Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Mizushina, Yoshiyuki ^b   Ishida, Tsukasa ^a   Yagi, Saori ^a   Irino, Yasuhiro ^c   Nishiumi, Shin ^c   Miki, Ikuya ^a   Kondo, Yasuyuki ^a   Mizuno, Shigeto ^a   Yoshida, Hiromi ^b   Azuma, Takeshi ^c   Yoshida, Masaru ^c  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE KAPPA; DNA DIRECTED DNA POLYMERASE LAMBDA; DNA POLYMERASE; GLYCYRRHETINIC ACID; GLYCYRRHIZATE DIPOTASSIUM; GLYCYRRHIZIC ACID; GLYCYRRHIZIC ACID DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OTITIS; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

EID: 80052774223     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/650514     Document Type: Article

References (50)

1. Hbscher U., Maga G., Spadari S., Eukaryotic DNA polymerases Annual Review of Biochemistry 2002 71 133 163 (Pubitemid 34800217)
2. Bebenek K., Kunkel T. A., Yang W., DNA repair and replication Advances in Protein Chemistry 2004 69 San Diego, Calif, USA Elsevier 137 165
3. Takata K. I., Shimizu T., Iwai S., Wood R. D., Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol Journal of Biological Chemistry 2006 281 33 23445 23455 (Pubitemid 44274119)
4. Friedberg E. C., Feaver W. J., Gerlach V. L., The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance Proceedings of the National Academy of Sciences of the United States of America 2000 97 11 5681 5683 (Pubitemid 30367454)
5. Sakaguchi K., Sugawara F., Mizushina Y., Inhibitors of eukaryotic DNA polymerases Seikagaku 2002 74 3 244 251
6. Mizushina Y., Specific inhibitors of mammalian DNA polymerase species Bioscience, Biotechnology and Biochemistry 2009 73 6 1239 1251
7. Eisenbrand G., Glycyrrhizin: opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) Molecular Nutrition and Food Research 2006 50 11 1087 1088 (Pubitemid 44861505)
8. Shibata S., A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice Yakugaku Zasshi 2000 120 10 849 862
9. Lin G., Nnane I. P., Cheng T. Y., The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats Toxicon 1999 37 9 1259 1270 (Pubitemid 29236212)
10. Mizushina Y., Kamisuki S., Kasai N., Ishidoh T., Shimazaki N., Takemura M., Asahara H., Linn S., Yoshida S., Koiwai O., Sugawara F., Yoshida H., Sakaguchi K., Petasiphenol: a DNA polymerase inhibitor Biochemistry 2002 41 49 14463 14471
11. Mizushina Y., Ishidoh T., Takeuchi T., Shimazaki N., Koiwai O., Kuramochi K., Kobayashi S., Sugawara F., Sakaguchi K., Yoshida H., Monoacetylcurcumin: a new inhibitor of eukaryotic DNA polymerase and a new ligand for inhibitor-affinity chromatography Biochemical and Biophysical Research Communications 2005 337 4 1288 1295 (Pubitemid 41505262)
12. Takeuchi T., Ishidoh T., Iijima H., Kuriyama I., Shimazaki N., Koiwai O., Kuramochi K., Kobayashi S., Sugawara F., Sakaguchi K., Yoshida H., Mizushina Y., Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase Genes to Cells 2006 11 3 223 235
13. Mizushina Y., Hirota M., Murakami C., Ishidoh T., Kamisuki S., Shimazaki N., Takemura M., Perpelescu M., Suzuki M., Yoshida H., Sugawara F., Koiwai O., Sakaguchi K., Some anti-chronic inflammatory compounds are DNA polymerase -specific inhibitors Biochemical Pharmacology 2003 66 10 1935 1944 (Pubitemid 37352856)
14. Mizushina Y., Takeuchi T., Kuramochi K., Kobayashi S., Sugawara F., Sakaguchi K., Yoshida H., Study on the molecular structure and bio-activity (DNA polymerase inhibitory activity, anti-inflammatory activity and anti-oxidant activity) relationship of curcumin derivatives Current Bioactive Compounds 2007 3 3 171 177
15. Nishida M., Nishiumi S., Mizushina Y., Fujishima Y., Yamamoto K., Masuda A., Mizuno S., Fujita T., Morita Y., Kutsumi H., Yoshida H., Azuma T., Yoshida M., Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF- B activation International Journal of Molecular Medicine 2010 25 5 761 767
16. Hecker E., Carcinogenesis 1978 New York, NY, USA Raben Press
17. Fujiki H., Sugimura T., Advances in Cancer Research 1987 London, UK Academic Press
18. Nakamura Y., Murakami A., Ohto Y., Torikai K., Tanaka T., Ohigashi H., Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'- acetoxychavicol acetate Cancer Research 1995 58 21 4832 4839 (Pubitemid 28503678)
19. Tamai K., Kojima K., Hanaichi T., Masaki S., Suzuki M., Umekawa H., Yoshida S., Structural study of immunoaffinity-purified DNA polymerase -DNA primase complex from calf thymus Biochimica et Biophysica Acta 1988 950 3 263 273
20. Umeda S., Muta T., Ohsato T., Takamatsu C., Hamasaki N., Kang D., The D-loop structure of human mtDNA is destabilized directly by 1- methyl-4-phenylpyridinium ion (MPP+), a parkinsonism-causing toxin European Journal of Biochemistry 2000 267 1 200 206 (Pubitemid 30029754)
21. Ohashi E., Murakumo Y., Kanjo N., Akagi J. I., Masutani C., Hanaoka F., Ohmori H., Interaction of hREV1 with three human Y-family DNA polymerases Genes to Cells 2004 9 6 523 531 (Pubitemid 38877782)
22. Shimazaki N., Yoshida K., Kobayashi T., Toji S., Tamai K., Koiwai O., Over-expression of human DNA polymerase in E. coli and characterization of the recombinant enzyme Genes to Cells 2002 7 7 639 651 (Pubitemid 34814756)
23. Mizushina Y., Tanaka N., Yagi H., Kurosawa T., Onoue M., Seto H., Horie T., Aoyagi N., Yamaoka M., Matsukage A., Yoshida S., Sakaguchi K., Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro Biochimica et Biophysica Acta 1996 1308 3 256 262 (Pubitemid 26290686)
24. Mizushina Y., Yoshida S., Matsukage A., Sakaguchi K., The inhibitory action of fatty acids on DNA polymerase Biochimica et Biophysica Acta 1997 1336 3 509 521 (Pubitemid 27467053)
25. Mosmann T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 1983 65 1-2 55 63 (Pubitemid 14203433)
26. Gschwendt M., Kittstein W., Furstenberger G., Marks F., The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion Cancer Letters 1984 25 2 177 185 (Pubitemid 15195080)
27. Aggarwal B. B., Signalling pathways of the TNF superfamily: a double-edged sword Nature Reviews Immunology 2003 3 9 745 756 (Pubitemid 41070815)
28. Garcia-Diaz M., Bebenek K., Sabariegos R., DNA polymerase, a novel DNA repair enzyme in human cells The Journal of Biological Chemistry 2002 277 13184 13191 (Pubitemid 34952689)
29. Singhal R. K., Wilson S. H., Short gap-filling synthesis by DNA polymerase is processive Journal of Biological Chemistry 1993 268 21 15906 15911 (Pubitemid 23222095)
30. Matsumoto Y., Kim K., Excision of deoxyribose phosphate residues by DNA polymerase during DNA repair Science 1995 269 5224 699 702
31. Sobol R. W., Horton J. K., Khn R., Gu H., Singhal R. K., Prasad R., Rajewsky K., Wilson S. H., Requirement of mammalian DNA polymerase- in base-excision repair Nature 1996 379 6561 183 186 (Pubitemid 26020204)
32. Ramadan K., Shevelev I. V., Maga G., Bscher U. H., DNA polymerase from calf thymus preferentially replicates damaged DNA Journal of Biological Chemistry 2002 277 21 18454 18458 (Pubitemid 34952392)
33. Sugo N., Aratani Y., Nagashima Y., Kubota Y., Koyama H., Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase EMBO Journal 2000 19 6 1397 1404 (Pubitemid 30151035)
34. Garca-Daz M., Bebenek K., Kunkel T. A., Blanco L., Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase : a possible role in base excision repair Journal of Biological Chemistry 2001 276 37 34659 34663
35. Hirose F., Hotta Y., Yamaguchi M., Matsukage A., Difference in the expression level of DNA polymerase among mouse tissues: high expression in the pachytene spermatocyte Experimental Cell Research 1989 181 1 169 180 (Pubitemid 19072800)
36. Garcia-Diaz M., Dominguez O., Lopez-Fernandez L. A., DNA polymerase, a novel DNA repair enzyme in human cells Journal of Molecular Biology 2000 301 851 867
37. Bertocci B., De Smet A., Flatter E., Dahan A., Bories J. C., Landreau C., Weill J. C., Reynaud C. A., Cutting edge: DNA polymerases and are dispensable for Ig gene hypermutation Journal of Immunology 2002 168 8 3702 3706 (Pubitemid 34298367)
38. Tanaka H., Hasegawa T., Matsushita M., Miichi H., Hayashi S., Quantitative evaluation of ocular anti-inflammatory drugs based on measurements of corneal temperature in rabbits: dexamethasone and glycyrrhizin Ophthalmic Research 1987 19 4 213 220 (Pubitemid 17128858)
39. Ohuchi K., Kamada Y., Levine L., Tsurufuji S., Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats Prostaglandins and Medicine 1981 7 5 457 463 (Pubitemid 12249608)
40. Ichikawa Y., Mizoguchi Y., Kioka K., Kobayashi K., Effect of glycyrrhizin on the production of platelet-activating factor from rat peritoneal exudate cells Japanese Journal of Allergology 1989 38 4 365 369 (Pubitemid 19143153)
41. Pompei R., Flore O., Marccialis M. A., Pani A., Loddo B., Glycyrrhizic acid inhibits virus growth and inactivates virus particles Nature 1979 281 5733 689 690 (Pubitemid 10249050)
42. Ito M., Nakashima H., Baba M., Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)] Antiviral Research 1987 7 127 137 (Pubitemid 17055228)
43. Abe N., Ebina T., Ishida N., Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice Microbiology and Immunology 1982 26 6 535 539 (Pubitemid 12068620)
44. Finney R. S. H., Somers G. F., The antiinflammatory activity of glycyrrhetinic acid and derivatives Journal of Pharmacy and Pharmacology 1958 10 613 620
45. Capasso F., Mascolo N., Autore G., Duraccio M. R., Glycyrrhetinic acid, leucocytes and prostaglandins Journal of Pharmacy and Pharmacology 1983 35 5 332 335 (Pubitemid 13124921)
46. Nishino H., Yoshioka K., Iwashima A., Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12- O -tetradecanoylphorbol-13- acetate in two-stage mouse skin carcinogenesis Japanese Journal of Cancer Research 1986 77 33 38 (Pubitemid 16156038)
47. Nose M., Ito M., Kamimura K., Shimizu M., Ogihara Y., A comparison of the antihepatotoxic activity between glycyrrhizin and glycyrrhetinic acid Planta Medica 1994 60 2 136 139 (Pubitemid 24120897)
48. Abe H., Ohya N., Yamamoto K. F., Shibuya T., Arichi S., Odashima S., Effects of glycyrrhizin and glycyrrhetinic acid on growth and melanogenesis in cultured B16 melanoma cells European Journal of Cancer and Clinical Oncology 1987 23 10 1549 1555
49. Monder C., Stewart P. M., Lakshmi V., Valentino R., Burt D., Edwards C. R. W., Licorice inhibits corticosteroid 11 -dehydrogenase of rat kidney and liver: in vivo and in vitro studies Endocrinology 1989 125 2 1046 1053 (Pubitemid 19205104)
50. Medeiros R., Otuki M. F., Avellar M. C. W., Calixto J. B., Mechanisms underlying the inhibitory actions of the pentacyclic triterpene -amyrin in the mouse skin inflammation induced by phorbol ester 12- O -tetradecanoylphorbol-13- acetate European Journal of Pharmacology 2007 559 2-3 227 235 (Pubitemid 46295405)