Impact of Cu(II) Binding on Structures and Dynamics of Aβ42 Monomer and Dimer: Molecular Dynamics Study

ACS Chemical Neuroscience

Volumn 7, Issue 10, 2016, Pages 1348-1363

  Huy, Pham Dinh Quoc ^a,b   Vuong, Quan Van ^b,c   La Penna, Giovanni ^d,e   Faller, Peter ^f   Li, Mai Suan ^a  

^a INSTITUTE OF PHYSICS   (Poland)

^b INSTITUTE FOR COMPUTATIONAL SCIENCE AND TECHNOLOGY   (Viet Nam)

^c NAGOYA UNIVERSITY   (Japan)

^d ICCOM CNR   (Italy)

^e INFN SEZIONE DI FIRENZE   (Italy)

^f UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Alzheimer's disease; Amyloid aggregation; amyloid peptide; A Cu interaction; copper binding to amyloid ; copper ions; fibril formation; metal ions; protein aggregation

Indexed keywords

AMYLOID; ASPARAGINE; COPPER ION; DIMER; HISTONE; LIGAND; LYSINE; MONOMER; PEPTIDE; SODIUM CHLORIDE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); COPPER; PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; DIMERIZATION; FIBER; GEOMETRY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; STOICHIOMETRY; SURFACE AREA; TIME; AMINO ACID SEQUENCE; CHEMICAL PHENOMENA; CHEMISTRY; ELASTICITY; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; STATIC ELECTRICITY;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; COPPER; ELASTICITY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; STATIC ELECTRICITY;

EID: 84992202428     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00109     Document Type: Article

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