ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

Neuron

Volumn 88, Issue 4, 2015, Pages 678-690

  Murakami, Tetsuro ^a   Qamar, Seema ^b   Lin, Julie Qiaojin ^c   Schierle, Gabriele S Kaminski ^c   Rees, Eric ^c   Miyashita, Akinori ^a   Costa, Ana R ^b   Dodd, Roger B ^b   Chan, Fiona T S ^c   Michel, Claire H ^c   Kronenberg Versteeg, Deborah ^b   Li, Yi ^b   Yang, Seung Pil ^a   Wakutani, Yosuke ^a   Meadows, William ^b   Ferry, Rodylyn Rose ^a   Dong, Liang ^b   Tartaglia, Gian Gaetano ^c,d,i   Favrin, Giorgio ^e   Lin, Wen Lang ^f   Dickson, Dennis W ^f   Zhen, Mei ^g   Ron, David ^b   Schmitt Ulms, Gerold ^a   Fraser, Paul E ^a   Shneider, Neil A ^h   Holt, Christine ^c   Vendruscolo, Michele ^c   Kaminski, Clemens F ^c   St George Hyslop, Peter ^a,b   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f MAYO CLINIC   (United States)

^g MOUNT SINAI HOSPITAL   (Canada)

^h NewYork Presbyterian Hospital   (United States)

ⁱ INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FUSED IN SARCOMA PROTEIN; RIBONUCLEOPROTEIN; CAENORHABDITIS ELEGANS PROTEIN; HYDROGEL; MESSENGER RNA; RNA BINDING PROTEIN FUS;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; EMBRYO; FRONTOTEMPORAL DEMENTIA; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; NERVE DEGENERATION; NERVE ENDING; NEUROTOXICITY; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RNA METABOLISM; RNA TRANSLATION; ANIMAL; CELL GRANULE; CHEMISTRY; DISEASE MODEL; GENETICS; LONGEVITY; METABOLISM; MOTOR ACTIVITY; MUTATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CYTOPLASMIC GRANULES; DISEASE MODELS, ANIMAL; FRONTOTEMPORAL LOBAR DEGENERATION; HYDROGELS; LONGEVITY; MOTOR ACTIVITY; MUTATION; PHASE TRANSITION; RIBONUCLEOPROTEINS; RNA, MESSENGER; RNA-BINDING PROTEIN FUS;

EID: 84960129723     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.10.030     Document Type: Article

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