Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 496, Issue 1-2, 2001, Pages 117-127

  Hu, Chao Chin ^a   Chen, Wen Kang ^a   Liao, Pel Hu ^a   Yu, Wei Che ^a   Lee, Yean Jang ^b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHANGHUA UNIVERSITY OF EDUCATION   (Taiwan)

Author keywords

Cadmium; Genotoxicity; Glycyrrhizin; Hprt; Quercetin

Indexed keywords

ACETALDEHYDE; CADMIUM CHLORIDE; GLYCYRRHIZIC ACID; LIPID PEROXIDE; MALONALDEHYDE; QUERCETIN; RHODAMINE 123; THIOBARBITURIC ACID;

ANIMAL CELL; CELL MEMBRANE POTENTIAL; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; GENE MUTATION; GENOTOXICITY; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TOXICITY TESTING;

ACETALDEHYDE; ANIMALS; ANTIMUTAGENIC AGENTS; CADMIUM CHLORIDE; CELL LINE; CELL SURVIVAL; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GLYCYRRHIZIC ACID; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTRACELLULAR MEMBRANES; LIPID PEROXIDATION; MEMBRANE POTENTIALS; MITOCHONDRIA; MUTAGENS; QUERCETIN;

EID: 0035922187     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00214-5     Document Type: Conference Paper

References (37)

1. Toxicological principles of metal carcinogenesis with emphasis on cadmium
2. Blood cadmium levels in a general malepopulation with special reference to smoking
3. Carcinogenicity of cadmium chloride aerosols in rats
4. Cadmium carcinogenesis in male Wister [Crl:(WI)BR] rats: Dose-response analysis of tumor induction in the prostate and testes and at the injection site
5. The effect of cadmium on chemical- and viral-induced tumor production in mice
6. Carcinogenicity of oral cadmium in the male Wister (WF/NCr) rat: Effect of chronic dietary zinc deficiency
7. Resistance to cadmium mediated by ubiquitin-dependent proteolysis
8. Metallothionein content correlates with the sensitivity of human small lung cancer cell lines to cisplatin
9. Human blood acetaldehyde concentration during ethanol oxidation (update 1982)
10. Liver damage: Mechanisms and management
11. Acetaldehyde: Genotoxicity and cytotoxicity in human lymphocytes
12. Role of DNA repair inhibition in lead- and cadmium-induced genotoxicity: A review
13. The effects of some redox-active metals and reactive aldehydes on DNA-protein cross-links in vitro
14. Comparative study of the damage produced by acute ethanol and acetaldehyde treatment in a human fetal hepatic cell line
15. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells)
16. Cancer chemoprevention: Principles and prospects
17. Proxident states and tumor promotion
18. Molecular mechanism of oxygen radical carcinogenesis and mutagenesis: The role of DNA base damage
19. Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes
20. Mechanism of anti-inflammatory action of glycyrrhizin: Effect on neutrophil functions including reactive oxygen species generation
21. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands
22. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
23. Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages
24. Review of the biology of quercetin and related bioflavonoids
25. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen elderly study
26. Feasibility of drug screening with panels of human tumor cell lines a microculture tetrazolium assay
27. Assays for the induction of mutagens to 6-thioguanine resistance in Chinese hamster V79 cells in culture
28. Lipid peroxides and human diseases
29. Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: Protection by fructose, cyclosporin A and trifluoperazine
30. Interactive cytotoxicities of selected organic and inorganic substances to brown cells of Mercenaria mercenaria
31. 2+-dependent and -independent mitochondrial damage in hepatocellular injury
32. 2+ and mitochondrial membrane potential preceding cell death in hepatocytes
33. Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by t-butyl hydroperoxide
34. Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibition, ionophores and oxidant chemicals
35. Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes
36. Synthesis of caffeic acid esters as Antioxidants by esterification via acyl chlorides
37. Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells