Can protein carbonyl/glutathione ratio be used as a potential biomarker to assess oxidative stress in alcoholic hepatitis

Indian Journal of Medical Sciences

Volumn 64, Issue 10, 2010, Pages 476-483

  Sripradha, Ramalingam ^a   Sridhar, Magadi Gopalakrishna ^a   Agrawal, Aparna ^b  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b LADY HARDINGE MEDICAL COLLEGE   (India)

Author keywords

Alcoholic liver disease; glutathione; oxidative stress; protein carbonyl

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARBONYL DERIVATIVE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; MALONALDEHYDE; PROTEIN; PROTEIN CARBONYL; SIALIC ACID; THIOBARBITURIC ACID; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ANALYTIC METHOD; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOANALYZER; CLINICAL ARTICLE; CONTROLLED STUDY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; MALE; OXIDATIVE STRESS; PROTEIN CARBONYLATION;

ADULT; BIOLOGICAL MARKERS; GLUTATHIONE; HEPATITIS, ALCOHOLIC; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; PROTEIN CARBONYLATION;

EID: 84867359281     PISSN: 00195359     EISSN: 19983654     Source Type: Journal    
DOI: 10.4103/0019-5359.101809     Document Type: Article

References (20)

1. Sherlock S. Alcohol and the liver. In: Sherlock S, editor. Diseases of the liver and biliary system. 6 th ed. London: Blackwell publications; 1995. p.385-403.
2. Neufeld KJ, Peters DH, Rani M, Bonu S, BroonerRK. Regular use of alcohol and tobacco in India and its association with age, gender, and poverty. Drug Alcohol Depend 2005;77:283-91. (Pubitemid 40283530)
3. Savolainen VT, Liesto K, Mnnikk A, Penttil A, Karhunen PJ. Alcohol consumption and alcoholic liver disease: Evidence of a threshold level of effects of ethanol. Alcohol Clin Exp Res 1993;17:1112-7. (Pubitemid 24000535)
4. Halliwell B. Free radical, reactive oxygen species and human disease. Br J Exp Pathol 1989;70:737-57.
5. Lieber CS, Leo MA. Metabolism of ethanol and some associated adverse effects on the liver and the stomach. Recent Dev Alcohol 1998;14:7-40.
6. Lluis JM, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernndez-Checa JC. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 2003;124:708-24. (Pubitemid 36268490)
7. Wiseman H, Halliwell B. Damage to DNA by reactiveoxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 1996;313:17-29. (Pubitemid 26013419)
8. Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997;324:1-18. (Pubitemid 27229359)
9. Chakraborty H, Ray SN, Chakraborty S. Lipidperoxidation associated protein damage in rat brain crude synaptosomal fraction mediated by iron and ascorbate. Neurochem Int 2000;39:311-7. (Pubitemid 32817101)
10. Beutler E, Duron OM, Kelly B. Improved method for determination of blood glutathione. J Lab Clin Med 1963;61:882-8.
11. Satoh K. Serum lipid peroxide in cerebrovascular disorders, determined by a new calorimetric method. Clin Chim Acta 1978;90:37-43. (Pubitemid 9055456)
12. Aminoff D. Methods for the quantitative estimation of neuraminic acid and their application to hydrolysates of sialomucoids. Biochem J 1961;81:384-92.
13. Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997;272:20313-6. (Pubitemid 27355575)
14. Stadtman ER, Berlett BS. Reactive oxygen- mediated protein oxidation in aging and disease. Chem Res Toxicol 1997;10:485-94. (Pubitemid 27217204)
15. Lee SL, Wang MF, Lee AI, Yin SJ. The metabolic role of human ADH3 functioning as ethanol dehydrogenase. FEBS Lett 2003;544:143-7.
16. Fariss MW, Chan CB, Patel M, Houten BV. Role of Mitochondria in Toxic Oxidative Stress. MolInterv 2005;5:94-111. (Pubitemid 40590509)
17. Goswami K, Nanda Kumar DN, Koner BC, Bobby Z, Sen SK. Oxidative changes and desialylation of serum proteins in hyperthyroidism. Clin Chim Acta 2003;337:163- 8. (Pubitemid 37329814)
18. diz N, Gvendik G, Bogelmez T, SylemezoluYB. Doan YB, lhan I. Serumsialic acid and g-glutamyltransferase levels in alcohol-dependent individuals. Forensic Sci Int 2004;146:S67-70.
19. Grune T, Reinheckel T, Joshi M, Davies KJA. Proteolysis in cultured liver epithelial cells during oxidative stress-role of the multicatalytic proteinase complex, proteasome. J Biol Chem 1995;270:2344-51.
20. Pantke U, Volk T, Schmutzler M, Kox WJ, Sitte N, Grune T. Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radic Biol Med 1999;27:1080-6. (Pubitemid 29507480)