopathology. Biological Psychiatry 79 (2016), 174–184.
60. Floch, M.H., Walker, W.A., Sanders, M.E., Nieuwdorp, M., Kim, A.S., Brenner, D.A., et al. Recommendations for probiotic use—2015 update: Proceedings and consensus opinion. Journal of Clinical Gastroenterology 49:Suppl. 1 (2015), S69–S73.
61. Foster, J.A., Mcvey Neufeld, K.A., Gut-brain axis: How the microbiome influences anxiety and depression. Trends in Neurosciences 36:5 (2013), 305–312.
62. Fujimura, K.E., Slusher, N.A., Cabana, M.D., Lynch, S.V., Role of the gut microbiota in defining human health. Expert Review of Anti-Infective Therapy 8 (2010), 435–454.
63. Galley, J.D., Nelson, M.C., Yu, Z., Dowd, S.E., Walter, J., Kumar, P.S., et al. Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota. BMC Microbiology, 14, 2014, 189.
64. Gao, C., Major, A., Rendon, D., Lugo, M., Jackson, V., Shi, Z., et al. Histamine H2 receptor-mediated suppression of intestinal inflammation by probiotic Lactobacillus reuteri. MBio, 6, 2015, e01358-15.
65. Gavrilenko, V.G., Esipov, V.K., Sivozhelezov, K.G., Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin. Morfologiia 124 (2003), 24–27.
66. Gimpl, G., Fahrenholz, F., Gene, C., The oxytocin receptor system: Structure, function, and regulation. Physiological Reviews 81 (2001), 629–683.
67. Gouin, J.P., Carter, C.S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W.B., Loving, T.J., et al. Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology 35 (2010), 1082–1090.
68. Gregor, M.F., Hotamisligil, G.S., Inflammatory mechanisms in obesity. Annual Review of Immunology 29 (2011), 415–445.
69. Gueniche, A., Bastien, P., Ovigne, J.M., Kermici, M., Courchay, G., Chevalier, V., et al. Bifidobacterium longum lysate, a new ingredient for reactive skin. Experimental Dermatology 16 (2010), 511–517.
70. Gurtner, G.C., Werner, S., Barrandon, Y., Longaker, M.T., Wound repair and regeneration. Nature 453 (2008), 314–321.
71. Hamasaki, M.Y., Barbeiro, H.V., Barbeiro, D.F., Cunha, D.M., Koike, M.K., Machado, M.C., et al. Neuropeptides in the brain defense against distant organ damage. Journal of Neuroimmunology 290 (2016), 33–35.
72. Hansenne, I., Louis, C., Martens, H., Dorban, G., Charlet-Renard, C., Peterson, P., et al. Aire and Foxp3 expression in a particular microenvironment for T cell differentiation. Neuroimmunomodulation 16 (2009), 35–44.
73. Hansenne, I., Rasier, G., Pequeux, C., Brilot, F., Renard, C., Breton, C., et al. Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network. Journal of Neuroimmunology 158 (2005), 67–75.
74. Hildebrandt, M.A., Hoffmann, C., Sherrill-Mix, S.A., Keilbaugh, S.A., Hamady, M., Chen, Y.Y., et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology, 137, 2009 1716-24.e1–2.
75. Ho, J.M., Blevins, J.E., Coming full circle: Contributions of central and peripheral oxytocin actions to energy balance. Endocrinology 154 (2013), 589–596.
76. Ho, J.T., Chan, G.C., Li, J.C., Systemic effects of gut microbiota and its relationship with disease and modulation. BMC Immunology, 16, 2015, 21.
77. Hou, C., Zeng, X., Yang, F., Liu, H., Qiao, S., Study and use of the probiotic Lactobacillus reuteri in pigs: A review. Journal of Animal Science and Biotechnology, 6, 2015, 14.
78. Houshmand, F., Faghihi, M., Zahediasl, S., Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats. Peptides 30 (2009), 2301–2308.
79. Hsieh, F.C., Lan, C.C., Huang, T.Y., Chen, K.W., Chai, C.Y., Chen, W.T., et al. Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats. Food & Function 7 (2016), 2374–2388.
80. Huang, W.C., Chen, Y.M., Kan, N.W., Ho, C.S., Wei, L., Chan, C.H., et al. Hypolipidemic effects and safety of Lactobacillus reuteri 263 in a hamster model of hyperlipidemia. Nutrients 7 (2015), 3767–3782.
81. Huseini, H.F., Rahimzadeh, G., Fazeli, M.R., Mehrazma, M., Salehi, M., Evaluation of wound healing activities of kefir products. Burns 38 (2012), 719–723.
82. Ibrahim, Y.M., Kearney, S.M., Levkovich, T., Springer, A., Mirabal, S., Poutahidis, T., et al. Maternal gut microbes control offspring sex and survival. Journal of Probiotics and Health, 2, 2014, 6, 10.4172/2329-8901.1000120.
83. Iseri, S.O., Dusunceli, F., Erzik, C., Uslu, B., Arbak, S., Yegen, B.C., Oxytocin or social housing alleviates local burn injury in rats. Journal of Surgical Research 162 (2010), 122–131.
84. Iseri, S.O., Gedik, I.E., Erzik, C., Uslu, B., Arbak, S., Gedik, N., et al. Oxytocin ameliorates skin damage and oxidant gastric injury in rats with thermal trauma. Burns 34 (2008), 361–369.
85. Iseri, S.O., Sener, G., Saglam, B., Gedik, N., Ercan, F., Yegen, B.C., Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism. Peptides 26 (2005), 483–491.
86. Iseri, S.O., Sener, G., Saglam, B., Gedik, N., Ercan, F., Yegen, B.C., Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils. Journal of Surgical Research 126 (2005), 73–81.
87. Iwasaki, M., Chromatin resetting mechanisms preventing transgenerational inheritance of epigenetic states. Frontiers in Plant Science, 6, 2015, 380.
88. Jankowski, M., Bissonauth, V., Gao, L., Gangal, M., Wang, D., Danalache, B., et al. Anti-inflammatory effect of oxytocin in rat myocardial infarction. Basic Research in Cardiology 105 (2010), 205–218.
89. Jia, H.Y., Liu, J.L., Zhou, C.J., Kong, F., Yuan, M.Z., Sun, W.D., et al. High expression of MICA in human kidney cancer tissue and renal cell carcinoma lines. Asian Pacific Journal of Cancer Prevention 15 (2014), 1715–1717.
90. Johnson, H.M., Torres, B.A., Regulation of lymphokine production by arginine vasopressin and oxytocin: Modulation of lymphocyte function by neurohypophyseal hormones. Journal of Immunology 135 (1985), 773s–775s.
91. Kallus, S.J., Brandt, L.J., The intestinal microbiota and obesity. Journal of Clinical Gastroenterology 46 (2012), 16–24.
92. Kamada, N., Nunez, G., Role of the gut microbiota in the development and function of lymphoid cells. Journal of Immunology 190 (2013), 1389–1395.
93. Karelina, K., Stuller, K.A., Jarrett, B., Zhang, N., Wells, J., Norman, G.J., et al. Oxytocin mediates social neuroprotection after cerebral ischemia. Stroke 42 (2011), 3606–3611.
94. Karimi, K., Inman, M.D., Bienenstock, J., Forsythe, P., Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. American Journal of Respiratory and Critical Care Medicine 179 (2009), 186–193.
95. Kelly, J.R., Clarke, G., Cryan, J.F., Dinan, T.G., Brain-gut-microbiota axis: Challenges for translation in psychiatry. Annals of Epidemiology 26 (2016), 366–372.
96. Knobloch, H.S., Grinevich, V., Evolution of oxytocin pathways in the brain of vertebrates. Frontiers in Behavioral Neuroscience, 8, 2014, 31.
97. Kobyliak, N., Virchenko, O., Falalyeyeva, T., Pathophysiological role of host microbiota in the development of obesity. Nutrition Journal, 15, 2016, 43.
98. Kokko, H., Jennions, M.D., Parental investment, sexual selection and sex ratios. Journal of Evolutionary Biology 21 (2008), 919–948.
99. Koren, O., Goodrich, J.K., Cullender, T.C., Spor, A., Laitinen, K., Backhed, H.K., et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150 (2012), 470–480.
100. Koren, L., Whiteside, D., Fahlman, S., Ruckstuhl, K., Kutz, S., Checkley, S., et al. Cortisol and corticosterone independence in cortisol-dominant wildlife. General and Comparative Endocrinology 177 (2012), 113–119.
101. Kosfeld, M., Heinrichs, M., Zak, P.J., Fischbacher, U., Fehr, E., Oxytocin increases trust in humans. Nature 435 (2005), 673–676.
102. Lakritz, J.R., Poutahidis, T., Levkovich, T., Varian, B.J., Ibrahim, Y.M., Chatzigiagkos, A., et al. Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. International Journal of Cancer 135 (2014), 529–540.
103. Lau, E., Carvalho, D., Pina-Vaz, C., Barbosa, J.A., Freitas, P., Beyond gut microbiota: Understanding obesity and type 2 diabetes. Hormones (Athens, Greece) 14:3 (2015), 358–369.
104. Lee, H.J., Caldwell, H.K., Macbeth, A.H., Tolu, S.G., Young, W.S. 3rd., A conditional knockout mouse line of the oxytocin receptor. Endocrinology 149 (2008), 3256–3263.
105. Lee, H.J., Macbeth, A.H., Pagani, J.H., Young, W.S. 3rd., Oxytocin: The great facilitator of life. Progress in Neurobiology 88 (2009), 127–151.
106. Lee, Y.K., Mazmanian, S.K., Has the microbiota played a critical role in the evolution of the adaptive immune system?. Science 330 (2010), 1768–1773.
107. Lefevre, A., Sirigu, A., The two fold role of oxytocin in social developmental disorders: A cause and a remedy?. Neuroscience and Biobehavioral Reviews 63 (2016), 168–176.
108. Leng, G., Ludwig, M., Intranasal oxytocin: Myths and delusions. Biological Psychiatry 79 (2016), 243–250.
109. Levkovich, T., Poutahidis, T., Smillie, C., Varian, B.J., Ibrahim, Y.M., Lakritz, J.R., et al. Probiotic bacteria induce a ‘glow of health’. PloS One, 8, 2013, e53867.
110. Lin, Y.P., Thibodeaux, C.H., Pena, J.A., Ferry, G.D., Versalovic, J., Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun. Inflammatory Bowel Diseases 14 (2008), 1068–1083.
111. Liu, Y., Fatheree, N.Y., Mangalat, N., Rhoads, J.M., Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation. American Journal of Physiology. Gastrointestinal and Liver Physiology 299 (2010), G1087–G1096.
112. Liu, Y., Fatheree, N.Y., Mangalat, N., Rhoads, J.M., Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology 302 (2012), G608–G617.
113. Livingston, M., Loach, D., Wilson, M., Tannock, G.W., Baird, M., Gut commensal Lactobacillus reuteri 100–23 stimulates an immunoregulatory response. Immunology and Cell Biology 88 (2010), 99–102.
114. Lokrantz, C.M., Uvnas-Moberg, K., Kaplan, J.M., Effects of central oxytocin administration on intraoral intake of glucose in deprived and nondeprived rats. Physiology & Behavior 62 (1997), 347–352.
115. Lorea Baroja, M., Kirjavainen, P.V., Hekmat, S., Reid, G., Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clinical and Experimental Immunology 149 (2007), 470–479.
116. Maccio, A., Madeddu, C., Chessa, P., Panzone, F., Lissoni, P., Mantovani, G., Oxytocin both increases proliferative response of peripheral blood lymphomonocytes to phytohemagglutinin and reverses immunosuppressive estrogen activity. In Vivo 24 (2010), 157–163.
117. Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., Yada, T., Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY) 3 (2011), 1169–1177.
118. Maejima, Y., Sedbazar, U., Suyama, S., Kohno, D., Onaka, T., Takano, E., et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metabolism 10 (2009), 355–365.
119. Manichanh, C., Borruel, N., Casellas, F., Guarner, F., The gut microbiota in IBD. Nature Reviews. Gastroenterology & Hepatology 9 (2012), 599–608.
120. Marchesi, J.R., Adams, D.H., Fava, F., Hermes, G.D., Hirschfield, G.M., Hold, G., et al. The gut microbiota and host health: A new clinical frontier. Gut 65 (2016), 330–339.
121. Matsuura, T., Kawasaki, M., Hashimoto, H., Yoshimura, M., Motojima, Y., Saito, R., et al. Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats. Neuroscience Letters 621 (2016), 104–110.
122. Mayes, T., Gottschlich, M.M., James, L.E., Allgeier, C., Weitz, J., Kagan, R.J., Clinical safety and efficacy of probiotic administration following burn injury. Journal of Burn Care & Research 36 (2015), 92–99.
123. Maynard, C.L., Elson, C.O., Hatton, R.D., Weaver, C.T., Reciprocal interactions of the intestinal microbiota and immune system. Nature 489 (2012), 231–241.
124. Mccabe, L.R., Irwin, R., Schaefer, L., Britton, R.A., Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. Journal of Cellular Physiology 228 (2013), 1793–1798.
125. Mcfall-Ngai, M., Hadfield, M.G., Bosch, T.C., Carey, H.V., Domazet-Loso, T., Douglas, A.E., et al. Animals in a bacterial world, a new imperative for the life sciences. Proceedings of the National Academy of Sciences of the United States of America 110 (2013), 3229–3236.
126. Mechoud, M.A., Mateos, M.V., De Valdez, G.F., Villena, J., Salvador, G.A., Rodriguez, A.V., Lactobacillus reuteri CRL1098 soluble factors modulate tumor necrosis factor alpha production in peripheral blood mononuclear cells: Involvement of lipid rafts. International Immunopharmacology 14 (2012), 446–453.
127. Milani, C., Ferrario, C., Turroni, F., Duranti, S., Mangifesta, M., Van Sinderen, D., et al. The human gut microbiota and its interactive connections to diet. Journal of Human Nutrition and Dietetics, 2016, 10.1111/jhn.12371 [Epub ahead of print].
128. Million, M., Angelakis, E., Maraninchi, M., Henry, M., Giorgi, R., Valero, R., et al. Correlation between body mass index and gut concentrations of Lactobacillus reuteri, Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli. International Journal of Obesity (London) 37:11 (2013), 1460–1466.
129. Million, M., Maraninchi, M., Henry, M., Armougom, F., Richet, H., Carrieri, P., et al. Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. International Journal of Obesity 36 (2012), 817–825.
130. Moghimian, M., Faghihi, M., Karimian, S.M., Imani, A., The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: Role of oxytocin. Stress 15 (2012), 385–392.
131. Molin, G., Jeppsson, B., Johansson, M.L., Ahrne, S., Nobaek, S., Stahl, M., et al. Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines. Journal of Applied Bacteriology 74 (1993), 314–323.
132. Moloney, R.D., Desbonnet, L., Clarke, G., Dinan, T.G., Cryan, J.F., The microbiome: Stress, health and disease. Mammalian Genome 25 (2014), 49–74.
133. Morton, G.J., Thatcher, B.S., Reidelberger, R.D., Ogimoto, K., Wolden-Hanson, T., Baskin, D.G., et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. American Journal of Physiology. Endocrinology and Metabolism 302 (2012), E134–E144.
134. Mozaffarian, D., Hao, T., Rimm, E.B., Willett, W.C., Hu, F.B., Changes in diet and lifestyle and long-term weight gain in women and men. New England Journal of Medicine 364 (2011), 2392–2404.
135. Muchmore, D.B., Little, S.A., De Haen, C., A dual mechanism of action of oxytocin in rat epididymal fat cells. Journal of Biological Chemistry 256 (1981), 365–372.
136. Mullis, K., Kay, K., Williams, D.L., Oxytocin action in the ventral tegmental area affects sucrose intake. Brain Research 1513 (2013), 85–91.
137. Murphy, E.F., Cotter, P.D., Healy, S., Marques, T.M., O'sullivan, O., Fouhy, F., et al. Composition and energy harvesting capacity of the gut microbiota: Relationship to diet, obesity and time in mouse models. Gut 59 (2010), 1635–1642.
138. Nagao-Kitamoto, H., Kitamoto, S., Kuffa, P., Kamada, N., Pathogenic role of the gut microbiota in gastrointestinal diseases. Intestinal Research 14 (2016), 127–138.
139. Nager, R.G., Monaghan, P., Griffiths, R., Houston, D.C., Dawson, R., Experimental demonstration that offspring sex ratio varies with maternal condition. Proceedings of the National Academy of Sciences of the United States of America 96 (1999), 570–573.
140. Nation, D.A., Szeto, A., Mendez, A.J., Brooks, L.G., Zaias, J., Herderick, E.E., et al. Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE −/− mice. Psychosomatic Medicine 72 (2010), 376–382.
141. Neish, A.S., Microbes in gastrointestinal health and disease. Gastroenterology 136 (2009), 65–80.
142. Nieuwdorp, M., Gilijamse, P.W., Pai, N., Kaplan, L.M., Role of the microbiome in energy regulation and metabolism. Gastroenterology 146 (2014), 1525–1533.
143. Niv, E., Naftali, T., Hallak, R., Vaisman, N., The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome—A double blind, placebo-controlled, randomized study. Clinical Nutrition 24 (2005), 925–931.
144. Nomura, T., Sakaguchi, S., Foxp3 and aire in thymus-generated Treg cells: A link in self-tolerance. Nature Immunology 8 (2007), 333–334.
145. Noverr, M.C., Huffnagle, G.B., Does the microbiota regulate immune responses outside the gut?. Trends in Microbiology 12 (2004), 562–568.
146. Oliva, S., Di Nardo, G., Ferrari, F., Mallardo, S., Rossi, P., Patrizi, G., et al. Randomised clinical trial: The effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis. Alimentary Pharmacology & Therapeutics 35 (2012), 327–334.
147. Olson, B.R., Drutarosky, M.D., Chow, M.S., Hruby, V.J., Stricker, E.M., Verbalis, J.G., Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides 12 (1991), 113–118.
148. Olszewski, P.K., Klockars, A., Olszewska, A.M., Fredriksson, R., Schioth, H.B., Levine, A.S., Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake. Endocrinology 151 (2010), 4736–4744.
149. O'toole, P.W., Jeffery, I.B., Gut microbiota and aging. Science 350 (2015), 1214–1215.
150. Peral, M.C., Martinez, M.A., Valdez, J.C., Bacteriotherapy with Lactobacillus plantarum in burns. International Wound Journal 6 (2009), 73–81.
151. Petersson, M., Wiberg, U., Lundeberg, T., Uvnas-Moberg, K., Oxytocin decreases carrageenan induced inflammation in rats. Peptides 22 (2001), 1479–1484.
152. Pittman, Q.J., A neuro-endocrine-immune symphony. Journal of Neuroendocrinology 23 (2011), 1296–1297.
153. Poggi, M., Bastelica, D., Gual, P., Iglesias, M.A., Gremeaux, T., Knauf, C., et al. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50 (2007), 1267–1276.
154. Poutahidis, T., Erdman, S.E., Commensal bacteria modulate the tumor microenvironment. Cancer Letters 380:1 (2016), 356–358.
155. Poutahidis, T., Kearney, S.M., Levkovich, T., Qi, P., Varian, B.J., Lakritz, J.R., et al. Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PloS One, 8(10), 2013, e78898.
156. Poutahidis, T., Kleinewietfeld, M., Erdman, S.E., Gut microbiota and the paradox of cancer immunotherapy. Frontiers in Immunology, 5, 2014, 157.
157. Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., et al. Microbial reprogramming inhibits Western diet-associated obesity. PloS One, 8, 2013, e68596.
158. Poutahidis, T., Springer, A., Levkovich, T., Qi, P., Varian, B.J., Lakritz, J.R., et al. Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice. PloS One, 9, 2014, e84877.
159. Poutahidis, T., Varian, B.J., Levkovich, T., Lakritz, J.R., Mirabal, S., Kwok, C., et al. Dietary microbes modulate transgenerational cancer risk. Cancer Research 75 (2015), 1197–1204.
160. Pryke, S.R., Rollins, L.A., Mothers adjust offspring sex to match the quality of the rearing environment. Proceedings of the Biological Sciences 279 (2012), 4051–4057.
161. Pryke, S.R., Rollins, L.A., Griffith, S.C., Context-dependent sex allocation: Constraints on the expression and evolution of maternal effects. Evolution 65 (2011), 2792–2799.
162. Qian, W., Zhu, T., Tang, B., Yu, S., Hu, H., Sun, W., et al. Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients. Journal of Clinical Endocrinology and Metabolism 99 (2014), 4683–4689.
163. Qiao, Y., Sun, J., Xia, S., Li, L., Li, Y., Wang, P., et al. Effects of different lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model. Journal of Functional Foods 14 (2015), 424–434.
164. Qin, J., Feng, M., Wang, C., Ye, Y., Wang, P.S., Liu, C., Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats. Neurogastroenterology and Motility 21 (2009), 430–438.
165. Rao, V.P., Poutahidis, T., Fox, J.G., Erdman, S.E., Breast cancer: Should gastrointestinal bacteria be on our radar screen?. Cancer Research 67 (2007), 847–850.
166. Rautava, S., Luoto, R., Salminen, S., Isolauri, E., Microbial contact during pregnancy, intestinal colonization and human disease. Nature Reviews. Gastroenterology & Hepatology 9 (2012), 565–576.
167. Ridaura, V.K., Faith, J.J., Rey, F.E., Cheng, J., Duncan, A.E., Kau, A.L., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 341, 2013, 1241214.
168. Rinaman, L., Vollmer, R.R., Karam, J., Phillips, D., Li, X., Amico, J.A., Dehydration anorexia is attenuated in oxytocin-deficient mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 288 (2005), R1791–R1799.
169. Rook, G.A., 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis. Clinical and Experimental Immunology 160 (2010), 70–79.
170. Rook, G.A., Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health. Proceedings of the National Academy of Sciences of the United States of America 110 (2013), 18360–18367.
171. Rosenberg, E., Zilber-Rosenberg, I., Symbiosis and development: The hologenome concept. Birth Defects Research. Part C, Embryo Today 93 (2011), 56–66.
172. Round, J.L., Mazmanian, S.K., The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews. Immunology 9 (2009), 313–323.
173. Salim, H.M., Kang, H.K., Akter, N., Kim, D.W., Kim, J.H., Kim, M.J., et al. Supplementation of direct-fed microbials as an alternative to antibiotic on growth performance, immune response, cecal microbial population, and ileal morphology of broiler chickens. Poultry Science 92 (2013), 2084–2090.
174. Sandrini, S., Aldriwesh, M., Alruways, M., Freestone, P., Microbial endocrinology: Host-bacteria communication within the gut microbiome. Journal of Endocrinology 225 (2015), R21–R34.
175. Schreiber, O., Petersson, J., Phillipson, M., Perry, M., Roos, S., Holm, L., Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions. American Journal of Physiology. Gastrointestinal and Liver Physiology 296 (2009), G534–G542.
176. Shen, H., Neuroscience: The hard science of oxytocin. Nature 522 (2015), 410–412.
177. Sherwin, E., Rea, K., Dinan, T.G., Cryan, J.F., A gut (microbiome) feeling about the brain. Current Opinion in Gastroenterology 32 (2016), 96–102.
178. Shoelson, S.E., Herrero, L., Naaz, A., Obesity, inflammation, and insulin resistance. Gastroenterology 132 (2007), 2169–2180.
179. Simon, M.C., Strassburger, K., Nowotny, B., Kolb, H., Nowotny, P., Burkart, V., et al. Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: A proof of concept. Diabetes Care 38 (2015), 1827–1834.
180. Singh, T.P., Malik, R.K., Katkamwar, S.G., Kaur, G., Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet. International Journal of Food Science and Nutrition 66 (2015), 71–75.
181. Smits, H.H., Engering, A., Van Der Kleij, D., De Jong, E.C., Schipper, K., Van Capel, T.M., et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. Journal of Allergy and Clinical Immunology 115 (2005), 1260–1267.
182. Smolinsky, A.N., Bergner, C.L., Laporte, J.L., Kalueff, A.V., Analysis of grooming behavior and its utility in studying animal stress, anxiety, and depression. Neuromethods 42 (2009), 21–36.
183. Sommer, F., Backhed, F., The gut microbiota—Masters of host development and physiology. Nature Reviews. Microbiology 11 (2013), 227–238.
184. Sommer, F., Stahlman, M., Ilkayeva, O., Arnemo, J.M., Kindberg, J., Josefsson, J., et al. The gut microbiota modulates energy metabolism in the hibernating brown bear Ursus arctos. Cell Reports 14 (2016), 1655–1661.
185. Sonnenburg, E.D., Smits, S.A., Tikhonov, M., Higginbottom, S.K., Wingreen, N.S., Sonnenburg, J.L., Diet-induced extinctions in the gut microbiota compound over generations. Nature 529 (2016), 212–215.
186. Souza-Moreira, L., Campos-Salinas, J., Caro, M., Gonzalez-Rey, E., Neuropeptides as pleiotropic modulators of the immune response. Neuroendocrinology 94 (2011), 89–100.
187. Spetter, M.S., Hallschmid, M., Intranasal neuropeptide administration to target the human brain in health and disease. Molecular Pharmaceutics 12 (2015), 2767–2780.
188. Stilling, R.M., Dinan, T.G., Cryan, J.F., The brain's Geppetto-microbes as puppeteers of neural function and behaviour?. Journal of Neurovirology 22 (2016), 14–21.
189. Sun, J., Qiao, Y., Qi, C., Jiang, W., Xiao, H., Shi, Y., et al. High-fat-diet-induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches. Nutrition 32 (2016), 265–272.
190. Sun, L., Tamma, R., Yuen, T., Colaianni, G., Ji, Y., Cuscito, C., et al. Functions of vasopressin and oxytocin in bone mass regulation. Proceedings of the National Academy of Sciences of the United States of America 113 (2016), 164–169.
191. Szajewska, H., Urbanska, M., Chmielewska, A., Weizman, Z., Shamir, R., Meta-analysis: Lactobacillus reuteri strain DSM 17938 (and the original strain ATCC 55730) for treating acute gastroenteritis in children. Beneficial Microbes 5 (2014), 285–293.
192. Szeto, A., Nation, D.A., Mendez, A.J., Dominguez-Bendala, J., Brooks, L.G., Schneiderman, N., et al. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. American Journal of Physiology. Endocrinology and Metabolism 295 (2008), E1495–E1501.
193. Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., Nishimori, K., Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport 19 (2008), 951–955.
194. Tamma, R., Colaianni, G., Zhu, L.L., Dibenedetto, A., Greco, G., Montemurro, G., et al. Oxytocin is an anabolic bone hormone. Proceedings of the National Academy of Sciences of the United States of America 106 (2009), 7149–7154.
195. Taranto, M.P., Medici, M., Perdigon, G., Ruiz Holgado, A.P., Valdez, G.F., Evidence for hypocholesterolemic effect of Lactobacillus reuteri in hypercholesterolemic mice. Journal of Dairy Science 81 (1998), 2336–2340.
196. Taylor, A.E., Lee, H.E., Buisman-Pijlman, F.T., Oxytocin treatment in pediatric populations. Frontiers in Behavioral Neuroscience, 8, 2014, 360.
197. Ting, W.J., Kuo, W.W., Kuo, C.H., Yeh, Y.L., Shen, C.Y., Chen, Y.H., et al. Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function. British Journal of Nutrition 114 (2015), 706–712.
198. Tremaroli, V., Backhed, F., Functional interactions between the gut microbiota and host metabolism. Nature 489 (2012), 242–249.
199. Trivers, R.L., Willard, D.E., Natural selection of parental ability to vary the sex ratio of offspring. Science 179 (1973), 90–92.
200. Turnbaugh, P.J., Hamady, M., Yatsunenko, T., Cantarel, B.L., Duncan, A., Ley, R.E., et al. A core gut microbiome in obese and lean twins. Nature 457:7228 (2009), 480–484.
201. Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006), 1027–1031.
202. Urbanska, M., Gieruszczak-Bialek, D., Szajewska, H., Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children. Alimentary Pharmacology & Therapeutics 43 (2016), 1025–1034.
203. Uvnas-Moberg, K., Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 23 (1998), 819–835.
204. Varian, B.J., Goureshetti, S., Poutahidis, T., Lakritz, J.R., Levkovich, T., Kwok, C., et al. Beneficial bacteria inhibit cachexia. Oncotarget 7 (2016), 11803–11816.
205. Varian, B.J., Levkovich, T., Poutahidis, T., Ibrahim, Y.M., Perrotta, A., Alm, E.J., et al. Beneficial dog bacteria up-regulate oxytocin and lower risk of obesity. Journal of Probiotics & Health 4 (2016), 1–9.
206. Varian, B.J., Poutahidis, T., Levkovich, T., Ibrahim, Y.M., Lakritz, J.R., Chatzigiagkos, A., et al. Beneficial bacteria stimulate youthful thyroid gland activity. Journal of Obesity and Weight Loss Therapy 4 (2014), 1–8.
207. Viero, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., et al. REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy. CNS Neuroscience & Therapeutics 16 (2010), e138–e156.
208. Vijay-Kumar, M., Aitken, J.D., Carvalho, F.A., Cullender, T.C., Mwangi, S., Srinivasan, S., et al. Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 328 (2010), 228–231.
209. Vila, I.K., Badin, P.M., Marques, M.A., Monbrun, L., Lefort, C., Mir, L., et al. Immune cell toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis. Cell Reports 7 (2014), 1116–1129.
210. Vitalo, A., Fricchione, J., Casali, M., Berdichevsky, Y., Hoge, E.A., Rauch, S.L., et al. Nest making and oxytocin comparably promote wound healing in isolation reared rats. PloS One, 4, 2009, e5523.
211. Walter, J., Britton, R.A., Roos, S., Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm. Proceedings of the National Academy of Sciences of the United States of America 108:Suppl. 1 (2011), 4645–4652.
212. Walters, W.A., Caporaso, J.G., Lauber, C.L., Berg-Lyons, D., Fierer, N., Knight, R., PrimerProspector: De novo design and taxonomic analysis of barcoded polymerase chain reaction primers. Bioinformatics 27 (2011), 1159–1161.
213. Wang, P., Yang, H.P., Tian, S., Wang, L., Wang, S.C., Zhang, F., et al. Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity. Journal of Neuroimmunology 289 (2015), 152–161.
214. Welch, M.G., Margolis, K.G., Li, Z., Gershon, M.D., Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology 307 (2014), G848–G862.
215. Wong, V.W., Martindale, R.G., Longaker, M.T., Gurtner, G.C., From germ theory to germ therapy: Skin microbiota, chronic wounds, and probiotics. Plastic and Reconstructive Surgery 132 (2013), 854e–861e.
216. Woting, A., Blaut, M., The intestinal microbiota in metabolic disease. Nutrients, 8(4), 2016, 202.
217. Wu, C.L., Hung, C.R., Chang, F.Y., Pau, K.Y., Wang, P.S., Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn-Schmiedeberg's Archives of Pharmacology 367 (2003), 406–413.
218. Yanai, H., Budovsky, A., Tacutu, R., Fraifeld, V.E., Is rate of skin wound healing associated with aging or longevity phenotype?. Biogerontology 12 (2011), 591–597.
219. Yang, H.P., Wang, L., Han, L., Wang, S.C., Nonsocial functions of hypothalamic oxytocin. ISRN Neuroscience, 2013, 2013, 179272.
220. Yoo, J.Y., Kim, S.S., Probiotics and prebiotics: Present status and future perspectives on metabolic disorders. Nutrients 8 (2016), 173–193.
221. Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L.J., Onaka, T., et al. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. Journal of Neuroscience 29 (2009), 2259–2271.
222. Yosten, G.L., Samson, W.K., The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 298 (2010), R1642–R1647.
223. Young, W.S. III, Gainer, H., Vasopressin/oxytocin and receptors. Squire, L.R., (eds.) Encyclopedia of neuroscience, 1st ed., 2009, Academic Press, Oxford.
224. Yuan, L., Liu, S., Bai, X., Gao, Y., Liu, G., Wang, X., et al. Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice. Journal of Neuroinflammation, 13, 2016, 77.
225. Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron 69 (2011), 523–535.
226. Zhang, G., Cai, D., Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. American Journal of Physiology. Endocrinology and Metabolism 301 (2011), E1004–E1012.
227. Zhang, J., Motyl, K.J., Irwin, R., Macdougald, O.A., Britton, R.A., Mccabe, L.R., Loss of bone and Wnt10b expression in male type 1 diabetic mice is blocked by the probiotic Lactobacillus reuteri. Endocrinology 156 (2015), 3169–3182.
228. Zhang, H., Wu, C., Chen, Q., Chen, X., Xu, Z., Wu, J., et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PloS One 8 (2013), 1–11.
229. Zingg, H.H., Laporte, S.A., The oxytocin receptor. Trends in Endocrinology and Metabolism 14 (2003), 222–227.