Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 6, 2008, Pages

  Szeto, Angela ^a   Nation, Daniel A ^a   Mendez, Armando J ^b   Dominguez Bendala, Juan ^b   Brooks, Larry G ^a   Schneiderman, Neil ^a   McCabe, Philip M ^a  

^a Department of Biology   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Interleukin 6; Reduced nicotinamide adenine dinucleotide phosphatase oxidase

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; OXYTOCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE;

AORTA MEDIA; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; HORMONAL REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE ACTIVATION; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL;

CELL DIFFERENTIATION; ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MONOCYTES; NADP; NADPH OXIDASE; OXYTOCIN; PHOSPHORYLATION; RECEPTORS, OXYTOCIN; SUPEROXIDES;

EID: 57349088269     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90718.2008     Document Type: Article

References (38)

1. Amico JA, Seif SM, Robinson AG. Oxytocin in human plasma: correlation with neurophysin and stimulation with estrogen. J Clin Endocrinol Metab 52: 988-993, 1981.
2. Bayraktutan U, Draper N, Lang D, Shah AM. Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells. Cardiovasc Res 38: 256-262, 1998.
3. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844, 2000.
4. Carter CS, Williams JR, Witt DM, Insel TR. Oxytocin and social bonding. Ann NY Acad Sci 652: 204-211, 1992.
5. Clodi M, Vila G, Geyeregger R, Riedl M, Stulnig TM, Struck J, Luger TA, Luger A. Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. Am J Physiol Endocrinol Metab 295: E686-E691, 2008.
6. Detillion CE, Craft TK, Glasper ER, Prendergast BJ, DeVries AC. Social facilitation of wound healing. Psychoneuroendocrinology 29: 1004-1011, 2004.
7. Devost D, Zingg HH. Novel in vitro system for functional assessment of oxytocin action. Am J Physiol Endocrinol Metab 292: E1-E6, 2007.
8. Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT. Social amnesia in mice lacking the oxytocin gene. Nat Genet 25: 284-288, 2000.
9. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994.
10. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000.
11. Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM. Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart. Proc Natl Acad Sci USA 94: 11704-11709, 1997.
12. Iseri SO, Sener G, Saglam B, Gedik N, Ercan F, Yegen BC. Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism. Peptides 26: 483-491, 2005.
13. Iseri SO, Sener G, Saglam B, Gedik N, Ercan F, Yegen BC. Oxytocin protects against sepsis-induced multiple organ damage: role of neutrophils. J Surg Res 126: 73-81, 2005.
14. Jankowski M, Hajjar F, Kawas SA, Mukaddam-Daher S, Hoffman G, McCann SM, Gutkowska J. Rat heart: a site of oxytocin production and action. Proc Natl Acad Sci USA 95: 14558-14563, 1998.
15. Jankowski M, Wang D, Hajjar F, Mukaddam-Daher S, McCann SM, Gutkowska J. Oxytocin and its receptors are synthesized in the rat vasculature. Proc Natl Acad Sci USA 97: 6207-6211, 2000.
16. Kimura T. Investigation of the oxytocin receptor at the molecular level. Adv Exp Med Biol 395: 259-268, 1995.
17. Kimura T, Makino Y, Bathgate R, Ivell R, Nobunaga T, Kubota Y, Kumazawa I, Saji F, Murata Y, Nishihara T, Hashimoto M, Kinoshita M. The role of N-terminal glycosylation in the human oxytocin receptor. Mol Hum Reprod 3: 957-963, 1997.
18. Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H. Structure and expression of a human oxytocin receptor. Nature 356: 526-529, 1992.
19. Kojro E, Hackenberg M, Zsigo J, Fahrenholz F. Identification and enzymatic deglycosylation of the myometrial oxytocin receptor using a radioiodinated photoreactive antagonist. J Biol Chem 266: 21416-21421, 1991.
20. Kramer KM, Cushing BS, Carter CS, Wu J, Ottinger MA. Sex and species differences in plasma oxytocin using an enzyme immunoassay. Canad J Zool 82: 1194-1200, 2004.
21. Li JM, Shah AM. Differential NADPH- versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidase. Cardiovasc Res 52: 477-486, 2001.
22. Li JM, Shah AM. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol 287: R1014-R1030, 2004.
23. Li Y, Zhu H, Kuppusamy P, Roubaud V, Zweier JL, Trush MA. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J Biol Chem 273: 2015-2023, 1998.
24. McCabe PM, Gonzales JA, Zaias J, Szeto A, Kumar M, Herron AJ, Schneiderman N. Social environment influences the progression of atherosclerosis in the watanabe heritable hyperlipidemic rabbit. Circulation 105: 354-359, 2002.
25. Moosmann B, Behl C. Secretory peptide hormones are biochemical antioxidants: structure-activity relationship. Mol Pharmacol 61: 260-268, 2002.
26. Nation DA, Gonzales JA, Mendez AJ, Zaias J, Szeto A, Brooks LG, Paredes J, D'Angola A, Schneiderman N, McCabe PM. The effect of social environment on markers of vascular oxidative stress and inflammation in the Watanabe heritable hyperlipidemic rabbit. Psychosom Med 70: 269-275, 2008.
27. Paredes J, Szeto A, Levine JE, Zaias J, Gonzales JA, Mendez AJ, Llabre MM, Schneiderman N, McCabe PM. Social experience influences hypothalamic oxytocin in the WHHL rabbit. Psychoneuroendocrinology 31: 1062-1075, 2006.
28. Petersson M, Wiberg U, Lundeberg T, Uvnas-Moberg K. Oxytocin decreases carrageenan induced inflammation in rats. Peptides 22: 1479 1484, 2001.
29. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126, 1999.
30. Schmid B, Wong S, Mitchell BF. Transcriptional regulation of oxytocin receptor by interleukin-1beta and interleukin-6. Endocrinology 142: 1380-1385, 2001.
31. Spangelo BL, deHoll PD, Kalabay L, Bond BR, Arnaud P. Neuro-intermediate pituitary lobe cells synthesize and release interleukin-6 in vitro: effects of lipopolysaccharide and interleukin-1 beta. Endocrinology 135: 556-563, 1994.
32. Strakova Z, Copland JA, Lolait SJ, Soloff MS. ERK2 mediates oxytocin-stimulated PGE2 synthesis. Am J Physiol Endocrinol Metab 274: E634-E641, 1998.
33. Thibonnier M, Conarty DM, Preston JA, Plesnicher CL, Dweik RA, Erzurum SC. Human vascular endothelial cells express oxytocin receptors. Endocrinology 140: 1301-1309, 1999.
34. Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer 26: 171-176, 1980.
35. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH, Skatchkov M, Heitzer T, Stasch JP, Griendling KK, Harrison DG, Bohm M, Meinertz T, Munzel T. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation 99: 2027-2033, 1999.
36. Windle RJ, Shanks N, Lightman SL, Ingram CD. Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 138: 2829-2834, 1997.
37. Yazawa H, Hirasawa A, Horie K, Saita Y, Iida E, Honda K, Tsujimoto G. Oxytocin receptors expressed and coupled to Ca2+ signalling in a human vascular smooth muscle cell line. Br J Pharmacol 117: 799-804, 1996.
38. Zhong M, Yang M, Sanborn BM. Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbeta-gamma and epidermal growth factor receptor tyrosine kinase activation. Endocrinology 144: 2947-2956, 2003.