Coming full circle: Contributions of central and peripheral oxytocin actions to energy balance

Endocrinology

Volumn 154, Issue 2, 2013, Pages 589-596

  Ho, Jacqueline M ^a   Blevins, James E ^a  

^a not available

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; OXYTOCIN; OXYTOCIN RECEPTOR;

ADIPOCYTE; BODY MASS; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; CORE TEMPERATURE; ENERGY BALANCE; ENERGY EXPENDITURE; FAT MASS; FOOD INTAKE; HEART RATE; HUMAN; HYPERPHAGIA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; OXYTOCIN BLOOD LEVEL; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; SATIETY; SHORT SURVEY; SOLITARY TRACT NUCLEUS; VAGUS NERVE DORSAL NUCLEUS; WEIGHT REDUCTION;

EID: 84872707009     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1751     Document Type: Short Survey

References (100)

1. Dale HH. On some physiological actions of ergot. J Physiol. 1906;34:163-206.
2. Insel TR. The challenge of translation in social neuroscience: A review of oxytocin, vasopressin, and affiliative behavior. Neuron. 2010;65:768-779.
3. McCall C, Singer T. The animal and human neuroendocrinology of social cognition, motivation and behavior. Nat Neurosci. 2012;15:681-688.
4. Ferguson JN, Young LJ, Insel TR. The neuroendocrine basis of social recognition. Front Neuroendocrinol. 2002;23:200-224. (Pubitemid 34309926)
5. Ludwig M. Dendritic release of vasopressin and oxytocin. J Neuroendocrinol. 1998;10:881-895. (Pubitemid 28544798)
6. Bergquist F, Ludwig M. Dendritic transmitter release: A comparison of two model systems. J Neuroendocrinol. 2008;20:677-686. (Pubitemid 351858717)
7. Arletti R, Benelli A, Bertolini A. Influence of oxytocin on feeding behavior in the rat. Peptides. 1989;10:89-93. (Pubitemid 19108042)
8. Zhang G, Cai D. Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. Am J Physiol Endocrinol Metab. 2011;301:E1004-E1012.
9. Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR. Oxytocin deficiency mediates hyperphagic obesity of sim1 haploinsufficient mice. Mol Endocrinol. 2008;22:1723-1734. (Pubitemid 351920403)
10. Johnstone LE, Fong TM, Leng G. Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell Metab. 2006;4:313-321. (Pubitemid 44430912)
11. Verbalis JG, McCann MJ, McHale CM, Stricker EM. Oxytocin secretion in response to cholecystokinin and food: Differentiation of nausea from satiety. Science. 1986;232:1417-1419. (Pubitemid 16059395)
12. Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR, Kublaoui BM. Postnatal sim1 deficiency causes hyperphagic obesity and reduced mc4r and oxytocin expression. J Neurosci. 2010;30:3803-3812.
13. Holder JL Jr, Butte NF, Zinn AR. Profound obesity associated with a balanced translocation that disrupts the sim1 gene. Hum Mol Genet. 2000;9:101-108. (Pubitemid 30145294)
14. Swarbrick MM, Evans DS, Valle MI, et al. Replication and extension of association between common genetic variants in sim1 and human adiposity. Obesity (Silver Spring). 2011;19:2394-2403.
15. Swaab DF, Purba JS, Hofman MA. Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in prader-willi syndrome: A study of five cases. J Clin Endocrinol Metab. 1995;80:573-579.
16. Ebstein RP, Knafo A, Mankuta D, Chew SH, Lai PS. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav. 2012;61:359-379.
17. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81:629-683. (Pubitemid 32267075)
18. Sanborn BM, Dodge K, Monga M, Qian A, Wang W, Yue C. Molecular mechanisms regulating the effects of oxytocin on myometrial intracellular calcium. Adv Exp Med Biol. 1998;449:277-286.
19. Blouet C, Jo YH, Li X, Schwartz GJ. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J Neurosci. 2009;29:8302-8311.
20. Lokrantz CM, Uvnas-Moberg K, Kaplan JM. Effects of central oxytocin administration on intraoral intake of glucose in deprived and nondeprived rats. Physiol Behav. 1997;62:347-352. (Pubitemid 27326905)
21. Olszewski PK, Klockars A, Olszewska AM, Fredriksson R, Schioth HB, Levine AS. Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake. Endocrinology. 2010;151:4736-4744.
22. Blevins JE, Schwartz MW, Baskin DG. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol. 2004;287:R87-R96. (Pubitemid 38856314)
23. Sawchenko PE. Evidence for differential regulation of corticotropin-releasing factor and vasopressin immunoreactivities in parvocellular neurosecretory and autonomic-related projections of the paraventricular nucleus. Brain Res. 1987;437:253-263. (Pubitemid 18016213)
24. Sawchenko PE, Swanson LW. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol. 1982;205:260-272. (Pubitemid 12135370)
25. Crawley JN, Schwaber JS. Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin. Peptides. 1983;4:743-747. (Pubitemid 14223725)
26. Raybould HE, Gayton RJ, Dockray GJ. CNS effects of circulating CCK8: involvement of brainstem neurones responding to gastric distension. Brain Res. 1985;342:187-190. (Pubitemid 16242885)
27. Reidelberger RD. Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats. Am J Physiol. 1992;263:R1354-R1358. (Pubitemid 23019137)
28. Ritter RC, Ladenheim EE. Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin. Am J Physiol. 1985;248:R501-R504. (Pubitemid 15058771)
29. Smith GP, Jerome C, Cushin BJ, Eterno R, Simansky KJ. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science. 1981;213:1036-1037.
30. Smith GP, Jerome C, Norgren R. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol. 1985;249:R638-R641. (Pubitemid 16204020)
31. Ohlsson B, Forsling ML, Rehfeld JF, Sjolund K. Cholecystokinin stimulation leads to increased oxytocin secretion in women. Eur J Surg. 2002;168:114-118. (Pubitemid 34478216)
32. Verbalis JG, Stricker EM, Robinson AG, Hoffman GE. Cholecystokinin activates c-fos expression in hypothalamic oxytocin and corticotropin-releasing hormone neurons. J Neuroendocrinol. 1991;3:205-213.
33. Renaud LP, Tang M, McCann MJ, Stricker EM, Verbalis JG. Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus. Am J Physiol. 1987;253:R661-R665.
34. Miaskiewicz SL, Stricker EM, Verbalis JG. Neurohypophyseal secretion in response to cholecystokinin but not meal-induced gastric distention in humans. J Clin Endocrinol Metab. 1989;68:837-843. (Pubitemid 19089018)
35. Peters JH, McDougall SJ, Kellett DO, Jordan D, Llewellyn-Smith IJ, Andresen MC. Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus. J Neurosci. 2008;28:11731-11740.
36. Kirchgessner AL, Sclafani A. PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome. Physiol Behav. 1988;42:517-528.
37. Blevins JE, Eakin TJ, Murphy JA, Schwartz MW, Baskin DG. Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin. Brain Res. 2003;993:30-41. (Pubitemid 37464580)
38. Baskin DG, Kim F, Gelling RW, et al. A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain. Endocrinology. 2010;151:4207-4213.
39. Douglas AJ, Johnstone LE, Leng G. Neuroendocrine mechanisms of change in food intake during pregnancy: a potential role for brain oxytocin. Physiol Behav. 2007;91:352-365. (Pubitemid 47016534)
40. Qi J, Yang JY, Wang F, Zhao YN, Song M, Wu CF. Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement. Neuropharmacology. 2009;56:856-865.
41. Qi J, Yang JY, Song M, Li Y, Wang F, Wu CF. Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice. Naunyn Schmiedebergs Arch Pharmacol. 2008;376:441-448.
42. Baracz SJ, Rourke PI, Pardey MC, Hunt GE, McGregor IS, Cornish JL. Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference. Behav Brain Res. 2012;228:185-193.
43. Carson DS, Hunt GE, Guastella AJ, et al. Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addict Biol. 2010;15:448-463.
44. Deblon N, Veyrat-Durebex C, Bourgoin L, et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One. 2011;6:e25565.
45. Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY). 2011;3:1169-1177.
46. Rinaman L, Vollmer RR, Karam J, Phillips D, Li X, Amico JA. Dehydration anorexia is attenuated in oxytocin-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1791-R1799. (Pubitemid 40720730)
47. Camerino C. Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity (Silver Spring). 2009;17:980-984.
48. Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K. Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport. 2008;19:951-955.
49. Morton GJ, Thatcher BS, Reidelberger RD, Ogimoto K, Wolden-Hanson T, Baskin DG, Schwartz MW, Blevins JE. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2012;302:E134-E144.
50. Lee HJ, Caldwell HK, Macbeth AH, Tolu SG, Young WS 3rd. A conditional knockout mouse line of the oxytocin receptor. Endocrinology. 2008;149:3256-3263. (Pubitemid 351919570)
51. Qin J, Feng M, Wang C, Ye Y, Wang PS, Liu C. Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats. Neurogastroenterol Motil. 2009;21:430-438.
52. Petring OU. The effect of oxytocin on basal and pethidine-induced delayed gastric emptying. Br J Clin Pharmacol. 1989;28:329-332.
53. Hashmonai M, Torem S, Argov S, Barzilai A, Schramek A. Prolonged post-vagotomy gastric atony treated by oxytocin. Br J Surg. 1979;66:550-551. (Pubitemid 10097538)
54. + currents and smooth muscle contraction of guinea-pig gastric antrum. Eur J Endocrinol. 1997;136:531-538.
55. Flanagan LM, Olson BR, Sved AF, Verbalis JG, Stricker EM. Gastric motility in conscious rats given oxytocin and an oxytocin antagonist centrally. Brain Res. 1992;578:256-260.
56. Wu CL, Hung CR, Chang FY, Pau KY, Wang JL, Wang PS. Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats. Pflugers Arch. 2002;445:187-193. (Pubitemid 35447513)
57. Wu CL, Hung CR, Chang FY, Pau KY, Wang PS. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:406-413. (Pubitemid 36535309)
58. Zhang G, Bai H, Zhang H, et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011;69:523-535.
59. Yoshida M, Takayanagi Y, Inoue K, et al. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci. 2009;29:2259-2271.
60. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience. 2002;110:515-526. (Pubitemid 34242779)
61. Jansen AS, Wessendorf MW, Loewy AD. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res. 1995;683:1-24.
62. Klassen GA, Rubin JW, McGregor M. The effect of synthetic oxytocin on impaired atrioventricular conduction. Am J Cardiol. 1963;12:523-526.
63. Panisset JC, Beaulnes A. The effect of oxytocin on experimental cardiac arrhythmias. Rev Can Biol. 1961;20:47-53.
64. Yashpal K, Gauthier S, Henry JL. Oxytocin administered intrathecally preferentially increases heart rate rather than arterial pressure in the rat. J Auton Nerv Syst. 1987;20:167-178. (Pubitemid 17144288)
65. Ochedalski T, Subburaju S, Wynn PC, Aguilera G. Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. J Neuroendocrinol. 2007;19:189-197. (Pubitemid 46210946)
66. Yu Q, Ji R, Gao X, et al. Oxytocin is expressed by both intrinsic sensory and secretomotor neurons in the enteric nervous system of guinea pig. Cell Tissue Res. 2011;344:227-237.
67. McCann MJ, Rogers RC. Oxytocin excites gastric-related neurones in rat dorsal vagal complex. J Physiol. 1990;428:95-108. (Pubitemid 20313647)
68. Gould BR, Zingg HH. Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-lacz reporter mouse. Neuroscience. 2003;122:155-167.
69. Tsuda T, Ueno Y, Yoshikawa T, Kojo H, Osawa T. Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochem Pharmacol. 2006;71:1184-1197. (Pubitemid 43357899)
70. Schaffler A, Binart N, Scholmerich J, Buchler C. Hypothesis paper brain talks with fat-evidence for a hypothalamic-pituitary-adipose axis? Neuropeptides. 2005;39:363-367. (Pubitemid 41073616)
71. Elabd C, Basillais A, Beaupied H, et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells. 2008;26:2399-2407.
72. Muchmore DB, Little SA, de Haen C. A dual mechanism of action of ocytocin in rat epididymal fat cells. J Biol Chem. 1981;256:365-372. (Pubitemid 12207120)
73. Gao ZY, Drews G, Henquin JC. Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets. Biochem J. 1991;276(Pt 1):169-174.
74. Dunning BE, Moltz JH, Fawcett CP. Modulation of insulin and glucagon secretion from the perfused rat pancreas by the neurohypophysial hormones and by desamino-D-arginine vasopressin (DDAVP). Peptides. 1984;5:871-875. (Pubitemid 15202585)
75. Bjorkstrand E, Eriksson M, Uvnas-Moberg K. Evidence of a peripheral and a central effect of oxytocin on pancreatic hormone release in rats. Neuroendocrinology. 1996;63:377-383. (Pubitemid 26117204)
76. Benelli A, Bertolini A, Arletti R. Oxytocin-induced inhibition of feeding and drinking: no sexual dimorphism in rats. Neuropeptides. 1991;20:57-62.
77. Arletti R, Benelli A, Bertolini A. Oxytocin inhibits food and fluid intake in rats. Physiol Behav. 1990;48:825-830.
78. Hicks C, Jorgensen W, Brown C, et al. The nonpeptide oxytocin receptor agonist way 267,464: Receptor-binding profile, prosocial effects and distribution of c-fos expression in adolescent rats. J Neuroendocrinol. 2012;24:1012-1029.
79. Harris MC, Jones PM, Robinson IC. Differences in the release of oxytocin into the blood and cerebrospinal fluid following hypothalamic and pituitary stimulation in rats. J Physiol (London). 1981;320:109-110.
80. Rinaman L. Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol. 1998;399:101-109. (Pubitemid 28391557)
81. Tung YC, Ma M, Piper S, Coll A, O'Rahilly S, Yeo GS. Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus. J Neurosci. 2008;28:12419-12426.
82. Liu H, Kishi T, Roseberry AG, et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci. 2003;23:7143-7154. (Pubitemid 36975878)
83. Yosten GL, Samson WK. The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1642-R1647.
84. Jankowski M, Hajjar F, Kawas SA, et al. Rat heart: a site of oxytocin production and action. Proc Natl Acad Sci U S A. 1998;95:14558-14563. (Pubitemid 28549406)
85. Ermisch A, Barth T, Ruhle HJ, Skopkova J, Hrbas P, Landgraf R. On the blood-brain barrier to peptides: accumulation of labelled vasopressin, desglynh2-vasopressin and oxytocin by brain regions. Endocrinol Exp. 1985;19:29-37. (Pubitemid 15062320)
86. Mens WB, Witter A, van Wimersma Greidanus TB. Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Res. 1983;262:143-149. (Pubitemid 13188658)
87. Maejima Y, Sedbazar U, Suyama S, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab. 2009;10:355-365.
88. Klein U, Fahrenholz F. Reconstitution of the myometrial oxytocin receptor into proteoliposomes. Dependence of oxytocin binding on cholesterol. Eur J Biochem. 1994;220:559-567. (Pubitemid 24092824)
89. Gimpl G, Klein U, Reilander H, Fahrenholz F. Expression of the human oxytocin receptor in baculovirus-infected insect cells: high-affinity binding is induced by a cholesterol-cyclodextrin complex. Biochemistry. 1995;34:13794-13801.
90. Evans JJ, Forrest-Owen W, McArdle CA. Oxytocin receptor-mediated activation of phosphoinositidase C and elevation of cytosolic calcium in the gonadotrope-derived αT3-1 cell line. Endocrinology. 1997;138:2049-2055. (Pubitemid 27180824)
91. Petersson M, Uvnas-Moberg K. Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood. Neurosci Lett. 2008;440:166-169.
92. Costa-E-Sousa RH, Pereira-Junior PP, Oliveira PF, et al. Cardiac effects of oxytocin: is there a role for this peptide in cardiovascular homeostasis? Regul Pept. 2005;132:107-112.
93. Hobo S, Hayashida K, Eisenach JC. Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg. 2012;114:442-449.
94. Fuchs AR, Fuchs F, Husslein P, Soloff MS, Fernstrom MJ. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science. 1982;215:1396-1398. (Pubitemid 12129721)
95. Murata T, Murata E, Liu CX, Narita K, Honda K, Higuchi T. Oxytocin receptor gene expression in rat uterus: Regulation by ovarian steroids. J Endocrinol. 2000;166:45-52. (Pubitemid 30435873)
96. Norman GJ, Cacioppo JT, Morris JS, Malarkey WB, Berntson GG, Devries AC. Oxytocin increases autonomic cardiac control: Moderation by loneliness. Biol Psychol. 2011;86:174-180.
97. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005;435:673-676. (Pubitemid 40825511)
98. Guastella AJ, Mitchell PB, Mathews F. Oxytocin enhances the encoding of positive social memories in humans. Biol Psychiatry. 2008;64:256-258.
99. De Dreu CK, Greer LL, Handgraaf MJ, et al. The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science. 2010;328:1408-1411.
100. Feifel D, Macdonald K, Nguyen A, et al. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol Psychiatry. 2010;68:678-680.