Inhibition of interferon-γ-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-COA reductase inhibitors1

Transplantation

Volumn 71, Issue 9, 2001, Pages 1262-1268

  Sadeghi, Mehran M ^a   Tiglio, Andrea ^a   Sadigh, Kaveh ^a   O'Donnell, Lynn ^a   Collinge, Mark ^a   Pardi, Ruggero ^b,c   Bender, Jeffrey R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA DR ANTIGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MEVALONIC ACID; PYROPHOSPHORIC ACID DERIVATIVE; SIMVASTATIN; SQUALENE; STAT1 PROTEIN; TRANSACTIVATOR PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; FLOW CYTOMETRY; GENE REPRESSION; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROVASCULATURE; PRENYLATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

EID: 0035872757     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200105150-00014     Document Type: Article

References (27)

1. Simvastatin decreases accelerated graft vessel disease after heart transplantation in an animal model
2. Coronary artery disease in cardiac allografts: Association with arteriolar endothelial HLA-DR and ICAM-1 antigens
3. Regulation of class II MHC expression
4. Quantitative control of MHC class II expression by the transactivator CIITA
5. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
6. IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes
7. Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1
8. Simvastatin reduces graft vessel disease and mortality after heart transplantation: A four-year randomized trial
9. Statins do more than just lower cholesterol
10. Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors
11. Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro: Evidence for preferential binding of natural killer cells
12. Permanent cell line expressing human factor VIII-related antigen established by hybridization
13. Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium
14. Class II transactivator-independent endothelial cell MHC class II gene activation induced by lymphocyte adhesion
15. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
16. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: Evidence for diverse transcriptional responses
17. IL-1 beta inhibits IFN-gamma-induced class II MHC expression by suppressing transcription of the class II transactivator gene
18. Regulation of the mevalonate pathway
19. Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48- kD DNA-binding protein, ISGF3-gamma
20. JAK/STAT signaling by cytokine receptors
21. Class II transactivator and class II MHC gene expression in microglia: Modulation by the cytokines TGF-beta, IL-4, IL-13 and IL-10
22. Effect of pravastatin on outcomes after cardiac transplantation
23. Dual roles of HMG-CoA reductase inhibitors in solid organ transplantation: Lipid lowering and immunosuppression
24. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
25. Protein prenylation: Molecular mechanisms and functional consequences
26. Role of the prenyl group on the G protein gamma subunit in coupling trimeric G proteins to A1 adenosine receptors
27. Rho GTPases and signaling networks