Identification of ACSL4 as a biomarker and contributor of ferroptosis

Biochemical and Biophysical Research Communications

Volumn 478, Issue 3, 2016, Pages 1338-1343

  Yuan, Hua ^a   Li, Xuemei ^b   Zhang, Xiuying ^a   Kang, Rui ^c   Tang, Daolin ^a,c,d  

^a JILIN UNIVERSITY   (China)

^b QINGDAO MUNICIPAL HOSPITAL   (China)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

ACSL; Biomarker; Ferroptosis; Hydroxyeicosatetraenoic acid; Lipid metabolism

Indexed keywords

5 HYDROXYICOSATETRAENOIC ACID; BIOLOGICAL MARKER; LONG CHAIN FATTY ACID COENZYME A LIGASE; SHORT HAIRPIN RNA; 5-HYDROXY-6,8,11,14-EICOSATETRAENOIC ACID; COENZYME A LIGASE; ERASTIN; HYDROXYICOSATETRAENOIC ACID; LONG-CHAIN-FATTY-ACID-COA LIGASE; PIPERAZINE DERIVATIVE; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; FERROPTOSIS; GENETIC TRANSFECTION; HEPG2 CELL LINE; HL 60 CELL LINE; HUMAN; HUMAN CELL; K562 CELL LINE; LIPID METABOLISM; LIPID PEROXIDATION; LNCAP CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; BIOSYNTHESIS; DRUG EFFECTS; GENE SILENCING; METABOLISM; TUMOR CELL LINE;

APOPTOSIS; BIOMARKERS, TUMOR; CELL LINE, TUMOR; COENZYME A LIGASES; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; PIPERAZINES;

EID: 84994182403     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.08.124     Document Type: Article

References (38)

1. [1] Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
2. [2] Vanden Berghe, T., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., Vandenabeele, P., Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat. Rev. Mol. Cell Biol. 15 (2014), 135–147.
3. [3] Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., Skouta, R., Zaitsev, E.M., Gleason, C.E., Patel, D.N., Bauer, A.J., Cantley, A.M., Yang, W.S., Morrison, B. 3rd, Stockwell, B.R., Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 (2012), 1060–1072.
4. [4] Sun, X., Niu, X., Chen, R., He, W., Chen, D., Kang, R., Tang, D., Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. Hepatology 64 (2016), 488–500.
5. [5] Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., Tang, D., Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63 (2016), 173–184.
6. [6] Jiang, L., Kon, N., Li, T., Wang, S.J., Su, T., Hibshoosh, H., Baer, R., Gu, W., Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520 (2015), 57–62.
7. [7] Sun, X., Ou, Z., Xie, M., Kang, R., Fan, Y., Niu, X., Wang, H., Cao, L., Tang, D., HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene 34 (2015), 5617–5625.
8. [8] Yang, W.S., SriRamaratnam, R., Welsch, M.E., Shimada, K., Skouta, R., Viswanathan, V.S., Cheah, J.H., Clemons, P.A., Shamji, A.F., Clish, C.B., Brown, L.M., Girotti, A.W., Cornish, V.W., Schreiber, S.L., Stockwell, B.R., Regulation of ferroptotic cancer cell death by GPX4. Cell 156 (2014), 317–331.
9. [9] Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G.W., Kopf, M., T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J. Exp. Med. 212 (2015), 555–568.
10. [10] Friedmann Angeli, J.P., Schneider, M., Proneth, B., Tyurina, Y.Y., Tyurin, V.A., Hammond, V.J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., Basavarajappa, D., Radmark, O., Kobayashi, S., Seibt, T., Beck, H., Neff, F., Esposito, I., Wanke, R., Forster, H., Yefremova, O., Heinrichmeyer, M., Bornkamm, G.W., Geissler, E.K., Thomas, S.B., Stockwell, B.R., O'Donnell, V.B., Kagan, V.E., Schick, J.A., Conrad, M., Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16 (2014), 1180–1191.
11. [11] Chen, L., Hambright, W.S., Na, R., Ran, Q., Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis. J. Biol. Chem. 290 (2015), 28097–28106.
12. [12] Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A.J., Yang, W.S., Fridman, D.J., Wolpaw, A.J., Smukste, I., Peltier, J.M., Boniface, J.J., Smith, R., Lessnick, S.L., Sahasrabudhe, S., Stockwell, B.R., RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 (2007), 864–868.
13. [13] Maldonado, E.N., Sheldon, K.L., DeHart, D.N., Patnaik, J., Manevich, Y., Townsend, D.M., Bezrukov, S.M., Rostovtseva, T.K., Lemasters, J.J., Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J. Biol. Chem. 288 (2013), 11920–11929.
14. [14] Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., Tang, D., Ferroptosis: process and function. Cell Death Differ. 23 (2016), 369–379.
15. [15] Wakil, S.J., Abu-Elheiga, L.A., Fatty acid metabolism: target for metabolic syndrome. J. Lipid Res. 50:Supp l (2009), S138–S143.
16. [16] Grevengoed, T.J., Klett, E.L., Coleman, R.A., Acyl-CoA metabolism and partitioning. Annu. Rev. Nutr. 34 (2014), 1–30.
17. [17] Chen, W.C., Wang, C.Y., Hung, Y.H., Weng, T.Y., Yen, M.C., Lai, M.D., Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme a synthetase family in Cancer. PLoS One, 11, 2016, e0155660.
18. [18] Reinartz, A., Ehling, J., Leue, A., Liedtke, C., Schneider, U., Kopitz, J., Weiss, T., Hellerbrand, C., Weiskirchen, R., Knuchel, R., Gassler, N., Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis. Biochim. Biophys. Acta 1801 (2010), 1025–1035.
19. [19] Saraswathi, V., Hasty, A.H., Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages. Arterioscler. Thromb. Vasc. Biol. 29 (2009), 1937–1943.
20. [20] Gassler, N., Roth, W., Funke, B., Schneider, A., Herzog, F., Tischendorf, J.J., Grund, K., Penzel, R., Bravo, I.G., Mariadason, J., Ehemann, V., Sykora, J., Haas, T.L., Walczak, H., Ganten, T., Zentgraf, H., Erb, P., Alonso, A., Autschbach, F., Schirmacher, P., Knuchel, R., Kopitz, J., Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology 133 (2007), 587–598.
21. [21] Tang, D., Kang, R., Livesey, K.M., Cheh, C.W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M.E., Tracey, K.J., Zeh, H.J. 3rd, Lotze, M.T., Endogenous HMGB1 regulates autophagy. J. Cell Biol. 190 (2010), 881–892.
22. [22] Xie, Y., Song, X., Sun, X., Huang, J., Zhong, M., Lotze, M.T., Zeh, H.J. 3rd, Kang, R., Tang, D., Identification of baicalein as a ferroptosis inhibitor by natural product library screening. Biochem. Biophys. Res. Commun. 473 (2016), 775–780.
23. [23] Chen, J., Brunzell, D.H., Jackson, K., van der Vaart, A., Ma, J.Z., Payne, T.J., Sherva, R., Farrer, L.A., Gejman, P., Levinson, D.F., Holmans, P., Aggen, S.H., Damaj, I., Kuo, P.H., Webb, B.T., Anton, R., Kranzler, H.R., Gelernter, J., Li, M.D., Kendler, K.S., Chen, X., ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS One, 6, 2011, e28790.
24. [24] Magtanong, L., Ko, P.J., Dixon, S.J., Emerging roles for lipids in non-apoptotic cell death. Cell Death Differ. 23 (2016), 1099–1109.
25. [25] Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., Lizard, G., Fatty acids - induced lipotoxicity and inflammation. Curr. Drug Metab. 13 (2012), 1358–1370.
26. [26] Dixon, S.J., Winter, G.E., Musavi, L.S., Lee, E.D., Snijder, B., Rebsamen, M., Superti-Furga, G., Stockwell, B.R., Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem. Biol. 10 (2015), 1604–1609.
27. [27] Yang, W.S., Stockwell, B.R., Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 26 (2016), 165–176.
28. [28] Eling, Nils, Reuter, Lukas, Hazin, John, Hamacher-Brady, Anne, Brady, N.R., Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience, 2, 2015, 517.
29. [29] Yu, Y., Xie, Y., Cao, L., Yang, L., Yang, M., Lotze, M.T., Zeh, H.J., Kang, R., Tang, D., The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol. Cell Oncol., 2, 2015, e1054549.
30. [30] Do Van, B., Gouel, F., Jonneaux, A., Timmerman, K., Gele, P., Petrault, M., Bastide, M., Laloux, C., Moreau, C., Bordet, R., Devos, D., Devedjian, J.C., Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC. Neurobiol. Dis. 94 (2016), 169–178.
31. [31] Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S.R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.S., Weinlich, R., Vanden Berghe, T., Vandenabeele, P., Pasparakis, M., Bleich, M., Weinberg, J.M., Reichel, C.A., Brasen, J.H., Kunzendorf, U., Anders, H.J., Stockwell, B.R., Green, D.R., Krautwald, S., Synchronized renal tubular cell death involves ferroptosis. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 16836–16841.
32. [32] Schott, C., Graab, U., Cuvelier, N., Hahn, H., Fulda, S., Oncogenic ras mutants confer resistance of RMS13 rhabdomyosarcoma cells to oxidative stress-induced ferroptotic cell death. Front. Oncol., 5, 2015, 131.
33. [33] Brash, A.R., Arachidonic acid as a bioactive molecule. J. Clin. Invest 107 (2001), 1339–1345.
34. [34] Maloberti, P.M., Duarte, A.B., Orlando, U.D., Pasqualini, M.E., Solano, A.R., Lopez-Otin, C., Podesta, E.J., Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells. PLoS One, 5, 2010, e15540.
35. [35] Yuan, H., Li, X., Zhang, X., Kang, R., Tang, D., CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation. Biochem. Biophys. Res. Commun., 2016 Aug 7, 10.1016/j.bbrc.2016.08.034 pii: S0006-291X(16)31289-X. [Epub ahead of print].
36. [36] Israel, E., Cohn, J., Dube, L., Drazen, J.M., Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA 275 (1996), 931–936.
37. [37] Liu, Y., Wang, W., Li, Y., Xiao, Y., Cheng, J., Jia, J., The 5-Lipoxygenase inhibitor zileuton confers neuroprotection against glutamate oxidative damage by inhibiting ferroptosis. Biol. Pharm. Bull. 38 (2015), 1234–1239.
38. [38] Kan, C.F., Singh, A.B., Stafforini, D.M., Azhar, S., Liu, J., Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation. J. Lipid Res. 55 (2014), 1657–1667.