Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation

Journal of Lipid Research

Volumn 55, Issue 8, 2014, Pages 1657-1667

  Kan, Chin Fung Kelvin ^a   Singh, Amar Bahadur ^a   Stafforini, Diana M ^b   Azhar, Salman ^a   Liu, Jingwen ^a  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Nonalcoholic fatty liver disease; Posttranslational regulation; Proteasome

Indexed keywords

ACYL COENZYME A SYNTHETASE 4; ARACHIDONIC ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; ROSIGLITAZONE; UBIQUITIN; UNCLASSIFIED DRUG; ACSL4 PROTEIN, MOUSE; COENZYME A LIGASE; LONG-CHAIN-FATTY-ACID-COA LIGASE; PROTEASOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSCRIPTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIPID DIET; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; RNA STABILITY; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; METABOLISM;

ANIMALS; ARACHIDONIC ACID; COENZYME A LIGASES; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HEPATOCYTES; HUMANS; MALE; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; UBIQUITINATION;

EID: 84905001256     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M045971     Document Type: Article

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