Pulse EPR spectroscopy reveals the coordination sphere of copper(II) Ions in the 1-16 amyloid-β peptide: A key role of the first two N-terminus residues

Angewandte Chemie - International Edition

Volumn 48, Issue 49, 2009, Pages 9273-9276

  Dorlet, Pierre ^a,b   Gambarelli, Serge ^c   Faller, Peter ^d,e   Hureau, Christelle ^d,e  

^a CNRS   (France)

^b SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^c CEA GRENOBLE   (France)

^d LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^e UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Amyloid peptides; Bioinorganic chemistry; Copper; Epr spectroscopy; Ligand interactions

Indexed keywords

ALZHEIMER'S DISEASE; BIOINORGANIC CHEMISTRY; COORDINATION SPHERE; COPPER IONS; CU IONS; EPR SPECTROSCOPY; ISOTOPIC LABELING; LIGAND INTERACTIONS; PHYSIOLOGICAL PH; PULSE EPR;

AMINES; AMINO ACIDS; BIOCHEMISTRY; COPPER; ELECTRON RESONANCE; GLYCOPROTEINS; LIGANDS; ORGANIC ACIDS; PARAMAGNETIC RESONANCE; PEPTIDES; PH EFFECTS; QUANTUM THEORY;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

AMYLOID BETA PROTEIN; COPPER; ION; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRON SPIN RESONANCE; HUMAN; METABOLISM; METHODOLOGY; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; IONS; MOLECULAR STRUCTURE; REACTIVE OXYGEN SPECIES;

EID: 72949092936     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904567     Document Type: Article

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