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Volumn 30, Issue 12, 2016, Pages 1943-1953

Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Author keywords

alcohol; AST, ALT; d mannitol; GGT; glutathione; glycyrrhizin; hepatoprotection

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLYCYRRHIZIC ACID; MANNITOL; ANTIINFLAMMATORY AGENT;

EID: 84994235821     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5699     Document Type: Article
Times cited : (28)

References (84)
  • 1
    • 21644482451 scopus 로고    scopus 로고
    • Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system
    • Ablise M, Leininger-Muller B, Wong CD, Siest G, Loppinet V, Visvikis S. 2004. Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system. Chem Pharm Bull 52: 1436–1439.
    • (2004) Chem Pharm Bull , vol.52 , pp. 1436-1439
    • Ablise, M.1    Leininger-Muller, B.2    Wong, C.D.3    Siest, G.4    Loppinet, V.5    Visvikis, S.6
  • 2
    • 0021080230 scopus 로고
    • Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress
    • Adams JD, Lauterburg BH, Mitchell JR. 1983. Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther 227: 749–754.
    • (1983) J Pharmacol Exp Ther , vol.227 , pp. 749-754
    • Adams, J.D.1    Lauterburg, B.H.2    Mitchell, J.R.3
  • 3
    • 61449100489 scopus 로고    scopus 로고
    • Biomarkers of liver status in heavy drinkers, moderate drinkers and abstainers
    • Alatalo P, Koivisto H, Puukka K, et al. 2009. Biomarkers of liver status in heavy drinkers, moderate drinkers and abstainers. Alcohol 44: 199–203.
    • (2009) Alcohol , vol.44 , pp. 199-203
    • Alatalo, P.1    Koivisto, H.2    Puukka, K.3
  • 4
    • 84860869284 scopus 로고    scopus 로고
    • Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes
    • Bansal S, Srinivasan S, Anandasadagopan S, et al. 2012. Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes. J Biol Chem 287: 15284–15297.
    • (2012) J Biol Chem , vol.287 , pp. 15284-15297
    • Bansal, S.1    Srinivasan, S.2    Anandasadagopan, S.3
  • 6
    • 33846172657 scopus 로고    scopus 로고
    • Effect of compound glycyrrhizin injection on liver function and cellular immunity of children with infectious mononucleosis complicated liver impairment
    • Cao ZX, Zhao ZF, Zhao XF. 2006. Effect of compound glycyrrhizin injection on liver function and cellular immunity of children with infectious mononucleosis complicated liver impairment. Chin J Integr Med 12: 268–272.
    • (2006) Chin J Integr Med , vol.12 , pp. 268-272
    • Cao, Z.X.1    Zhao, Z.F.2    Zhao, X.F.3
  • 7
    • 0020658262 scopus 로고
    • Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine
    • Cederbaum AI, Dicker E. 1983. Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine. Biochem J 210: 107–113.
    • (1983) Biochem J , vol.210 , pp. 107-113
    • Cederbaum, A.I.1    Dicker, E.2
  • 8
    • 84888367970 scopus 로고    scopus 로고
    • Hepatoprotection of noni juice against chronic alcohol consumption: lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation
    • Chang YY, Lin YL, Yang DJ, et al. 2013. Hepatoprotection of noni juice against chronic alcohol consumption: lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation. J Agric Food Chem 61: 10016–10024.
    • (2013) J Agric Food Chem , vol.61 , pp. 10016-10024
    • Chang, Y.Y.1    Lin, Y.L.2    Yang, D.J.3
  • 9
    • 77949468187 scopus 로고    scopus 로고
    • Licorice infusion: chemical profile and effects on the activation and the cell cycle progression of human lymphocytes
    • Cheel J, Onofre G, Vokurkova D, Tůmová L, Neugebauerová J. 2010. Licorice infusion: chemical profile and effects on the activation and the cell cycle progression of human lymphocytes. Pharmacogn Mag 6: 26–33.
    • (2010) Pharmacogn Mag , vol.6 , pp. 26-33
    • Cheel, J.1    Onofre, G.2    Vokurkova, D.3    Tůmová, L.4    Neugebauerová, J.5
  • 10
    • 84881034952 scopus 로고    scopus 로고
    • The use of mannitol in partial and live donor nephrectomy: an international survey
    • Cosetino M, Breda A, Sanguedoice F, et al. 2013. The use of mannitol in partial and live donor nephrectomy: an international survey. World J Urol 31: 977–982.
    • (2013) World J Urol , vol.31 , pp. 977-982
    • Cosetino, M.1    Breda, A.2    Sanguedoice, F.3
  • 12
    • 84999950780 scopus 로고    scopus 로고
    • A study of biochemical and hematological markers in alcoholic liver cirrhosis
    • Deshpande N, Kandi S, Muddeshwar M, Das R, Ramana KV. 2014. A study of biochemical and hematological markers in alcoholic liver cirrhosis. World J Nutr Hlth 2: 24–27.
    • (2014) World J Nutr Hlth , vol.2 , pp. 24-27
    • Deshpande, N.1    Kandi, S.2    Muddeshwar, M.3    Das, R.4    Ramana, K.V.5
  • 13
    • 84947461497 scopus 로고    scopus 로고
    • Immune dysfunction in acute alcoholic hepatitis
    • Dhanda AD, Collins PL. 2015. Immune dysfunction in acute alcoholic hepatitis. World J Gastroenterol 21: 14–21.
    • (2015) World J Gastroenterol , vol.21 , pp. 14-21
    • Dhanda, A.D.1    Collins, P.L.2
  • 14
    • 0345566946 scopus 로고    scopus 로고
    • Influence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass
    • England MD, Cavarocchi NC, O'Brien IF, et al. 1996. Influence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass. Circulation 74: 134–137.
    • (1996) Circulation , vol.74 , pp. 134-137
    • England, M.D.1    Cavarocchi, N.C.2    O'Brien, I.F.3
  • 15
    • 0025105234 scopus 로고
    • High blood alcohol levels in women: the role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism
    • Frezza M, Di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS. 1990. High blood alcohol levels in women: the role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. New Engl J Med 322: 95–99.
    • (1990) New Engl J Med , vol.322 , pp. 95-99
    • Frezza, M.1    Di Padova, C.2    Pozzato, G.3    Terpin, M.4    Baraona, E.5    Lieber, C.S.6
  • 17
    • 0034931390 scopus 로고    scopus 로고
    • Protective effect of mannitol, glucose-fructose-sucrose-maltose mixture, and natural honey hyperosmolar solutions against ethanol-induced gastric mucosal damage in rats
    • Gharzouli K, Gharzouli A, Amira S, Khennouf S. 2001. Protective effect of mannitol, glucose-fructose-sucrose-maltose mixture, and natural honey hyperosmolar solutions against ethanol-induced gastric mucosal damage in rats. Exp Tox Path 53: 175–180.
    • (2001) Exp Tox Path , vol.53 , pp. 175-180
    • Gharzouli, K.1    Gharzouli, A.2    Amira, S.3    Khennouf, S.4
  • 18
    • 84855471701 scopus 로고    scopus 로고
    • Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1
    • Gong G, Yuan LB, Hu L, et al. 2012. Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1. Acta Pharmacol Sin 33: 11–18.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 11-18
    • Gong, G.1    Yuan, L.B.2    Hu, L.3
  • 19
    • 84897086481 scopus 로고    scopus 로고
    • Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats
    • Gong G, Xiang L, Yuan L, et al. 2014. Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats. PLoS One 9: e89450.
    • (2014) PLoS One , vol.9
    • Gong, G.1    Xiang, L.2    Yuan, L.3
  • 20
    • 84906054083 scopus 로고    scopus 로고
    • Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism
    • Gu XJ, Xu J, Ma BY, et al. 2014. Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism. Chin J Traumatol 17: 1–7.
    • (2014) Chin J Traumatol , vol.17 , pp. 1-7
    • Gu, X.J.1    Xu, J.2    Ma, B.Y.3
  • 21
    • 84953375435 scopus 로고    scopus 로고
    • Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes
    • Han KH, Hashimoto N, Fukushima M. 2016. Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes. World J Gastroenterol 21: 37–49.
    • (2016) World J Gastroenterol , vol.21 , pp. 37-49
    • Han, K.H.1    Hashimoto, N.2    Fukushima, M.3
  • 22
    • 58849148335 scopus 로고    scopus 로고
    • Quantifying the global cellular thiol-disulfide status
    • Hansen RE, Roth D, Winther JR. 2009. Quantifying the global cellular thiol-disulfide status. Proc Natl Acad Sci U S A 106: 422–427.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 422-427
    • Hansen, R.E.1    Roth, D.2    Winther, J.R.3
  • 23
    • 27744524656 scopus 로고    scopus 로고
    • Serum γ-glutamyl transferase in alcoholics, moderate drinkers and abstainers: effect on GGT reference intervals at population level
    • Hietala J, Puukka K, Koivisto H, Anttila P, Niemelä O. 2005. Serum γ-glutamyl transferase in alcoholics, moderate drinkers and abstainers: effect on GGT reference intervals at population level. Alcohol 40: 511–514.
    • (2005) Alcohol , vol.40 , pp. 511-514
    • Hietala, J.1    Puukka, K.2    Koivisto, H.3    Anttila, P.4    Niemelä, O.5
  • 24
    • 84906842107 scopus 로고    scopus 로고
    • The protective effect of glycyrrhizic acid on renal tubular epithelial cell injury induced by high glucose
    • Hou S, Zheng F, Li Y, Gao L, Zhang J. 2014. The protective effect of glycyrrhizic acid on renal tubular epithelial cell injury induced by high glucose. Int J Mol Sci 15: 15026–15043.
    • (2014) Int J Mol Sci , vol.15 , pp. 15026-15043
    • Hou, S.1    Zheng, F.2    Li, Y.3    Gao, L.4    Zhang, J.5
  • 25
    • 84934911212 scopus 로고    scopus 로고
    • Glycyrrhizin, silymarin, and ursodeoxycholic acid regulate a common hepatoprotective pathway in HepG2 cells
    • Hsiang CY, Lin LJ, Kao ST, Lo HY, Chou ST, Ho TY. 2015. Glycyrrhizin, silymarin, and ursodeoxycholic acid regulate a common hepatoprotective pathway in HepG2 cells. Phytomedicine 22: 768–777.
    • (2015) Phytomedicine , vol.22 , pp. 768-777
    • Hsiang, C.Y.1    Lin, L.J.2    Kao, S.T.3    Lo, H.Y.4    Chou, S.T.5    Ho, T.Y.6
  • 26
    • 0035922187 scopus 로고    scopus 로고
    • Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin
    • Hu CC, Chen WK, Liao PH, Yu WC, Lee YJ. 2001. Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin. Mutat Res 496: 117–127.
    • (2001) Mutat Res , vol.496 , pp. 117-127
    • Hu, C.C.1    Chen, W.K.2    Liao, P.H.3    Yu, W.C.4    Lee, Y.J.5
  • 28
    • 0028926374 scopus 로고
    • Expression of an active glycosylated human γ-glutamyl transpeptidase mutant that lacks a membrane anchor domain
    • Ikeda Y, Fujii J, Taniguchi N, Meister A. 1995. Expression of an active glycosylated human γ-glutamyl transpeptidase mutant that lacks a membrane anchor domain. Proc Natl Acad Sci U S A 92: 126–130.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 126-130
    • Ikeda, Y.1    Fujii, J.2    Taniguchi, N.3    Meister, A.4
  • 29
    • 80052774223 scopus 로고    scopus 로고
    • Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities
    • 650514
    • Ishida T, Mizushina Y, Yagi S, et al. 2012. Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities. Evid Based Complement Alternat Med 2012: 650514.
    • (2012) Evid Based Complement Alternat Med , vol.2012
    • Ishida, T.1    Mizushina, Y.2    Yagi, S.3
  • 30
    • 84965064402 scopus 로고    scopus 로고
    • A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies
    • Izzo AA, Hoon-Kim S, Radhakrishnan R, Williamson EM. 2016. A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytother Res 30: 691–700.
    • (2016) Phytother Res , vol.30 , pp. 691-700
    • Izzo, A.A.1    Hoon-Kim, S.2    Radhakrishnan, R.3    Williamson, E.M.4
  • 31
    • 0037181156 scopus 로고    scopus 로고
    • Induction of inducible nitric oxide synthase expression by 18β-glycyrrhetinic acid in macrophages
    • Jeong HG, Kim JY. 2003. Induction of inducible nitric oxide synthase expression by 18β-glycyrrhetinic acid in macrophages. FEBS Lett 513: 208–212.
    • (2003) FEBS Lett , vol.513 , pp. 208-212
    • Jeong, H.G.1    Kim, J.Y.2
  • 32
    • 0027588330 scopus 로고
    • Glutathione, a biochemical indicator for different types of cellular oxidative stress. Ethanol poisoning
    • Jerca L, Busuioc A, Serban F. 1993. Glutathione, a biochemical indicator for different types of cellular oxidative stress. Ethanol poisoning. Rev Med Chir Soc Med Nat Iasi 97: 253–256.
    • (1993) Rev Med Chir Soc Med Nat Iasi , vol.97 , pp. 253-256
    • Jerca, L.1    Busuioc, A.2    Serban, F.3
  • 33
    • 84955353038 scopus 로고    scopus 로고
    • Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease
    • Jung JC, Lee YH, Kim SH, et al. 2016. Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease. BMC Compl Alt Med 16: 19. DOI:10.1186/s12906-0997-0.
    • (2016) BMC Compl Alt Med , vol.16 , pp. 19
    • Jung, J.C.1    Lee, Y.H.2    Kim, S.H.3
  • 34
    • 84870170759 scopus 로고    scopus 로고
    • Modulation of genotoxicity of oxidative mutagens by glycyrrhizic acid from Glycyrrhiza glabra L
    • Kaur P, Sharma N, Singh B, Kumar S, Kaur S. 2012. Modulation of genotoxicity of oxidative mutagens by glycyrrhizic acid from Glycyrrhiza glabra L. Pharmacog Res 4: 189–195.
    • (2012) Pharmacog Res , vol.4 , pp. 189-195
    • Kaur, P.1    Sharma, N.2    Singh, B.3    Kumar, S.4    Kaur, S.5
  • 35
    • 84945313876 scopus 로고    scopus 로고
    • Factor analysis of the biochemical markers related to liver fibrosis
    • Kim HJ, Lee HK, Cho JH. 2015. Factor analysis of the biochemical markers related to liver fibrosis. Pak J Med Sci 31: 1043–1046.
    • (2015) Pak J Med Sci , vol.31 , pp. 1043-1046
    • Kim, H.J.1    Lee, H.K.2    Cho, J.H.3
  • 36
    • 84953403595 scopus 로고    scopus 로고
    • Optimal management for alcoholic liver disease: conventional medications, natural therapy or combination?
    • Kim MS, Ong M, Qu X. 2016. Optimal management for alcoholic liver disease: conventional medications, natural therapy or combination? World J Gastroenterol 22: 8–23.
    • (2016) World J Gastroenterol , vol.22 , pp. 8-23
    • Kim, M.S.1    Ong, M.2    Qu, X.3
  • 37
    • 84917673325 scopus 로고    scopus 로고
    • Autophagy activation and antiviral activity of a licorice triterpene
    • Laconi S, Madeddu MA, Pompei E. 2014. Autophagy activation and antiviral activity of a licorice triterpene. Phytother Res 28: 1890–1892.
    • (2014) Phytother Res , vol.28 , pp. 1890-1892
    • Laconi, S.1    Madeddu, M.A.2    Pompei, E.3
  • 38
    • 0021140733 scopus 로고
    • Ethanol suppresses hepatic glutathione synthesis in rats in vivo
    • Lauterburg BH, Davis S, Mitchell JT. 1984. Ethanol suppresses hepatic glutathione synthesis in rats in vivo. J Pharmacol Exp Ther 230: 7–11.
    • (1984) J Pharmacol Exp Ther , vol.230 , pp. 7-11
    • Lauterburg, B.H.1    Davis, S.2    Mitchell, J.T.3
  • 39
    • 0023748625 scopus 로고
    • Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity
    • Lauterburg BH, Velez ME. 1988. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 29: 1153–1157.
    • (1988) Gut , vol.29 , pp. 1153-1157
    • Lauterburg, B.H.1    Velez, M.E.2
  • 40
    • 0027933540 scopus 로고
    • Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators
    • Lecomte E, Herbeth B, Pirollet P, et al. 1994. Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators. Am J Clin Nutr 60: 255–261.
    • (1994) Am J Clin Nutr , vol.60 , pp. 255-261
    • Lecomte, E.1    Herbeth, B.2    Pirollet, P.3
  • 41
    • 1642453886 scopus 로고    scopus 로고
    • Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis
    • Lee TD, Sadda MR, Mendler MH, et al. 2004. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 28: 173–181.
    • (2004) Alcohol Clin Exp Res , vol.28 , pp. 173-181
    • Lee, T.D.1    Sadda, M.R.2    Mendler, M.H.3
  • 42
    • 35348993141 scopus 로고    scopus 로고
    • Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice
    • Lee CH, Park SW, Kim YS, et al. 2007. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol Pharm Bull 30: 1898–1904.
    • (2007) Biol Pharm Bull , vol.30 , pp. 1898-1904
    • Lee, C.H.1    Park, S.W.2    Kim, Y.S.3
  • 43
    • 84946595368 scopus 로고    scopus 로고
    • The role of oxidative stress and antioxidants in liver diseases
    • Li S, Tan HY, Wang N, et al. 2015. The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 16: 26087–26124.
    • (2015) Int J Mol Sci , vol.16 , pp. 26087-26124
    • Li, S.1    Tan, H.Y.2    Wang, N.3
  • 44
    • 84862952502 scopus 로고    scopus 로고
    • Evaluation of the immunity activity of glycyrrhizin in AR mice
    • Li XL, Zhou AG. 2012. Evaluation of the immunity activity of glycyrrhizin in AR mice. Molecules 17: 716–727.
    • (2012) Molecules , vol.17 , pp. 716-727
    • Li, X.L.1    Zhou, A.G.2
  • 45
    • 84929000101 scopus 로고    scopus 로고
    • Glychrrhizic acid inhibits apoptosis and fibrosis in carbon tetrachloride-induced rat liver injury
    • Liang B, Guo XL, Jin J, Ma YC, Feng ZQ. 2015. Glychrrhizic acid inhibits apoptosis and fibrosis in carbon tetrachloride-induced rat liver injury. World J Gastroenterol 21: 5271–5280.
    • (2015) World J Gastroenterol , vol.21 , pp. 5271-5280
    • Liang, B.1    Guo, X.L.2    Jin, J.3    Ma, Y.C.4    Feng, Z.Q.5
  • 47
    • 55549122117 scopus 로고
    • The effects of 10 triterpenoid compounds on experimental liver injury in mice
    • Liu J, Liu Y, Mao Q, Klaassen CD. 1994. The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol 22: 34–40.
    • (1994) Fundam Appl Toxicol , vol.22 , pp. 34-40
    • Liu, J.1    Liu, Y.2    Mao, Q.3    Klaassen, C.D.4
  • 48
    • 0031393259 scopus 로고    scopus 로고
    • Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute and chronic alcohol abuse: in vivo and in vitro studies
    • Loquercio C, Clot P, Albano E, et al. 1997. Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute and chronic alcohol abuse: in vivo and in vitro studies. Ital J Gastroenterol Hepatol 29: 168–173.
    • (1997) Ital J Gastroenterol Hepatol , vol.29 , pp. 168-173
    • Loquercio, C.1    Clot, P.2    Albano, E.3
  • 49
    • 0032698860 scopus 로고    scopus 로고
    • Ethanol consumption, amino acid and glutathione blood levels in patients with and without chronic liver disease
    • Loquercio C, Blanco FD, De Girolamo V, et al. 1999. Ethanol consumption, amino acid and glutathione blood levels in patients with and without chronic liver disease. Alcohol Clin Exp Res 23: 1780–1784.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 1780-1784
    • Loquercio, C.1    Blanco, F.D.2    De Girolamo, V.3
  • 50
    • 84856492849 scopus 로고    scopus 로고
    • Management of alcoholic hepatitis
    • Mathurin P, Lucey MR. 2012. Management of alcoholic hepatitis. J Hepatol 56(Suppl 1): S39–S45.
    • (2012) J Hepatol , vol.56 , pp. S39-S45
    • Mathurin, P.1    Lucey, M.R.2
  • 51
    • 0028859425 scopus 로고
    • Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits
    • Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G. 1995. Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits. Clin Chem 41: 1509–1517.
    • (1995) Clin Chem , vol.41 , pp. 1509-1517
    • Michelet, F.1    Gueguen, R.2    Leroy, P.3    Wellman, M.4    Nicolas, A.5    Siest, G.6
  • 52
    • 84873602791 scopus 로고    scopus 로고
    • Influence of alcohol consumption on oxidative stress and antioxidant status in cancer patients—case control study from western Nepal
    • Nagamma T, Bhutia RD, Pokharel DR, Yadav S, Baxi J. 2012. Influence of alcohol consumption on oxidative stress and antioxidant status in cancer patients—case control study from western Nepal. Asian Pac J Cancer Prev 13: 3513–3517.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 3513-3517
    • Nagamma, T.1    Bhutia, R.D.2    Pokharel, D.R.3    Yadav, S.4    Baxi, J.5
  • 53
    • 0023919486 scopus 로고
    • Changes in serum enzymes in moderate drinkers after an alcohol challenge
    • Nemesanszky E, Lott JA, Arato M. 1988. Changes in serum enzymes in moderate drinkers after an alcohol challenge. Clin Chem 34: 525–527.
    • (1988) Clin Chem , vol.34 , pp. 525-527
    • Nemesanszky, E.1    Lott, J.A.2    Arato, M.3
  • 54
    • 84897930943 scopus 로고    scopus 로고
    • Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats
    • Nwozo SO, Osunmadewa DA, Oyinloye BE. 2014. Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats. J Integr Med 12: 59–65.
    • (2014) J Integr Med , vol.12 , pp. 59-65
    • Nwozo, S.O.1    Osunmadewa, D.A.2    Oyinloye, B.E.3
  • 55
    • 3242752034 scopus 로고    scopus 로고
    • High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking
    • Nyblom H, Berggren U, Balldin J, Olsson R. 2004. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol 39: 336–339.
    • (2004) Alcohol , vol.39 , pp. 336-339
    • Nyblom, H.1    Berggren, U.2    Balldin, J.3    Olsson, R.4
  • 58
    • 84904976799 scopus 로고    scopus 로고
    • Effect of glycyrrhizic acid on titanium dioxide nanoparticle-induced hepatotoxicity in rats
    • Orazizadeh M, Khorsandi L, Fakhredini F, Mansouri E. 2014. Effect of glycyrrhizic acid on titanium dioxide nanoparticle-induced hepatotoxicity in rats. Biochem Biol Interact 220: 214–221.
    • (2014) Biochem Biol Interact , vol.220 , pp. 214-221
    • Orazizadeh, M.1    Khorsandi, L.2    Fakhredini, F.3    Mansouri, E.4
  • 59
    • 84876554153 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effect of Garcinia indica fruit rind in ethanol-induced hepatic damage in rodents
    • Panda V, Ashar H, Srinath S. 2012. Antioxidant and hepatoprotective effect of Garcinia indica fruit rind in ethanol-induced hepatic damage in rodents. Interdiscip Toxicol 5: 207–213.
    • (2012) Interdiscip Toxicol , vol.5 , pp. 207-213
    • Panda, V.1    Ashar, H.2    Srinath, S.3
  • 60
    • 84956648916 scopus 로고    scopus 로고
    • Mannitol in Plants, fungi, and plant-fungal interactions
    • Patel TK, Williamson JD. 2016. Mannitol in Plants, fungi, and plant-fungal interactions. Trends Plant Sci 21: 486–497.
    • (2016) Trends Plant Sci , vol.21 , pp. 486-497
    • Patel, T.K.1    Williamson, J.D.2
  • 61
    • 24744456677 scopus 로고    scopus 로고
    • Non-invasive monitoring of oxidative stress in alcoholic liver disease
    • Pemberton PW, Smith A, Warnes TW. 2005. Non-invasive monitoring of oxidative stress in alcoholic liver disease. Scand J Gastroenterol 40: 1102–1108.
    • (2005) Scand J Gastroenterol , vol.40 , pp. 1102-1108
    • Pemberton, P.W.1    Smith, A.2    Warnes, T.W.3
  • 62
    • 0022551202 scopus 로고
    • Increased hepatic efflux of glutathione after chronic ethanol feeding
    • Pierson JL, Mitchell MC. 1986. Increased hepatic efflux of glutathione after chronic ethanol feeding. Biochem Pharmacol 35: 1533–1537.
    • (1986) Biochem Pharmacol , vol.35 , pp. 1533-1537
    • Pierson, J.L.1    Mitchell, M.C.2
  • 63
    • 84931292388 scopus 로고    scopus 로고
    • Association of alcohol consumption with specific biomarkers: a cross-sectional study in South Africa
    • Pisa PT, Vorster HH, Kruger A, Margetts B, Loots du T. 2015. Association of alcohol consumption with specific biomarkers: a cross-sectional study in South Africa. J Health Popul Nutr 33: 146–156.
    • (2015) J Health Popul Nutr , vol.33 , pp. 146-156
    • Pisa, P.T.1    Vorster, H.H.2    Kruger, A.3    Margetts, B.4    Loots du, T.5
  • 64
    • 84999918651 scopus 로고    scopus 로고
    • Relationship between DDR@ and alcoholic liver fibrosis and responses to compound glycyrrhizin tablets on them: an experimental study
    • Quan ZY, Ming Y, Hong ZX, Min LH. 2009. Relationship between DDR@ and alcoholic liver fibrosis and responses to compound glycyrrhizin tablets on them: an experimental study. J Shandong Univ 47: 80–84.
    • (2009) J Shandong Univ , vol.47 , pp. 80-84
    • Quan, Z.Y.1    Ming, Y.2    Hong, Z.X.3    Min, L.H.4
  • 65
    • 84999926092 scopus 로고    scopus 로고
    • Alcoholic liver disease. Implications of oxidative stress
    • Qureshi MS, Ahmad R, Rizwan R, et al. 2015. Alcoholic liver disease. Implications of oxidative stress. Prof Med J 22: 896–903.
    • (2015) Prof Med J , vol.22 , pp. 896-903
    • Qureshi, M.S.1    Ahmad, R.2    Rizwan, R.3
  • 66
    • 0023488842 scopus 로고
    • Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro
    • Reinke LA, Lai EK, DuBose CM, McCay PB. 1987. Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro. Proc Natl Acad Sci U S A 84: 9223–9227.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9223-9227
    • Reinke, L.A.1    Lai, E.K.2    DuBose, C.M.3    McCay, P.B.4
  • 67
  • 68
    • 84867359281 scopus 로고    scopus 로고
    • Can protein carbonyl/glutathione ratio be used as a potential biomarker to assess oxidative stress in alcoholic hepatitis?
    • Sripradha R, Sridhar MG, Agarwal A. 2010. Can protein carbonyl/glutathione ratio be used as a potential biomarker to assess oxidative stress in alcoholic hepatitis? Ind J Med Sci 64: 476–483.
    • (2010) Ind J Med Sci , vol.64 , pp. 476-483
    • Sripradha, R.1    Sridhar, M.G.2    Agarwal, A.3
  • 69
    • 84942880971 scopus 로고    scopus 로고
    • Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental animal model
    • Sil R, Ray D, Chakraborti AS. 2015. Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental animal model. Mol Cell Biochem 409: 177–189.
    • (2015) Mol Cell Biochem , vol.409 , pp. 177-189
    • Sil, R.1    Ray, D.2    Chakraborti, A.S.3
  • 70
    • 84872191827 scopus 로고    scopus 로고
    • Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells
    • Thomes PG, Ehlers RA, Trambly CS, et al. 2013. Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells. Autophagy 9: 63–73.
    • (2013) Autophagy , vol.9 , pp. 63-73
    • Thomes, P.G.1    Ehlers, R.A.2    Trambly, C.S.3
  • 71
    • 58149488688 scopus 로고    scopus 로고
    • Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes
    • Tripathi M, Singh BK, Kakkar P. 2009. Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes. Food Chem Toxicol 47: 339–347.
    • (2009) Food Chem Toxicol , vol.47 , pp. 339-347
    • Tripathi, M.1    Singh, B.K.2    Kakkar, P.3
  • 72
    • 0024342548 scopus 로고
    • Increased plasma levels of glutathione and malondialdehyde after acute ethanol ingestion in humans
    • Vendemiale G, Altomare E, Grattagliano I, Albano O. 1989. Increased plasma levels of glutathione and malondialdehyde after acute ethanol ingestion in humans. J Hepatol 9: 359–365.
    • (1989) J Hepatol , vol.9 , pp. 359-365
    • Vendemiale, G.1    Altomare, E.2    Grattagliano, I.3    Albano, O.4
  • 73
    • 0033088938 scopus 로고    scopus 로고
    • Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats
    • Wang J, Guo J, Liu S. 1999. Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats. Zhonghue Gan Zang Bin Za Zhi 7: 42–43.
    • (1999) Zhonghue Gan Zang Bin Za Zhi , vol.7 , pp. 42-43
    • Wang, J.1    Guo, J.2    Liu, S.3
  • 74
    • 84876253763 scopus 로고    scopus 로고
    • Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid
    • Wang W, Luo M, Fu Y, Wang S, Efferth T, Zu Y. 2013. Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid. Int J Nanomedicine 8: 1377–1383.
    • (2013) Int J Nanomedicine , vol.8 , pp. 1377-1383
    • Wang, W.1    Luo, M.2    Fu, Y.3    Wang, S.4    Efferth, T.5    Zu, Y.6
  • 75
    • 84925348946 scopus 로고    scopus 로고
    • Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes
    • Wang J, Zhang Y, Liu R, Li X, Cui Y, Qu L. 2015a. Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes. Can J Physiol Pharmacol 93: 261–267.
    • (2015) Can J Physiol Pharmacol , vol.93 , pp. 261-267
    • Wang, J.1    Zhang, Y.2    Liu, R.3    Li, X.4    Cui, Y.5    Qu, L.6
  • 76
    • 84928631450 scopus 로고    scopus 로고
    • Dendrobium huoshanense polysaccharide prevents ethanol-induced liver injury in mice by metabolomics analysis
    • Wang XY, Lou JP, Chen R, Zha XQ, Pan LH. 2015b. Dendrobium huoshanense polysaccharide prevents ethanol-induced liver injury in mice by metabolomics analysis. Int J Biol Macromol 78: 354–362.
    • (2015) Int J Biol Macromol , vol.78 , pp. 354-362
    • Wang, X.Y.1    Lou, J.P.2    Chen, R.3    Zha, X.Q.4    Pan, L.H.5
  • 77
    • 85000659048 scopus 로고    scopus 로고
    • Natural products for the prevention and treatment of hangover and alcohol use disorder
    • Wang F, Li Y, Zhang YJ, Zhou Y, Li HB. 2016. Natural products for the prevention and treatment of hangover and alcohol use disorder. Molecules 21: 64. DOI:10.3390/molecules21010064.
    • (2016) Molecules , vol.21 , pp. 64
    • Wang, F.1    Li, Y.2    Zhang, Y.J.3    Zhou, Y.4    Li, H.B.5
  • 78
    • 84875672652 scopus 로고    scopus 로고
    • Montgomery GW, Martin NG. Metabolic and biochemical effects of low-to-moderate alcohol consumption
    • Whitfield JB, Heath AC, Madden PA, Pergadia ML. 2013. Montgomery GW, Martin NG. Metabolic and biochemical effects of low-to-moderate alcohol consumption. Alcohol Clin Exp Res 37: 575–586.
    • (2013) Alcohol Clin Exp Res , vol.37 , pp. 575-586
    • Whitfield, J.B.1    Heath, A.C.2    Madden, P.A.3    Pergadia, M.L.4
  • 79
    • 84922454872 scopus 로고    scopus 로고
    • Protective effects of glycyrrhizic acid and 18β-glycyrrhetinic acid against cisplatin-induced nephrotoxicity in BALB/c mice
    • 2015. PMID 25588318
    • Wu CH, Chen AZ, Yen GC. 2015. Protective effects of glycyrrhizic acid and 18β-glycyrrhetinic acid against cisplatin-induced nephrotoxicity in BALB/c mice. J Agric Food Chem 2015. PMID: 25588318.
    • (2015) J Agric Food Chem
    • Wu, C.H.1    Chen, A.Z.2    Yen, G.C.3
  • 80
    • 84891814808 scopus 로고    scopus 로고
    • The effects of glycyrrhizin on experimental acute pancreatitis in rats
    • Yildirim AQ, Ince M, Evi YE, et al. 2013. The effects of glycyrrhizin on experimental acute pancreatitis in rats. Eur Rev Med Pharmacol Sci 17: 2981–2987.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 2981-2987
    • Yildirim, A.Q.1    Ince, M.2    Evi, Y.E.3
  • 81
    • 84902271402 scopus 로고    scopus 로고
    • Targeted metabolomics study indicting glycyrrhizin's protection against acetaminophen-induced liver damage through reversing fatty acid metbolism
    • Yu J, Jiang YS, Jiang Y, et al. 2014. Targeted metabolomics study indicting glycyrrhizin's protection against acetaminophen-induced liver damage through reversing fatty acid metbolism. Phytother Res 28: 933–936.
    • (2014) Phytother Res , vol.28 , pp. 933-936
    • Yu, J.1    Jiang, Y.S.2    Jiang, Y.3
  • 82
    • 34547602615 scopus 로고    scopus 로고
    • Activity of mannitol and hypertonic saline therapy on the oxidant and antioxidant system during the acute term after traumatic brain injury in the rats
    • Yilmaz N, Dulger J, Kiymaz N, Yilmaz C, Gudu BO, Demir I. 2007. Activity of mannitol and hypertonic saline therapy on the oxidant and antioxidant system during the acute term after traumatic brain injury in the rats. Brain Res 1164: 132–15.
    • (2007) Brain Res , vol.1164 , pp. 115-132
    • Yilmaz, N.1    Dulger, J.2    Kiymaz, N.3    Yilmaz, C.4    Gudu, B.O.5    Demir, I.6
  • 83
    • 81155148125 scopus 로고    scopus 로고
    • Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes
    • Zelickson BR, Benavides GA, Johnson MS, et al. 2011. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim Biophys Acta 1807: 1573–1582.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 1573-1582
    • Zelickson, B.R.1    Benavides, G.A.2    Johnson, M.S.3
  • 84
    • 84962476175 scopus 로고    scopus 로고
    • Effects of 20 selected fruits on ethanol metabolism: potential health benefits and harmful impacts
    • Zhang YJ, Wang F, Zhou Y, et al. 2016. Effects of 20 selected fruits on ethanol metabolism: potential health benefits and harmful impacts. Env Res Publ Health 13: 339. DOI:10.3390/iherph.13040399.
    • (2016) Env Res Publ Health , vol.13 , pp. 339
    • Zhang, Y.J.1    Wang, F.2    Zhou, Y.3


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