C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

Cell

Volumn 167, Issue 3, 2016, Pages 774-788.e17

  Lee, Kyung Ha ^a   Zhang, Peipei ^a   Kim, Hong Joo ^a   Mitrea, Diana M ^a   Sarkar, Mohona ^a   Freibaum, Brian D ^a   Cika, Jaclyn ^a   Coughlin, Maura ^a   Messing, James ^a   Molliex, Amandine ^a   Maxwell, Brian A ^a   Kim, Nam Chul ^a   Temirov, Jamshid ^a   Moore, Jennifer ^a   Kolaitis, Regina Maria ^a   Shaw, Timothy I ^a   Bai, Bing ^a   Peng, Junmin ^a   Kriwacki, Richard W ^a,b   Taylor, J Paul ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

amyotrophic lateral sclerosis; C9ORF72; dipeptide repeat; membrane less organelle; nucleolus; phase separation; stress granule

Indexed keywords

ARGININE; ARGININE DERIVATIVE; BINDING PROTEIN; DIPEPTIDE; DIPEPTIDE REPEAT PROTEIN; POLYGLYCYLARGININE; POLYPROLYLARGININE; PROTEIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; PEPTIDE; POLYARGININE; POLYGLYCINE; POLYPROLINE; REPETITIVE DNA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL GRANULE; CELL MEMBRANE; CELL ORGANELLE; CELL STRESS; CHROMOSOME 9; CONTROLLED STUDY; DROSOPHILA; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LOW COMPLEXITY SEQUENCE DOMAIN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR PORE COMPLEX; NUCLEOLUS; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; DROSOPHILA MELANOGASTER; FRONTOTEMPORAL DEMENTIA; GENETICS; INTRACELLULAR MEMBRANE; METABOLISM; NUCLEAR PORE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL NUCLEOLUS; CYTOPLASMIC GRANULES; DIPEPTIDES; DNA REPEAT EXPANSION; DROSOPHILA MELANOGASTER; FRONTOTEMPORAL DEMENTIA; HUMANS; INTRACELLULAR MEMBRANES; NUCLEAR PORE; PEPTIDES; PROTEINS; RNA-BINDING PROTEINS;

EID: 84992371797     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.002     Document Type: Article

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