The 5-lipoxygenase inhibitor zileuton confers neuroprotection against glutamate oxidative damage by inhibiting ferroptosis

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 8, 2015, Pages 1234-1239

  Liu, Yang ^a   Wang, Wei ^a   Li, Yuyao ^a   Xiao, Yunqi ^a   Cheng, Jian ^a   Jia, Jia ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

5 lipoxygenase inhibitor; Ferroptosis; Glutamate oxidative toxicity; Neuroprotection

Indexed keywords

CASPASE INHIBITOR; CHONDROITIN SULFATE IRON; GLUTAMIC ACID; GLUTATHIONE; LIPOXYGENASE INHIBITOR; REACTIVE OXYGEN METABOLITE; ZILEUTON; ARACHIDONATE 5 LIPOXYGENASE; CYCLOHEXYLAMINE DERIVATIVE; FERROSTATIN-1; HYDROXYUREA; IRON; NEUROPROTECTIVE AGENT; PHENYLENEDIAMINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL CULTURE; ENZYME SYNTHESIS; FERROPTOSIS; GLUTATHIONE METABOLISM; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; METABOLISM; NERVE CELL;

ANIMALS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE; CYCLOHEXYLAMINES; GLUTAMIC ACID; HYDROXYUREA; IRON; LIPOXYGENASE INHIBITORS; MICE; NEURONS; NEUROPROTECTION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHENYLENEDIAMINES; REACTIVE OXYGEN SPECIES;

EID: 84940944514     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00048     Document Type: Article

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