Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 12, 2014, Pages 4683-4689

  Qian, Weiyun ^a   Zhu, Tianyi ^a   Tang, Bingqian ^a   Yu, Shuqin ^a   Hu, Hao ^a   Sun, Wenjun ^a   Pan, Ruirong ^a   Wang, Jifang ^a   Wang, Dong ^a   Yang, Ling ^a   Mao, Chaoming ^a   Zhou, Libin ^b   Yuan, Guoyue ^a  

^a JIANGSU UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; GLYCOLIPID; HIGHLY SENSITIVE C REACTIVE PROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYTOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLYCOSYLATED HEMOGLOBIN;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OXYTOCIN BLOOD LEVEL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; WAIST CIRCUMFERENCE; WAIST HIP RATIO; AGED; BLOOD; METABOLISM; MIDDLE AGED; PANCREAS FUNCTION TEST; PATHOLOGY; PHYSIOLOGY;

ADIPOSITY; ADULT; AGED; C-REACTIVE PROTEIN; DIABETES MELLITUS, TYPE 2; FEMALE; GLYCOLIPIDS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; OBESITY; OXYTOCIN; PANCREATIC FUNCTION TESTS;

EID: 84916613594     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2206     Document Type: Article

References (30)

1. Sarnyai Z, Kovács GL. Oxytocin in learning and addiction: From early discoveries to the present. Pharmacol Biochem Behav. 2014;119:3-9.
2. Robinson DA, Wei F, Wang GD, et al. Oxytocin mediates stress-induced analgesia in adult mice. J Physiol. 2002;540:593-606.
3. Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT. Social amnesia in mice lacking the oxytocin gene. Nat Genet. 2000;25:284-288.
4. Gil M, Bhatt R, Picotte KB, Hull EM. Sexual experience increases oxytocin receptor gene expression and protein in the medial preoptic area of the male rat. Psychoneuroendocrinology. 2013;38:1688-1697.
5. Donaldson ZR, Young LJ. Oxytocin, vasopressin, and the neurogenetics of sociality. Science. 2008;322:900-904.
6. Bartz JA, Zaki J, Ochsner KN, et al. Effects of oxytocin on recollections of maternal care and closeness. Proc Natl Acad Sci U S A. 2010;107:21371-21375.
7. Bick J, Dozier M, Bernard K, Grasso D, Simons R. Foster mother-infant bonding: associations between foster mothers' oxytocin production, electrophysiological brain activity, feelings of commitment, and caregiving quality. Child Dev. 2013;84:826-840.
8. Zhang G, Bai H, Zhang H, et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011;69:523-535.
9. Castro G C Areias MF, Weissmann L, et al. Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats. FEBS Open Bio. 2013;3:443-449.
10. Cai D, Purkayastha S. A new horizon: oxytocin as a novel therapeutic option for obesity and diabetes. Drug Discov Today Dis Mech. 2013;10:e63-e68.
11. Blevins JE, Ho JM. Role of oxytocin signaling in the regulation of body weight. Rev Endocr Metab Disord. 2013;14:311-329.
12. Chaves VE, Tilelli CQ, Brito NA, Brito MN. Role of oxytocin in energy metabolism. Peptides. 2013;45:9-14.
13. Kontoangelos K, Raptis AE, Papageorgiou CC, et al. Oxytocin and psychological factors affecting type 2 diabetes mellitus. Exp Diabetes Res. 2012;2012:560864.
14. Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR. Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol. 2008;22:1723-1734.
15. Wu Z, Xu Y, Zhu Y, et al. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One. 2012;7:e45167.
16. Morton GJ, Thatcher BS, Reidelberger RD, et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2012;302:E134-E144.
17. Deblon N, Veyrat-Durebex C, Bourgoin L, et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. Plos One. 2011;6:e25565.
18. Anuurad E, Shiwaku K, Nogi A, et al. The new BMI criteria for Asians by the regional office for the Western pacific region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers. J Occup Health. 2003;45:335-343.
19. Kujath AS, Quinn L, Elliott ME, et al. Oxytocin levels are lower in premenopausal women with type 1 diabetes mellitus compared to matched controls. Diabetes Metab Res Rev. In press.
20. Stock S, Granström L, Backman L, Matthiesen AS, Uvnäs-Moberg K. Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Int J Obes. 1989;13:213-222.
21. Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K. Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport. 2008;19:951-955.
22. Eckertova M, Ondrejcakova M, Krskova K, Zorad S, Jezova D. Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis. Br J Pharmacol. 2011;162:452-463.
23. Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY). 2011;3:1169-1177.
24. Zhang G, Cai D. Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. Am J Physiol Endocrinol Metab. 2011;3019:E1004-E1012.
25. Ho JM, Anekonda VT, Thompson BW, et al. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014;155:2845-2857.
26. Zhang H, Wu C, Chen Q, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. Plos One. 2013;8:e61477.
27. Camerino C. Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity (Silver Spring). 2009;17:980-984.
28. Gao ZY, Drews G, Henquin JC. Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets. Biochem J. 1991;276:169-174.
29. Björkstrand E, Eriksson M, Uvnäs-Moberg K. Evidence of a peripheral and a central effect of oxytocin on pancreatic hormone release in rats. Neuroendocrinology. 1996;63:377-383.
30. Szeto A, Rossetti MA, Mendez AJ, et al. Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits. Psychoneuroendocrinology. 2013;38:685-693.