Oxytocin may mediate the benefits of positive social interaction and emotions

Psychoneuroendocrinology

Volumn 23, Issue 8, 1998, Pages 819-835

  Uvnäs Moberg, Kerstin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Growth; Healing; Oxytocin; Somatosensory stimuli; Stress

Indexed keywords

OXYTOCIN;

ANIMAL EXPERIMENT; BEHAVIOR; BREAST FEEDING; CONFERENCE PAPER; CONTROLLED STUDY; EMOTION; FEMALE; HYPNOSIS; IMAGERY; MALE; NONHUMAN; OXYTOCIN RELEASE; PRIORITY JOURNAL; RAT; SOCIAL INTERACTION; SOMATOSENSORY STIMULATION; STRESS; WEIGHT GAIN; WOUND HEALING;

ANIMALS; BREAST FEEDING; EMOTIONS; FEMALE; HUMANS; INTERPERSONAL RELATIONS; LACTATION; MALE; NEUROSECRETORY SYSTEMS; OBJECT ATTACHMENT; OXYTOCIN; PARENTS;

EID: 0345059241     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(98)00056-0     Document Type: Conference Paper

References (73)

1. Ågren G., Lundeberg T., Uvnäs-Moberg K., Sato A. The oxytocin antagonist 1-deamino-2-D-Tyr (Oet)-4-Thr-8-Orn oxytocin reverses the increase in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats. Neuroscience Letters. 187:1995;49-52.
2. Ågren G., Uvnäs-Moberg K., Lundberg T. Olfactory cues from an oxytocin-injected male rat can induce antinociception in its cage mates. NeuroReport. 8:1997;3073-3076.
3. Altemus M., Deuster P. A., Gallivan E., Carter C. S., Gold P. W. Suppression of hypothalamic-pituitary-adrenal axis to stress in lactating women. Journal of Clinical Endocrinology and Metabolism. 80:1995;2954-2959.
4. Amico J., Johnston J. M., Vagnucci A. H. Suckling induced attenuation of plasma cortisol concentrations in postpartum lactating women. Endocrinological Research. 20:1994;79-87.
5. Araki T., Ito K., Kurosawa M., Sato A. Responses of adrenal sympathetic nerve activity and catecholamine secretion to cutaneous stimulation in anesthetized rats. Neuroscience. 12:1984;289-299.
6. Argiolas A., Gessa G. L. Central function of oxytocin. Neuroscience and Biobehavior. 15:1991;217-231.
7. Aston-Jones, J. G., Foote, S. L., Bloom, F. E. (1984) Anatomy and physiology of locus coeruleus neurons: functional implications. In: Ziegler, M., Lohe, C.R. (Eds.) Norepinephrine. Wilkins and Wilkins, Baltimore, MD. Frontiers in Clinical Neuroscience 2, 92-116.
8. Björkstrand E., Eriksson M., Uvnäs-Moberg K. Evidence of a peripheral and a central effect of oxytocin on pancreatic hormone release in rats. Neuroendocrinology. 63:1996;377-383.
9. 1A receptor agonist 8-OH-DPAT on plasma levels of insulin, cholecystokinin and somatostatin. Regulatory Peptides. 63:1996;47-52.
10. Cannon W. B. The Wisdom of the Body. 1932;W.W. Norton, New York.
11. Carter C. S. Oxytocin and sexual behavior. Neuroscience and Biobehavior. 16:1992;131-144.
12. Carter C. S., DeVries A. C., Getz L. L. Physiological substrates of mammalian monogamy: The prairie vole model. Neuroscience and Biobehavior Reviews. 19:1995;303-314.
13. Eriksson M., Lundeberg T., Uvnäs-Moberg K. Studies on cutaneous blood flow in the mammary gland of lactating rats. Acta Physiologica Scandinavica. 158:1996;1-6.
14. Ferris C. F., Delville Y. Vasopressin and serotonin interactions in the control of agonistic behavior. Psychoneuroendocrinology. 19:1994;593-601.
15. Ferris C. F., Albers H. E., Wesolowski S. M., Goldman B. D., Luman S. E. Vasopressin injected into the hypothalamus triggers a complex stereotypic behavior in golden hamsters. Science. 224:1984;521-523.
16. Field T., Morrow C., Valdeon C., Larson S., Kuhn C., Schanberg S. Massage reduces anxiety in child and adolescent psychiatric patients. Journal of the American Academy of Child Adolescence. 31:1992;125-131.
17. Folkow B. Physiological organization of neurohormonal responses to psychosocial stimuli: implications for health and disease. Annals in Behavior Medicine. 15:1993;236-244.
18. Folkow B. Physiological aspects of the 'defence' and 'defeat' reactions. Acta Physiologica Scandinavica. 161:1997;34-37.
19. Gillies G. E., Linton E. A., Lowry P. J. Corticotropin releasing activity of the new CRF is potential several times by vasopressin. Nature (London). 299:1982;355-357.
20. Gonzalez J., Field T., Yando R., Gonzales K., Lasko D., Bendell D. Adolescent's perceptions of their risk-taking behavior. Adolescence. 29:1994;701-709.
21. Hatton G. I., Tweedle C. D. Magnocellular neuropeptidergic neurons in hypothalamus: increases in membrane apposition and number of specialized synapses from pregnancy to lactation. Brain Research Bulletin. 8:1982;197-204.
22. Henry J. P. Biological basis of the stress response. News of Physiological Science. 8:1993;69-73.
23. Henry J. P. Psychological and physiological responses to stress: the right hemisphere and the hypothalamo-pituitary-adrenal axis. An inquiry into problems of human bonding. Integrative Physiology and Behavioral Science. 28:1993;368-386.
24. Kendrick K. M., Keverne E., Baldwin B. Intracerebroventricular oxytocin stimulates maternal behaviour in sheep. Neuroendocrinology. 46:1987;56-61.
25. Kendrick K. M., Keverne E. B., Chapman C., Baldwin B. A. Intracranial dialysis measurement of oxytocin monoamine and uric release from the olfactory bulb and substantia nigra of sheep during parturition, suckling, separation from lambs and eating. Brain Research. 439:1988;1-10.
26. Klaus M. H., Jerauld R., Kreger N. C., McAlpine W., Steffa M., Kennell J. H. Maternal attachment: importance of the first postpartum days. New England Journal Medicine. 286:1972;460-463.
27. Knox, S. S. and Uvnäs-Moberg, K. (1998) Social isolation and cardiovascular disease: an atherosclerotic pathway? Psychoneuroendocrinology 23, 877-890.
28. Kurosawa M., Suzuki A., Utsugi K., Araki T. Response of adrenal efferent nerve activity to non-noxious mechanical stimulation of the skin in rats. Neuroscience Letters. 34:1982;295-300.
29. Kurosawa M., Saito H., Sato A., Tsuchiya T. Reflex changes in sympathoadrenal medullary functions in response to various thermal cutaneous stimulations in anesthetized rats. Neuroscience Letters. 56:1985;149-154.
30. Kurosawa M., Sato A., Swenson R. S., Takahashi Y. Sympatho-adrenal medullary functions in response to intracerebroventricularly injected corticotropin-releasing factor in anesthetized rats. Brain Research. 367:1986;250-257.
31. Kurosawa M., Lundeberg T., Ågren G., Uvnäs-Moberg K. The massage-like stroking of abdomen lowers blood pressure in anaesthetized rats. Journal of the Autonomic Nervous System. 56:1995;140-145.
32. Lundeberg T., Uvnäs-Moberg K., Ågren G., Bruzelius G. Anti-nociceptive effects of oxytocin in rats and mice. Neuroscience Letters. 170:1994;153-157.
33. McCabe P. M., Duan Y. F., Winters R. W., Green E. J., Huan Y. G., Schneiderman N. Comparison of peripheral blood flow pattern associated with the defence reaction and the vigilance reaction in rabbits. Physiology and Behavior. 56(5):1994;1101-1106.
34. Nicholas A. P., Hökfelt T., Pieribone V. A. The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends in Pharmacological Science. 17:1996;245-255.
35. Nissen E., Lilja G., Widström A. M., Uvnäs-Moberg K. Elevation of oxytocin levels early post partum in women. Acta Obstetrica Gynecologica Scandinavica. 74:1995;580-588.
36. Nissen E., Uvnäs-Moberg K., Svensson K., Stock S., Widström A. M., Winberg J. Different patterns of oxytocin, prolactin but not cortisol release during breastfeeding in women delivered by caesarean section or by the vaginal route. Early Human Development. 45:1996;103-118.
37. Nissen E., Gustavsson P., Widström A. M., Uvnäs-Moberg K. Oxytocin, prolactin and cortisol levels in response to nursing in women after Sectio Caesarea and vaginal delivery-relationship with changes in personality patterns post partum. Journal of Psychosomatic Obstetics and Gynaecology. 19:1998;49-58.
38. Petersson M., Alster P., Lundeberg T., Uvnäs-Moberg K. Oxytocin causes a long-term decrease of blood pressure in female and male rats. Physiology and Behavior. 60:1996;1311-1315.
39. Petersson M., Alster P., Lundeberg T., Uvnäs-Moberg K. Oxytocin increases nociceptive pain threshold in a long-term perspective in female and male rats. Neuroscience. 212:1996;87-90.
40. Petersson, M., Lundeberg, T., Wiberg U., Uvnäs-Moberg, K. (in press a) Oxytocin increases the survival of musculocutaneous flaps. Naunyn-Schmiedeberg's Archives in Pharmacology (Berlin).
41. Petersson, M., Uvnäs-Moberg, K., Erhardt, S. and Engberg, G. (in press b) Oxytocin increases locus coeruleus alpha 2 adrenocetor responsiveness. Neurosci. Lett.
42. Pittman Q. J., Veale W. L., Lederis K. Central neurohypophyseal pathways: inter-actions with endocrine and other autonomic functions. Peptides. 5:1982;515-520.
43. Richard P., Moos F., Mercier M. J. (1991) Central effects of oxytocin. Physiology Reviews, 331-370.
44. Ryff C. D., Singer B. Human health: New directions for the next millennium. Psychology Inquiry. 9:1998;69-85.
45. Salariya E. M., Easton P. M., Cater J. J. Duration of breastfeeding after early initiation and frequent feeding. Lancet. ii:1978;1141-1143.
46. Shumaker S., Czajkowski S. M. Social Support and Cardiovascular Disease. 1994;Plenum Press, New York.
47. Smedh U., Uvnäs-Moberg K. Intracerebroventricularly administered corticotropin-releasing factor releases somatostatin through a vagal pathway in freely fed, but not in food-deprived rats. Acta Physiologica Scandinavica. 151:1994;241-248.
48. Sofroniew M. W. Vasopressin and oxytocin in the mammalian brain and spinal cord. Trends in Neuroscience. 6:1983;467-472.
49. Sosa R., Klaus M., Kennell J. H., Urrutia J. J. The effect of early mother-infant contact on breast-feeding and growth. Breast-feeding and the Mother. Ciba Foundation Symposium 45. 1976;179-193 Elsevier, Amsterdam.
50. Spadaro F., Berridge C. W., Baldwin H. A., Dunn A. J. Corticotropin-releasing factor acts via a third ventricle site to reduce exploratory behavior in rats. Pharmacology and Biochemical Behavior. 36:1990;305-309.
51. Stock S., Uvnäs-Moberg K. Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in response to touch and pinch in anaesthetized rats. Acta Physiologica Scandinavica. 132:1988;29-34.
52. 3H]oxytocin binding sites within the islets of Langerhans. Regulatory Peptides. 30:1990;1-13.
53. Theodosis D. T., Chapman D. B., Montageneses C., Poulain D. A., Morris K. F. Structural plasticity in the hypothalamic supraoptic nucleus at lactation affects oxytocin but not vasopressin-secreting neurons. Neuroscience. 17:1986;661-678.
54. Uvnäs-Moberg K. Neuroendocrinology of the mother-child interaction. Trends in Endocrinology and Metabolism. 7:1996;126-131.
55. Uvnäs-Moberg, K. (1997a) Physiological and endocrine effects of social contacts with special reference to oxytocin. In: Carter, C. S., Lederhendler, I., Kirkpatrick, B. (Eds.) The Integrative Neurobiology of Affiliation. Annals of the New York Academy of Science 807, 146-163.
56. Uvnäs-Moberg K. Oxytocin linked antistress effects-the relaxation and growth response. Acta Physiologica Scandinavica. 161:1997;38-42.
57. Uvnäs-Moberg K. Antistress pattern induced by oxytocin. News in Physiological Science. 13:1998;22-26.
58. Uvnäs-Moberg K., Eriksson M. Breastfeeding: physiological, endocrine and behavioural adaptations caused by oxytocin and local neurogenic activity in the nipple and the mammary gland. Acta Paediatrica (Oslo). 85:1996;525-530.
59. Uvnäs-Moberg K., Posloncec B., Åhlberg L. Influence on plasma levels of somatostatin, gastrin, glucagon, insulin and VIP-like immunoreactivity in peripheral venous blood of anesthetized cats induced by low intensity afferent stimulation of the sciatic nerve. Acta Physiologica Scandinavica. 126:1986;225-230.
60. Uvnäs-Moberg K., Widström A. M., Nissen E., Björvell H. Personality traits in women 4 days post partum and their correlation with plasma levels of oxytocin and prolactin. Journal of Psychosomatic Obstetics and Gynaecology. 11:1990;261-273.
61. Uvnäs-Moberg K., Lundeberg T., Bruzelius G., Alster P. Vagally mediated release of gastrin and cholecystokinin following sensory stimulation. Acta Physiologica Scandinavica. 146:1992;349-356.
62. Uvnäs-Moberg K., Bruzelius G., Alster P., Lundeberg T. The antinociceptive effect of non-noxious sensory stimulation is partly mediated through oxytocinergic mechanisms. Acta Physiologica Scandinavica. 149:1993;199-204.
63. Uvnäs-Moberg K., Ahlenius S., Hillegaart V., Alster P. High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats. Pharmacology Biochemistry and Behavior. 49:1994;101-106.
64. Uvnäs-Moberg K., Alster P., Petersson M. Dissociation of oxytocin effects on body weight in two variants of female Sprague-Dawley rats. Integrative Physiology and Behavioral Science (New Brunswick, NJ). 31:1996;44-55.
65. Uvnäs-Moberg K., Alster P., Lund I., Lundeberg T., Kurosawa M., Ahlenius S. Stroking of the abdomen causes decreased locomotor activity in conscious male rats. Physiology and Behavior. 60(6):1996;1409-1411.
66. Uvnäs-Moberg et al., to be published.
67. Van Backstaele E. J., Aston-Jones G. Integration in the ventral medulla and coordination of sympathetic, pain and arousal functions. Clinical and Experimental Hypertension. 17:1995;153-165.
68. Wakerley J. B., Clarke G., Summerlee J. S. Milk ejection and its control. Knobil E., Neill J. D. The Physiology of Reproduction. II:1994;1131-1177 Raven Press, New York.
69. Widström A. M., Ransjö-Arvidsson A. B., Christensson K., Matthiesen A. S., Winberg J., Uvnäs-Moberg K. Gastric suction in healthy newborn infants. Effects on circulation and developing feeding behaviour. Acta Paediatrica Scandinavica. 76:1987;566-572.
70. Widström A. M., Wahlberg V., Matthiesen A. S., Eneroth P., Uvnäs-Moberg K., Werner S., Winberg J. Short-term effects of early suckling on maternal behaviour and breast-feeding performance. Early Human Development. 21:1990;153-163.
71. Williams J. R., Insel T. R., Harbaugh C. R., Carter C. S. Oxytocin centrally administered facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster). Journal of Neuroendocrinology. 6:1994;247-250.
72. Witt D. M., Winslow J. T., Insel T. Enhanced social interaction in rats following chronic, centrally infused oxytocin. Pharmology and Biochemical Behavior. 43:1992;855-861.
73. 1-adrenergic receptors are involved in CRF-induced defensive withdrawal. Pharmacology and Biochemical Behavior. 36:1990;847-851.