Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 1, 2010, Pages 204-209

  Humrich, Jens Y ^a   Morbach, Henner ^b   Undeutsch, Reinmar ^a   Enghard, Philipp ^a   Rosenberger, Stefan ^a   Weigert, Olivia ^a   Kloke, Lutz ^a   Heimann, Juliane ^a   Gaber, Timo ^a   Brandenburg, Susan ^c   Scheffold, Alexander ^c   Huehn, Jochen ^a,d   Radbruch, Andreas ^c   Burmester, Gerd Rüdiger ^a   Riemekasten, Gabriela ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c German Rheumatism Research Center   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Autoimmunity; Homeostasis; Immunotherapy; Interleukin 2; SLE

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; EFFECTOR CELL; FEMALE; HOMEOSTASIS; INTERLEUKIN 2 DEFICIENCY; LYMPHOCYTE PROLIFERATION; LYMPHOID ORGAN; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOPTIVE TRANSFER; AGING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HOMEOSTASIS; INTERLEUKIN-2; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

MURINAE; MUS;

EID: 76249100290     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903158107     Document Type: Article

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