Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-β signal transduction

Immunology

Volumn 130, Issue 4, 2010, Pages 484-493

  Kim, Yong Chan ^a   Kim, Kee Kwang ^b   Shevach, Ethan M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Foxp3; geranylgeranylation; simvastatin; Smad6; Smad7; T regulatory cells; transforming growth factor

Indexed keywords

MEVALONIC ACID; SIMVASTATIN; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELLS, CULTURED; DNA METHYLATION; FORKHEAD TRANSCRIPTION FACTORS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; SIMVASTATIN; SMAD6 PROTEIN; SMAD7 PROTEIN; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 77954497611     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03269.x     Document Type: Article

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