Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 12, 2004, Pages 1436-1439

  Ablise, Mourboul ^a,b   Leininger Muller, Brigitte ^a   Wong, Choi Dal ^a   Siest, Gérard ^a   Loppinet, Vincent ^a   Visvikis, Sophie ^a  

^a INSERM   (France)

^b XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Antioxidant activity; Cytochrome P450 NADPH reductase; Glycyrrhetinic acid derivative

Indexed keywords

18BETA OLEAN 11,13 (18)DIENE 3BETA,30 DIOL; 18BETA OLEAN 12 ENE 3BETA,11ALPHA,30 TRIOL; 18BETA OLEAN 12 ENE 3BETA,11BETA,30 TRIOL; 18BETA OLEAN 9 (11),12 DIENE 3BETA,30 DIOL; 3BETA HYDROXY 11 OXO 18BETA OLEAN 12 EN 30 OIC ACID; ALKADIENE; ALPHA TOCOPHEROL; CYTOCHROME P450; GLYCYRRHETINIC ACID DERIVATIVE; GLYCYRRHIZIC ACID; HYDROXYACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; ANTILIPEMIC AGENT; ANTIOXIDANT; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FREE RADICAL; GLYCYRRHETINIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS; MALE; MOLECULAR PROBE; NONHUMAN; OXIDATION; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; LIVER MICROSOME; METABOLISM; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; ANTILIPEMIC AGENTS; ANTIOXIDANTS; FREE RADICALS; GLYCYRRHETINIC ACID; INDICATORS AND REAGENTS; MALE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; VITAMIN E;

EID: 21644482451     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.52.1436     Document Type: Article

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