Identification of baicalein as a ferroptosis inhibitor by natural product library screening

Biochemical and Biophysical Research Communications

Volumn 473, Issue 4, 2016, Pages 775-780

  Xie, Yangchun ^a,b   Song, Xinxin ^a   Sun, Xiaofang ^c   Huang, Jin ^b   Zhong, Meizuo ^b   Lotze, Michael T ^a   Zeh, Herbert J ^a   Kang, Rui ^a   Tang, Daolin ^a,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Baicalein; Ferroptosis; GPX4; Lipid peroxidation; Natural product

Indexed keywords

BAICALEIN; DEFEROXAMINE MESYLATE; FERROSTATIN 1; GLUTATHIONE; IRON; LIPROXSTATIN 1; MERCAPTOETHANOL; NATURAL PRODUCT; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; UNCLASSIFIED DRUG; BAICILEIN; FLAVONOID; PROTEIN BINDING;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; FERROPTOSIS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PLANT ROOT; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCUTELLARIA BAICALENSIS; SCUTELLARIA LATERIFLORA; TISSUE INJURY; BINDING SITE; CELL DEATH; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; BINDING SITES; CELL DEATH; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GLUTATHIONE; HUMANS; IRON; LIPID PEROXIDATION; PANCREATIC NEOPLASMS; PROTEIN BINDING;

EID: 84962022157     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.03.052     Document Type: Article

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