Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- Mice

Psychosomatic Medicine

Volumn 72, Issue 4, 2010, Pages 376-382

  Nation, Daniel A ^a   Szeto, Angela ^b   Mendez, Armando J ^c   Brooks, Larry G ^b   Zaias, Julia ^c   Herderick, Edward E ^d   Gonzales, Julie ^b   Noller, Crystal M ^b   Schneiderman, Neil ^b   McCabe, Philip M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Biology   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d Edward Herderick eehscience LLC   (United States)

Author keywords

Atherosclerosis; Inflammation; Interleukin 6; Oxytocin; Visceral adipose tissue

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; INSULIN; INTERLEUKIN 6; LIPID; OXYTOCIN; OXYTOCIN RECEPTOR; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; HYPERLIPIDEMIA; INFLAMMATION; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; MALE; MOUSE; NEUROHYPOPHYSIS; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RISK FACTOR; SOCIAL BEHAVIOR; SOCIAL ISOLATION; SOCIAL STRESS; THORACIC AORTA;

ADIPOSE TISSUE; ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; INFLAMMATION; INTERLEUKIN-6; MALE; MICE; OXYTOCIN; RECEPTORS, OXYTOCIN; SOCIAL ISOLATION; SYMPATHETIC NERVOUS SYSTEM;

EID: 77952425954     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e3181d74c48     Document Type: Article

References (36)

1. Shively CA, Clarkson TB, Kaplan JR. Social deprivation and coronary artery atherosclerosis in female cynomolgus monkeys. Atherosclerosis 1989;77:69-76.
2. McCabe PM, Gonzales JA, Zaias J, Szeto A, Kumar M, Herron A, Schneiderman N. Social environment influences the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Circulation 2002;105:354-359
3. Paredes J, Szeto A, Levine JE, Zaias J, Gonzales JA, Mendez AJ, Llabre MM, Schneiderman N, McCabe PM. Social experience influences hypo-thalamic oxytocin in the WHHL rabbit. Psychoneuroendocrinology 2006; 31:1062-1075
4. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-630
5. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb Vasc Biol 1994;14:133-140
6. Bernberg E, Andersson IJ, Gan LM, Naylor AS, Johansson ME, Berg-ström G. Effects of social isolation and environmental enrichment on atherosclerosis in apomice. Stress 2008;11:381-389
7. Kaplan JR, Manuck SB, Clarkson TB, Lusso FM, Taub DM. Social status, environment, and atherosclerosis in cynomolgus monkeys. Arteriosclerosis 1982;2:359-368
8. Kaplan JR, Manuck SB, Clarkson TB, Lusso FM, Taub DM, Miller EW. Social stress and atherosclerosis in normocholesterolemic monkeys. Science 1983;220:733-735
9. Nation DA, Gonzales J, Szeto A, Mendez AJ, Paredes J, Brooks L, Schneiderman N, McCabe PM. The effect of social environment on markers of vascular oxidant stress and inflammation. Psychosom Med 2008;70:269-275
10. Kaplan JR, Manuck SB, Adams MR, Weingand KW, Clarkson TB. Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Circulation 1987;76: 1364-1372
11. Szeto A, Nation DA, Mendez AJ, Dominguez-Bendala J, Brooks LG, Schneiderman N, McCabe PM. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab 2008;295:E1495-501.
12. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001;81:629-683
13. Gutkowska J, Jankowsi M, Mukaddam-Daher S, McCann SM. Oxytocin is a cardiovascular hormone. Braz J Med Biol Res 2000;33:625-633
14. Jankowski M, Wang D, Hajjar F, Mukaddam-Daher S, McCann SM, Gutkowska J. Oxytocin and its receptors are synthesized in the rat vasculature. PNAS 2000;97:6207-6211
15. Thibonnier M, Conarty DM, Preston JA, Plesnicher CL, Dweik RA, Erzurum SC. Human vascular endothelial cells express oxytocin receptors. Endocrinology 1999;140:1301-1309
16. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874
17. Pang G, Couch L, Batey R, Clancy R, Cripps A. GM-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccha-ride, IL-1 alpha and TNF-alpha. Clin Exp Immunol 1994;96:437-443
18. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000;148:209-214
19. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007;56:16-23.
20. Ohman MK, Shen Y, Obimba CI, Wright AP, Warnock M, Lawrence DA, Eitzman DT. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein deficient mice. Circulation 2008;117: 798-805.
21. Petersson M, Uvnas-Moberg K. Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood. Neurosci Lett 2008;440:166-169
22. Maier T, Dai W-J, Csikos T, Jirikowski GF, Unger T, Culman J. Oxy-tocin pathways mediate the cardiovascular and behavioral responses to substance P in the rat brain. Hypertension 1998;31:480-486
23. Karra R, Vemullapalli S, Dong C, Herderick EE, Song X, Slosek K, Nevins JR, West M, Goldschmidt-Clermont PJ, Seo D. Molecular evidence for arterial repair in atherosclerosis. Proc Natl Acad Sci USA 2005;102:16789-16794
24. de Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 2008;54:945-955
25. VanderLaan PA, Reardon CA, Getz GS. Site specificity of atherosclerosis: site-selective responses to atherosclerotic. Arterioscler Thromb Vasc Biol 2004;24:12-22.
26. Iseri SO, Sener G, Saglam B, Gedik N, Ercan F, Yegan BC. Oxytocin ameliorates oxidative colonic inflammation by neutrophil-dependent mechanism. Peptides 2005;26:483-491
27. Petersson M, Lundeberg T, Sohlstrom A, Wilberg U, Uvnas-Moberg U. Oxytocin increases the survival of musculocutaneous flaps. Naunyn Schmiedebergs Arch Pharmacol 1998;357:701-704
28. Petersson M, Wiberg U, Lundeberg T, Uvnäs-Moberg K. Oxytocin decreases carrageenan induced inflammation in rats. Peptides 2001;22: 1479-1484
29. Uvnas-Moberg, Ahlenius V, Hillegaart V, Alter P. High doses of oxyto-cin cause sedation and low doses cause an anxiolytic-like effect in male rats. Pharmacol Biochem Behav 1994;49:101-106
30. Uvnäs-Moberg K. Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 1998;23:819-835
31. Grewen KM, Girdler SS, Amico J, Light KC. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom Med 2005;67:531-538
32. Holt-Lunstad J, Birmingham WA, Light KC. Influence of a "warm touch" support enhancement intervention among married couples on ambulatory blood pressure, oxytocin, alpha amylase, and cortisol. Psy-chosom Med 2008;70:976-985
33. Light KC, Grewen KM, Amico JA. More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women. Biol Psychol 2005;69:5-21.
34. Lund I, Ge Y, Yu LC, Uvnas-Moberg K, Wang J, Yu C, Kurosawa M, Agren G, Rosén A, Lekman M, Lundeberg T. Repeated massage-like stimulation induces long-term effects on nociception: contribution of oxytocinergic mechanisms. Eur J Neurosci 2002;16:330-338
35. Uvnäs-Moberg K. Oxytocin linked antistress effects\the relaxation and growth response. Acta Physiol Scand Suppl 1997;640:38-42.
36. Nerem RM, Levesque MJ, Cornhill JF. Social environment as a factor in diet-induced atherosclerosis. Science 1980;208:1475-1476