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Volumn 21, Issue 10, 2016, Pages

Artemisinin and its derivatives as a repurposing anticancer agent: What else do we need to do?

Author keywords

Anticancer Activity; Artemisinin; Clinical Trials; Repurposed; Specific Drug Delivery System

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; ARTEMISININ DERIVATIVE;

EID: 84992397336     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21101331     Document Type: Review
Times cited : (68)

References (102)
  • 2
    • 84902266776 scopus 로고    scopus 로고
    • Aspirin in gastrointestinal oncology: New data on an old friend
    • Langley, R.E.; Rothwell, P.M. Aspirin in gastrointestinal oncology: New data on an old friend. Curr. Opin. Oncol. 2014, 26, 441-447.
    • (2014) Curr. Opin. Oncol , vol.26 , pp. 441-447
    • Langley, R.E.1    Rothwell, P.M.2
  • 3
    • 84863412124 scopus 로고    scopus 로고
    • Short-Term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials
    • Rothwell, P.M.; Price, J.F.; Fowkes, F.G.; Zanchetti, A.; Roncaglioni, M.C.; Tognoni, G.; Lee, R.; Belch, J.F.; Wilson, M.; Mehta, Z.; et al. Short-Term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet 2012, 379, 1602-1612.
    • (2012) Lancet , vol.379 , pp. 1602-1612
    • Rothwell, P.M.1    Price, J.F.2    Fowkes, F.G.3    Zanchetti, A.4    Roncaglioni, M.C.5    Tognoni, G.6    Lee, R.7    Belch, J.F.8    Wilson, M.9    Mehta, Z.10
  • 4
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-Term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials
    • Algra, A.M.; Rothwell, P.M. Effects of regular aspirin on long-Term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 2012, 13, 518-527.
    • (2012) Lancet Oncol , vol.13 , pp. 518-527
    • Algra, A.M.1    Rothwell, P.M.2
  • 5
    • 84938954215 scopus 로고    scopus 로고
    • Aspirin and NSAIDs for breast cancer chemoprevention
    • Yiannakopoulou, E.C. Aspirin and NSAIDs for breast cancer chemoprevention. Eur. J. Cancer Prev. 2015, 24, 416-421.
    • (2015) Eur. J. Cancer Prev , vol.24 , pp. 416-421
    • Yiannakopoulou, E.C.1
  • 11
    • 0018356468 scopus 로고
    • Antitumour effect of cimetidine
    • Armitage, J.O.; Sidner, R.D. Antitumour effect of cimetidine. Lancet 1979, 1, 882-893.
    • (1979) Lancet , vol.1 , pp. 882-893
    • Armitage, J.O.1    Sidner, R.D.2
  • 12
    • 77950826446 scopus 로고    scopus 로고
    • Arsenic trioxide controls the fate of the PML-RAR- oncoprotein by directly binding PML
    • Zhang, X.W.; Yan, X.J.; Zhou, Z.R.; Yang, F.F.; Chen, S.J.; Chen, Z. Arsenic trioxide controls the fate of the PML-RAR- oncoprotein by directly binding PML. Science 2010, 328, 240-253.
    • (2010) Science , vol.328 , pp. 240-253
    • Zhang, X.W.1    Yan, X.J.2    Zhou, Z.R.3    Yang, F.F.4    Chen, S.J.5    Chen, Z.6
  • 14
    • 0000831597 scopus 로고
    • Collaboration research group for qinghaosu a novel kind of sesquiterpene lactone-Artemisinin
    • Collaboration Research Group for Qinghaosu. A novel kind of sesquiterpene lactone-Artemisinin. Chin. Sci. Bullet. 1977, 22, 142.
    • (1977) Chin. Sci. Bullet , vol.22 , pp. 142
  • 15
    • 0001566484 scopus 로고
    • Structure and reaction of qinghaosu (Arteannuin)
    • Liu, J.M.; Ni, M.Y.; Zhou, W.S. Structure and reaction of qinghaosu (Arteannuin). Acta. Chimica Sinica 1979, 37, 129-141.
    • (1979) Acta. Chimica Sinica , vol.37 , pp. 129-141
    • Liu, J.M.1    Ni, M.Y.2    Zhou, W.S.3
  • 16
    • 0021948029 scopus 로고
    • Qinghaosu (artemisinin An antimalarial drug from China
    • Klayman, D.L. Qinghaosu (artemisinin): An antimalarial drug from China. Science 1985, 228, 1049-1055.
    • (1985) Science , vol.228 , pp. 1049-1055
    • Klayman, D.L.1
  • 17
    • 84982286030 scopus 로고    scopus 로고
    • Efficacy of artemisinin-based combination therapies for the treatment of falciparum malaria in Pakistan 2007-2015 vivo response and dhfr and dhps mutations
    • Kakar, Q.; Sheikh, S.; Ahmed, I.; Khan, M.A.; Jamil, M.; ElMohammady, H.; Warsame, M. Efficacy of artemisinin-based combination therapies for the treatment of falciparum malaria in Pakistan (2007-2015): In vivo response and dhfr and dhps mutations. Acta. Trop. 2016, 164, 17-22.
    • Acta. Trop , vol.2016 , Issue.164 , pp. 17-22
    • Kakar, Q.1    Sheikh, S.2    Ahmed, I.3    Khan, M.A.4    Jamil, M.5    ElMohammady, H.6    Warsame, M.7
  • 20
    • 53049086416 scopus 로고    scopus 로고
    • Experimental therapy of hepatoma with artemisinin and its derivatives vitro and in vivo activity, chemosensitization, and mechanisms of action
    • Hou, J.; Wang, D.; Zhang, R.; Wang, H. Experimental therapy of hepatoma with artemisinin and its derivatives: In vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin. Cancer Res. 2008, 14, 5519-5530.
    • (2008) Clin. Cancer Res , vol.14 , pp. 5519-5530
    • Hou, J.1    Wang, D.2    Zhang, R.3    Wang, H.4
  • 21
    • 68149173166 scopus 로고    scopus 로고
    • Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy
    • Chen, T.; Li, M.; Zhang, R.;Wang, H. Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy. J. Cell. Mol. Med. 2009, 13, 1358-1370.
    • (2009) J. Cell. Mol. Med , vol.13 , pp. 1358-1370
    • Chen, T.1    Li, M.2    Zhang, R.3    Wang, H.4
  • 22
    • 84876120652 scopus 로고    scopus 로고
    • Artemether combined with shRNA interference of vascular cell adhesion molecule-1 significantly inhibited the malignant biological behavior of human glioma cells
    • Wang, Y.B.; Hu, Y.; Li, Z.; Wang, P.; Xue, Y.X.; Yao, Y.L.; Yu, B.; Liu, Y.H. Artemether combined with shRNA interference of vascular cell adhesion molecule-1 significantly inhibited the malignant biological behavior of human glioma cells. PLoS ONE 2013, 8, e60834.
    • (2013) PLoS ONE , vol.8 , pp. e60834
    • Wang, Y.B.1    Hu, Y.2    Li, Z.3    Wang, P.4    Xue, Y.X.5    Yao, Y.L.6    Yu, B.7    Liu, Y.H.8
  • 25
    • 84922073603 scopus 로고    scopus 로고
    • Population pharmacokinetics of artesunate and dihydroartemisinin during long-Term oral administration of artesunate to patients with metastatic breast cancer
    • Ericsson, T.; Blank, A.; von Hagens, C.; Ashton, M.; Abelö, A. Population pharmacokinetics of artesunate and dihydroartemisinin during long-Term oral administration of artesunate to patients with metastatic breast cancer. Eur. J. Clin. Pharmacol. 2014, 70, 1453-1463.
    • (2014) Eur. J. Clin. Pharmacol , vol.70 , pp. 1453-1463
    • Ericsson, T.1    Blank, A.2    Von Hagens, C.3    Ashton, M.4    Abelö, A.5
  • 26
    • 80053976628 scopus 로고    scopus 로고
    • The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
    • Tu, Y.Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat. Med. 2011, 17, 1217-1220.
    • (2011) Nat. Med , vol.17 , pp. 1217-1220
    • Tu, Y.Y.1
  • 29
    • 84884926518 scopus 로고    scopus 로고
    • Research advance in antitumor activities of artemisinin and its derivatives
    • Yang, H.; Tan, X.J. Research advance in antitumor activities of artemisinin and its derivatives. Zhong Guo Yi Xue Ke Xue Yuan Xue Bao 2013, 35, 466-471.
    • (2013) Zhong Guo Yi Xue Ke Xue Yuan Xue Bao , vol.35 , pp. 466-471
    • Yang, H.1    Tan, X.J.2
  • 30
    • 65549151898 scopus 로고    scopus 로고
    • Novel classes of dimer antitumour drug candidates
    • Chow, L.M.; Chan, T.H. Novel classes of dimer antitumour drug candidates. Curr. Pharm. Des. 2009, 15, 659-674.
    • (2009) Curr. Pharm. des , vol.15 , pp. 659-674
    • Chow, L.M.1    Chan, T.H.2
  • 31
    • 84861586454 scopus 로고    scopus 로고
    • Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5
    • Kong, R.; Jia, G.; Chen, Z.X.; Wang, Y.W.; Mu, M.; Wang, S.J.; Pan, S.H.; Gao, Y.; Jian, H.C.; Dong, D.L.; et al. Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5. PLoS ONE 2012, 7, e37222.
    • (2012) PLoS ONE , vol.7 , pp. e37222
    • Kong, R.1    Jia, G.2    Chen, Z.X.3    Wang, Y.W.4    Mu, M.5    Wang, S.J.6    Pan, S.H.7    Gao, Y.8    Jian, H.C.9    Dong, D.L.10
  • 32
    • 83355166871 scopus 로고    scopus 로고
    • Artesunateinduces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells
    • Berdelle, N.; Nikolova, T.; Quiros, S.; Efferth, T.; Kaina, B. Artesunateinduces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells. Mol. Cancer Ther. 2011, 10, 2224-2233.
    • (2011) Mol. Cancer Ther , vol.10 , pp. 2224-2233
    • Berdelle, N.1    Nikolova, T.2    Quiros, S.3    Efferth, T.4    Kaina, B.5
  • 33
    • 78651404852 scopus 로고    scopus 로고
    • The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials
    • Mercer, A.E.; Copple, I.M.; Maggs, J.L.; O'Neill, P.M.; Park, B.K. The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. J. Biol. Chem. 2011, 286, 987-996.
    • (2011) J. Biol. Chem , vol.286 , pp. 987-996
    • Mercer, A.E.1    Copple, I.M.2    Maggs, J.L.3    O'Neill, P.M.4    Park, B.K.5
  • 34
    • 33646024956 scopus 로고    scopus 로고
    • Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
    • Efferth, T. Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells. Curr. Drug Targets 2006, 7, 407-421.
    • (2006) Curr. Drug Targets , vol.7 , pp. 407-421
    • Efferth, T.1
  • 36
    • 56149102126 scopus 로고    scopus 로고
    • Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-Activated protein kinase activation but independent of reactive oxygen species
    • Lu, J.J.; Meng, L.H.; Cai, Y.J.; Chen, Q.; Tong, L.J.; Lin, L.P.; Ding, J. Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-Activated protein kinase activation but independent of reactive oxygen species. Cancer Biol. Ther. 2008, 7, 1017-1023.
    • (2008) Cancer Biol. Ther , vol.7 , pp. 1017-1023
    • Lu, J.J.1    Meng, L.H.2    Cai, Y.J.3    Chen, Q.4    Tong, L.J.5    Lin, L.P.6    Ding, J.7
  • 37
    • 84891353549 scopus 로고    scopus 로고
    • Cytotoxicity of dihydroartemisinin toward Molt-4 cells attenuated by N-Tert-butyl-phenylnitrone and deferoxamine
    • Chan, H.W.; Singh, N.P.; Lai, H.C. Cytotoxicity of dihydroartemisinin toward Molt-4 cells attenuated by N-Tert-butyl-phenylnitrone and deferoxamine. Anticancer Res. 2013, 33, 4389-4393.
    • (2013) Anticancer Res , vol.33 , pp. 4389-4393
    • Chan, H.W.1    Singh, N.P.2    Lai, H.C.3
  • 38
    • 84862780354 scopus 로고    scopus 로고
    • Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells
    • Jiang, Z.; Chai, J.; Chuang, H.H.; Li, S.; Wang, T.; Cheng, Y.; Chen, W.; Zhou, D. Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells. Anticancer Drugs. 2012, 23, 606-613.
    • (2012) Anticancer Drugs , vol.23 , pp. 606-613
    • Jiang, Z.1    Chai, J.2    Chuang, H.H.3    Li, S.4    Wang, T.5    Cheng, Y.6    Chen, W.7    Zhou, D.8
  • 39
    • 84981306403 scopus 로고    scopus 로고
    • Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1
    • Chen, G.; Gong, R.; Shi, X.; Yang, D.; Zhang, G.; Lu, A.; Yue, J.; Bian, Z. Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1. Oncotarget 2016.
    • (2016) Oncotarget
    • Chen, G.1    Gong, R.2    Shi, X.3    Yang, D.4    Zhang, G.5    Lu, A.6    Yue, J.7    Bian, Z.8
  • 40
    • 59049096024 scopus 로고    scopus 로고
    • Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression
    • Willoughby, J.A., Sr.; Sundar, S.N.; Cheung, M.; Tin, A.S.; Modiano, J.; Firestone, G.L. Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression. J. Biol. Chem. 2009, 284, 2203-2213.
    • (2009) J. Biol. Chem , vol.284 , pp. 2203-2213
    • Willoughby, J.A.1    Sundar, S.N.2    Cheung, M.3    Tin, A.S.4    Modiano, J.5    Firestone, G.L.6
  • 41
    • 84992375491 scopus 로고    scopus 로고
    • Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells
    • Chen, K.; Shou, L.M.; Lin, F.; Duan, W.M.; Wu, M.Y.; Xie, X.; Xie, Y.F.; Li, W.; Tao, M. Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells. Eur. J. Haematol. 2013, 91, 339-346.
    • (2013) Eur. J. Haematol , vol.91 , pp. 339-346
    • Chen, K.1    Shou, L.M.2    Lin, F.3    Duan, W.M.4    Wu, M.Y.5    Xie, X.6    Xie, Y.F.7    Li, W.8    Tao, M.9
  • 42
    • 78650944133 scopus 로고    scopus 로고
    • Effects of artesunate on cytokinesis and G0/M cell cycle progression of tumour cells and budding yeast
    • Steinbröck, L.; Pereira, G.; Efferth, T. Effects of artesunate on cytokinesis and G0/M cell cycle progression of tumour cells and budding yeast. Cancer Geno. Proteom. 2010, 7, 337-346.
    • (2010) Cancer Geno. Proteom , vol.7 , pp. 337-346
    • Steinbröck, L.1    Pereira, G.2    Efferth, T.3
  • 43
    • 77952420656 scopus 로고    scopus 로고
    • Dihydroartemisinin inactivates NF-B and potentiates the anti-Tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
    • Wang, S.J.; Gao, Y.; Chen, H.; Kong, R.; Jiang, H.C.; Pan, S.H.; Xue, D.B.; Bai, X.W.; Sun, B. Dihydroartemisinin inactivates NF-B and potentiates the anti-Tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett. 2010, 293, 99-108.
    • (2010) Cancer Lett , vol.293 , pp. 99-108
    • Wang, S.J.1    Gao, Y.2    Chen, H.3    Kong, R.4    Jiang, H.C.5    Pan, S.H.6    Xue, D.B.7    Bai, X.W.8    Sun, B.9
  • 44
    • 84878133739 scopus 로고    scopus 로고
    • The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells
    • Cheng, R.; Li, C.; Li, C.; Wei, L.; Li, L.; Zhang, Y.; Yao, Y.; Gu, X.; Cai, W.; Yang, Z.; et al. The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells. Investig. Ophthalmol. Vis. Sci. 2013, 54, 3400-3409.
    • (2013) Investig. Ophthalmol. Vis. Sci , vol.54 , pp. 3400-3409
    • Cheng, R.1    Li, C.2    Li, C.3    Wei, L.4    Li, L.5    Zhang, Y.6    Yao, Y.7    Gu, X.8    Cai, W.9    Yang, Z.10
  • 45
    • 73449131476 scopus 로고    scopus 로고
    • Effect ofartesunateon inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NF-B p65
    • Li, S.; Xue, F.; Cheng, Z.; Yang, X.;Wang, S.; Geng, F.; Pan, L. Effect ofartesunateon inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NF-B p65. Int. J. Hematol. 2009, 90, 513-521.
    • (2009) Int. J. Hematol , Issue.90 , pp. 513-521
    • Li, S.1    Xue, F.2    Cheng, Z.3    Yang, X.4    Wang, S.5    Geng, F.6    Pan, L.7
  • 46
    • 79951678330 scopus 로고    scopus 로고
    • Artesunatemitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase
    • Zeng, Q.P.; Zhang, P.Z. Artesunatemitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase. Nitric Oxide 2011, 24, 110-112.
    • (2011) Nitric Oxide , vol.24 , pp. 110-112
    • Zeng, Q.P.1    Zhang, P.Z.2
  • 47
    • 84912078502 scopus 로고    scopus 로고
    • Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin
    • Yang, N.D.; Tan, S.H.; Ng, S.; Shi, Y.; Zhou, J.; Tan, K.S.;Wong, W.S.; Shen, H.M. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J. Biol. Chem. 2014, 289, 33425-33441.
    • (2014) J. Biol. Chem , vol.289 , pp. 33425-33441
    • Yang, N.D.1    Tan, S.H.2    Ng, S.3    Shi, Y.4    Zhou, J.5    Tan, K.S.6    Wong, W.S.7    Shen, H.M.8
  • 48
    • 84865427860 scopus 로고    scopus 로고
    • Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells
    • Zhou, C.; Pan, W.; Wang, X.P.; Chen, T.S. Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J. Cell. Physiol. 2012, 227, 3778-3786.
    • (2012) J. Cell. Physiol , vol.227 , pp. 3778-3786
    • Zhou, C.1    Pan, W.2    Wang, X.P.3    Chen, T.S.4
  • 49
    • 79953194472 scopus 로고    scopus 로고
    • Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production
    • Hamacher-Brady, A.; Stein, H.A.; Turschner, S.; Toegel, I.; Mora, R.; Jennewein, N.; Efferth, T.; Eils, R.; Brady, N.R. Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J. Biol. Chem. 2011, 286, 6587-6601.
    • (2011) J. Biol. Chem , vol.286 , pp. 6587-6601
    • Hamacher-Brady, A.1    Stein, H.A.2    Turschner, S.3    Toegel, I.4    Mora, R.5    Jennewein, N.6    Efferth, T.7    Eils, R.8    Brady, N.R.9
  • 51
    • 84884818481 scopus 로고    scopus 로고
    • Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate
    • Holien, T.; Olsen, O.E.; Misund, K.; Hella, H.; Waage, A.; Rø, T.B.; Sundan, A. Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate. Eur. J. Haematol. 2013, 91, 339-346.
    • (2013) Eur. J. Haematol , vol.91 , pp. 339-346
    • Holien, T.1    Olsen, O.E.2    Misund, K.3    Hella, H.4    Waage, A.5    øt, B.R.6    Sundan, A.7
  • 52
    • 34347389476 scopus 로고    scopus 로고
    • Dihydroartemisinin is an inhibitor of ovarian cancer cell growth
    • Jiao, Y.; Ge, C.M.; Meng, Q.H.; Cao, J.P.; Tong, J.; Fan, S.J. Dihydroartemisinin is an inhibitor of ovarian cancer cell growth. Acta Pharmacol. Sin. 2007, 28, 1045-1056.
    • (2007) Acta Pharmacol. Sin , vol.28 , pp. 1045-1056
    • Jiao, Y.1    Ge, C.M.2    Meng, Q.H.3    Cao, J.P.4    Tong, J.5    Fan, S.J.6
  • 53
    • 77951651771 scopus 로고    scopus 로고
    • Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: Involvement of cell cycle arrest and inactivation of nuclear factor-B
    • Chen, H.; Sun, B.; Wang, S.; Pan, S.; Gao, Y.; Bai, X.; Xue, D. Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: Involvement of cell cycle arrest and inactivation of nuclear factor-B. J. Cancer Res. Clin. Oncol. 2010, 136, 897-903.
    • (2010) J. Cancer Res. Clin. Oncol , vol.136 , pp. 897-903
    • Chen, H.1    Sun, B.2    Wang, S.3    Pan, S.4    Gao, Y.5    Bai, X.6    Xue, D.7
  • 57
    • 27644565158 scopus 로고    scopus 로고
    • Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an in vitro replicative system
    • Romero, M.R.; Efferth, T.; Serrano, M.A.; Castaño, B.; Macias, R.I.; Briz, O.; Marin, J.J. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral. Res. 2005, 68, 75-83.
    • (2005) Antiviral. Res , vol.68 , pp. 75-83
    • Romero, M.R.1    Efferth, T.2    Serrano, M.A.3    Castaño, B.4    Macias, R.I.5    Briz, O.6    Marin, J.J.7
  • 59
    • 33947385343 scopus 로고    scopus 로고
    • Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells
    • Mu, D.; Chen, W.; Yu, B.; Zhang, C.; Zhang, Y.; Qi, H. Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells. Methods Find Exp. Clin. Pharmacol. 2007, 29, 33-38.
    • (2007) Methods Find Exp. Clin. Pharmacol , vol.29 , pp. 33-38
    • Mu, D.1    Chen, W.2    Yu, B.3    Zhang, C.4    Zhang, Y.5    Qi, H.6
  • 60
    • 38049022026 scopus 로고    scopus 로고
    • The role of calcium P38 MAPK in dihydroartemisinin-induced apoptosis of lung cancer PC-14 cells
    • Mu, D.; Zhang, W.; Chu, D.; Liu, T.; Xie, Y.; Fu, E.; Jin, F. The role of calcium, P38 MAPK in dihydroartemisinin-induced apoptosis of lung cancer PC-14 cells. Cancer Chemother Pharmacol. 2008, 61, 639-645.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 639-645
    • Mu, D.1    Zhang, W.2    Chu, D.3    Liu, T.4    Xie, Y.5    Fu, E.6    Jin, F.7
  • 61
    • 84892473066 scopus 로고    scopus 로고
    • The activation of c-Jun NH2-Terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells
    • Jia, G.; Kong, R.; Ma, Z.B.; Han, B.; Wang, Y.W.; Pan, S.H.; Li, Y.H.; Sun, B. The activation of c-Jun NH2-Terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells. J. Exp. Clin. Cancer Res. 2014, 33, 8.
    • (2014) J. Exp. Clin. Cancer Res , vol.33 , pp. 8
    • Jia, G.1    Kong, R.2    Ma, Z.B.3    Han, B.4    Wang, Y.W.5    Pan, S.H.6    Li, Y.H.7    Sun, B.8
  • 62
    • 84979515477 scopus 로고    scopus 로고
    • Vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin
    • Njokah, M.J.; Kang'ethe, J.N.; Kinyua, J.; Kariuki, D.; Kimani, F.T. In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin. Malar. J. 2016, 15, 381.
    • (2016) Malar. J , vol.15 , pp. 381
    • Njokah, M.J.1    Kang'ethe, J.N.2    Kinyua, J.3    Kariuki, D.4    Kimani, F.T.5
  • 64
    • 84918546040 scopus 로고    scopus 로고
    • Dihydroartemisin in targets VEGFR2 via the NF-B pathway in endothelial cells to inhibit angiogenesis
    • Dong, F.; Zhou, X.; Li, C.; Yan, S.; Deng, X.; Cao, Z.; Li, L.; Tang, B.; Allen, T.D.; Liu, J. Dihydroartemisin in targets VEGFR2 via the NF-B pathway in endothelial cells to inhibit angiogenesis. Cancer Biol. Ther. 2014, 15, 1479-1488.
    • (2014) Cancer Biol. Ther , vol.15 , pp. 1479-1488
    • Dong, F.1    Zhou, X.2    Li, C.3    Yan, S.4    Deng, X.5    Cao, Z.6    Li, L.7    Tang, B.8    Allen, T.D.9    Liu, J.10
  • 65
    • 84908206790 scopus 로고    scopus 로고
    • Dihydroartemisin in inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-Activated protein kinase-independent pathway
    • Guo, L.; Dong, F.; Hou, Y.; Cai, W.; Zhou, X.; Huang, A.L.; Yang, M.; Allen, T.D.; Liu, J. Dihydroartemisin in inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-Activated protein kinase-independent pathway. Exp. Ther. Med. 2014, 8, 1707-1712.
    • (2014) Exp. Ther. Med , vol.8 , pp. 1707-1712
    • Guo, L.1    Dong, F.2    Hou, Y.3    Cai, W.4    Zhou, X.5    Huang, A.L.6    Yang, M.7    Allen, T.D.8    Liu, J.9
  • 66
    • 84928382772 scopus 로고    scopus 로고
    • Quantitative structure-Activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1
    • Saeed, M.E.; Kadioglu, O.; Seo, E.J.; Greten, H.J.; Brenk, R.; Efferth, T. Quantitative structure-Activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1. Anticancer Res. 2015, 35, 1929-1934.
    • (2015) Anticancer Res , vol.35 , pp. 1929-1934
    • Saeed, M.E.1    Kadioglu, O.2    Seo, E.J.3    Greten, H.J.4    Brenk, R.5    Efferth, T.6
  • 67
    • 78549287434 scopus 로고    scopus 로고
    • Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells
    • Chen, H.; Shi, L.; Yang, X.; Li, S.; Guo, X.; Pan, L. Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells. Int. J. Hematol. 2010, 92, 587-597.
    • (2010) Int. J. Hematol , vol.92 , pp. 587-597
    • Chen, H.1    Shi, L.2    Yang, X.3    Li, S.4    Guo, X.5    Pan, L.6
  • 68
    • 62749166519 scopus 로고    scopus 로고
    • The role of downstream signaling pathways of the epidermal growth factor receptor for artesunate's activity in cancer cells
    • Konkimalla, V.B.; McCubrey, J.A.; Efferth, T. The role of downstream signaling pathways of the epidermal growth factor receptor for artesunate's activity in cancer cells. Curr. Cancer Drug Targets. 2009, 9, 72-80.
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 72-80
    • Konkimalla, V.B.1    McCubrey, J.A.2    Efferth, T.3
  • 69
    • 84555189779 scopus 로고    scopus 로고
    • The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model
    • Ma, H.; Yao, Q.; Zhang, A.M.; Lin, S.;Wang, X.X.;Wu, L.; Sun, J.G.; Chen, Z.T. The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model. Molecules 2011, 16, 10556-10569.
    • (2011) Molecules , vol.16 , pp. 10556-10569
    • Ma, H.1    Yao, Q.2    Zhang, A.M.3    Lin, S.4    Wang, X.X.5    Wu, L.6    Sun, J.G.7    Chen, Z.T.8
  • 70
    • 44249089228 scopus 로고    scopus 로고
    • Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of-catenin and E-cadherin
    • Li, L.N.; Zhang, H.D.; Yuan, S.J.; Yang, D.X.;Wang, L.; Sun, Z.X. Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of -catenin and E-cadherin. Eur. J. Pharmacol. 2008, 588, 1-8.
    • (2008) Eur. J. Pharmacol , vol.588 , pp. 1-8
    • Li, L.N.1    Zhang, H.D.2    Yuan, S.J.3    Yang, D.X.4    Wang, L.5    Sun, Z.X.6
  • 71
    • 84886678708 scopus 로고    scopus 로고
    • Synergistic inhibition of angiogenesis by artesunate and captopril in vitro and in vivo
    • Krusche, B.; Arend, J.; Efferth, T. Synergistic inhibition of angiogenesis by artesunate and captopril in vitro and in vivo. Evid. Based Compl. Alternat. Med. 2013, 2013, 454783.
    • (2013) Evid. Based Compl. Alternat. Med , vol.2013 , pp. 454783
    • Krusche, B.1    Arend, J.2    Efferth, T.3
  • 73
    • 75749097693 scopus 로고    scopus 로고
    • Severe embryotoxicity of artemisinin derivatives in experimental animals, but possibly safe in pregnant women
    • Li, Q.; Weina, P.J. Severe embryotoxicity of artemisinin derivatives in experimental animals, but possibly safe in pregnant women. Molecules 2009, 15, 40-57.
    • (2009) Molecules , vol.15 , pp. 40-57
    • Li, Q.1    Weina, P.J.2
  • 74
    • 84981343975 scopus 로고    scopus 로고
    • Clinical and non-clinical safety of artemisinin derivatives in pregnancy
    • Gomes, C.; Boareto, A.C.; Dalsenter, P.R. Clinical and non-clinical safety of artemisinin derivatives in pregnancy. Reprod. Toxicol. 2016, 65, 194-203.
    • (2016) Reprod. Toxicol , vol.65 , pp. 194-203
    • Gomes, C.1    Boareto, A.C.2    Dalsenter, P.R.3
  • 79
    • 84992364534 scopus 로고    scopus 로고
    • Application Value of Interventional Ultrasound in Treatment of Primary Hepatic
    • Zhang, Y.; Zhang, Y.; Ren, J. Application Value of Interventional Ultrasound in Treatment of Primary Hepatic. Mod. Diag. Treat. 2007, 18, 121.
    • (2007) Mod. Diag. Treat , vol.18 , pp. 121
    • Zhang, Y.1    Zhang, Y.2    Ren, J.3
  • 80
    • 39149087695 scopus 로고    scopus 로고
    • Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial
    • Zhang, Z.Y.; Yu, S.Q.; Miao, L.Y.; Huang, X.Y.; Zhang, X.P.; Zhu, Y.P.; Xia, X.H.; Li, D.Q. Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial. Zhong Xi Yi Jie He Xue Bao 2008, 6, 134-138.
    • (2008) Zhong Xi Yi Jie He Xue Bao , vol.6 , pp. 134-138
    • Zhang, Z.Y.1    Yu, S.Q.2    Miao, L.Y.3    Huang, X.Y.4    Zhang, X.P.5    Zhu, Y.P.6    Xia, X.H.7    Li, D.Q.8
  • 81
    • 33750858216 scopus 로고    scopus 로고
    • Case report of a pituitary macro adenoma treated with artemether
    • Singh, N.P.; Panwar, V.K. Case report of a pituitary macro adenoma treated with artemether. Integr. Cancer Ther. 2006, 5, 391-394.
    • (2006) Integr. Cancer Ther , vol.5 , pp. 391-394
    • Singh, N.P.1    Panwar, V.K.2
  • 82
    • 84978908850 scopus 로고    scopus 로고
    • The production and exportation of artemisinin-derived drugs in China: Current status and existing challenges
    • Huang, Y.; Li, H.; Peng, D.;Wang, Y.; Ren, Q.; Guo, Y. The production and exportation of artemisinin-derived drugs in China: current status and existing challenges. Malar. J. 2016, 15, 365.
    • (2016) Malar. J , vol.15 , pp. 365
    • Huang, Y.1    Li, H.2    Peng, D.3    Wang, Y.4    Ren, Q.5    Guo, Y.6
  • 83
    • 84898027188 scopus 로고    scopus 로고
    • Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function
    • Shen, J.; Sheng, X.; Chang, Z.; Wu, Q.; Wang, S.; Xuan, Z.; Li, D.; Wu, Y.; Shang, Y.; Kong, X.; et al. Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Cell Rep. 2014, 7, 180-193.
    • (2014) Cell Rep , vol.7 , pp. 180-193
    • Shen, J.1    Sheng, X.2    Chang, Z.3    Wu, Q.4    Wang, S.5    Xuan, Z.6    Li, D.7    Wu, Y.8    Shang, Y.9    Kong, X.10
  • 84
    • 84865009936 scopus 로고    scopus 로고
    • Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1
    • Ba, Q.; Zhou, N.; Duan, J.; Chen, T.; Hao, M.; Yang, X.; Li, J.; Yin, J.; Chu, R.;Wang, H. Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. PLoS ONE 2012, 7, e42703.
    • (2012) PLoS ONE , vol.7 , pp. e42703
    • Ba, Q.1    Zhou, N.2    Duan, J.3    Chen, T.4    Hao, M.5    Yang, X.6    Li, J.7    Yin, J.8    Chu, R.9    Wang, H.10
  • 85
    • 49249122781 scopus 로고    scopus 로고
    • Artesunate derived from traditional Chinese medicine induces DNA damage and repair
    • Li, P.C.; Lam, E.; Roos, W.P.; Zdzienicka, M.Z.; Kaina, B.; Efferth, T. Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res. 2008, 68, 4347-4351.
    • (2008) Cancer Res , vol.68 , pp. 4347-4351
    • Li, P.C.1    Lam, E.2    Roos, W.P.3    Zdzienicka, M.Z.4    Kaina, B.5    Efferth, T.6
  • 86
    • 84887035153 scopus 로고    scopus 로고
    • Artemisinin rewires the protein interaction network in cancer cells: Network analysis, pathway identification, and target prediction
    • Huang, C.; Ba, Q.; Yue, Q.; Li, J.; Li, J.; Chu, R.;Wang, H. Artemisinin rewires the protein interaction network in cancer cells: Network analysis, pathway identification, and target prediction. Mol. Biosyst. 2013, 9, 3091-3100.
    • (2013) Mol. Biosyst , vol.9 , pp. 3091-3100
    • Huang, C.1    Ba, Q.2    Yue, Q.3    Li, J.4    Li, J.5    Chu, R.6    Wang, H.7
  • 87
    • 84979018731 scopus 로고    scopus 로고
    • Alendronate-Loaded Modified Drug Delivery Lipid Particles Intended for Improved Oral and Topical Administration
    • Ochiuz, L.; Grigoras, C.; Popa, M.; Stoleriu, I.; Munteanu, C.; Timofte, D.; Profire, L.; Grigoras, A.G. Alendronate-Loaded Modified Drug Delivery Lipid Particles Intended for Improved Oral and Topical Administration. Molecules 2016, 21, 858.
    • (2016) Molecules , vol.21 , pp. 858
    • Ochiuz, L.1    Grigoras, C.2    Popa, M.3    Stoleriu, I.4    Munteanu, C.5    Timofte, D.6    Profire, L.7    Grigoras, A.G.8
  • 88
    • 84884209406 scopus 로고    scopus 로고
    • Preparation and optimization of transferrin-modifiedartemether lipid nanospheres based on the orthogonal design of emulsion formulation and physically electrostatic adsorption
    • Eltayeb, S.E.; Su, Z.; Shi, Y.; Li, S.; Xiao, Y.; Ping, Q. Preparation and optimization of transferrin-modifiedartemether lipid nanospheres based on the orthogonal design of emulsion formulation and physically electrostatic adsorption. Int. J. Pharm. 2013, 452, 321-332.
    • (2013) Int. J. Pharm , vol.452 , pp. 321-332
    • Eltayeb, S.E.1    Su, Z.2    Shi, Y.3    Li, S.4    Xiao, Y.5    Ping, Q.6
  • 89
    • 84902546485 scopus 로고    scopus 로고
    • Preparation characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin
    • Gharib, A.; Faezizadeh, Z.; Mesbah-Namin, S.A.; Saravani, R. Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin. DARU J. Pharm. Sci. 2014, 22, 44.
    • (2014) DARU J. Pharm. Sci , vol.22 , pp. 44
    • Gharib, A.1    Faezizadeh, Z.2    Mesbah-Namin, S.A.3    Saravani, R.4
  • 90
    • 84879028743 scopus 로고    scopus 로고
    • Vivo study of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice
    • Jin, M.; Shen, X.; Zhao, C.; Qin, X.; Liu, H.; Huang, L.; Qiu, Z.; Liu, Y. In vivo study of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice. Drug Deliv. 2013, 20, 127-133.
    • (2013) Drug Deliv , vol.20 , pp. 127-133
    • Jin, M.1    Shen, X.2    Zhao, C.3    Qin, X.4    Liu, H.5    Huang, L.6    Qiu, Z.7    Liu, Y.8
  • 91
    • 84860677660 scopus 로고    scopus 로고
    • An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs
    • Wang, S.; Wang, H.; Liang, W.; Huang, Y. An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs. Nanoscale Res. Lett. 2012, 7, 219.
    • (2012) Nanoscale Res. Lett , vol.7 , pp. 219
    • Wang, S.1    Wang, H.2    Liang, W.3    Huang, Y.4
  • 92
    • 84899936214 scopus 로고    scopus 로고
    • Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin
    • Yang, Y.; Zhang, X.;Wang, X.; Zhao, X.; Ren, T.;Wang, F.; Yu, B. Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin. Int. J. Pharm. 2014, 467, 113-122.
    • (2014) Int. J. Pharm , vol.467 , pp. 113-122
    • Yang, Y.1    Zhang, X.2    Wang, X.3    Zhao, X.4    Ren, T.5    Wang, F.6    Yu, B.7
  • 93
    • 84865955591 scopus 로고    scopus 로고
    • LyP-1 modification to enhance delivery of artemisinin or fluorescent probe loaded polymeric micelles to highly metastatic tumor and its lymphatics
    • Wang, Z.; Yu, Y.; Ma, J.; Zhang, H.; Zhang, H.;Wang, X.;Wang, J.; Zhang, X.; Zhang, Q. LyP-1 modification to enhance delivery of artemisinin or fluorescent probe loaded polymeric micelles to highly metastatic tumor and its lymphatics. Mol. Pharm. 2012, 9, 2646-2657.
    • (2012) Mol. Pharm , vol.9 , pp. 2646-2657
    • Wang, Z.1    Yu, Y.2    Ma, J.3    Zhang, H.4    Zhang, H.5    Wang, X.6    Wang, J.7    Zhang, X.8    Zhang, Q.9
  • 94
    • 84901419789 scopus 로고    scopus 로고
    • Multifunctional mesoporous nanoparticles as pH-responsive Fe2+ reservoirs and artemisinin vehicles for synergistic inhibition of tumor growth
    • Chen, J.; Guo, Z.; Wang, H.B.; Zhou, J.J.; Zhang, W.J.; Chen, Q.W. Multifunctional mesoporous nanoparticles as pH-responsive Fe2+ reservoirs and artemisinin vehicles for synergistic inhibition of tumor growth. Biomaterials 2014, 35, 6498-6507.
    • (2014) Biomaterials , vol.35 , pp. 6498-6507
    • Chen, J.1    Guo, Z.2    Wang, H.B.3    Zhou, J.J.4    Zhang, W.J.5    Chen, Q.W.6
  • 95
    • 84939874157 scopus 로고    scopus 로고
    • Enhancing the in vitro anti-cancer efficacy of artesunate by loading into poly-D L-lactide-co-glycolide (PLGA) nanoparticles
    • Nguyen, H.T.; Tran, T.H.; Kim, J.O.; Yong, C.S.; Nguyen, C.N. Enhancing the in vitro anti-cancer efficacy of artesunate by loading into poly-D, L-lactide-co-glycolide (PLGA) nanoparticles. Arch. Pharm. Res. 2015, 38, 716-724.
    • (2015) Arch. Pharm. Res , vol.38 , pp. 716-724
    • Nguyen, H.T.1    Tran, T.H.2    Kim, J.O.3    Yong, C.S.4    Nguyen, C.N.5
  • 96
    • 84936856083 scopus 로고    scopus 로고
    • Nanoparticlesand the Blood-BrainBarrier: Advancing from in-Vitro Models towards Therapeutic Significance
    • McCarthy, D.J.; Malhotra, M.; O'Mahony, A.M.; Cryan, J.F.; O'Driscoll, C.M. Nanoparticlesand the Blood-BrainBarrier: Advancing from in-Vitro Models towards Therapeutic Significance. Pharm. Res. 2015, 32, 1161-1185.
    • (2015) Pharm. Res , vol.32 , pp. 1161-1185
    • McCarthy, D.J.1    Malhotra, M.2    O'Mahony, A.M.3    Cryan, J.F.4    O'Driscoll, C.M.5
  • 97
    • 84908428874 scopus 로고    scopus 로고
    • A multifunctional polymeric nanotheranostic system delivers doxorubicin and imaging agents across the blood-brain barrier targeting brain metastases of breast cancer
    • Li, J.; Cai, P.; Shalviri, A.; Henderson, J.T.; He, C.; Foltz, W.D.; Prasad, P.; Brodersen, P.M.; Chen, Y.; DaCosta, R.; et al. A multifunctional polymeric nanotheranostic system delivers doxorubicin and imaging agents across the blood-brain barrier targeting brain metastases of breast cancer. ACS Nano. 2014, 8, 9925-9940.
    • (2014) ACS Nano , vol.8 , pp. 9925-9940
    • Li, J.1    Cai, P.2    Shalviri, A.3    Henderson, J.T.4    He, C.5    Foltz, W.D.6    Prasad, P.7    Brodersen, P.M.8    Chen, Y.9    DaCosta, R.10
  • 98
    • 84905819966 scopus 로고    scopus 로고
    • Vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery
    • Jose, S.; Anju, S.S.; Cinu, T.A.; Aleykutty, N.A.; Thomas, S.; Souto, E.B. In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery. Int. J. Pharm. 2014, 474, 6-13.
    • (2014) Int. J. Pharm , vol.474 , pp. 6-13
    • Jose, S.1    Anju, S.S.2    Cinu, T.A.3    Aleykutty, N.A.4    Thomas, S.5    Souto, E.B.6
  • 99
    • 34948884588 scopus 로고    scopus 로고
    • Creation and revelation: Two different routes to advancement in the biomedical sciences
    • Goldstein, J.L. Creation and revelation: Two different routes to advancement in the biomedical sciences. Nat. Med. 2007, 13, 1151-1154.
    • (2007) Nat. Med , vol.13 , pp. 1151-1154
    • Goldstein, J.L.1
  • 100
    • 84873856866 scopus 로고    scopus 로고
    • Development of artemisinin compounds for cancer treatment
    • Lai, H.C.; Singh, N.P.; Sasaki, T. Development of artemisinin compounds for cancer treatment. Investig. New Drugs. 2013, 31, 230-246.
    • (2013) Investig. New Drugs , vol.31 , pp. 230-246
    • Lai, H.C.1    Singh, N.P.2    Sasaki, T.3
  • 102
    • 81855168327 scopus 로고    scopus 로고
    • Artesunate enhances radio sensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase
    • Zhao, Y.; Jiang, W.; Li, B.; Yao, Q.; Dong, J.; Cen, Y.; Pan, X.; Li, J.; Zheng, J.; Pang, X.; et al. Artesunate enhances radio sensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase. Int. Immunopharmacol. 2011, 11, 2039-2046.
    • (2011) Int. Immunopharmacol , vol.11 , pp. 2039-2046
    • Zhao, Y.1    Jiang, W.2    Li, B.3    Yao, Q.4    Dong, J.5    Cen, Y.6    Pan, X.7    Li, J.8    Zheng, J.9    Pang, X.10


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