Modulation of genotoxicity of oxidative mutagens by glycyrrhizic acid from Glycyrrhiza glabra L.

Pharmacognosy Research

Volumn 4, Issue 4, 2012, Pages 189-195

  Kaur, Prabhjit ^a   Sharma, Neha ^a   Singh, Bikram ^b   Kumar, Subodh ^a   Kaur, Satwinderjeet ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

Author keywords

4NQO; Chemoprevention; Glycyrrhiza glabra L.; Glycyrrhizic acid; H2O 2; Oxidative mutagens

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; FREE RADICAL; GLYCYRRHIZIC ACID; HYDROGEN PEROXIDE; METHANOL; MUTAGENIC AGENT; SCAVENGER;

ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; CELL FRACTIONATION; CHEMOPROPHYLAXIS; COLUMN CHROMATOGRAPHY; COMET ASSAY; CONTROLLED STUDY; ENZYME ACTIVITY; GENOTOXICITY; GLYCYRRHIZA GLABRA; HUMAN; HUMAN CELL; LYMPHOCYTE; OXIDATIVE STRESS; SOS CHROMOTEST; TRADITIONAL MEDICINE;

EID: 84870170759     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.102260     Document Type: Article

References (37)

1. Eldeen IM, Elgorashi EE, van Staden J. Antibacterial, antiinflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. J Ethnopharmacol 2005;102: 457-64.
2. Dohi S, Terasaki M, Makino M. Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils. J Agric Food Chem 2009;57: 4313-8.
3. Verschaeve L, Van Staden J. Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants. J Ethnopharmacol 2008;119: 575-87.
4. Kumar SS, Rao MRK, Balasubramanian MP. Anticarcinogenic effects of Indigofera aspalathoideson 20-Methylcholanthrene induced fibrosarcoma in rats. Res J Med Plant 2011;5: 747-55.
5. Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D. A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol 2005;99: 317-24.
6. Siracusa L, Saija A, Cristani M, Cimino F, D'Arrigo M, Trombetta D, et al. Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves-chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity. Fitoterapia 2011;82: 546-56.
7. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol 2006;46: 167-92.
8. Mukherjee M, Bhaskaran N, Srinath R, Shivaprasad HN, Allan JJ, Shekhar D, et al. Anti-ulcer and antioxidant activity of GutGard. Indian J Exp Biol 2010;48: 269-74.
9. Kamei J, Nakamura R, Ichiki H, Kubo M. Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang). Eur J Pharmacol 2003;469: 159-63.
10. Quillardet P, Hofnung M. The SOS Chromotest, a colorimetric bacterial assay for genotoxins: Procedures. Mutat Res 1985;147: 65-78.
11. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175: 184-91.
12. Böyum A. Separation of leukocytes from blood and bone marrow. Introduction. Scand J Clin Lab Invest Suppl 1968;97:7.
13. Nath JL, Hanjan ST. Handbook of practical immunology. New Delhi: Vikas publishing house; 1983.
14. Blois MS. Antioxidant determinations by the use of a stable free radical. Nature 1958;181: 1199-200.
15. Mayers LS, Grossen NE. Analysis of independent group designs. In: Behavioural Research, Theory, Procedure and Design. 2nd edn. San Francisco: W.H. Freeman; 1974. p. 237-52.
16. Petronelli A, Pannitteri G, Testa U. Triterpenoids as new promising anticancer drugs. Anticancer Drugs 2009;20: 880-92.
17. Rezanka T, Siristova L, Sigler K. Sterols and triterpenoids with antiviral activity. Antiinfect Agents Med Chem 2009;8: 193-210.
18. Kuo RY, Qian K, Morris-Natschke SL, Lee KH. Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents. Nat Prod Rep 2009;26: 1321-44.
19. Topçu G, Yapar G, Türkmen Z, Gören AC, Öksüz S, Schilling JK, Kingston DGI. Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh. Phytochem Lett 2011.
20. Song QY, Qi WY, Li ZM, Zhao J, Chen JJ, Gao K. Antifungal activities of triterpenoids from the roots of Astilbe myriantha Diels. Chemistry 2011;128: 495-99.
21. Ito N. The Nitroquinolines. In: Sugimora T, editor. Carcinogenesis-A Comprehensive Survey. New York: Raven Press; 1981. p. 117-53.
22. Varnes ME, Biaglow JE. Interactions of the carcinogen 4-nitroquinoline 1-oxide with the non-protein thiols of mammalian cells. Cancer Res 1979;39: 2960-5.
23. Ratnam GV, Abu-Eshy S, Morad N, Almutawa AM. Adult extrarenal Wilms' tumour: A case report and review of literature. West Afr J Med 2006;25: 75-8.
24. Obolentseva GV, Litvinenko VI, Ammosov AS, Popova TP, Sampiev AM. Pharmacological and therapeutic properties of Licorice preparations (A review). Pharm Chem J 1999;33: 24-31.
25. Chan HT, Chan C, Ho JW. Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells. Toxicology 2003;188: 211-7.
26. Rahman S, Sultana S. Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13- acetate-induced cutaneous oxidative stress and tumor promotion in Swiss albino mice. J Enzyme Inhib Med Chem 2007;22: 363-9.
27. Gandhi NM, Maurya DK, Salvi V, Kapoor S, Mukherjee T, Nair CK. Radioprotection of DNA by glycyrrhizic acid through scavenging free radicals. J Radiat Res 2004;45: 461-8.
28. Chandrasekharan DK, Nair CK. Effect of silver nanoparticle and glycyrrhizic acid (SN-GLY) complex on repair of whole body radiation-induced cellular DNA damage and genomic instability in mice. Int J Low Radiation 2010;7: 453-66.
29. Qamar W, Khan R, Khan AQ, Rehman MU, Lateef A, Tahir M, et al. Alleviation of lung injury by glycyrrhizic acid in benzo(a) pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase. Toxicology 2012;291: 25-31.
30. Cherng JM, Tsai KD, Yu YW, Lin JC. Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Radiat Res 2011;176: 177-86.
31. Chandramouli C, Ting YS, Lyn LY, Ha TS, Kadir KA. Glycyrrhizic Acid Improves Lipid and Glucose Metabolism in High-Sucrose- Fed Rats. J Endocrinol Metab 2011;1: 125-41.
32. Gumpricht E, Dahl R, Devereaux MW, Sokol RJ. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. J Biol Chem 2005;280: 10556-63.
33. Yoshida T, Tsuda Y, Takeuchi D, Kobayashi M, Pollard RB, Suzuki F. Glycyrrhizin inhibits neutrophil-associated generation of alternatively activated macrophages. Cytokine 2006;33:317- 22.
34. Wang CY, Kao TC, Lo WH, Yen GC. Glycyrrhizic acid and 18®-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110™ and p110 inhibitions. J Agric Food Chem 2011;59:7726- 33.
35. Hong YK, Wu HT, Ma T, Liu WJ, He XJ. Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice. Int J Biol Macromol 2009;45: 61-4.
36. Tripathi M, Singh BK, Kakkar P. Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes. Food Chem Toxicol 2009;47: 339-47.
37. Kaur P, Kaur S, Kumar S, Singh P. Rubia cordifolia L. and Glycyrrhiza glabra L. medicinal plants as potential source of COX-2 inhibitors. Am J Biomed Sci 2010;2: 108-20