Repurposing drugs in oncology (ReDo)-cimetidine as an anti-cancer agent

ecancermedicalscience

Volumn 8, Issue , 2014, Pages

  Pantziarka, Pan ^a,b   Bouche, Gauthier ^a   Meheus, Lydie ^a   Sukhatme, Vidula ^c   Sukhatme, Vikas P ^c,d  

^a Anticancer Fund   (Belgium)

^b George Pantziarka TP53 Trust   (United Kingdom)

^c GlobalCures Inc   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cimetidine; Drug repurposing; Immunostimulant; Redo project

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CIMETIDINE; CYCLOPHOSPHAMIDE; DICLOFENAC; IMMUNOSTIMULATING AGENT; SALAZOSULFAPYRIDINE;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CELL ADHESION; COLORECTAL CANCER; DISEASE FREE SURVIVAL; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG REPOSITIONING; HUMAN; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LONG TERM CARE; MAINTENANCE CHEMOTHERAPY; MAXIMUM PLASMA CONCENTRATION; MELANOMA; OVARY CARCINOMA; OVERALL SURVIVAL; PANCREAS CANCER; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL (TOPIC); STOMACH CANCER;

EID: 84919918206     PISSN: None     EISSN: 17546605     Source Type: Journal    
DOI: 10.3332/ecancer.2014.485     Document Type: Article

References (148)

1. Sabesin SM (1993) Safety issues relating to long-term treatment with histamine H2-receptor antagonists Aliment Pharmacol Ther 7 Suppl 2 35-40 PMID: 8103374
2. Chandrasekhara KL, Iyer SK and Macchia RJ (1981) Leucopenia and thrombocytopenia with cimetidine J Natl Med Assoc 73 (2) 92, 98 PMID: 7205981 PMCID: 2552636
3. Joint Formulary Committee (2013) British National Formulary 66th edn (BMJ Group and Pharmaceutical Press)
4. Bodemar G, Norlander B and Walan A (1981) Pharmacokinetics of cimetidine after single doses and during continuous treatment Clin Pharmacokinet 6 (4) 306-15 DOI: 10.2165/00003088-198106040-00005 PMID: 7249489
5. Bodemar G et al (1979) The absorption of cimetidine before and during maintenance treatment with cimetidine and the influence of a meal on the absorption of cimetidine-studies in patients with peptic ulcer disease Br J Clin Pharmacol 7 (1) 23-31 DOI: 10.1111/j.1365-2125.1979.tb00892.x PMID: 760739 PMCID: 1429608
6. Martínez C et al (1999) Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists Clin Pharmacol Ther 65 (4) 369-76 DOI: 10.1016/S0009-9236 (99) 70129-3 PMID: 10223772
7. Michalets EL (1998) Update: clinically significant cytochrome P-450 drug interactions Pharmacotherapy 18 (1) 84-112 PMID: 9469685
8. Murray LS et al (1998) The effect of cimetidine on the pharmacokinetics of epirubicin in patients with advanced breast cancer: preliminary evidence of a potentially common drug interaction Clin Oncol (R Coll Radiol) 10 (1) 35-8 DOI: 10.1016/S0936-6555 (98) 80109-X
9. Bekhti A and Pirotte J (1987) Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts Br J Clin Pharmacol 24 (3) 390-2 DOI: 10.1111/j.1365-2125.1987.tb03186.x PMID: 3663452 PMCID: 1386263
10. Teshima T et al (1990) Radiation therapy of the para-aortic lymph nodes in carcinoma of the uterine cervix: the concurrent use of cimetidine to reduce acute and subacute side effects from radiation Clin Ther 12 (1) 71-7 PMID: 2183942
11. Vassilomanolakis M et al (2001) Prevention of vinorelbine phlebitis with cimetidine. A two-step design study Suppor Care Cancer 9 (2) 108-11 DOI: 10.1007/s005200000190
12. Sprowl JA et al (2013) Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance Clini Pharmacol Ther 94 (5) 585-92 DOI: 10.1038/clpt.2013.145
13. Buttle GA et al (1962) Histamine formation and tumor growth Br Journal Cancer 16 131-40 DOI: 10.1038/bjc.1962.13
14. Burtin C et al (1981) Increased tissue histamine in tumour-bearing mice and rats Br J Cancer 43 (5) 684-8 DOI: 10.1038/bjc.1981.99 PMID: 7248152 PMCID: 2010678
15. Burtin C et al (1983) Decreased blood histamine levels in patients with solid malignant tumours Br J Cancer 47 (3) 367-72 DOI: 10.1038/bjc.1983.55 PMID: 6830687 PMCID: 2011313
16. Tutton PJ and Barkla DH (1978) Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata Cell Biol Int Rep 2 (2) 199-202 DOI: 10.1016/0309-1651 (78) 90043-7 PMID: 667962
17. Burtin C et al (1982) Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors Br J Cancer 45 (1) 54-60 DOI: 10.1038/bjc.1982.7 PMID: 7059465 PMCID: 2010957
18. Gifford RR, Ferguson RM and Voss BV (1981) Cimetidine reduction of tumour formation in mice Lancet 1 (8221) 638-40 DOI: 10.1016/S0140-6736 (81) 91555-5 PMID: 6110865
19. Osband ME et al (1981) Successful tumour immunotherapy with cimetidine in mice Lancet 1 (8221) 636-8 DOI: 10.1016/S0140-6736 (81) 91554-3 PMID: 6110864
20. Gifford RR, Voss BV and Ferguson RM (1981) Cimetidine protection against lethal tumor challenge in mice Surgery 90 (2) 344-51 PMID: 6454981
21. Dorr RT and Alberts DS (1982) Cimetidine enhancement of cyclophosphamide antitumour activity Br J cancer 45 (1) 35-43 DOI: 10.1038/bjc.1982.5 PMID: 7059463 PMCID: 2010952
22. Hannant D et al (1982) Cimetidine and therapy of rodent tumours Br J Cancer 45 (4) 613-4 DOI: 10.1038/bjc.1982.98 PMID: 7073951 PMCID: 2010991
23. Collins M and Hellmann K (1982) Histamine receptor antagonism and anti-tumour activity Br J Cancer 46 (5) 817-20 DOI: 10.1038/bjc.1982.276 PMID: 6128996 PMCID: 2011159
24. Nordlund JJ and Askenase PW (1983) The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice J Invest Dermatol 81 (1) 28-31 DOI: 10.1111/1523-1747.ep12538356 PMID: 6863977
25. Szincsák N et al (2002) Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice Cell Biol Int 26 (9) 833-6 DOI: 10.1016/S1065-6995 (02) 90934-0 PMID: 12377215
26. Kikuchi Y et al (1985) Effects of cimetidine on tumor growth and immune function in nude mice bearing human ovarian carcinoma J Natl Cancer Inst 74 (2) 495-8 PMID: 3871872
27. Adams WJ, Lawson JA and Morris DL (1994) Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth Gut 35 (11) 1632-6 DOI: 10.1136/gut.35.11.1632 PMID: 7828988 PMCID: 1375627
28. Jiang C-G et al (2010) Cimetidine induces apoptosis in gastric cancer cells in vitro and inhibits tumor growth in vivo Oncol Rep 23 (3) 693-700 PMID: 20127008
29. Sürücü O et al (2004) Tumour growth inhibition of human pancreatic cancer xenografts in SCID mice by cimetidine Inflamm Res 53 Suppl 1 S39-40 PMID: 15054609
30. Zheng Y et al (2013) Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells Mol Immunol 54 (1) 74-83 DOI: 10.1016/j.molimm.2012.10.035
31. Lefranc F et al (2005) Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts J Neurosurg 102 (4) 706-14 DOI: 10.3171/jns.2005.102.4.0706 PMID: 15871514
32. Pantziarka P et al (2014) Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent Ecancermedicalscience 8 443 PMID: 25075217 PMCID: 4096024
33. Armitage JO and Sidner RD (1979) Antitumour effect of cimetidine Lancet 1 (8121) 882-3 DOI: 10.1016/S0140-6736 (79) 91306-0 PMID: 86136
34. Adams WJ et al (1994) Cimetidine preserves non-specific immune function after colonic resection for cancer Aust N Z J Surg 64 (12) 847-52 DOI: 10.1111/j.1445-2197.1994.tb04562.x PMID: 7980260
35. Adams WJ and Morris DL (1994) Short-course cimetidine and survival with colorectal cancer Lancet 344 (8939-8940) 1768-9 DOI: 10.1016/S0140-6736 (94) 92907-6 PMID: 7997018
36. Adams WJ and Morris DL (1997) Pilot study-cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: results of a small randomized control trial Cancer 80 (1) 15-21 DOI: 10.1002/(SICI) 1097-0142 (19970701) 80:1<15::AID-CNCR3>3.0. CO;2-E PMID: 9210704
37. Svendsen LB et al (1995) Cimetidine as an adjuvant treatment in colorectal cancer. A double-blind, randomized pilot study Dis Colon Rectum 38 (5) 514-8 DOI: 10.1007/BF02148852 PMID: 7736883
38. Kelly MD et al (1999) Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes Cancer 85 (8) 1658-63 DOI: 10.1002/(SICI) 1097-0142 (19990415) 85:8<1658::AID-CNCR3>3.0. CO;2-Q PMID: 10223557
39. Matsumoto S et al (2002) Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells Br J Cancer 86 (2) 161-7 DOI: 10.1038/sj.bjc.6600048 PMID: 11870500 PMCID: 2375187
40. Lin CY et al (2004) Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial World J Gastroenterol 10 136-42 PMID: 14695785
41. Deva S and Jameson M (2012) Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer Cochrane Database Syst Rev 8(8), p. CD007814 PMID: 22895966
42. Thornes RD, Lynch G and Sheehan MV (1983) Coumarin and cimetidine in malignant melanoma. Irish Medical Journal 76 (1) 53 PMID: 6826342
43. Borgström S et al (1982) Human leukocyte interferon and cimetidine for metastatic melanoma N Engl J Med 307 (17) 1080-1 DOI: 10.1056/NEJM198210213071716 PMID: 7121522
44. Flodgren P et al (1983) Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha (Le)] and cimetidine Int J Cancer 32 (6) 657-65 DOI: 10.1002/ijc.2910320603 PMID: 6654521
45. Morton RF et al (1987) Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma J Clin Oncol 5 (7) 1078-82 PMID: 3598611
46. Creagan ET et al (1987) Three consecutive phase II studies of recombinant interferon alfa-2a in advanced malignant melanoma. Updated analyses Cancer 59 (3 Suppl) 638-46 DOI: 10.1002/1097-0142 (19870201) 59:3+<638::AID-CNCR2820591312>3.0. CO;2-0 PMID: 10822463
47. Creagan ET et al (1990) Disseminated malignant melanoma and recombinant interferon: analysis of seven consecutive phase II investigations J Invest Dermatol 95 (6 Suppl) 188S-192S DOI: 10.1111/1523-1747.ep12875512 PMID: 2124246
48. Schmidt H et al (2000) Subcutaneous interleukin-2 and interferon-alpha plus cisplatin with and without prophylactic cimetidine in patients with metastatic malignant melanoma: a phase II study Melanoma Res 10 (1) 66-77 DOI: 10.1097/00008390-200010010-00009 PMID: 10711642
49. Foster GR and Finter NB (1998) Are all type I human interferons equivalent? J Viral Hepat 5 (3) 143-52 DOI: 10.1046/j.1365-2893-.1998.00103.x PMID: 9658366
50. Mandanas R et al (1991) Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial Am J Clin Oncol 14 (5) 397-9 DOI: 10.1097/00000421-199110000-00007 PMID: 1951177
51. Arnot RS (1977) Cimetidine and gastric carcinoma Br Med J 2 (6093) p. 1022 DOI: 10.1136/bmj.2.6093.1022-a PMID: 922362 PMCID: 1631768
52. Elder JB, Ganguli PC and Gillespie IE (1979) Cimetidine and gastric cancer Lancet 1 (8124) 1005-6 DOI: 10.1016/S0140-6736 (79) 92757-0 PMID: 86721
53. Colin-Jones DG et al (1991) Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus Q J Med 78 (285) 13-9 PMID: 1670060
54. Tønnesen H et al (1988) Effect of cimetidine on survival after gastric cancer Lancet 2 (8618) 990-2 DOI: 10.1016/S0140-6736 (88) 90743-X PMID: 2902494
55. Langman MJS et al (1999) Prospective, double-blind, placebo-controlled randomized trial of cimetidine in gastric cancer. British Stomach Cancer Group Br J Cancer 81 1356-1362 DOI: 10.1038/sj.bjc.6690457 PMID: 10604733 PMCID: 2362962
56. Marshall ME et al (1987) Treatment of metastatic renal cell carcinoma with coumarin (1, 2-benzopyrone) and cimetidine: a pilot study J Clin Oncol 5 (6) 862-6 PMID: 3585442
57. Herrmann R et al (1990) Phase II trial of coumarin and cimetidine in advanced renal cell carcinoma Ann Oncol 1 (6) 445-6 PMID: 2083188
58. Venook AP, Davenport Y and Tseng A (1989) Activity of coumarin and cimetidine in metastatic renal cell carcinoma J Clin Oncol 7 (3) 402-3 PMID: 2918335
59. Kinouchi T et al (1997) Treatment of advanced renal cell carcinoma with a combination of human lymphoblastoid interferonalpha and cimetidine J Urol 157 (5) 1604-7 DOI: 10.1016/S0022-5347 (01) 64806-7 PMID: 9112486
60. Kinouchi T et al (2006) Prospective randomized trial of natural interferon-alpha versus natural interferon-alpha plus cimetidine in advanced renal cell carcinoma with pulmonary metastasis J Cancer Res Clin Oncol 132 (8) 499-504 DOI: 10.1007/s00432-006-0095-7 PMID: 16586071
61. Tatokoro M et al (2011) Phase-II trial of combination treatment of interferon-α, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma Cancer Sci 102 (1) 137-143 DOI: 10.1111/j.1349-7006.2010.01756.x
62. Inhorn L et al (1992) High-dose cimetidine for the treatment of metastatic renal cell carcinoma. A Hoosier Oncology Group study Am J Clin Oncol 15 (2) 157-9 DOI: 10.1097/00000421-199204000-00012 PMID: 1553905
63. Bowrey PF et al (2000) Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? Br J Cancer 82 (1) 167-70 DOI: 10.1054/bjoc.1999.0895 PMID: 10638985 PMCID: 2363200
64. Breuer S et al (2013) TL-118-anti-angiogenic treatment in pancreatic cancer: a case report Med Oncol 30 (2) 585 DOI: 10.1007/s12032-013-0585-9 PMID: 23609193
65. Marshall ME, Butler K and Hermansen D (1990) Treatment of hormone-refractory stage D carcinoma of prostate with coumarin (1, 2-benzopyrone) and cimetidine: a pilot study Prostate 17 (2) 95-9 DOI: 10.1002/pros.2990170203 PMID: 2399194
66. Niwa K et al (2008) Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression Mol Med Rep 1 (1) 119-22 PMID: 21479387
67. Smith TJ and Kaplowitz LG (1991) Pilot study of cimetidine in the treatment of Kaposi-s sarcoma in patients with acquired immunodeficiency syndrome J Nat Cancer Inst 83 (2) 139-41 DOI: 10.1093/jnci/83.2.139-a PMID: 1988689
68. Jameson MB et al (2014) A randomized, placebo-controlled, double-blind phase II trial of peri-operative cimetidine in early colorectal cancer J Clin Oncol 32 (suppl 3) p. abstr 509
69. Medina VA and Rivera ES (2010) Histamine receptors and cancer pharmacology Br J Pharmacol 161 (4) 755-67 DOI: 10.1111/j.1476-5381.2010.00961.x PMID: 20636392 PMCID: 2992892
70. Kennedy L et al (2012) Histamine and histamine receptor regulation of gastrointestinal cancers Transl Gastrointest Cancer 1 (3) 215-227 PMID: 24639917 PMCID: 3955103
71. Watson SA et al (1993) Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine Gut 34 (8) 1091-6 DOI: 10.1136/gut.34.8.1091 PMID: 8174960 PMCID: 1374360
72. Hahm KB et al (1996) Comparison of antiproliferative effects of 1-histamine-2 receptor antagonists, cimetidine, ranitidine, and famotidine, in gastric cancer cells Int J Immunopharmacol 18 (6-7) 393-9 DOI: 10.1016/S0192-0561 (96) 00044-6 PMID: 9024941
73. Rajendra S et al (2004) The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines Dig Dis Sci 49 (10) 1634-40 DOI: 10.1023/B:DDAS.0000043377.30075.ac PMID: 15573918
74. Mackenzie GG, Huang L, Alston N and Ouyang N et al (2013) Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. Schneider, G. (ed.) PloS one 8 (5) e61532 DOI: 10.1371/journal. pone.0061532 PMID: 23650499 PMCID: 3641121
75. O-Mahony L, Akdis M and Akdis CA (2011) Regulation of the immune response and inflammation by histamine and histamine receptors J Allergy Clin Immunol 128 (6) 1153-62 DOI: 10.1016/j.jaci.2011.06.051
76. Li Y et al (2005) Effects of perioperative cimetidine administration on peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: results of a randomized controlled clinical trial Hepatogastroenterology 52 (62) 504-8 PMID: 15816467
77. Martin RK et al (2014) Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells J Leukoc Biol 96 (July) 1-9 DOI: 10.1189/jlb.5A1213-644R PMID: 24610880
78. Elenkov IJ et al (1998) Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors J Immunol 161 (5) 2586-93 PMID: 9725260
79. Hegyesi H et al (2007) Impact of systemic histamine deficiency on the crosstalk between mammary adenocarcinoma and T cells J Pharmacol Sci 105 (1) 66-73 DOI: 10.1254/jphs. FP0070636 PMID: 17895589
80. Lindau D et al (2013) The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells Immunology 138 (2) 105-15 DOI: 10.1111/imm.12036 PMCID: 3575763
81. Kubota T et al (2002) Cimetidine modulates the antigen presenting capacity of dendritic cells from colorectal cancer patients Br J Cancer 86 (8) 1257-61 DOI: 10.1038/sj.bjc.6600233 PMID: 11953882 PMCID: 2375332
82. Katoh J et al (1998) Cimetidine reduces impairment of cellular immunity after cardiac operations with cardiopulmonary bypass J Thorac Cardiovasc Surg 116 (2) 312-8 DOI: 10.1016/S0022-5223 (98) 70132-1 PMID: 9699585
83. Kobayashi K et al (2000) Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression Cancer Res 60 (14) 3978-84 PMID: 10919677
84. Bobek V et al (2003) Inhibition of adhesion breast cancer cells by anticoagulant drugs and cimetidine Neoplasma 50 (2) 148-51 PMID: 12740651
85. Fukuda M, Kusama K and Sakashita H (2008) Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression BMC Cancer 8 376 DOI: 10.1186/1471-2407-8-376 PMID: 19091137 PMCID: 2635382
86. Liu F-R et al (2011) Cimetidine inhibits the adhesion of gastric cancer cells expressing high levels of sialyl Lewis x in human vascular endothelial cells by blocking E-selectin expression Int J Mol Med 27 (4) 537-44 PMID: 21327325
87. Ghosh AK, Hirasawa N and Ohuchi K (2001) Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H (2) receptors Br J Pharmacol 134 (7) 1419-28 DOI: 10.1038/sj.bjp. 0704372 PMID: 11724747 PMCID: 1573073
88. Tomita K, Izumi K and Okabe S (2003) Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice J Pharmacol Sci 93 (3) 321-30 DOI: 10.1254/jphs.93.321 PMID: 14646250
89. Chihara Y et al (2009) Anti-tumor effect of cimetidine via inhibiting angiogenesis factors in N-butyl-N-(4-hydroxybutyl) nitrosamine-induced mouse and rat bladder carcinogenesis Oncol Rep 22 (1) 23-8 DOI: 10.3892/or-00000401 PMID: 19513500
90. Cianchi F et al (2005) The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer Clin Cancer Res 11 (19 Pt 1) 6807-15 DOI: 10.1158/1078-0432. CCR-05-0675 PMID: 16203768
91. Lu Q et al (2013) Histamine synergistically promotes bFGF-induced angiogenesis by enhancing VEGF production via H1 receptor J Cell Biochem 114 (5) 1009-19 DOI: 10.1002/jcb.24440
92. Shakhar G and Ben-Eliyahu S (2003) Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients? Ann Surg Oncol 10 (8) 972-92 DOI: 10.1245/ASO.2003.02.007 PMID: 14527919
93. Forget P, Simonet O and De Kock M (2013) Cancer surgery induces inflammation, immunosuppression and neo-angiogenesis, but is it influenced by analgesics? F1000Res 2 102 PMID: 24358839 PMCID: 3752648
94. Forget P et al (2013) Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial Med Hypotheses 81 (4) 707-12 DOI: 10.1016/j.mehy.2013.07.033 PMID: 23937996
95. Bosset J-F et al (2014) Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study The Lancet Oncol 15 (2) 184-90 DOI: 10.1016/S1470-2045 (13) 70599-0
96. André N, Carré M and Pasquier E (2014) Metronomics: towards personalized chemotherapy? Nat Rev Clin Oncol 11 (7) 413-31 DOI: 10.1038/nrclinonc.2014.89 PMID: 24913374
97. Lien K et al (2013) Low-dose metronomic chemotherapy: a systematic literature analysis Eur J Cancer 49 (16) 3387-95 DOI: 10.1016/j.ejca.2013.06.038 PMID: 23880474
98. Nars MS and Kaneno R (2013) Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy Int J cancer 132 (11) 2471-8 DOI: 10.1002/ijc.27801
99. Hahnfeldt P, Folkman J and Hlatky L (2003) Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis J Theor Biol 220 (4) 545-54 DOI: 10.1006/jtbi.2003.3162 PMID: 12623285
100. Lasalvia-Prisco E et al (2012) Addition of an induction regimen of antiangiogenesis and antitumor immunity to standard chemotherapy improves survival in advanced malignancies Med Oncol 29 (5) 3626-33 DOI: 10.1007/s12032-012-0301-1 PMID: 22810591 PMCID: 3505507
101. Soriano JL et al (2011) Metronomic cyclophosphamide and methotrexate chemotherapy combined with 1E10 anti-idiotype vaccine in metastatic breast cancer Int J Breast Cancer 2011 (Mc) Article ID 710292 DOI: 10.4061/2011/710292
102. Kim DJ et al (2014) Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma J Clin Oncol pp. 1-7 DOI: 10.1200/JCO.2013.49.9525
103. Rudin CM et al (2013) Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer J Thorac Oncol 8 (5) 619-23 PMID: 23546045 PMCID: 3636564
104. Tsubamoto H et al (2014) Impact of combination chemotherapy with itraconazole on survival of patients with refractory ovarian cancer Anticancer Res 34 (5) 2481-7 PMID: 24778064
105. Tsubamoto H, Sonoda T and Inoue K (2014) Impact of itraconazole on the survival of heavily pre-treated patients with triplenegative breast cancer Anticancer Res 34 (7) 3839-44 PMID: 24982411
106. Chong CR et al (2007) Inhibition of angiogenesis by the antifungal drug itraconazole ACS Chem Biol 2 (4) 263-70 DOI: 10.1021/cb600362d PMID: 17432820
107. Antonarakis ES et al (2013) Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer Oncologist 18 (2) 163-73 DOI: 10.1634/theoncologist.2012-314 PMID: 23340005 PMCID: 3579600
108. Hamada S, Masamune A and Shimosegawa T (2013) Novel therapeutic strategies targeting tumor-stromal interactions in pancreatic cancer Front Physiol 4 331 DOI: 10.3389/fphys.2013.00331 PMID: 24273517 PMCID: 3822297
109. Karyekar CS et al (2004) Renal interaction between itraconazole and cimetidine J Clin Pharmacol 44 (8) 919-27 DOI: 10.1177/0091270004266783 PMID: 15286096
110. Forget P et al (2014) Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery Br J Anaesth 1-6 DOI: 10.1093/bja/aet464 PMID: 24464611
111. Zerbini LF et al (2011) Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy PloS One 6 (9) e24285 DOI: 10.1371/journal.pone.0024285 PMCID: 3171406
112. Gottfried E et al (2013) New aspects of an old drug-diclofenac targets MYC and glucose metabolism in tumor cells PloS One 8 (7) e66987 DOI: 10.1371/journal.pone.0066987 PMID: 23874405 PMCID: 3706586
113. Chirasani SR et al (2013) Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model Int J Cancer 132 (4) 843-53 DOI: 10.1002/ijc.27712
114. Lackner H et al (2004) Multimodal treatment of children with unresectable or recurrent desmoid tumors: an 11-year longitudinal observational study J Pediatr Hematol Oncol 26 (8) 518-22 DOI: 10.1097/01.mph.0000130219.26284.b3 PMID: 15284591
115. Wasserman J et al (1989) Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors Bull N Y Acad Med 65 (1) 36-44 PMID: 2513994 PMCID: 1807786
116. Ng TB (1998) A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae) Gen Pharmacol 30 (1) 1-4 DOI: 10.1016/S0306-3623 (97) 00076-1 PMID: 9457474
117. Maehara Y et al (2012) Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN (®)): review of development and future perspectives Surg Today 42 (1) 8-28 DOI: 10.1007/s00595-011-0075-7 PMCID: 3253283
118. Tsang KW et al (2003) Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer Respir Med 97 (6) 618-24 DOI: 10.1053/rmed.2003.1490 PMID: 12814145
119. Brown DC and Reetz J (2012) Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma Evid Based Complement Alternat Med eCAM DOI: 10.1155/2012/384301 PMCID: 3440946
120. Onishi H et al (2013) Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia Cancer Lett 335 (2) 289-98 DOI: 10.1016/j.canlet.2013.02.041 PMID: 23485726
121. Pantziarka P et al (2014) Repurposing drugs in oncology (ReDO)-mebendazole as an anti-cancer agent Ecancermedicalscience 8 443 PMID: 25075217 PMCID: 4096024
122. Doudican N, Rodriguez A, Osman I and Orlow SJ (2008) Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells Mol Cancer Res 6 (8) 1308-15 DOI: 10.1158/1541-7786. MCR-07-2159 PMID: 18667591
123. Bai R et al (2011) Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme Neuro Oncol 13 (9) 974-82 DOI: 10.1093/neuonc/nor077 PMID: 21764822 PMCID: 3158014
124. Bekhti A and Pirotte J (1987) Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts Br J Clin Pharmacol 24 (3) 390-2 DOI: 10.1111/j.1365-2125.1987.tb03186.x PMID: 3663452 PMCID: 1386263
125. Carew JS, Kelly KR and Nawrocki ST (2012) Autophagy as a target for cancer therapy: new developments. Cancer Manag Res 4 357-65 PMID: 23091399 PMCID: 3474143
126. Choi KS (2012) Autophagy and cancer Exp Mol Med 44 (2) 109-20 DOI: 10.3858/emm.2012.44.2.033 PMID: 22257886 PMCID: 3296807
127. Ko A et al (2014) Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling Cell Death Differ 21 (1) 92-9 DOI: 10.1038/cdd.2013.124
128. Bugaut H et al (2013) Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells PloS One 8 (6) e65181 DOI: 10.1371/journal.pone.0065181 PMID: 23762310 PMCID: 3676388
129. Garg AD et al (2013) ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death Autophagy 9 (9) 1292-307 DOI: 10.4161/auto.25399 PMID: 23800749
130. Michaud M et al (2011) Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice Science 334 (6062) 1573-7 DOI: 10.1126/science.1208347 PMID: 22174255
131. Moriya S et al (2013) Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells Int J Oncol 42 (5) 1541-50 DOI: 10.3892/ijo.2013.1870 PMCID: 3661227
132. Thun MJ, Jacobs EJ and Patrono C (2012) The role of aspirin in cancer prevention Nat Rev Clin Oncol 9 (5) 259-267 DOI: 10.1038/nrclinonc.2011.199 PMID: 22473097
133. Bastiaannet E et al (2012) Use of Aspirin postdiagnosis improves survival for colon cancer patients Br J Cancer 106 (1532-1827 (Electronic)), 1564-70 DOI: 10.1038/bjc.2012.101 PMID: 22454078 PMCID: 3341868
134. Langley RE et al (2011) Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy? Br J Cancer 105 (8) 1107-13 DOI: 10.1038/bjc.2011.289 PMID: 21847126 PMCID: 3208483
135. Fraser DM et al (2014) Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study Br J Cancer 111 (3) 623-7 DOI: 10.1038/bjc.2014.264 PMID: 24945997 PMCID: 4119969
136. Phillips I et al (2013) Aspirin as a treatment for cancer Clin Oncol 25 (6) 333-5 DOI: 10.1016/j.clon. 2013.03.001
137. Fontaine E et al (2010) Aspirin and non-small cell lung cancer resections: effect on long-term survival Eur J Cardiothorac Surg 38 21-26 DOI: 10.1016/j.ejcts.2010.01.015 PMID: 20359903
138. Bhatt RS et al (2010) A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma Cancer 116 (7) 1751-6 DOI: 10.1002/cncr.24902 PMID: 20120033 PMCID: 2847062
139. Borne E et al (2010) Oral metronomic cyclophosphamide in elderly with metastatic melanoma Invest New Drugs 28 (5) 684-9 DOI: 10.1007/s10637-009-9298-5
140. Doudican NA et al (2013) XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts Anticancer Drugs 24 (2) 181-8 DOI: 10.1097/CAD.0b013e32835a43f1
141. Briasoulis E et al (2009) Dose-ranging study of metronomic oral vinorelbine in patients with advanced refractory cancer Clin Cancer Res 15 (20) 6454-61 DOI: 10.1158/1078-0432. CCR-09-0970 PMID: 19808873
142. Nygren P et al (2013) Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer J Cancer Res Clin Oncol 139 (12) 2133-40 DOI: 10.1007/s00432-013-1539-5 PMID: 24135855 PMCID: 3825534
143. André N et al (2011) Pilot study of a pediatric metronomic 4-drug regimen Oncotarget 2 (12) 960-5 PMID: 22156656 PMCID: 3282100
144. Mukhopadhyay T et al (2002) Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo Clin Cancer Res 8 (9) 2963-9 PMID: 12231542
145. Tatokoro M et al (2011) Phase-II trial of combination treatment of interferon-α, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma Cancer Sci 102 (1) 137-143 DOI: 10.1111/j.1349-7006.2010.01756.x
146. Nacev BA et al (2011) The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells J Biol Chem 286 (51) 44045-56 DOI: 10.1074/jbc. M111.278754 PMID: 22025615 PMCID: 3243534
147. Han X et al (2014) Effect of celecoxib plus standard chemotherapy on serum levels of vascular endothelial growth factor and cyclooxygenase-2 in patients with gastric cancer Biomed Rep 2 (2) 183-187 PMID: 24649093 PMCID: 3917754
148. Song Z et al (2011) Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer PloS One 6 (3) e17687 DOI: 10.1371/journal.pone.0017687 PMID: 21394208 PMCID: 3048871