Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6587-6601

  Hamacher Brady, Anne ^a,b   Stein, Henning A ^a,d   Turschner, Simon ^a   Toegel, Ina ^b   Mora, Rodrigo ^a   Jennewein, Nina ^b   Efferth, Thomas ^c   Eils, Roland ^a,b   Brady, Nathan R ^a,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; AUTOPHAGOSOMES; BAFILOMYCIN; BREAST CANCER CELLS; CANCER CELLS; CANCER TREATMENT; CLINICAL USE; FOOD VACUOLES; IRON CHELATION; IRON LOADING; LATE ENDOSOMES; MALARIA PARASITE; MAMMALIAN CELLS; MCF-7 BREAST CANCER CELLS; MEASURED PARAMETERS; MITOCHONDRIAL APOPTOSIS; OUTER MEMBRANE; PROGRAMMED CELL DEATHS; REACTIVE OXYGEN SPECIES; REDOX-ACTIVE IRON;

CELL DEATH; MAMMALS; MITOCHONDRIA; OXYGEN; PORPHYRINS; SIGNALING;

DISEASES;

ARTESUNATE; IRON; PROTEIN BID; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CATALYSIS; CELL ADHESION; CELL METABOLISM; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG MECHANISM; ENDOSOME; HUMAN; HUMAN CELL; IRON CHELATION; LYSOSOME; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; NUCLEOTIDE SEQUENCE; PHAGOSOME; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION;

ANTIMALARIALS; APOPTOSIS; ARTEMISININS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHLOROQUINE; ENZYME INHIBITORS; FEMALE; HUMANS; IRON; LYSOSOMES; MACROLIDES; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PERMEABILITY; REACTIVE OXYGEN SPECIES;

ARTESUNATE; MAMMALIA;

EID: 79953194472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.210047     Document Type: Article

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