Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Gong, Gu ^a   Xiang, Lei ^b   Yuan, Libang ^c   Hu, Ling ^a   Wu, Wei ^a   Cai, Lin ^a   Yin, Liang ^a   Dong, Hailong ^c  

^a The Chinese People's Liberation Army   (China)

^b TIANJIN HUANHU HOSPITAL   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOCHROME C; GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEUROPROTECTIVE AGENT; PROTEIN INHIBITOR; RECOMBINANT HIGH MOBILITY GROUP B1 PROTEIN; RECOMBINANT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN TISSUE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENCEPHALITIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; INTRACELLULAR SIGNALING; LOCOMOTION; MALE; MEDIATOR; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR MECHANICS; MONOTHERAPY; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; RAT; REPERFUSION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CEREBRAL INFARCTION; COMPLICATION; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; CEREBRAL INFARCTION; GLYCYRRHIZIC ACID; HMGB1 PROTEIN; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84897086481     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089450     Document Type: Article

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