The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

Nature

Volumn 525, Issue 7567, 2015, Pages 56-61

  Zhang, Ke ^a   Donnelly, Christopher J ^a   Haeusler, Aaron R ^b   Grima, Jonathan C ^a   Machamer, James B ^a   Steinwald, Peter ^b   Daley, Elizabeth L ^a   Miller, Sean J ^a   Cunningham, Kathleen M ^a   Vidensky, Svetlana ^a   Gupta, Saksham ^a   Thomas, Michael A ^a   Hong, Ingie ^a   Chiu, Shu Ling ^a   Huganir, Richard L ^a   Ostrow, Lyle W ^a   Matunis, Michael J ^b   Wang, Jiou ^b   Sattler, Rita ^a   Lloyd, Thomas E ^a   Rothstein, Jeffrey D ^a   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GUANINE QUADRUPLEX; NUCLEAR PROTEIN; RAN PROTEIN; RANGAP PROTEIN; RNA; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; DROSOPHILA PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN; RANGAP1 PROTEIN, HUMAN; REPETITIVE DNA; SEGREGATION DISTORTER PROTEIN, DROSOPHILA;

CYTOPLASM; DRUG; FLY; GENE EXPRESSION; NEUROLOGY; PROTEIN; TOXICITY TEST;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DROSOPHILA; FRUIT FLY MODEL; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MOTONEURON; NERVE DEGENERATION; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR IMPORT; NUCLEOCYTOPLASMIC TRANSPORT; OPEN READING FRAME; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; ACTIVE TRANSPORT; ANIMAL; BRAIN; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; DROSOPHILA MELANOGASTER; FEMALE; FRONTOTEMPORAL DEMENTIA; GENETICS; METABOLISM; NERVE CELL; NUCLEAR PORE; PATHOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN; CELL NUCLEUS; DNA REPEAT EXPANSION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FRONTOTEMPORAL DEMENTIA; G-QUADRUPLEXES; GTPASE-ACTIVATING PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; NEURONS; NUCLEAR PORE; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; OPEN READING FRAMES; PROTEINS; RNA;

EID: 84940923271     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14973     Document Type: Article

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