Influenza B virus NS1-truncated mutants: Live-attenuated vaccine approach

Journal of Virology

Volumn 82, Issue 21, 2008, Pages 10580-10590

  Hai, Rong ^a   Martínez Sobrido, Luis ^a   Fraser, Kathryn A ^a   Ayllon, Juan ^b   García Sastre, Adolfo ^a   Palese, Peter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE RECEPTOR ANTAGONIST; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INFLUENZA VACCINE; LIVE VACCINE; NONSTRUCTURAL PROTEIN 1; VIRUS ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; FEMALE; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLUENZA; INFLUENZA VIRUS B; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION; VIROGENESIS; VIRUS MUTANT; VIRUS RECOMBINANT; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; BODY WEIGHT; C57BL MOUSE; CELL LINE; CERCOPITHECUS; DOG; GENETICS; IMMUNOLOGY; LUNG; MOUSE MUTANT; NOSE MUCOSA; ORTHOMYXOVIRUS INFECTION; SURVIVAL; VIRUS CULTURE;

CERCOPITHECINE HERPESVIRUS 1; INFLUENZA B VIRUS; MUS; ORTHOMYXOVIRIDAE;

ANIMALS; ANTIBODIES, VIRAL; BODY WEIGHT; CELL LINE; CERCOPITHECUS AETHIOPS; DOGS; FEMALE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFLUENZA B VIRUS; INFLUENZA VACCINES; INTERFERON TYPE II; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NASAL MUCOSA; ORTHOMYXOVIRIDAE INFECTIONS; PLAQUE ASSAY; SURVIVAL ANALYSIS; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS;

EID: 55249118428     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01213-08     Document Type: Article

References (39)

1. Air, G. M., W. G. Laver, and R. G. Webster. 1990. Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase. J. Virol. 64:5797-5803.
2. Bergmann, M., A. Garcia-Sastre, E. Carnero, H. Pehamberger, K. Wolff, P. Palese, and T. Muster. 2000. Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J. Virol. 74:6203-6206.
3. Brown, E. G. 1990. Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8. J. Virol. 64:4523-4533.
4. Dauber, B., G. Heins, and T. Wolff. 2004. The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction. J. Virol. 78:1865-1872.
5. Dauber, B., J. Schneider, and T. Wolff. 2006. Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon. J. Virol. 80:11667-11677.
6. Donelan, N. R., C. F. Basler, and A. Garcia-Sastre. 2003. A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J. Virol. 77:13257-13266.
7. Donelan, N. R., B. Dauber, X. Wang, C. F. Basler, T. Wolff, and A. Garcia-Sastre. 2004. The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation. J. Virol. 78:11574-11582.
8. Ferko, B., J. Stasakova, J. Romanova, C. Kittel, S. Sereinig, H. Katinger, and A. Egorov. 2004. Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J. Virol. 78:13037-13045.
9. Fodor, E., L. Devenish, O. G. Engelhardt, P. Palese, G. G. Brownlee, and A. Garcia-Sastre. 1999. Rescue of influenza A virus from recombinant DNA. J. Virol. 73:9679-9682.
10. Garcia-Sastre, A., A. Egorov, D. Matassov, S. Brandt, D. E. Levy, J. E. Durbin, P. Palese, and T. Muster. 1998. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252:324-330.
11. Hoffmann, E., G. Neumann, G. Hobom, R. G. Webster, and Y. Kawaoka. 2000. "Ambisense" approach for the generation of influenza A virus: vRNA and mRNA synthesis from one template. Virology 267:310-317.
12. Krystal, M., J. F. Young, P. Palese, I. A. Wilson, J. J. Skehel, and D. C. Wiley. 1983. Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains. Proc. Natl. Acad. Sci. USA 80:4527-4531.
13. Le Bon, A., N. Etchart, C. Rossmann, M. Ashton, S. Hou, D. Gewert, P. Borrow, and D. F. Tough. 2003. Cross-priming of CD86+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 4:1009-1015.
14. Le Bon, A., G. Schiavoni, G. D'Agostino, I. Gresser, F. Belardelli, and D. F. Tough. 2001. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14:461-470.
15. Le Bon, A., C. Thompson, E. Kamphuis, V. Durand, C. Rossmann, U. Kalinke, and D. F. Tough. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J. Immunol. 176:2074-2078.
16. Martinez-Sobrido, L., E. I. Zuniga, D. Rosario, A. Garcia-Sastre, and J. C. de la Torre. 2006. Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. J. Virol. 80:9192-9199.
17. McCullers, J. A., E. Hoffmann, V. C. Huber, and A. D. Nickerson. 2005. A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence. Virology 336: 318-326.
18. McCullers, J. A., T. Saito, and A. R. Iverson. 2004. Multiple genotypes of influenza B virus circulated between 1979 and 2003. J. Virol. 78:12817-12828.
19. McCullers, J. A., G. C. Wang, S. He, and R. G. Webster. 1999. Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature. J. Virol. 73:7343-7348.
20. Murphy, B. R., and K. Coelingh. 2002. Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines. Viral Immunol. 15:295-323.
21. Nakaya, T., J. Cros, M. S. Park, Y. Nakaya, H. Zheng, A. Sagrera, E. Villar, A. Garcia-Sastre, and P. Palese. 2001. Recombinant Newcastle disease virus as a vaccine vector. J. Virol. 75:11868-11873.
22. Nerome, R., Y. Hiromoto, S. Sugita, N. Tanabe, M. Ishida, M. Matsumoto, S. E. Lindstrom, T. Takahashi, and K. Nerome. 1998. Evolutionary characteristics of influenza B virus since its first isolation in 1940: dynamic circulation of deletion and insertion mechanism. Arch. Virol. 143:1569-1583.
23. Nicholson, K. G., J. M. Wood, and M. Zambon. 2003. Influenza. Lancet 362:1733-1745.
24. Nobusawa, E., and K. Sato. 2006. Comparison of the mutation rates of human influenza A and B viruses. J. Virol. 80:3675-3678.
25. Osterhaus, A. D., G. F. Rimmelzwaan, B. E. Martina, T. M. Bestebroer, and R. A. Fouchier. 2000. Influenza B virus in seals. Science 288:1051-1053.
26. Palese, P. 2006. Making better influenza virus vaccines? Emerg. Infect. Dis. 12:61-65.
27. Palese, P., and M. L. Shaw. 2007. Orthomyxoviridae: the viruses and their replication, p. 1647-1689. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. Straus (ed.), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
28. Pechirra, P., B. Nunes, A. Coelho, C. Ribeiro, P. Goncalves, S. Pedro, L. C. Castro, and H. Rebelo-de-Andrade. 2005. Molecular characterization of the HA gene of influenza type B viruses. J. Med. Virol. 77:541-549.
29. Quan, F. S., R. W. Compans, H. H. Nguyen, and S. M. Kang. 2008. Induction of heterosubtypic immunity to influenza virus by intranasal immunization. J. Virol. 82:1350-1359.
30. Quinlivan, M., D. Zamarin, A. Garcia-Sastre, A. Cullinane, T. Chambers, and P. Palese. 2005. Attenuation of equine influenza viruses through truncations of the NS1 protein. J. Virol. 79:8431-8439.
31. Rangel-Moreno, J., D. M. Carragher, R. S. Misra, K. Kusser, L. Hartson, A. Moquin, F. E. Lund, and T. D. Randall. 2008. B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms. J. Immunol. 180:454-463.
32. Richt, J. A., P. Lekcharoensuk, K. M. Lager, A. L. Vincent, C. M. Loiacono, B. H. Janke, W. H. Wu, K. J. Yoon, R. J. Webby, A. Solorzano, and A. Garcia-Sastre. 2006. Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. J. Virol. 80:11009-11018.
33. Solorzano, A., R. J. Webby, K. M. Lager, B. H. Janke, A. Garcia-Sastre, and J. A. Richt. 2005. Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J. Virol. 79: 7535-7543.
34. Talon, J., M. Salvatore, R. E. O'Neill, Y. Nakaya, H. Zheng, T. Muster, A. Garcia-Sastre, and P. Palese. 2000. Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proc. Natl. Acad. Sci. USA 97: 4309-4314.
35. Wang, W., and R. M. Krug. 1996. The RNA-binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses. Virology 223:41-50.
36. Xu, X., S. E. Lindstrom, M. W. Shaw, C. B. Smith, H. E. Hall, B. A. Mungall, K. Subbarao, N. J. Cox, and A. Klimov. 2004. Reassortment and evolution of current human influenza A and B viruses. Virus Res. 103:55-60.
37. Yamashita, M., M. Krystal, W. M. Fitch, and P. Palese. 1988. Influenza B virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C viruses. Virology 163:112-122.
38. Yang, Y. L., L. F. Reis, J. Pavlovic, A. Aguzzi, R. Schafer, A. Kumar, B. R. Williams, M. Aguet, and C. Weissmann. 1995. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14: 6095-6106.
39. Yuan, W., and R. M. Krug. 2001. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. EMBO J. 20:362-371.