An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs

Nanoscale Research Letters

Volumn 7, Issue , 2012, Pages

  Wang, Shuo ^a   Wang, Hua ^a   Liang, Wenquan ^a   Huang, Yongzhuo ^b,c  

^a ZHEJIANG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Dihydroartemisinin; Drug delivery; Nano emulsion; Nanoparticle; Poor solubility

Indexed keywords

CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG PRODUCTS; EMULSIFICATION; EMULSIONS; FAILURE ANALYSIS; LIPOSOMES; MICELLES; NANOPARTICLES; SOLUBILITY;

ANTI-TUMOR ACTIVITIES; DIHYDROARTEMISININ; DRUG LOADING CAPACITY; HYBRID NANOPARTICLE; NANO-EMULSIONS; POOR SOLUBILITIES; POORLY SOLUBLE DRUGS; SUBMICRON EMULSION;

TARGETED DRUG DELIVERY;

EID: 84860677660     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1186/1556-276X-7-219     Document Type: Article

References (16)

1. Fahr A, Liu X: Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007, 4:403-416.
2. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001, 46:3-26.
3. Bansal T, Mustafa G, Khan ZI, Ahmad FJ, Khar RK, Talegaonkar S: Solid selfnanoemulsifying delivery systems as a platform technology for formulation of poorly soluble drugs. Crit Rev Ther Drug Carrier Syst 2008, 25:63-116.
4. Chen Y, Li G, Wu X, Chen Z, Hang J, Qin B, Chen S, Wang R: Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biol Pharm Bull 2008, 31:118-125.
5. Hanafy A, Spahn-Langguth H, Vergnault G, Grenier P, Tubic Grozdanis M, Lenhardt T, Langguth P: Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug. Adv Drug Deliv Rev 2007, 59:419-426.
6. Ye J, Wang Q, Zhou X, Zhang N: Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis. Int J Pharm 2008, 352:273-279.
7. Pastorino F, Brignole C, Marimpietri D, Cilli M, Gambini C, Ribatti D, Longhi R, Allen TM, Corti A, Ponzoni M: Vascular damage and anti-angiogenic effects of tumor vesseltargeted liposomal chemotherapy. Cancer Res 2003, 63:7400-7409.
8. Harvey RD, Barlow DJ, Drake AF, Kudsiova L, Lawrence MJ, Brain AP, Heenan RK: The effect of electrolyte on the encapsulation efficiency of vesicles formed by the nonionic surfactant, 2C18E12. J Colloid Interface Sci 2007, 315:648-661.
9. Klayman DL: Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
10. Grace JM, Aguilar AJ, Trotman KM, Peggins JO, Brewer TG: Metabolism of betaarteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450. Drug Metab Dispos 1998, 26:313-317.
11. WHO: WHO World Malaria Report 2010. Geneva; 2010.
12. Lee J, Zhou HJ, Wu XH: Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells. Cancer Chemother Pharmacol 2006, 57:213-220.
13. Disbrow GL, Baege AC, Kierpiec KA, Yuan H, Centeno JA, Thibodeaux CA, Hartmann D, Schlegel R: Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. Cancer Res 2005, 65:10854-10861.
14. Singh NP, Lai HC: Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells. Anticancer Res 2005, 25:4325-4331.
15. Gao Y, Li N, Hilfert L, Zhang S, Zheng L, Yu L: Temperature-induced microstructural changes in ionic liquid-based microemulsions. Langmuir 2009, 25:1360-1365.
16. Weber CH, Chiche A, Krausch G, Rosenfeldt S, Ballauff M, Harnau L, Gottker-Schnetmann I, Tong Q, Mecking S: Single lamella nanoparticles of polyethylene. Nano Lett 2007, 7:2024-2029.