Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

Biochemical and Biophysical Research Communications

Volumn 348, Issue 2, 2006, Pages 682-688

  Eckhart, Leopold ^a   Kittel, Christian ^a   Gawlas, Sonja ^a   Gruber, Florian ^a   Mildner, Michael ^a   Jilma, Bernd ^b   Tschachler, Erwin ^a,c  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Centre de Recherches et d'Investigations Epidermiques et Sensorielles CERIES   (France)

Author keywords

Alternative splicing; Apoptosis; Caspase 11; Caspase 5; Inflammation; Lipopolysaccharide; Promoter; Start site of translation

Indexed keywords

CASPASE 11; CASPASE 5; LIPOPOLYSACCHARIDE; MESSENGER RNA;

ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; CASPASE 5 GENE; CONTROLLED STUDY; ENZYME STRUCTURE; EXON; FEMALE; GENE; GENE CONTROL; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA SPLICING; UPREGULATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CASPASES; EXONS; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; UP-REGULATION;

EID: 33746927898     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.07.104     Document Type: Article

References (24)

1. Degterev A., Boyce M., and Yuan J. A decade of caspases. Oncogene 22 (2003) 8543-8567
2. Kang S.J., Wang S., Hara H., Peterson E.P., Namura S., Amin-Hanjani S., Huang Z., Srinivasan A., Tomaselli K.J., Thornberry N.A., Moskowitz M.A., and Yuan J. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J. Cell Biol. 149 (2000) 613-622
3. Fischer H., Koenig U., Eckhart L., and Tschachler E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293 (2002) 722-726
4. Martinon F., and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117 (2004) 561-574
5. Lamkanfi M., Declercq W., Kalai M., Saelens X., and Vandenabeele P. Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ. 9 (2002) 358-361
6. Munday N.A., Vaillancourt J.P., Ali A., Casano F.J., Miller D.K., Molineaux S.M., Yamin T.T., Yu V.L., and Nicholson D.W. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270 (1995) 15870-15876
7. Faucheu C., Blanchet A.M., Collard-Dutilleul V., Lalanne J.L., and Diu-Hercend A. Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme. Eur. J. Biochem. 236 (1996) 207-213
8. Hisahara S., Yuan J., Momoi T., Okano H., and Miura M. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J. Exp. Med. 193 (2001) 111-122
9. Kang S.J., Wang S., Kuida K., and Yuan J. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ. 9 (2002) 1115-1125
10. Schwartz Jr. S., Yamamoto H., Navarro M., Maestro M., Reventos J., and Perucho M. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res. 59 (1999) 2995-3002
11. Miyaki M., Iijima T., Shiba K., Aki T., Kita Y., Yasuno M., Mori T., Kuroki T., and Iwama T. Alterations of repeated sequences in 5′ upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome. Oncogene 20 (2001) 5215-5218
12. Martinon F., Burns K., and Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10 (2002) 417-426
13. Lin X.Y., Choi M.S., and Porter A.G. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. J. Biol. Chem. 275 (2000) 39920-39926
14. Wang S., Miura M., Jung Y., Zhu H., Gagliardini V., Shi L., Greenberg A.H., and Yuan J. Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271 (1996) 20580-20587
15. Wang S., Miura M., Jung Y.K., Zhu H., Li E., and Yuan J. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92 (1998) 501-509
16. Schauvliege R., Vanrobaeys J., Schotte P., and Beyaert R. Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1. J. Biol. Chem. 277 (2002) 41624-41630
17. Eckhart L., Ban J., Ballaun C., Weninger W., and Tschachler E. Reverse transcription-polymerase chain reaction products of alternatively spliced mRNAs form DNA heteroduplexes and heteroduplex complexes. J. Biol. Chem. 274 (1999) 2613-2615
18. Heinemeyer T., Wingender E., Reuter I., Hermjakob H., Kel A.E., Kel O.V., Ignatieva E.V., Ananko E.A., Podkolodnaya O.A., Kolpakov F.A., Podkolodny N.L., and Kolchanov N.A. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26 (1998) 362-367
19. Jilma B., Marsik C., Mayr F., Graninger M.T., Taylor Jr. F.B., Ribel M.C., Erhardtsen E., Handler S., and Eichler H.G. Pharmacodynamics of active site inhibited factor VIIa (ASIS, FFR-rFVIIa) in endotoxin induced coagulation in humans. Clin. Pharmacol. Ther. 72 (2002) 403-410
20. Leitner J.M., Firbas C., Mayr F.B., Reiter R.A., Steinlechner B., and Jilma B. Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia. Clin. Pharmacol. Ther. 79 (2006) 23-34
21. Gruber F., Hufnagl P., Hofer-Warbinek R., Schmid J.A., Breuss J.M., Huber-Beckmann R., Lucerna M., Papac N., Harant H., Lindley I., de Martin R., and Binder B.R. Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF alpha -induced PAI-1 expression. Blood 101 (2003) 3042-3048
22. Breathnach R., and Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50 (1981) 349-383
23. Eckhart L., Ballaun C., Uthman A., Kittel C., Stichenwirth M., Buchberger M., Fischer H., Sipos W., and Tschachler E. Identification and characterization of a novel mammalian caspase with proapoptotic activity. J. Biol. Chem. 280 (2005) 35077-35080
24. Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., and Dixit V.M. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 103 (2000) 99-111