Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

Cancer Biology and Therapy

Volumn 7, Issue 7, 2008, Pages 1017-1023

  Lu, Jin Jian ^a   Meng, Ling Hua ^a   Cai, Yu Jun ^a   Chen, Qin ^a   Tong, Lin Jiang ^a   Lin, Li Ping ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Anti tumor; Apoptosis; Dihydroartemisinin; HL 60; Iron; p38 MAPK; Reactive oxygen species

Indexed keywords

CASPASE; DIHYDROARTEMISININ; IRON; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; ARTEMISININ DERIVATIVE; DIHYDROQUINGHAOSU; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN HL 60; COLON CANCER; CYTOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIVER CANCER; LUNG CANCER; MELANOMA; OSTEOSARCOMA; OVARY CANCER; PROSTATE CANCER; RHABDOMYOSARCOMA; SQUAMOUS CELL CARCINOMA; STOMACH CANCER; UTERINE CERVIX CANCER; CELL MEMBRANE POTENTIAL; CELL STRAIN K 562; ENZYME ACTIVATION; HELA CELL; IC 50; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARTEMISININS; CELL LINE, TUMOR; ENZYME ACTIVATION; HELA CELLS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; IRON; K562 CELLS; MEMBRANE POTENTIALS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 56149102126     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.7.6035     Document Type: Article

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