Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1795-1801

  Juang, Yuang Taung ^a   Rauen, Thomas ^a   Wang, Ying ^b   Ichinose, Kunihiro ^a   Benedyk, Konrad ^c   Tenbrock, Klaus ^c   Tsokos, George C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; DEPHOSPHORYLATIONS; DNA BINDING; GENE TRANSCRIPTIONS; HUMAN T CELLS; LEUCINE-ZIPPER TRANSCRIPTION FACTORS; PROMOTER ACTIVITIES; PROTEIN PHOSPHATASE 2A; SERINE RESIDUES; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELL RECEPTOR; T CELLS; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL ACTIVITY;

AMINO ACIDS; CELL MEMBRANES; FETAL MONITORING; PHOSPHATASES; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; TRANSCRIPTION FACTOR SP1;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RNA EXTRACTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

ADULT; BIOLOGICAL MARKERS; CYCLIC AMP RESPONSE ELEMENT MODULATOR; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-2; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN PHOSPHATASE 2; RECEPTORS, ANTIGEN, T-CELL; SP1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 78751488886     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.166785     Document Type: Article

References (20)

1. Rahman, A., and Isenberg, D. A. (2008) N. Engl. J. Med. 358, 929-939
2. Tenbrock, K., Juang, Y. T., Kyttaris, V. C., and Tsokos, G. C. (2007) Rheumatology 46, 1525-1530
3. Solomou, E. E., Juang, Y. T., Gourley, M. F., Kammer, G. M., and Tsokos, G. C. (2001) J. Immunol. 166, 4216-4222
4. Tenbrock, K., Kyttaris, V. C., Ahlmann, M., Ehrchen, J. M., Tolnay, M., Melkonyan, H., Mawrin, C., Roth, J., Sorg, C., Juang, Y. T., and Tsokos, G. C. (2005) J. Immunol. 175, 5975-5980
5. Kyttaris, V. C., Juang, Y. T., Tenbrock, K., Weinstein, A., and Tsokos, G. C. (2004) J. Immunol. 173, 3557-3563
6. Sassone-Corsi, P. (1995) Annu. Rev. Cell Dev. Biol. 11, 355-377
7. Juang, Y. T., Wang, Y., Solomou, E. E., Li, Y., Mawrin, C., Tenbrock, K., Kyttaris, V. C., and Tsokos, G. C. (2005) J. Clin. Invest. 115, 996-1005
8. Kyttaris, V. C., Wang, Y., Juang, Y. T., Weinstein, A., and Tsokos, G. C. (2006) Lupus 15, 840-844
9. Iliopoulos, A. G., and Tsokos, G. C. (1996) Semin. Arthritis Rheum. 25, 318-336
10. Tenbrock, K., Juang, Y. T., Gourley, M. F., Nambiar, M. P., and Tsokos, G. C. (2002) J. Immunol. 169, 4147-4152
11. Foulkes, N. S., Borrelli, E., and Sassone-Corsi, P. (1991) Cell 64, 739-749
12. Laoide, B. M., Foulkes, N. S., Schlotter, F., and Sassone-Corsi, P. (1993) EMBO J. 12, 1179-1191
13. Della Fazia, M. A., Servillo, G., Foulkes, N. S., and Sassone-Corsi, P. (1998) FEBS Lett. 434, 33-36
14. Hochberg, M. C. (1997) Arthritis Rheum. 40, 1725
15. Evans, D. R., Myles, T., Hofsteenge, J., and Hemmings, B. A. (1999) J. Biol. Chem. 274, 24038-24046
16. Solomou, E. E., Juang, Y. T., and Tsokos, G. C. (2001) J. Immunol. 166, 5665-5674
17. Moulton, V. R., and Tsokos, G. C. (2010) J. Biol. Chem. 285, 12490-12496
18. Vicart, A., Lefebvre, T., Imbert, J., Fernandez, A., and Kahn-Perlès, B. (2006) J. Mol. Biol. 364, 897-908
19. Katsiari, C. G., Kyttaris, V. C., Juang, Y. T., and Tsokos, G. C. (2005) J. Clin. Invest. 115, 3193-3204
20. Lieberman, L. A., and Tsokos, G. C. (2010) J. Biomed. Biotechnol., in Press