Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity

Journal of Experimental Medicine

Volumn 213, Issue 11, 2016, Pages 2365-2382

  Napier, Brooke A ^a   Brubaker, Sky W ^a   Sweeney, Timothy E ^a   Monette, Patrick ^b   Rothmeier, Greggory H ^c   Gertsvolf, Nina A ^a   Puschnik, Andreas ^a   Carette, Jan E ^a   Khatri, Purvesh ^a   Monack, Denise M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MIDDLEBURY COLLEGE   (United States)

^c Blue Bottle Coffee   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE B; CARBOXYPEPTIDASE B1; CASPASE 11; CASPASE 4; CASPASE 5; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; AUTACOID; CASP11 PROTEIN, MOUSE; CASPASE; COMPLEMENT; COMPLEMENT C3A RECEPTOR; ENDOTOXIN; INTERFERON RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; INFLAMMATION; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; LIPOPOLYSACCHARIDE-INDUCED SEPSIS; MACROPHAGE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SHIGELLA FLEXNERI; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BLOOD; ENDOTOXEMIA; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RAW 264.7 CELL LINE; SALMONELLA; SEPSIS; SHIGELLA; SIGNAL TRANSDUCTION;

ANIMALS; CARBOXYPEPTIDASE B; CASPASES; CELL DEATH; COMPLEMENT C3; COMPLEMENT SYSTEM PROTEINS; CRISPR-CAS SYSTEMS; ENDOTOXEMIA; ENDOTOXINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, BIOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RAW 264.7 CELLS; RECEPTORS, COMPLEMENT; RECEPTORS, INTERFERON; SALMONELLA; SEPSIS; SHIGELLA; TOLL-LIKE RECEPTOR 4;

EID: 84994490206     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20160027     Document Type: Article

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