Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats

Neurogastroenterology and Motility

Volumn 21, Issue 4, 2009, Pages 430-438

  Qin, J ^a   Feng, M ^a   Wang, C ^a   Ye, Y ^a   Wang, P S ^b   Liu, C ^a  

^a SHANDONG UNIVERSITY   (China)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Gastric motility; Oxytocin; Oxytocin receptor

Indexed keywords

ATROPINE; CHOLECYSTOKININ A RECEPTOR; DEVAZEPIDE; OXYTOCIN; OXYTOCIN RECEPTOR; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PYLORUS STENOSIS; RAT; SMOOTH MUSCLE; STOMACH ANTRUM; STOMACH MOTILITY; STOMACH PRESSURE; TISSUE DISTRIBUTION;

ANIMALS; BLOTTING, WESTERN; DEVAZEPIDE; GASTROINTESTINAL MOTILITY; HORMONE ANTAGONISTS; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; ORGAN CULTURE TECHNIQUES; OXYTOCIN; RATS; RATS, WISTAR; RECEPTORS, OXYTOCIN; STOMACH; VASOTOCIN;

EID: 62449098540     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01282.x     Document Type: Article

References (25)

1. Olson BR, Hoffman GE, Sved AF, Stricker EM, Verbalis JG. Cholecystokinin induces c-fos expression in hypothalamic oxytocinergic neurons projecting to the dorsal vagal complex. Brain Res 1992 569 : 238 48.
2. Lefebvre DL, Giaid A, Zingg HH. Expression of the oxytocin gene in rat placenta. Endocrinology 1992 130 : 1185 92.
3. Lefebvre DL, Giaid A, Bennett H, Lariviere R, Zingg HH. Oxytocin gene expression in rat uterus. Science 1992 256 : 1553 5.
4. Xie DP, Chen LB, Liu CY, Liu JZ, Liu KJ. Effect of oxytocin on contraction of rabbit proximal colon in vitro. World J Gastroenterol 2003 9 : 165 8.
5. Duridanova DB, Nedelcheva MD, Gagov HS. Oxytocin-induced changes in single cell K+ currents and smooth muscle contraction of guinea-pig gastric antrum. Eur J Endocrinol/Eur Fed Endocr Soc 1997 136 : 531 8.
6. Wu CL, Hung CR, Chang FY, Pau KY, Wang PS. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch Pharmacol 2003 367 : 406 13.
7. Liu CY, Liu JZ, Xie DP, Liu PY, Wang PS. Endogenous oxytocin excites phasic contraction of gallbladder in rabbits through oxytocin receptor. Chin J Physiol 2003 46 : 95 101.
8. Ohlsson B, Bjorgell O, Ekberg O, Darwiche G. The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human. BMC Gastroenterol 2006 6 : 11.
9. Monstein HJ, Grahn N, Truedsson M, Ohlsson B. Oxytocin and oxytocin-receptor mRNA expression in the human gastrointestinal tract: a polymerase chain reaction study. Regul Pept 2004 119 : 39 44.
10. Li L, Kong X, Liu H, Liu C. Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits. Neurogastroenterol Motil 2007 19 : 839 44.
11. Wang SL, Xie DP, Liu KJ et al. Nitric oxide mediates the inhibitory effect of ethanol on the motility of isolated longitudinal muscle of proximal colon in rats. Neurogastroenterol Motil 2007 19 : 515 21.
12. Bitar KN, Makhlouf GM. Receptors on smooth muscle cells: characterization by contraction and specific antagonists. Am J Physiol 1982 242 : G400 7.
13. Lindfors PH, Voikar V, Rossi J, Airaksinen MS. Deficient nonpeptidergic epidermis innervation and reduced inflammatory pain in glial cell line-derived neurotrophic factor family receptor alpha2 knock-out mice. J Neurosci 2006 26 : 1953 60.
14. Wu CL, Hung CR, Chang FY, Pau KY, Wang JL, Wang PS. Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats. Pflugers Arch 2002 445 : 187 93.
15. Costa ESRH, Pereira-Junior PP, Oliveira PF et al. Cardiac effects of oxytocin: is there a role for this peptide in cardiovascular homeostasis? Regul Pept 2005 132 : 107 12.
16. Naruse S, Takagi T, Kato M, Ozaki T. Interdigestive gastric blood flow: the relation to motor and secretory activities in conscious dogs. Exp Physiol 1992 77 : 701 8.
17. Wu CL, Doong ML, Wang PS. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats. Eur J Pharmacol 2008 580 : 407 15.
18. Wang BJ, Cui ZJ. How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humans. Am J Physiol 2007 292 : R666 78.
19. Dufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev 2006 86 : 805 47.
20. Colucci S, Colaianni G, Mori G, Grano M, Zallone A. Human osteoclasts express oxytocin receptor. Biochem Biophys Res Commun 2002 297 : 442 5.
21. Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 1984 150 : 734 41.
22. Fuchs AR, Fuchs F, Soloff MS. Oxytocin receptors in nonpregnant human uterus. J Clin Endocrinol Metab 1985 60 : 37 41.
23. Thibonnier M, Conarty DM, Preston JA, Plesnicher CL, Dweik RA, Erzurum SC. Human vascular endothelial cells express oxytocin receptors. Endocrinology 1999 140 : 1301 9.
24. Lollivier V, Marnet PG, Delpal S et al. Oxytocin stimulates secretory processes in lactating rabbit mammary epithelial cells. J Physiol 2006 570 : 125 40.
25. Ohlsson B, Truedsson M, Djerf P, Sundler F. Oxytocin is expressed throughout the human gastrointestinal tract. Regul Pept 2006 135 : 7 11.