A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway

mBio

Volumn 3, Issue 6, 2012, Pages

  Jobling, Michael G ^a   Yang, Zhijie ^a,d   Kam, Wendy R ^b   Lencer, Wayne I ^b,c   Holmes, Randall K ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; GANGLIOSIDE GM1; HOLOTOXIN; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BACTERIAL STRAIN; BINDING SITE; CELL FUNCTION; CELL INVASION; CELL MEMBRANE; CELL MEMBRANE REMODELING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; CTXA GENE; CTXB GENE; ENDOPLASMIC RETICULUM; GENE; GENE EXPRESSION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

VIBRIO CHOLERAE;

EID: 84872143843     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00401-12     Document Type: Article

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