-
1
-
-
0017199306
-
Selective in vitro growth of T lymphocytes from normal human bone marrows
-
Sep
-
D.A.Morgan, F.W.Ruscetti, R.Gallo Selective in vitro growth of T lymphocytes from normal human bone marrows. Science. 1976 Sep 10;193(4257):1007–1008.• Identification of IL-2 as a T-cell growth factor.
-
(1976)
Science
, vol.193
, Issue.4257
, pp. 1007-1008
-
-
Morgan, D.A.1
Ruscetti, F.W.2
Gallo, R.3
-
2
-
-
0005222146
-
Structure of the human interleukin 2 gene
-
Dec
-
T.Fujita, C.Takaoka, H.Matsui, et al. Structure of the human interleukin 2 gene. Proc Natl Acad Sci U S A. 1983 Dec;80(24):7437–7441.
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, Issue.24
, pp. 7437-7441
-
-
Fujita, T.1
Takaoka, C.2
Matsui, H.3
-
3
-
-
0020699991
-
Structure and expression of a cloned cDNA for human interleukin-2
-
Mar
-
T.Taniguchi, H.Matsui, T.Fujita, et al. Structure and expression of a cloned cDNA for human interleukin-2. Nature. 1983 Mar 24–30;302(5906):305–310.
-
(1983)
Nature
, vol.302
, Issue.5906
, pp. 305-310
-
-
Taniguchi, T.1
Matsui, H.2
Fujita, T.3
-
4
-
-
0026848650
-
Structure and function of IL-2 and IL-2 receptors
-
Apr
-
T.Taniguchi. Structure and function of IL-2 and IL-2 receptors. Behring Inst Mitt. 1992 Apr;91:87–95.
-
(1992)
Behring Inst Mitt
, vol.91
, pp. 87-95
-
-
Taniguchi, T.1
-
5
-
-
41949097030
-
The biology of interleukin-2
-
T.R.Malek. The biology of interleukin-2. Annu Rev Immunol. 2008;26:453–479.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
6
-
-
77955890953
-
Interleukin-2 receptor signaling: at the interface between tolerance and immunity
-
Aug
-
T.R.Malek, I.Castro. Interleukin-2 receptor signaling:at the interface between tolerance and immunity. Immunity. 2010 Aug 27;33(2):153–165.
-
(2010)
Immunity
, vol.33
, Issue.2
, pp. 153-165
-
-
Malek, T.R.1
Castro, I.2
-
7
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Oct
-
B.Sadlack, H.Merz, H.Schorle, et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 1993 Oct 22;75(2):253–261.•• This study provided the first evidence for the role of IL-2 in immune tolerance.
-
(1993)
Cell
, vol.75
, Issue.2
, pp. 253-261
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
-
8
-
-
0028783963
-
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
-
Nov
-
B.Sadlack, J.Löhler, H.Schorle, et al. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol. 1995 Nov;25(11):3053–3059.
-
(1995)
Eur J Immunol
, vol.25
, Issue.11
, pp. 3053-3059
-
-
Sadlack, B.1
Löhler, J.2
Schorle, H.3
-
9
-
-
0030560797
-
Interleukin-2 is indispensable for development of immunological self-tolerance
-
Dec
-
G.Klebb, I.B.Autenrieth, H.Haber, et al. Interleukin-2 is indispensable for development of immunological self-tolerance. Clin Immunol Immunopathol. 1996 Dec;81(3):282–286.
-
(1996)
Clin Immunol Immunopathol
, vol.81
, Issue.3
, pp. 282-286
-
-
Klebb, G.1
Autenrieth, I.B.2
Haber, H.3
-
10
-
-
27544481941
-
A function for interleukin 2 in Foxp3-expressing regulatory T cells
-
Nov
-
J.D.Fontenot, J.P.Rasmussen, M.A.Gavin, et al. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005 Nov;6(11):1142–1151.• One of the first studies that proved that IL-2 is a key factor in Treg biology.
-
(2005)
Nat Immunol
, vol.6
, Issue.11
, pp. 1142-1151
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Gavin, M.A.3
-
11
-
-
27544446622
-
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
-
Nov
-
L.M.D’Cruz, L.Klein. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol. 2005 Nov;6(11):1152–1159.
-
(2005)
Nat Immunol
, vol.6
, Issue.11
, pp. 1152-1159
-
-
D’Cruz, L.M.1
Klein, L.2
-
12
-
-
15444374646
-
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
-
Mar
-
R.Setoguchi, S.Hori, T.Takahashi, et al. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005 Mar 7;201(5):723–735.• One of the first studies that proved that IL-2 is a key factor in Treg biology.
-
(2005)
J Exp Med
, vol.201
, Issue.5
, pp. 723-735
-
-
Setoguchi, R.1
Hori, S.2
Takahashi, T.3
-
13
-
-
33947667310
-
Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells
-
Apr
-
A.L.Bayer, A.Yu, T.R.Malek. Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J Immunology. 2007 Apr 1;178(7):4062–4071.
-
(2007)
J Immunology
, vol.178
, Issue.7
, pp. 4062-4071
-
-
Bayer, A.L.1
Yu, A.2
Malek, T.R.3
-
14
-
-
49649124868
-
IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells
-
Jun
-
S.Brandenburg, T.Takahashi, M.de la Rosa, et al. IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells. Eur J Immunol. 2008 Jun;38(6):1643–1653.
-
(2008)
Eur J Immunol
, vol.38
, Issue.6
, pp. 1643-1653
-
-
Brandenburg, S.1
Takahashi, T.2
de la Rosa, M.3
-
15
-
-
16844365788
-
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
-
Apr
-
S.Sakaguchi. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005 Apr;6(4):345–352.
-
(2005)
Nat Immunol
, vol.6
, Issue.4
, pp. 345-352
-
-
Sakaguchi, S.1
-
16
-
-
0028266553
-
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
-
Mar
-
S.A.Rosenberg, J.C.Yang, S.L.Topalian, et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA. 1994 Mar 23–30;271(12):907–913.
-
(1994)
JAMA
, vol.271
, Issue.12
, pp. 907-913
-
-
Rosenberg, S.A.1
Yang, J.C.2
Topalian, S.L.3
-
17
-
-
33644784733
-
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients
-
Mar
-
M.Ahmadzadeh, S.A.Rosenberg. IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients. Blood. 2006 Mar 15;107(6):2409–2414.
-
(2006)
Blood
, vol.107
, Issue.6
, pp. 2409-2414
-
-
Ahmadzadeh, M.1
Rosenberg, S.A.2
-
18
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Aug
-
S.Sakaguchi, N.Sakaguchi, M.Asano, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunology. 1995 Aug 1;155(3):1151–1164.•• The ‘birth’ of regulatory T cells and of the modern concepts of immune regulation and tolerance. A real milestone.
-
(1995)
J Immunology
, vol.155
, Issue.3
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
-
19
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Apr
-
J.D.Fontenot, M.A.Gavin, A.Y.Rudensky. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003 Apr;4(4):330–336.
-
(2003)
Nat Immunol
, vol.4
, Issue.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
20
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
Jul
-
S.Sakaguchi, M.Miyara, C.M.Costantino, et al. FOXP3+ regulatory T cells in the human immune system. Nat Revi Immunol. 2010 Jul;10(7):490–500.
-
(2010)
Nat Revi Immunol
, vol.10
, Issue.7
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
-
21
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
Feb
-
J.M.Kim, J.P.Rasmussen, A.Y.Rudensky. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007 Feb;8(2):191–197.
-
(2007)
Nat Immunol
, vol.8
, Issue.2
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
22
-
-
33746379546
-
The role of the transcription factor Foxp3 in the development of regulatory T cells
-
Aug
-
J.M.Kim, A.Rudensky. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol Rev. 2006 Aug;212:86–98.
-
(2006)
Immunol Rev
, vol.212
, pp. 86-98
-
-
Kim, J.M.1
Rudensky, A.2
-
23
-
-
43949105866
-
T cells and immune tolerance
-
May
-
S.Sakaguchi, T.Yamaguchi, T.Nomura, et al. T cells and immune tolerance. Cell. 2008 May 30;133(5):775–787.
-
(2008)
Cell
, vol.133
, Issue.5
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
-
24
-
-
74049164847
-
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
-
Jan
-
K.Wing, S.Sakaguchi. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010 Jan;11(1):7–13.
-
(2010)
Nat Immunol
, vol.11
, Issue.1
, pp. 7-13
-
-
Wing, K.1
Sakaguchi, S.2
-
25
-
-
80053262406
-
Human FoxP3 + regulatory T cells in systemic autoimmune diseases
-
Oct
-
M.Miyara, G.Gorochov, M.Ehrenstein, et al. Human FoxP3 + regulatory T cells in systemic autoimmune diseases. Autoimmun Rev. 2011 Oct;10(12):744–755.
-
(2011)
Autoimmun Rev
, vol.10
, Issue.12
, pp. 744-755
-
-
Miyara, M.1
Gorochov, G.2
Ehrenstein, M.3
-
26
-
-
84922691219
-
Regulatory T cells and rheumatic diseases
-
Feb
-
J.Y.Humrich, T.Kamradt, G.Riemekasten. Regulatory T cells and rheumatic diseases. Z Rheumatol. 2015 Feb;74(1):26–32.
-
(2015)
Z Rheumatol
, vol.74
, Issue.1
, pp. 26-32
-
-
Humrich, J.Y.1
Kamradt, T.2
Riemekasten, G.3
-
27
-
-
33645819388
-
Regulatory T cells in human disease and their potential for therapeutic manipulation
-
May
-
L.S.Taams, D.B.Palmer, A.N.Akbar, et al. Regulatory T cells in human disease and their potential for therapeutic manipulation. Immunology. 2006 May;118(1):1–9.
-
(2006)
Immunology
, vol.118
, Issue.1
, pp. 1-9
-
-
Taams, L.S.1
Palmer, D.B.2
Akbar, A.N.3
-
28
-
-
32644459908
-
Antigen-specific regulatory T cells – ex vivo expansion and therapeutic potential
-
Apr
-
E.L.Masteller, Q.Tang, J.A.Bluestone. Antigen-specific regulatory T cells – ex vivo expansion and therapeutic potential. Semin Immunol. 2006 Apr;18(2):103–110.
-
(2006)
Semin Immunol
, vol.18
, Issue.2
, pp. 103-110
-
-
Masteller, E.L.1
Tang, Q.2
Bluestone, J.A.3
-
29
-
-
65549127618
-
Human T regulatory cell therapy: take a billion or so and call me in the morning
-
May
-
J.L.Riley, C.H.June, B.R.Blazar. Human T regulatory cell therapy:take a billion or so and call me in the morning. Immunity. 2009 May;30(5):656–665.
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 656-665
-
-
Riley, J.L.1
June, C.H.2
Blazar, B.R.3
-
30
-
-
27144495833
-
How do CD4+CD25+ regulatory T cells control autoimmunity?
-
Dec
-
J.A.Bluestone, Q.Tang. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol. 2005 Dec;17(6):638–642.
-
(2005)
Curr Opin Immunol
, vol.17
, Issue.6
, pp. 638-642
-
-
Bluestone, J.A.1
Tang, Q.2
-
31
-
-
84908089142
-
TRE G-cell therapies for autoimmune rheumatic diseases
-
Sep
-
M.Miyara, Y.Ito, S.Sakaguchi. TRE G-cell therapies for autoimmune rheumatic diseases. Nat Rev Rheumatol. 2014 Sep;10(9):543–551.
-
(2014)
Nat Rev Rheumatol
, vol.10
, Issue.9
, pp. 543-551
-
-
Miyara, M.1
Ito, Y.2
Sakaguchi, S.3
-
32
-
-
29144516273
-
Global natural regulatory T cell depletion in active systemic lupus erythematosus
-
Dec
-
M.Miyara, Z.Amoura, C.Parizot, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunology. 2005 Dec 15;175(12):8392–8400.
-
(2005)
J Immunology
, vol.175
, Issue.12
, pp. 8392-8400
-
-
Miyara, M.1
Amoura, Z.2
Parizot, C.3
-
33
-
-
65449149735
-
Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus
-
Jun
-
J.L.Suen, H.T.Li, Y.J.Jong, et al. Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology. 2009 Jun;127(2):196–205.
-
(2009)
Immunology
, vol.127
, Issue.2
, pp. 196-205
-
-
Suen, J.L.1
Li, H.T.2
Jong, Y.J.3
-
34
-
-
33746214867
-
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells
-
Aug
-
K.J.Scalapino, Q.Tang, J.A.Bluestone, et al. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunology. 2006 Aug 1;177(3):1451–1459.
-
(2006)
J Immunology
, vol.177
, Issue.3
, pp. 1451-1459
-
-
Scalapino, K.J.1
Tang, Q.2
Bluestone, J.A.3
-
35
-
-
76249100290
-
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
-
Jan
-
J.Y.Humrich, H.Morbach, R.Undeutsch, et al. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):204–209.•• First proof of the pathogenetic relevance of IL-2 deficiency and related Treg defects in murine lupus.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.1
, pp. 204-209
-
-
Humrich, J.Y.1
Morbach, H.2
Undeutsch, R.3
-
36
-
-
42449123048
-
Foxp 3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis
-
May
-
M.Bonelli, K.von Dalwigk, A.Savitskaya, et al. Foxp 3 expression in CD4+ T cells of patients with systemic lupus erythematosus:a comparative phenotypic analysis. Ann Rheum Dis. 2008 May;67(5):664–671.
-
(2008)
Ann Rheum Dis
, vol.67
, Issue.5
, pp. 664-671
-
-
Bonelli, M.1
von Dalwigk, K.2
Savitskaya, A.3
-
37
-
-
63149094153
-
Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus
-
Feb
-
M.Bonelli, A.Savitskaya, C.W.Steiner, et al. Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunology. 2009 Feb 1;182(3):1689–1695.
-
(2009)
J Immunology
, vol.182
, Issue.3
, pp. 1689-1695
-
-
Bonelli, M.1
Savitskaya, A.2
Steiner, C.W.3
-
38
-
-
84992071354
-
Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
-
Aug
-
C.von Spee-Mayer, E.Siegert, D.Abdirama, et al. Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann Rheum Dis. 2015 Aug;31.• First proof-of-concept study of low-dose IL-2 therapy in SLE patients.
-
(2015)
Ann Rheum Dis
, pp. 31
-
-
von Spee-Mayer, C.1
Siegert, E.2
Abdirama, D.3
-
39
-
-
84874223419
-
CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice
-
O.Weigert, C.von Spee, R.Undeutsch, et al. CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice. Arthritis Res Ther. 2013;15(1):R35.
-
(2013)
Arthritis Res Ther
, vol.15
, Issue.1
, pp. R35
-
-
Weigert, O.1
von Spee, C.2
Undeutsch, R.3
-
40
-
-
82755189414
-
Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus
-
Dec
-
J.B.Engler, R.Undeutsch, L.Kloke, et al. Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus. Ann Rheum Dis. 2011 Dec;70(12):2176–2183.
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.12
, pp. 2176-2183
-
-
Engler, J.B.1
Undeutsch, R.2
Kloke, L.3
-
41
-
-
1642321982
-
IL-2, regulatory T cells, and tolerance
-
Apr
-
B.H.Nelson. IL-2, regulatory T cells, and tolerance. J Immunology. 2004 Apr 1;172(7):3983–3988.
-
(2004)
J Immunology
, vol.172
, Issue.7
, pp. 3983-3988
-
-
Nelson, B.H.1
-
42
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
-
Jun
-
H.Suzuki, T.M.Kundig, C.Furlonger, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science. 1995 Jun 9;268(5216):1472–1476.
-
(1995)
Science
, vol.268
, Issue.5216
, pp. 1472-1476
-
-
Suzuki, H.1
Kundig, T.M.2
Furlonger, C.3
-
43
-
-
84908403082
-
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
-
Aug
-
Y.Feng, A.Arvey, T.Chinen, et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 2014 Aug 14;158(4):749–763.
-
(2014)
Cell
, vol.158
, Issue.4
, pp. 749-763
-
-
Feng, Y.1
Arvey, A.2
Chinen, T.3
-
44
-
-
84861423126
-
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
-
May
-
A.Ballesteros-Tato, B.León, B.A.Graf, et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity. 2012 May 25;36(5):847–856.
-
(2012)
Immunity
, vol.36
, Issue.5
, pp. 847-856
-
-
Ballesteros-Tato, A.1
León, B.2
Graf, B.A.3
-
45
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Mar
-
A.Laurence, C.M.Tato, T.S.Davidson, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity. 2007 Mar;26(3):371–381.
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
-
46
-
-
43049174722
-
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
-
May
-
Q.Tang, J.Y.Adams, C.Penaranda, et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity. 2008 May;28(5):687–697.
-
(2008)
Immunity
, vol.28
, Issue.5
, pp. 687-697
-
-
Tang, Q.1
Adams, J.Y.2
Penaranda, C.3
-
47
-
-
65549091509
-
In vivo expansion of Treg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
-
Apr
-
K.E.Webster, S.Walters, R.E.Kohler, et al. In vivo expansion of Treg cells with IL-2-mAb complexes:induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med. 2009 Apr 13;206(4):751–760.
-
(2009)
J Exp Med
, vol.206
, Issue.4
, pp. 751-760
-
-
Webster, K.E.1
Walters, S.2
Kohler, R.E.3
-
48
-
-
77956257716
-
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Aug
-
Y.Grinberg-Bleyer, A.Baeyens, S.You, et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010 Aug 30;207(9):1871–1878.
-
(2010)
J Exp Med
, vol.207
, Issue.9
, pp. 1871-1878
-
-
Grinberg-Bleyer, Y.1
Baeyens, A.2
You, S.3
-
49
-
-
0019825716
-
Interleukin 2 deficiency is a common feature of autoimmune mice
-
Dec
-
M.J.Dauphinee, S.B.Kipper, D.Wofsy, et al. Interleukin 2 deficiency is a common feature of autoimmune mice. J Immunology. 1981 Dec;127(6):2483–2487.
-
(1981)
J Immunology
, vol.127
, Issue.6
, pp. 2483-2487
-
-
Dauphinee, M.J.1
Kipper, S.B.2
Wofsy, D.3
-
50
-
-
0019787151
-
Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene
-
Nov
-
D.Wofsy, E.D.Murphy, J.B.Roths, et al. Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. J Exp Med. 1981 Nov 1;154(5):1671–1680.
-
(1981)
J Exp Med
, vol.154
, Issue.5
, pp. 1671-1680
-
-
Wofsy, D.1
Murphy, E.D.2
Roths, J.B.3
-
51
-
-
0020546709
-
Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)
-
Jun
-
M.Linker-Israeli, A.C.Bakke, R.C.Kitridou, et al. Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunology. 1983 Jun;130(6):2651–2655.• First study providing evidence for IL-2 deficiency in SLE patients.
-
(1983)
J Immunology
, vol.130
, Issue.6
, pp. 2651-2655
-
-
Linker-Israeli, M.1
Bakke, A.C.2
Kitridou, R.C.3
-
52
-
-
0025289913
-
Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus
-
Jul
-
J.C.Gutierrez-Ramos, J.L.Andreu, Y.Revilla, et al. Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus. Nature. 1990 Jul 19;346(6281):271–274.
-
(1990)
Nature
, vol.346
, Issue.6281
, pp. 271-274
-
-
Gutierrez-Ramos, J.C.1
Andreu, J.L.2
Revilla, Y.3
-
53
-
-
0035869333
-
Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus
-
Mar
-
E.E.Solomou, Y.T.Juang, M.F.Gourley, et al. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunology. 2001 Mar 15;166(6):4216–4222.
-
(2001)
J Immunology
, vol.166
, Issue.6
, pp. 4216-4222
-
-
Solomou, E.E.1
Juang, Y.T.2
Gourley, M.F.3
-
54
-
-
0037108487
-
Antisense cyclic adenosine 5ʹ-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus
-
Oct
-
K.Tenbrock, Y.T.Juang, M.F.Gourley, et al. Antisense cyclic adenosine 5ʹ-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J Immunology. 2002 Oct 15;169(8):4147–4152.
-
(2002)
J Immunology
, vol.169
, Issue.8
, pp. 4147-4152
-
-
Tenbrock, K.1
Juang, Y.T.2
Gourley, M.F.3
-
55
-
-
16844376445
-
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
-
Apr
-
Y.T.Juang, Y.Wang, E.E.Solomou, et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest. 2005 Apr;115(4):996–1005.
-
(2005)
J Clin Invest
, vol.115
, Issue.4
, pp. 996-1005
-
-
Juang, Y.T.1
Wang, Y.2
Solomou, E.E.3
-
56
-
-
31144451804
-
Transcriptional repression of interleukin-2 in human systemic lupus erythematosus
-
Feb
-
C.G.Katsiari, G.C.Tsokos. Transcriptional repression of interleukin-2 in human systemic lupus erythematosus. Autoimmun Rev. 2006 Feb;5(2):118–121.
-
(2006)
Autoimmun Rev
, vol.5
, Issue.2
, pp. 118-121
-
-
Katsiari, C.G.1
Tsokos, G.C.2
-
57
-
-
78751488886
-
Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus
-
Jan
-
Y.T.Juang, T.Rauen, Y.Wang, et al. Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus. J Biol Chem. 2011 Jan 21;286(3):1795–1801.
-
(2011)
J Biol Chem
, vol.286
, Issue.3
, pp. 1795-1801
-
-
Juang, Y.T.1
Rauen, T.2
Wang, Y.3
-
58
-
-
83355166950
-
cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus
-
Dec
-
C.M.Hedrich, T.Rauen, G.C.Tsokos. cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene:implications in systemic lupus erythematosus. J Biol Chem. 2011 Dec 16;286(50):43429–43436.
-
(2011)
J Biol Chem
, vol.286
, Issue.50
, pp. 43429-43436
-
-
Hedrich, C.M.1
Rauen, T.2
Tsokos, G.C.3
-
59
-
-
84867351076
-
cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus
-
Oct
-
C.M.Hedrich, J.C.Crispin, T.Rauen, et al. cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16606–16611.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.41
, pp. 16606-16611
-
-
Hedrich, C.M.1
Crispin, J.C.2
Rauen, T.3
-
60
-
-
84875846171
-
cAMP responsive element modulator: a critical regulator of cytokine production
-
Apr
-
T.Rauen, C.M.Hedrich, K.Tenbrock, et al. cAMP responsive element modulator:a critical regulator of cytokine production. Trends Mol Med. 2013 Apr;19(4):262–269.
-
(2013)
Trends Mol Med
, vol.19
, Issue.4
, pp. 262-269
-
-
Rauen, T.1
Hedrich, C.M.2
Tenbrock, K.3
-
61
-
-
69649083354
-
Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalities
-
Sep
-
D.Gómez-Martín, M.Díaz-Zamudio, J.C.Crispín, et al. Interleukin 2 and systemic lupus erythematosus:beyond the transcriptional regulatory net abnormalities. Autoimmun Rev. 2009 Sep;9(1):34–39.
-
(2009)
Autoimmun Rev
, vol.9
, Issue.1
, pp. 34-39
-
-
Gómez-Martín, D.1
Díaz-Zamudio, M.2
Crispín, J.C.3
-
62
-
-
84907023082
-
IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells
-
Sep
-
M.Mizui, T.Koga, L.A.Lieberman, et al. IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells. J Immunology. 2014 Sep 1;193(5):2168–2177.
-
(2014)
J Immunology
, vol.193
, Issue.5
, pp. 2168-2177
-
-
Mizui, M.1
Koga, T.2
Lieberman, L.A.3
-
63
-
-
84930416867
-
Interleukin-2 treatment reverses effects of cAMP-responsive element modulator alpha-over-expressing T cells in autoimmune-prone mice
-
Jul
-
K.Ohl, A.Wiener, A.Schippers, et al. Interleukin-2 treatment reverses effects of cAMP-responsive element modulator alpha-over-expressing T cells in autoimmune-prone mice. Clin Exp Immunol. 2015 Jul;181(1):76–86.
-
(2015)
Clin Exp Immunol
, vol.181
, Issue.1
, pp. 76-86
-
-
Ohl, K.1
Wiener, A.2
Schippers, A.3
-
64
-
-
82555196118
-
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
-
Dec
-
D.Saadoun, M.Rosenzwajg, F.Joly, et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N Engl J Med. 2011 Dec 1;365(22):2067–2077.•• Pioneer study for the clinical implementation of low-dose IL-2 therapy in immune-mediated diseases.
-
(2011)
N Engl J Med
, vol.365
, Issue.22
, pp. 2067-2077
-
-
Saadoun, D.1
Rosenzwajg, M.2
Joly, F.3
-
65
-
-
82555168440
-
Interleukin-2 and regulatory T cells in graft-versus-host disease
-
Dec
-
J.Koreth, K.Matsuoka, H.T.Kim, et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med. 2011 Dec 1;365(22):2055–2066.•• Pioneer study for the clinical implementation of low-dose IL-2 therapy in immune-mediated diseases.
-
(2011)
N Engl J Med
, vol.365
, Issue.22
, pp. 2055-2066
-
-
Koreth, J.1
Matsuoka, K.2
Kim, H.T.3
-
66
-
-
1942456867
-
CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis
-
May
-
O.Boyer, D.Saadoun, J.Abriol, et al. CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood. 2004 May 1;103(9):3428–3430.
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3428-3430
-
-
Boyer, O.1
Saadoun, D.2
Abriol, J.3
-
67
-
-
27144500976
-
Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease
-
Oct
-
E.Zorn, H.T.Kim, S.J.Lee, et al. Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood. 2005 Oct 15;106(8):2903–2911.
-
(2005)
Blood
, vol.106
, Issue.8
, pp. 2903-2911
-
-
Zorn, E.1
Kim, H.T.2
Lee, S.J.3
-
68
-
-
0031778158
-
Interleukin-2 and systemic lupus erythematosus – fifteen years later
-
J.C.Crispin, J.Alcocer-Varela. Interleukin-2 and systemic lupus erythematosus – fifteen years later. Lupus. 1998;7(4):214–222.
-
(1998)
Lupus
, vol.7
, Issue.4
, pp. 214-222
-
-
Crispin, J.C.1
Alcocer-Varela, J.2
-
69
-
-
84865478468
-
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
-
Sep
-
S.A.Long, M.Rieck, S.Sanda, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes. 2012 Sep;61(9):2340–2348.
-
(2012)
Diabetes
, vol.61
, Issue.9
, pp. 2340-2348
-
-
Long, S.A.1
Rieck, M.2
Sanda, S.3
-
70
-
-
84887024554
-
IL-2 therapy in type 1 diabetes: ‘trials’ and tribulations
-
Dec
-
S.A.Long, J.H.Buckner, C.J.Greenbaum. IL-2 therapy in type 1 diabetes:‘trials’ and tribulations. Clin Immunol. 2013 Dec;149(3):324–331.
-
(2013)
Clin Immunol
, vol.149
, Issue.3
, pp. 324-331
-
-
Long, S.A.1
Buckner, J.H.2
Greenbaum, C.J.3
-
71
-
-
84928589620
-
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
-
M.Rosenzwajg, G.Churlaud, R.Mallone, et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun. 2015;58:48–58.
-
(2015)
J Autoimmun
, vol.58
, pp. 48-58
-
-
Rosenzwajg, M.1
Churlaud, G.2
Mallone, R.3
-
72
-
-
84910143200
-
Interleukin 2 in the pathogenesis and therapy of type 1 diabetes
-
Dec
-
M.Rosenzwajg, G.Churlaud, A.Hartemann, et al. Interleukin 2 in the pathogenesis and therapy of type 1 diabetes. Curr Diab Rep. 2014 Dec;14(12):553.
-
(2014)
Curr Diab Rep
, vol.14
, Issue.12
, pp. 553
-
-
Rosenzwajg, M.1
Churlaud, G.2
Hartemann, A.3
-
73
-
-
84904130542
-
Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata
-
Jul
-
E.Castela, F.Le Duff, C.Butori, et al. Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata. JAMA Dermatol. 2014 Jul;150(7):748–751.
-
(2014)
JAMA Dermatol
, vol.150
, Issue.7
, pp. 748-751
-
-
Castela, E.1
Le Duff, F.2
Butori, C.3
-
74
-
-
84925652648
-
Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE
-
Apr
-
J.Y.Humrich, C.von Spee-Mayer, E.Siegert, et al. Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE. Ann Rheum Dis. 2015 Apr;74(4):791–792.• Case report on the first SLE patient treated with low doses of IL-2.
-
(2015)
Ann Rheum Dis
, vol.74
, Issue.4
, pp. 791-792
-
-
Humrich, J.Y.1
von Spee-Mayer, C.2
Siegert, E.3
-
75
-
-
0035874522
-
Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
-
May
-
M.A.Cooper, T.A.Fehniger, S.C.Turner, et al. Human natural killer cells:a unique innate immunoregulatory role for the CD56(bright) subset. Blood. 2001 May 15;97(10):3146–3151.
-
(2001)
Blood
, vol.97
, Issue.10
, pp. 3146-3151
-
-
Cooper, M.A.1
Fehniger, T.A.2
Turner, S.C.3
-
76
-
-
84876012054
-
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
-
Apr
-
K.Matsuoka, J.Koreth, H.T.Kim, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med. 2013 Apr 3;5(179):179ra43.
-
(2013)
Sci Transl Med
, vol.5
, Issue.179
, pp. 179ra43
-
-
Matsuoka, K.1
Koreth, J.2
Kim, H.T.3
-
77
-
-
84928591321
-
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
-
May
-
D.Klatzmann, A.K.Abbas. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Revi Immunol. 2015 May;15(5):283–294.
-
(2015)
Nat Revi Immunol
, vol.15
, Issue.5
, pp. 283-294
-
-
Klatzmann, D.1
Abbas, A.K.2
|