Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis

Journal of Biological Chemistry

Volumn 290, Issue 47, 2015, Pages 28097-28106

  Chen, Liuji ^a   Hambright, William Sealy ^a   Na, Ren ^a   Ran, Qitao ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABLATION; BRAIN; CELL DEATH; CHEMICAL ACTIVATION; LIPIDS; MAMMALS; PEPTIDES;

ANTIOXIDANT DEFENSE; CASPASE-3 ACTIVATION; CEREBRAL CORTEX; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE DAMAGE; REACTIVE OXYGEN SPECIES;

NEURONS;

ALPHA TOCOPHEROL; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DISEASE COURSE; ENZYME INHIBITION; FEMALE; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MITOCHONDRION; MOTOR NEURON DEGENERATION; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION; ANIMAL; CELL DEATH; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOTONEURON; PATHOLOGY; SPINAL CORD;

ANIMALS; CELL DEATH; GLUTATHIONE PEROXIDASE; MICE; MICE, KNOCKOUT; MOTOR NEURONS; PARALYSIS; REACTIVE OXYGEN SPECIES; SPINAL CORD;

EID: 84947786974     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.680090     Document Type: Article

References (24)

1. Brigelius-Flohé, R. (1999) Tissue-specific functions of individual glutathione peroxidases. Free Radic. Biol. Med. 27, 951-965
2. Imai, H., and Nakagawa, Y. (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med. 34, 145-169
3. +/- mice: a novel model for studying the role of membrane peroxidation in biological processes. Free Radic. Biol. Med. 35, 1101-1109
4. Ran, Q., Liang, H., Gu, M., Qi, W., Walter, C. A., Roberts, L. J., 2nd, Herman, B., Richardson, A., and Van Remmen, H. (2004) Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J. Biol. Chem. 279, 55137-55146
5. Yang, W. S., and Stockwell, B. R. (2008) Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem. Biol. 15, 234-245
6. Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060-1072
7. Yang, W. S., Sri Ramaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., Brown, L. M., Girotti, A. W., Cornish, V. W., Schreiber, S. L., and Stockwell, B. R. (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317-331
8. Yant, L. J., Ran, Q., Rao, L., Van Remmen, H., Shibatani, T., Belter, J. G., Motta, L., Richardson, A., and Prolla, T. A. (2003) The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic. Biol. Med. 34, 496-502
9. Imai, H., Hirao, F., Sakamoto, T., Sekine, K., Mizukura, Y., Saito, M., Kitamoto, T., Hayasaka, M., Hanaoka, K., and Nakagawa, Y. (2003) Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem. Biophys. Res. Commun. 305, 278-286
10. Yoo, S. E., Chen, L., Na, R., Liu, Y., Rios, C., Van Remmen, H., Richardson, A., and Ran, Q. (2012) Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic. Biol. Med. 52, 1820-1827
11. Chen, L., Na, R., and Ran, Q. (2014) Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline. Neurobiol. Aging 35, 2552-2561
12. Young, P., Qiu, L., Wang, D., Zhao, S., Gross, J., and Feng, G. (2008) Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice. Nat. Neurosci. 11, 721-728
13. Heimer-McGinn, V., and Young, P. (2011) Efficient inducible Pan-neuronal cre-mediated recombination in SLICK-H transgenic mice. Genesis 49, 942-949
14. Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., Lein, E. S., and Zeng, H. (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133-140
15. Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., Smith, R., Lessnick, S. L., Sahasrabudhe, S., and Stockwell, B. R. (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447, 864-868
16. Elmore, S. (2007) Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35, 495-516
17. Dixon, S. J., and Stockwell, B. R. (2014) The role of iron and reactive oxygen species in cell death. Nat. Chem. Biol. 10, 9-17
18. Girotti, A. W. (1998) Lipid hydroperoxide generation, turnover, and effector action in biological systems. J. Lipid Res. 39, 1529-1542
19. Liang, H., Van Remmen, H., Frohlich, V., Lechleiter, J., Richardson, A., and Ran, Q. (2007) Gpx4 protects mitochondrial ATP generation against oxidative damage. Biochem. Biophys. Res. Commun. 356, 893-898
20. Kiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., and Zoing, M. C. (2011) Amyotrophic lateral sclerosis. Lancet 377, 942-955
21. Guegan, C., and Przedborski, S. (2003) Programmed cell death in amyotrophic lateral sclerosis. J. Clin. Invest. 111, 153-161
22. Sathasivam, S., and Shaw, P. J. (2005) Apoptosis in amyotrophic lateral sclerosis: what is the evidence? Lancet Neurol. 4, 500-509
23. Tomik, B., Adamek, D., Pierzchalski, P., Banares, S., Duda, A., Partyka, D., Pawlik, W., Kaluza, J., Krajewski, S., and Szczudlik, A. (2005) Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues. Folia Neuropathol. 43, 75-80
24. Yamazaki, M., Esumi, E., and Nakano, I. (2005) Is motoneuronal cell death in amyotrophic lateral sclerosis apoptosis? Neuropathology 25, 381-387