Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

Phytomedicine

Volumn 22, Issue 11, 2015, Pages 1045-1054

  Ooko, Edna ^a   Saeed, Mohamed E M ^a   Kadioglu, Onat ^a   Sarvi, Shabnam ^a   Colak, Merve ^a   Elmasaoudi, Kaoutar ^a   Janah, Rabab ^a   Greten, Henry J ^b,c   Efferth, Thomas ^b,c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF PORTO   (Portugal)

^c Heidelberg School of Chinese Medicine   (Germany)

Author keywords

Cancer; Cell death; Iron; Microarray; Pharmacogenomics

Indexed keywords

2 OXOGLUTARIC ACID; ARTEANUIN B; ARTEETHER; ARTEMETHER; ARTEMISININ; ARTEMISININ DERIVATIVE; ARTEMISITENE; ARTESUNATE; CD71 ANTIGEN; CHONDROITIN SULFATE IRON; DEFEROXAMINE; DIHYDROARTEMISININ; FERREDOXIN; FERRITIN; IRON; LACTOFERRIN; MESSENGER RNA; SUCCINATE DEHYDROGENASE; TRANSFERRIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; CYCLOHEXYLAMINE DERIVATIVE; FERROSTATIN-1; PHENYLENEDIAMINE DERIVATIVE;

APOPTOSIS; ARTICLE; DRUG CYTOTOXICITY; FERROPTOSIS; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; IC50; IMMUNOHISTOCHEMISTRY; IRON METABOLISM; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESAZURIN ASSAY; STATISTICAL SIGNIFICANCE; TUMOR CELL; CELL DEATH; CHEMICAL STRUCTURE; CHEMISTRY; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION REGULATION; TUMOR CELL LINE;

APOPTOSIS; ARTEMISININS; CELL DEATH; CELL LINE, TUMOR; CYCLOHEXYLAMINES; DEFEROXAMINE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; IRON; MOLECULAR STRUCTURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENYLENEDIAMINES;

EID: 84941550824     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.08.002     Document Type: Article

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