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Volumn 12, Issue 11, 2016, Pages 1153-1160

Restoring regulation – IL-2 therapy in systemic lupus erythematosus

Author keywords

immune homeostasis; immunotherapy; interleukin 2; regulatory T cell; SLE; systemic lupus erythematosus; tolerance

Indexed keywords

INTERLEUKIN 2; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

EID: 84992143164     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1080/1744666X.2016.1199957     Document Type: Review
Times cited : (37)

References (77)
  • 1
    • 0017199306 scopus 로고
    • Selective in vitro growth of T lymphocytes from normal human bone marrows
    • Sep
    • D.A.Morgan, F.W.Ruscetti, R.Gallo Selective in vitro growth of T lymphocytes from normal human bone marrows. Science. 1976 Sep 10;193(4257):1007–1008.• Identification of IL-2 as a T-cell growth factor.
    • (1976) Science , vol.193 , Issue.4257 , pp. 1007-1008
    • Morgan, D.A.1    Ruscetti, F.W.2    Gallo, R.3
  • 2
    • 0005222146 scopus 로고
    • Structure of the human interleukin 2 gene
    • Dec
    • T.Fujita, C.Takaoka, H.Matsui, et al. Structure of the human interleukin 2 gene. Proc Natl Acad Sci U S A. 1983 Dec;80(24):7437–7441.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , Issue.24 , pp. 7437-7441
    • Fujita, T.1    Takaoka, C.2    Matsui, H.3
  • 3
    • 0020699991 scopus 로고
    • Structure and expression of a cloned cDNA for human interleukin-2
    • Mar
    • T.Taniguchi, H.Matsui, T.Fujita, et al. Structure and expression of a cloned cDNA for human interleukin-2. Nature. 1983 Mar 24–30;302(5906):305–310.
    • (1983) Nature , vol.302 , Issue.5906 , pp. 305-310
    • Taniguchi, T.1    Matsui, H.2    Fujita, T.3
  • 4
    • 0026848650 scopus 로고
    • Structure and function of IL-2 and IL-2 receptors
    • Apr
    • T.Taniguchi. Structure and function of IL-2 and IL-2 receptors. Behring Inst Mitt. 1992 Apr;91:87–95.
    • (1992) Behring Inst Mitt , vol.91 , pp. 87-95
    • Taniguchi, T.1
  • 5
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • T.R.Malek. The biology of interleukin-2. Annu Rev Immunol. 2008;26:453–479.
    • (2008) Annu Rev Immunol , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 6
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: at the interface between tolerance and immunity
    • Aug
    • T.R.Malek, I.Castro. Interleukin-2 receptor signaling:at the interface between tolerance and immunity. Immunity. 2010 Aug 27;33(2):153–165.
    • (2010) Immunity , vol.33 , Issue.2 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 7
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Oct
    • B.Sadlack, H.Merz, H.Schorle, et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 1993 Oct 22;75(2):253–261.•• This study provided the first evidence for the role of IL-2 in immune tolerance.
    • (1993) Cell , vol.75 , Issue.2 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3
  • 8
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • Nov
    • B.Sadlack, J.Löhler, H.Schorle, et al. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol. 1995 Nov;25(11):3053–3059.
    • (1995) Eur J Immunol , vol.25 , Issue.11 , pp. 3053-3059
    • Sadlack, B.1    Löhler, J.2    Schorle, H.3
  • 9
    • 0030560797 scopus 로고    scopus 로고
    • Interleukin-2 is indispensable for development of immunological self-tolerance
    • Dec
    • G.Klebb, I.B.Autenrieth, H.Haber, et al. Interleukin-2 is indispensable for development of immunological self-tolerance. Clin Immunol Immunopathol. 1996 Dec;81(3):282–286.
    • (1996) Clin Immunol Immunopathol , vol.81 , Issue.3 , pp. 282-286
    • Klebb, G.1    Autenrieth, I.B.2    Haber, H.3
  • 10
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Nov
    • J.D.Fontenot, J.P.Rasmussen, M.A.Gavin, et al. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005 Nov;6(11):1142–1151.• One of the first studies that proved that IL-2 is a key factor in Treg biology.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3
  • 11
    • 27544446622 scopus 로고    scopus 로고
    • Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    • Nov
    • L.M.D’Cruz, L.Klein. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol. 2005 Nov;6(11):1152–1159.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1152-1159
    • D’Cruz, L.M.1    Klein, L.2
  • 12
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Mar
    • R.Setoguchi, S.Hori, T.Takahashi, et al. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005 Mar 7;201(5):723–735.• One of the first studies that proved that IL-2 is a key factor in Treg biology.
    • (2005) J Exp Med , vol.201 , Issue.5 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3
  • 13
    • 33947667310 scopus 로고    scopus 로고
    • Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells
    • Apr
    • A.L.Bayer, A.Yu, T.R.Malek. Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J Immunology. 2007 Apr 1;178(7):4062–4071.
    • (2007) J Immunology , vol.178 , Issue.7 , pp. 4062-4071
    • Bayer, A.L.1    Yu, A.2    Malek, T.R.3
  • 14
    • 49649124868 scopus 로고    scopus 로고
    • IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells
    • Jun
    • S.Brandenburg, T.Takahashi, M.de la Rosa, et al. IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells. Eur J Immunol. 2008 Jun;38(6):1643–1653.
    • (2008) Eur J Immunol , vol.38 , Issue.6 , pp. 1643-1653
    • Brandenburg, S.1    Takahashi, T.2    de la Rosa, M.3
  • 15
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Apr
    • S.Sakaguchi. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005 Apr;6(4):345–352.
    • (2005) Nat Immunol , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 16
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
    • Mar
    • S.A.Rosenberg, J.C.Yang, S.L.Topalian, et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA. 1994 Mar 23–30;271(12):907–913.
    • (1994) JAMA , vol.271 , Issue.12 , pp. 907-913
    • Rosenberg, S.A.1    Yang, J.C.2    Topalian, S.L.3
  • 17
    • 33644784733 scopus 로고    scopus 로고
    • IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients
    • Mar
    • M.Ahmadzadeh, S.A.Rosenberg. IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients. Blood. 2006 Mar 15;107(6):2409–2414.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 18
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Aug
    • S.Sakaguchi, N.Sakaguchi, M.Asano, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunology. 1995 Aug 1;155(3):1151–1164.•• The ‘birth’ of regulatory T cells and of the modern concepts of immune regulation and tolerance. A real milestone.
    • (1995) J Immunology , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 19
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Apr
    • J.D.Fontenot, M.A.Gavin, A.Y.Rudensky. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003 Apr;4(4):330–336.
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 20
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in the human immune system
    • Jul
    • S.Sakaguchi, M.Miyara, C.M.Costantino, et al. FOXP3+ regulatory T cells in the human immune system. Nat Revi Immunol. 2010 Jul;10(7):490–500.
    • (2010) Nat Revi Immunol , vol.10 , Issue.7 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3
  • 21
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Feb
    • J.M.Kim, J.P.Rasmussen, A.Y.Rudensky. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007 Feb;8(2):191–197.
    • (2007) Nat Immunol , vol.8 , Issue.2 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 22
    • 33746379546 scopus 로고    scopus 로고
    • The role of the transcription factor Foxp3 in the development of regulatory T cells
    • Aug
    • J.M.Kim, A.Rudensky. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol Rev. 2006 Aug;212:86–98.
    • (2006) Immunol Rev , vol.212 , pp. 86-98
    • Kim, J.M.1    Rudensky, A.2
  • 23
    • 43949105866 scopus 로고    scopus 로고
    • T cells and immune tolerance
    • May
    • S.Sakaguchi, T.Yamaguchi, T.Nomura, et al. T cells and immune tolerance. Cell. 2008 May 30;133(5):775–787.
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3
  • 24
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Jan
    • K.Wing, S.Sakaguchi. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010 Jan;11(1):7–13.
    • (2010) Nat Immunol , vol.11 , Issue.1 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 25
    • 80053262406 scopus 로고    scopus 로고
    • Human FoxP3 + regulatory T cells in systemic autoimmune diseases
    • Oct
    • M.Miyara, G.Gorochov, M.Ehrenstein, et al. Human FoxP3 + regulatory T cells in systemic autoimmune diseases. Autoimmun Rev. 2011 Oct;10(12):744–755.
    • (2011) Autoimmun Rev , vol.10 , Issue.12 , pp. 744-755
    • Miyara, M.1    Gorochov, G.2    Ehrenstein, M.3
  • 26
    • 84922691219 scopus 로고    scopus 로고
    • Regulatory T cells and rheumatic diseases
    • Feb
    • J.Y.Humrich, T.Kamradt, G.Riemekasten. Regulatory T cells and rheumatic diseases. Z Rheumatol. 2015 Feb;74(1):26–32.
    • (2015) Z Rheumatol , vol.74 , Issue.1 , pp. 26-32
    • Humrich, J.Y.1    Kamradt, T.2    Riemekasten, G.3
  • 27
    • 33645819388 scopus 로고    scopus 로고
    • Regulatory T cells in human disease and their potential for therapeutic manipulation
    • May
    • L.S.Taams, D.B.Palmer, A.N.Akbar, et al. Regulatory T cells in human disease and their potential for therapeutic manipulation. Immunology. 2006 May;118(1):1–9.
    • (2006) Immunology , vol.118 , Issue.1 , pp. 1-9
    • Taams, L.S.1    Palmer, D.B.2    Akbar, A.N.3
  • 28
    • 32644459908 scopus 로고    scopus 로고
    • Antigen-specific regulatory T cells – ex vivo expansion and therapeutic potential
    • Apr
    • E.L.Masteller, Q.Tang, J.A.Bluestone. Antigen-specific regulatory T cells – ex vivo expansion and therapeutic potential. Semin Immunol. 2006 Apr;18(2):103–110.
    • (2006) Semin Immunol , vol.18 , Issue.2 , pp. 103-110
    • Masteller, E.L.1    Tang, Q.2    Bluestone, J.A.3
  • 29
    • 65549127618 scopus 로고    scopus 로고
    • Human T regulatory cell therapy: take a billion or so and call me in the morning
    • May
    • J.L.Riley, C.H.June, B.R.Blazar. Human T regulatory cell therapy:take a billion or so and call me in the morning. Immunity. 2009 May;30(5):656–665.
    • (2009) Immunity , vol.30 , Issue.5 , pp. 656-665
    • Riley, J.L.1    June, C.H.2    Blazar, B.R.3
  • 30
    • 27144495833 scopus 로고    scopus 로고
    • How do CD4+CD25+ regulatory T cells control autoimmunity?
    • Dec
    • J.A.Bluestone, Q.Tang. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol. 2005 Dec;17(6):638–642.
    • (2005) Curr Opin Immunol , vol.17 , Issue.6 , pp. 638-642
    • Bluestone, J.A.1    Tang, Q.2
  • 31
    • 84908089142 scopus 로고    scopus 로고
    • TRE G-cell therapies for autoimmune rheumatic diseases
    • Sep
    • M.Miyara, Y.Ito, S.Sakaguchi. TRE G-cell therapies for autoimmune rheumatic diseases. Nat Rev Rheumatol. 2014 Sep;10(9):543–551.
    • (2014) Nat Rev Rheumatol , vol.10 , Issue.9 , pp. 543-551
    • Miyara, M.1    Ito, Y.2    Sakaguchi, S.3
  • 32
    • 29144516273 scopus 로고    scopus 로고
    • Global natural regulatory T cell depletion in active systemic lupus erythematosus
    • Dec
    • M.Miyara, Z.Amoura, C.Parizot, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunology. 2005 Dec 15;175(12):8392–8400.
    • (2005) J Immunology , vol.175 , Issue.12 , pp. 8392-8400
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3
  • 33
    • 65449149735 scopus 로고    scopus 로고
    • Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus
    • Jun
    • J.L.Suen, H.T.Li, Y.J.Jong, et al. Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology. 2009 Jun;127(2):196–205.
    • (2009) Immunology , vol.127 , Issue.2 , pp. 196-205
    • Suen, J.L.1    Li, H.T.2    Jong, Y.J.3
  • 34
    • 33746214867 scopus 로고    scopus 로고
    • Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells
    • Aug
    • K.J.Scalapino, Q.Tang, J.A.Bluestone, et al. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunology. 2006 Aug 1;177(3):1451–1459.
    • (2006) J Immunology , vol.177 , Issue.3 , pp. 1451-1459
    • Scalapino, K.J.1    Tang, Q.2    Bluestone, J.A.3
  • 35
    • 76249100290 scopus 로고    scopus 로고
    • Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
    • Jan
    • J.Y.Humrich, H.Morbach, R.Undeutsch, et al. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):204–209.•• First proof of the pathogenetic relevance of IL-2 deficiency and related Treg defects in murine lupus.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.1 , pp. 204-209
    • Humrich, J.Y.1    Morbach, H.2    Undeutsch, R.3
  • 36
    • 42449123048 scopus 로고    scopus 로고
    • Foxp 3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis
    • May
    • M.Bonelli, K.von Dalwigk, A.Savitskaya, et al. Foxp 3 expression in CD4+ T cells of patients with systemic lupus erythematosus:a comparative phenotypic analysis. Ann Rheum Dis. 2008 May;67(5):664–671.
    • (2008) Ann Rheum Dis , vol.67 , Issue.5 , pp. 664-671
    • Bonelli, M.1    von Dalwigk, K.2    Savitskaya, A.3
  • 37
    • 63149094153 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus
    • Feb
    • M.Bonelli, A.Savitskaya, C.W.Steiner, et al. Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunology. 2009 Feb 1;182(3):1689–1695.
    • (2009) J Immunology , vol.182 , Issue.3 , pp. 1689-1695
    • Bonelli, M.1    Savitskaya, A.2    Steiner, C.W.3
  • 38
    • 84992071354 scopus 로고    scopus 로고
    • Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
    • Aug
    • C.von Spee-Mayer, E.Siegert, D.Abdirama, et al. Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann Rheum Dis. 2015 Aug;31.• First proof-of-concept study of low-dose IL-2 therapy in SLE patients.
    • (2015) Ann Rheum Dis , pp. 31
    • von Spee-Mayer, C.1    Siegert, E.2    Abdirama, D.3
  • 39
    • 84874223419 scopus 로고    scopus 로고
    • CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice
    • O.Weigert, C.von Spee, R.Undeutsch, et al. CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice. Arthritis Res Ther. 2013;15(1):R35.
    • (2013) Arthritis Res Ther , vol.15 , Issue.1 , pp. R35
    • Weigert, O.1    von Spee, C.2    Undeutsch, R.3
  • 40
    • 82755189414 scopus 로고    scopus 로고
    • Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus
    • Dec
    • J.B.Engler, R.Undeutsch, L.Kloke, et al. Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus. Ann Rheum Dis. 2011 Dec;70(12):2176–2183.
    • (2011) Ann Rheum Dis , vol.70 , Issue.12 , pp. 2176-2183
    • Engler, J.B.1    Undeutsch, R.2    Kloke, L.3
  • 41
    • 1642321982 scopus 로고    scopus 로고
    • IL-2, regulatory T cells, and tolerance
    • Apr
    • B.H.Nelson. IL-2, regulatory T cells, and tolerance. J Immunology. 2004 Apr 1;172(7):3983–3988.
    • (2004) J Immunology , vol.172 , Issue.7 , pp. 3983-3988
    • Nelson, B.H.1
  • 42
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Jun
    • H.Suzuki, T.M.Kundig, C.Furlonger, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science. 1995 Jun 9;268(5216):1472–1476.
    • (1995) Science , vol.268 , Issue.5216 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3
  • 43
    • 84908403082 scopus 로고    scopus 로고
    • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
    • Aug
    • Y.Feng, A.Arvey, T.Chinen, et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 2014 Aug 14;158(4):749–763.
    • (2014) Cell , vol.158 , Issue.4 , pp. 749-763
    • Feng, Y.1    Arvey, A.2    Chinen, T.3
  • 44
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • May
    • A.Ballesteros-Tato, B.León, B.A.Graf, et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity. 2012 May 25;36(5):847–856.
    • (2012) Immunity , vol.36 , Issue.5 , pp. 847-856
    • Ballesteros-Tato, A.1    León, B.2    Graf, B.A.3
  • 45
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Mar
    • A.Laurence, C.M.Tato, T.S.Davidson, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity. 2007 Mar;26(3):371–381.
    • (2007) Immunity , vol.26 , Issue.3 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3
  • 46
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • May
    • Q.Tang, J.Y.Adams, C.Penaranda, et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity. 2008 May;28(5):687–697.
    • (2008) Immunity , vol.28 , Issue.5 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 47
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of Treg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Apr
    • K.E.Webster, S.Walters, R.E.Kohler, et al. In vivo expansion of Treg cells with IL-2-mAb complexes:induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med. 2009 Apr 13;206(4):751–760.
    • (2009) J Exp Med , vol.206 , Issue.4 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3
  • 48
    • 77956257716 scopus 로고    scopus 로고
    • IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
    • Aug
    • Y.Grinberg-Bleyer, A.Baeyens, S.You, et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010 Aug 30;207(9):1871–1878.
    • (2010) J Exp Med , vol.207 , Issue.9 , pp. 1871-1878
    • Grinberg-Bleyer, Y.1    Baeyens, A.2    You, S.3
  • 49
    • 0019825716 scopus 로고
    • Interleukin 2 deficiency is a common feature of autoimmune mice
    • Dec
    • M.J.Dauphinee, S.B.Kipper, D.Wofsy, et al. Interleukin 2 deficiency is a common feature of autoimmune mice. J Immunology. 1981 Dec;127(6):2483–2487.
    • (1981) J Immunology , vol.127 , Issue.6 , pp. 2483-2487
    • Dauphinee, M.J.1    Kipper, S.B.2    Wofsy, D.3
  • 50
    • 0019787151 scopus 로고
    • Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene
    • Nov
    • D.Wofsy, E.D.Murphy, J.B.Roths, et al. Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. J Exp Med. 1981 Nov 1;154(5):1671–1680.
    • (1981) J Exp Med , vol.154 , Issue.5 , pp. 1671-1680
    • Wofsy, D.1    Murphy, E.D.2    Roths, J.B.3
  • 51
    • 0020546709 scopus 로고
    • Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)
    • Jun
    • M.Linker-Israeli, A.C.Bakke, R.C.Kitridou, et al. Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunology. 1983 Jun;130(6):2651–2655.• First study providing evidence for IL-2 deficiency in SLE patients.
    • (1983) J Immunology , vol.130 , Issue.6 , pp. 2651-2655
    • Linker-Israeli, M.1    Bakke, A.C.2    Kitridou, R.C.3
  • 52
    • 0025289913 scopus 로고
    • Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus
    • Jul
    • J.C.Gutierrez-Ramos, J.L.Andreu, Y.Revilla, et al. Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus. Nature. 1990 Jul 19;346(6281):271–274.
    • (1990) Nature , vol.346 , Issue.6281 , pp. 271-274
    • Gutierrez-Ramos, J.C.1    Andreu, J.L.2    Revilla, Y.3
  • 53
    • 0035869333 scopus 로고    scopus 로고
    • Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus
    • Mar
    • E.E.Solomou, Y.T.Juang, M.F.Gourley, et al. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunology. 2001 Mar 15;166(6):4216–4222.
    • (2001) J Immunology , vol.166 , Issue.6 , pp. 4216-4222
    • Solomou, E.E.1    Juang, Y.T.2    Gourley, M.F.3
  • 54
    • 0037108487 scopus 로고    scopus 로고
    • Antisense cyclic adenosine 5ʹ-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus
    • Oct
    • K.Tenbrock, Y.T.Juang, M.F.Gourley, et al. Antisense cyclic adenosine 5ʹ-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J Immunology. 2002 Oct 15;169(8):4147–4152.
    • (2002) J Immunology , vol.169 , Issue.8 , pp. 4147-4152
    • Tenbrock, K.1    Juang, Y.T.2    Gourley, M.F.3
  • 55
    • 16844376445 scopus 로고    scopus 로고
    • Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    • Apr
    • Y.T.Juang, Y.Wang, E.E.Solomou, et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest. 2005 Apr;115(4):996–1005.
    • (2005) J Clin Invest , vol.115 , Issue.4 , pp. 996-1005
    • Juang, Y.T.1    Wang, Y.2    Solomou, E.E.3
  • 56
    • 31144451804 scopus 로고    scopus 로고
    • Transcriptional repression of interleukin-2 in human systemic lupus erythematosus
    • Feb
    • C.G.Katsiari, G.C.Tsokos. Transcriptional repression of interleukin-2 in human systemic lupus erythematosus. Autoimmun Rev. 2006 Feb;5(2):118–121.
    • (2006) Autoimmun Rev , vol.5 , Issue.2 , pp. 118-121
    • Katsiari, C.G.1    Tsokos, G.C.2
  • 57
    • 78751488886 scopus 로고    scopus 로고
    • Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus
    • Jan
    • Y.T.Juang, T.Rauen, Y.Wang, et al. Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus. J Biol Chem. 2011 Jan 21;286(3):1795–1801.
    • (2011) J Biol Chem , vol.286 , Issue.3 , pp. 1795-1801
    • Juang, Y.T.1    Rauen, T.2    Wang, Y.3
  • 58
    • 83355166950 scopus 로고    scopus 로고
    • cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus
    • Dec
    • C.M.Hedrich, T.Rauen, G.C.Tsokos. cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene:implications in systemic lupus erythematosus. J Biol Chem. 2011 Dec 16;286(50):43429–43436.
    • (2011) J Biol Chem , vol.286 , Issue.50 , pp. 43429-43436
    • Hedrich, C.M.1    Rauen, T.2    Tsokos, G.C.3
  • 59
    • 84867351076 scopus 로고    scopus 로고
    • cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus
    • Oct
    • C.M.Hedrich, J.C.Crispin, T.Rauen, et al. cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16606–16611.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.41 , pp. 16606-16611
    • Hedrich, C.M.1    Crispin, J.C.2    Rauen, T.3
  • 60
    • 84875846171 scopus 로고    scopus 로고
    • cAMP responsive element modulator: a critical regulator of cytokine production
    • Apr
    • T.Rauen, C.M.Hedrich, K.Tenbrock, et al. cAMP responsive element modulator:a critical regulator of cytokine production. Trends Mol Med. 2013 Apr;19(4):262–269.
    • (2013) Trends Mol Med , vol.19 , Issue.4 , pp. 262-269
    • Rauen, T.1    Hedrich, C.M.2    Tenbrock, K.3
  • 61
    • 69649083354 scopus 로고    scopus 로고
    • Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalities
    • Sep
    • D.Gómez-Martín, M.Díaz-Zamudio, J.C.Crispín, et al. Interleukin 2 and systemic lupus erythematosus:beyond the transcriptional regulatory net abnormalities. Autoimmun Rev. 2009 Sep;9(1):34–39.
    • (2009) Autoimmun Rev , vol.9 , Issue.1 , pp. 34-39
    • Gómez-Martín, D.1    Díaz-Zamudio, M.2    Crispín, J.C.3
  • 62
    • 84907023082 scopus 로고    scopus 로고
    • IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells
    • Sep
    • M.Mizui, T.Koga, L.A.Lieberman, et al. IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells. J Immunology. 2014 Sep 1;193(5):2168–2177.
    • (2014) J Immunology , vol.193 , Issue.5 , pp. 2168-2177
    • Mizui, M.1    Koga, T.2    Lieberman, L.A.3
  • 63
    • 84930416867 scopus 로고    scopus 로고
    • Interleukin-2 treatment reverses effects of cAMP-responsive element modulator alpha-over-expressing T cells in autoimmune-prone mice
    • Jul
    • K.Ohl, A.Wiener, A.Schippers, et al. Interleukin-2 treatment reverses effects of cAMP-responsive element modulator alpha-over-expressing T cells in autoimmune-prone mice. Clin Exp Immunol. 2015 Jul;181(1):76–86.
    • (2015) Clin Exp Immunol , vol.181 , Issue.1 , pp. 76-86
    • Ohl, K.1    Wiener, A.2    Schippers, A.3
  • 64
    • 82555196118 scopus 로고    scopus 로고
    • Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    • Dec
    • D.Saadoun, M.Rosenzwajg, F.Joly, et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N Engl J Med. 2011 Dec 1;365(22):2067–2077.•• Pioneer study for the clinical implementation of low-dose IL-2 therapy in immune-mediated diseases.
    • (2011) N Engl J Med , vol.365 , Issue.22 , pp. 2067-2077
    • Saadoun, D.1    Rosenzwajg, M.2    Joly, F.3
  • 65
    • 82555168440 scopus 로고    scopus 로고
    • Interleukin-2 and regulatory T cells in graft-versus-host disease
    • Dec
    • J.Koreth, K.Matsuoka, H.T.Kim, et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med. 2011 Dec 1;365(22):2055–2066.•• Pioneer study for the clinical implementation of low-dose IL-2 therapy in immune-mediated diseases.
    • (2011) N Engl J Med , vol.365 , Issue.22 , pp. 2055-2066
    • Koreth, J.1    Matsuoka, K.2    Kim, H.T.3
  • 66
    • 1942456867 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis
    • May
    • O.Boyer, D.Saadoun, J.Abriol, et al. CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood. 2004 May 1;103(9):3428–3430.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3428-3430
    • Boyer, O.1    Saadoun, D.2    Abriol, J.3
  • 67
    • 27144500976 scopus 로고    scopus 로고
    • Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease
    • Oct
    • E.Zorn, H.T.Kim, S.J.Lee, et al. Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood. 2005 Oct 15;106(8):2903–2911.
    • (2005) Blood , vol.106 , Issue.8 , pp. 2903-2911
    • Zorn, E.1    Kim, H.T.2    Lee, S.J.3
  • 68
    • 0031778158 scopus 로고    scopus 로고
    • Interleukin-2 and systemic lupus erythematosus – fifteen years later
    • J.C.Crispin, J.Alcocer-Varela. Interleukin-2 and systemic lupus erythematosus – fifteen years later. Lupus. 1998;7(4):214–222.
    • (1998) Lupus , vol.7 , Issue.4 , pp. 214-222
    • Crispin, J.C.1    Alcocer-Varela, J.2
  • 69
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
    • Sep
    • S.A.Long, M.Rieck, S.Sanda, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes. 2012 Sep;61(9):2340–2348.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2340-2348
    • Long, S.A.1    Rieck, M.2    Sanda, S.3
  • 70
    • 84887024554 scopus 로고    scopus 로고
    • IL-2 therapy in type 1 diabetes: ‘trials’ and tribulations
    • Dec
    • S.A.Long, J.H.Buckner, C.J.Greenbaum. IL-2 therapy in type 1 diabetes:‘trials’ and tribulations. Clin Immunol. 2013 Dec;149(3):324–331.
    • (2013) Clin Immunol , vol.149 , Issue.3 , pp. 324-331
    • Long, S.A.1    Buckner, J.H.2    Greenbaum, C.J.3
  • 71
    • 84928589620 scopus 로고    scopus 로고
    • Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
    • M.Rosenzwajg, G.Churlaud, R.Mallone, et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun. 2015;58:48–58.
    • (2015) J Autoimmun , vol.58 , pp. 48-58
    • Rosenzwajg, M.1    Churlaud, G.2    Mallone, R.3
  • 72
    • 84910143200 scopus 로고    scopus 로고
    • Interleukin 2 in the pathogenesis and therapy of type 1 diabetes
    • Dec
    • M.Rosenzwajg, G.Churlaud, A.Hartemann, et al. Interleukin 2 in the pathogenesis and therapy of type 1 diabetes. Curr Diab Rep. 2014 Dec;14(12):553.
    • (2014) Curr Diab Rep , vol.14 , Issue.12 , pp. 553
    • Rosenzwajg, M.1    Churlaud, G.2    Hartemann, A.3
  • 73
    • 84904130542 scopus 로고    scopus 로고
    • Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata
    • Jul
    • E.Castela, F.Le Duff, C.Butori, et al. Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata. JAMA Dermatol. 2014 Jul;150(7):748–751.
    • (2014) JAMA Dermatol , vol.150 , Issue.7 , pp. 748-751
    • Castela, E.1    Le Duff, F.2    Butori, C.3
  • 74
    • 84925652648 scopus 로고    scopus 로고
    • Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE
    • Apr
    • J.Y.Humrich, C.von Spee-Mayer, E.Siegert, et al. Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE. Ann Rheum Dis. 2015 Apr;74(4):791–792.• Case report on the first SLE patient treated with low doses of IL-2.
    • (2015) Ann Rheum Dis , vol.74 , Issue.4 , pp. 791-792
    • Humrich, J.Y.1    von Spee-Mayer, C.2    Siegert, E.3
  • 75
    • 0035874522 scopus 로고    scopus 로고
    • Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    • May
    • M.A.Cooper, T.A.Fehniger, S.C.Turner, et al. Human natural killer cells:a unique innate immunoregulatory role for the CD56(bright) subset. Blood. 2001 May 15;97(10):3146–3151.
    • (2001) Blood , vol.97 , Issue.10 , pp. 3146-3151
    • Cooper, M.A.1    Fehniger, T.A.2    Turner, S.C.3
  • 76
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
    • Apr
    • K.Matsuoka, J.Koreth, H.T.Kim, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med. 2013 Apr 3;5(179):179ra43.
    • (2013) Sci Transl Med , vol.5 , Issue.179 , pp. 179ra43
    • Matsuoka, K.1    Koreth, J.2    Kim, H.T.3
  • 77
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
    • May
    • D.Klatzmann, A.K.Abbas. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Revi Immunol. 2015 May;15(5):283–294.
    • (2015) Nat Revi Immunol , vol.15 , Issue.5 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2


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