Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers

Cell

Volumn 167, Issue 3, 2016, Pages 789-802.e12

  Lin, Yi ^a   Mori, Eiichiro ^a   Kato, Masato ^a   Xiang, Siheng ^a   Wu, Leeju ^a   Kwon, Ilmin ^b   McKnight, Steven L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

1,6 hexanediol; amyloid like polymers; C9orf72; cellular puncta not invested by surrounding membranes; intermediate filaments; labile; low complexity sequence polymers; toxic PRn and GRn poly dipeptides

Indexed keywords

ACTIN; ALKANOL; DIPEPTIDE DERIVATIVE; INTERMEDIATE FILAMENT PROTEIN; POLYMER; PR POLY DIPEPTIDE DERIVATIVE; RNA BINDING PROTEIN; TUBULIN; UNCLASSIFIED DRUG; VIMENTIN; C9ORF72 PROTEIN, HUMAN; DIPEPTIDE; PEPTIDE; POLYARGININE; POLYPROLINE; PROTEIN; REPETITIVE DNA;

AMINO TERMINAL SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CROSS LINKING; DEPOLYMERIZATION; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOPRECIPITATION; INTERMEDIATE FILAMENT; MELTING POINT; MICROTUBULE; MOLECULAR GENETICS; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEOMICS; U2OS CELL LINE; WESTERN BLOTTING; CHEMISTRY; FRONTOTEMPORAL DEMENTIA; GENETICS; METABOLISM;

AMYOTROPHIC LATERAL SCLEROSIS; DIPEPTIDES; DNA REPEAT EXPANSION; FRONTOTEMPORAL DEMENTIA; HELA CELLS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; PEPTIDES; PROTEIN DOMAINS; PROTEINS;

EID: 84992491195     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.003     Document Type: Article

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