Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

Acta Neuropathologica

Volumn 126, Issue 6, 2013, Pages 881-893

  Mori, Kohji ^a   Arzberger, Thomas ^a,b   Grässer, Friedrich A ^c   Gijselinck, Ilse ^d,e   May, Stephanie ^b   Rentzsch, Kristin ^b   Weng, Shih Ming ^b   Schludi, Martin H ^b   Van Der Zee, Julie ^d,e   Cruts, Marc ^d,e   Van Broeckhoven, Christine ^d,e   Kremmer, Elisabeth ^b,f,g   Kretzschmar, Hans A ^a   Haass, Christian ^a,b,g   Edbauer, Dieter ^a,b,g  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

^g Germany 3 Munich Cluster for Systems Neurology   (Germany)

Author keywords

ALS; C9orf72; FTLD; Neurodegeneration; RAN translation

Indexed keywords

DIPEPTIDE; HYBRID PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; C9ORF72 GENE; CELL INCLUSION; CEREBELLUM; FRONTAL CORTEX; FRONTOTEMPORAL DEMENTIA; GENE; HIPPOCAMPUS; HUMAN; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MOLECULAR GENETICS; MOTOR CORTEX; MUSCLE WEAKNESS; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PURIFICATION; SOUTHERN BLOTTING; SPINAL CORD; START CODON; TEMPORAL CORTEX; THALAMUS;

AMYOTROPHIC LATERAL SCLEROSIS; BRAIN; DNA REPEAT EXPANSION; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; PROTEIN BIOSYNTHESIS; PROTEINS;

EID: 84892585689     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1189-3     Document Type: Article

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