메뉴 건너뛰기




Volumn 7, Issue 4, 1998, Pages 214-222

Interleukin-2 and systemic lupus erythematosus - Fifteen years later

Author keywords

Autoimmunity; Cytokines; Interleukin 2; Systemic lupus erythematosus

Indexed keywords

CYTOKINE; INTERLEUKIN 2;

EID: 0031778158     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/096120398678920028     Document Type: Article
Times cited : (26)

References (96)
  • 2
    • 0020553443 scopus 로고
    • Cellular bases of the production of and response to interleukin-2 in man: Role of autologous rosette-forming T-cell subsets defined with monoclonal antibodies
    • Fishbein E, Alcocer-Varela J, Alarcón-Segovia D. Cellular bases of the production of and response to interleukin-2 in man: role of autologous rosette-forming T-cell subsets defined with monoclonal antibodies. Immunology 1983; 50: 223-227.
    • (1983) Immunology , vol.50 , pp. 223-227
    • Fishbein, E.1    Alcocer-Varela, J.2    Alarcón-Segovia, D.3
  • 3
    • 0028131273 scopus 로고
    • Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor
    • Carson WE, et al. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 1994; 180: 1395-1403.
    • (1994) J Exp Med , vol.180 , pp. 1395-1403
    • Carson, W.E.1
  • 5
    • 43949164661 scopus 로고
    • Signal transduction events leading to T-cell lymphokine gene expression
    • Fraser JD, Straus D, Weiss A. Signal transduction events leading to T-cell lymphokine gene expression Immunol Today 1993; 14: 357-362.
    • (1993) Immunol Today , vol.14 , pp. 357-362
    • Fraser, J.D.1    Straus, D.2    Weiss, A.3
  • 6
    • 0025255387 scopus 로고
    • Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function. the missing link
    • Ullman KS, Northrop JP, Verweij CL, Crabtree GR. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function. The missing link Annu Rev Immunol 1990; 8: 421-452.
    • (1990) Annu Rev Immunol , vol.8 , pp. 421-452
    • Ullman, K.S.1    Northrop, J.P.2    Verweij, C.L.3    Crabtree, G.R.4
  • 7
    • 0021045819 scopus 로고
    • Transient expression of interleukin 2 receptors. Consequences for T cell growth
    • Cantrell DA, Smith KA. Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med 1983; 158: 1895-1911.
    • (1983) J Exp Med , vol.158 , pp. 1895-1911
    • Cantrell, D.A.1    Smith, K.A.2
  • 8
    • 0025948916 scopus 로고
    • Interleukm-2, autotolerance and autoimmunity
    • Kroemer G, et al. Interleukm-2, autotolerance and autoimmunity Adv Immunol 1991; 50: 147-235.
    • (1991) Adv Immunol , vol.50 , pp. 147-235
    • Kroemer, G.1
  • 11
    • 0027372258 scopus 로고
    • B-cell and T-cell function in systemic lupus erythematosus
    • Via CS, Handwerger BS B-cell and T-cell function in systemic lupus erythematosus. Curr Opin Rheumatol 1993; 5: 570-574.
    • (1993) Curr Opin Rheumatol , vol.5 , pp. 570-574
    • Via, C.S.1    Handwerger, B.S.2
  • 12
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • Sadlack B, et al. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol 1995; 25: 3053-3059.
    • (1995) Eur J Immunol , vol.25 , pp. 3053-3059
    • Sadlack, B.1
  • 13
    • 0029414785 scopus 로고
    • Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance
    • Horak I, Löhler J, Ma A, Smith KA. Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance. Immunol Rev 1995; 148: 35-44.
    • (1995) Immunol Rev , vol.148 , pp. 35-44
    • Horak, I.1    Löhler, J.2    Ma, A.3    Smith, K.A.4
  • 14
    • 0029794103 scopus 로고    scopus 로고
    • Induction of sensitivity to activation-induced death in primary CD4+ cells: A role for interleukin-2 in the negative regulation of responses by mature CD4+ T cells
    • Wang R, Rogers AM, Rush BJ, Russell JH. Induction of sensitivity to activation-induced death in primary CD4+ cells: a role for interleukin-2 in the negative regulation of responses by mature CD4+ T cells. Eur J Immunol 1996; 26: 2263-2270
    • (1996) Eur J Immunol , vol.26 , pp. 2263-2270
    • Wang, R.1    Rogers, A.M.2    Rush, B.J.3    Russell, J.H.4
  • 15
    • 0030560797 scopus 로고    scopus 로고
    • Interleukin-2 is indispensable for development of imrminological self-tolerance
    • Klebb G, et al. Interleukin-2 is indispensable for development of imrminological self-tolerance. Clm Immunol Immunopathol 1996; 81: 282-286.
    • (1996) Clm Immunol Immunopathol , vol.81 , pp. 282-286
    • Klebb, G.1
  • 16
    • 0030026869 scopus 로고    scopus 로고
    • IL-2 rescues antigen-specific T cells from radiation of dexamethasone-induced apoptosis. Correlation with induction of bcl-2
    • Mor F, Cohen IR. IL-2 rescues antigen-specific T cells from radiation of dexamethasone-induced apoptosis. Correlation with induction of bcl-2. J Immunol 1996; 156: 515-522.
    • (1996) J Immunol , vol.156 , pp. 515-522
    • Mor, F.1    Cohen, I.R.2
  • 17
    • 0027372257 scopus 로고
    • Murine models of autoimmune disease and Sjögren's syndrome
    • Mountz JD, Cause WC. Murine models of autoimmune disease and Sjögren's syndrome. Curr Opin Rheumatol 1993; 5: 557-569.
    • (1993) Curr Opin Rheumatol , vol.5 , pp. 557-569
    • Mountz, J.D.1    Cause, W.C.2
  • 18
    • 0025289913 scopus 로고
    • Recovery from autoimmunity of MRL/lpr mice after infection with an interleukm-2/vaccinia recombinant virus
    • Gutierrez-Ramos JC, et al. Recovery from autoimmunity of MRL/lpr mice after infection with an interleukm-2/vaccinia recombinant virus. Nature 1990; 346: 271-274.
    • (1990) Nature , vol.346 , pp. 271-274
    • Gutierrez-Ramos, J.C.1
  • 19
    • 0029021257 scopus 로고
    • Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery
    • Raz E, et al. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 1995; 4: 286-292.
    • (1995) Lupus , vol.4 , pp. 286-292
    • Raz, E.1
  • 20
    • 0026474396 scopus 로고
    • In vivo administration of interleukin-2 turns on anergic self-reactive T cells and leads to autoimmune disease
    • Gutierrez-Ramos JC, Moreno de Alboran I, Martinez-A C. In vivo administration of interleukin-2 turns on anergic self-reactive T cells and leads to autoimmune disease. Eur J Immunol 1992; 22: 2867-2872.
    • (1992) Eur J Immunol , vol.22 , pp. 2867-2872
    • Gutierrez-Ramos, J.C.1    Moreno de Alboran, I.2    Martinez-A, C.3
  • 21
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25)
    • Sakaguchi S, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). J Immunol 1995; 155: 1151-1164
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1
  • 22
    • 0029946516 scopus 로고    scopus 로고
    • Administration of anti-interleukin-2 receptor α antibody in vivo induces localized autoimmune disease
    • Taguchi O, Takahashi T. Administration of anti-interleukin-2 receptor α antibody in vivo induces localized autoimmune disease. Eur J Immunol 1996; 26: 1608-1616.
    • (1996) Eur J Immunol , vol.26 , pp. 1608-1616
    • Taguchi, O.1    Takahashi, T.2
  • 23
    • 0019787151 scopus 로고
    • Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the Ipr gene
    • Wofsy D, et al Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the Ipr gene. J Exp Med 1981; 154: 1671-1680.
    • (1981) J Exp Med , vol.154 , pp. 1671-1680
    • Wofsy, D.1
  • 24
    • 0019490514 scopus 로고
    • Analysis of T cell function in autoimmune murine strains. Defects in production of and responsiveness to interleukin 2
    • Altman A, et al. Analysis of T cell function in autoimmune murine strains. Defects in production of and responsiveness to interleukin 2. J Exp Med 1981; 154: 791-808.
    • (1981) J Exp Med , vol.154 , pp. 791-808
    • Altman, A.1
  • 25
    • 0019825716 scopus 로고
    • Interleukin 2 deficiency is a common feature of autoimmune mice
    • Dauphinée MJ, Kipper SB, Wofsy D, Talal N Interleukin 2 deficiency is a common feature of autoimmune mice. J Immunol 1981; 127: 2483-2487.
    • (1981) J Immunol , vol.127 , pp. 2483-2487
    • Dauphinée, M.J.1    Kipper, S.B.2    Wofsy, D.3    Talal, N.4
  • 26
    • 0029061223 scopus 로고
    • Age-related differential mRNA expression of T cell cytokines in NZB/NZW F1 mice
    • Yoshii H, et al. Age-related differential mRNA expression of T cell cytokines in NZB/NZW F1 mice. Lupus 1995; 4: 213-216.
    • (1995) Lupus , vol.4 , pp. 213-216
    • Yoshii, H.1
  • 27
    • 0024583973 scopus 로고
    • B cell hyperresponsiveness to interleukin 2 and the age-associated decline in murine lupus
    • Sekigawa I, et al. B cell hyperresponsiveness to interleukin 2 and the age-associated decline in murine lupus. Clin Immunol Immunopathol 1989; 51: 172-184.
    • (1989) Clin Immunol Immunopathol , vol.51 , pp. 172-184
    • Sekigawa, I.1
  • 28
    • 0017364660 scopus 로고
    • Lymphocyte reactivity to mitogens in subjects with systemic lupus erythematosus, rheumatoid arthritis and scleroderma
    • Horwitz DA, Garrett MA. Lymphocyte reactivity to mitogens in subjects with systemic lupus erythematosus, rheumatoid arthritis and scleroderma. Clin Exp Immunol 1977; 27: 92-99.
    • (1977) Clin Exp Immunol , vol.27 , pp. 92-99
    • Horwitz, D.A.1    Garrett, M.A.2
  • 29
    • 0019948507 scopus 로고
    • Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus
    • Alcocer-Varela J, Alarcón-Segovia D. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 1982; 69: 1388-1392.
    • (1982) J Clin Invest , vol.69 , pp. 1388-1392
    • Alcocer-Varela, J.1    Alarcón-Segovia, D.2
  • 30
    • 0020546709 scopus 로고
    • Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)
    • Linker-Israeli M, et al. Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol 1983; 130: 2651-2655.
    • (1983) J Immunol , vol.130 , pp. 2651-2655
    • Linker-Israeli, M.1
  • 31
    • 0021326234 scopus 로고
    • Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus
    • Miyasaka N, Nakamura T, Russell IJ, Talal N. Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol 1984; 31: 109-117.
    • (1984) Clin Immunol Immunopathol , vol.31 , pp. 109-117
    • Miyasaka, N.1    Nakamura, T.2    Russell, I.J.3    Talal, N.4
  • 32
    • 0023929444 scopus 로고
    • Interleukin-2 abnormalities in systemic lupus erythematosus and rheumatoid arthritis. A role for overproduction of interleukin-2 in human autoimmunity?
    • Warrington RJ. Interleukin-2 abnormalities in systemic lupus erythematosus and rheumatoid arthritis. A role for overproduction of interleukin-2 in human autoimmunity? J Rheumatol 1988; 15: 616-620.
    • (1988) J Rheumatol , vol.15 , pp. 616-620
    • Warrington, R.J.1
  • 33
    • 0021961446 scopus 로고
    • Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematous
    • Murakawa Y, et al. Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematous. J Immunol 1985; 134: 187-195.
    • (1985) J Immunol , vol.134 , pp. 187-195
    • Murakawa, Y.1
  • 34
    • 0021979083 scopus 로고
    • Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells
    • Linker-Israeli M, Bakke AC, Quismorio FP, Horwitz DA. Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells. J Clin Invest 1985; 75. 762-768.
    • (1985) J Clin Invest , vol.75 , pp. 762-768
    • Linker-Israeli, M.1    Bakke, A.C.2    Quismorio, F.P.3    Horwitz, D.A.4
  • 35
    • 0028308645 scopus 로고
    • 8 T cells: Their activation and effector functions
    • 8 T cells: their activation and effector functions. Curr Opin Immunol 1994; 6: 453-457.
    • (1994) Curr Opin Immunol , vol.6 , pp. 453-457
    • Le Gros, G.1    Erard, F.2
  • 36
    • 0023005796 scopus 로고
    • The interleukin 2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells
    • Huang Y-P, Miescher PA, Zubler RH. The interleukin 2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells. J Immunol 1986; 137: 3515-3520.
    • (1986) J Immunol , vol.137 , pp. 3515-3520
    • Huang, Y.-P.1    Miescher, P.A.2    Zubler, R.H.3
  • 37
    • 0024373285 scopus 로고
    • Reversible interleukin-2 response defects in systemic lupus erythematosus
    • Warrington RJ, Sauder PJ, Homik J, Ofosu-Appiah W. Reversible interleukin-2 response defects in systemic lupus erythematosus. Clin Exp Immunol 1989; 77: 163-167.
    • (1989) Clin Exp Immunol , vol.77 , pp. 163-167
    • Warrington, R.J.1    Sauder, P.J.2    Homik, J.3    Ofosu-Appiah, W.4
  • 38
    • 0020564532 scopus 로고
    • In vitro correction of the interleukin 2 defect of autoimmune mice
    • Santoro TJ, et al. In vitro correction of the interleukin 2 defect of autoimmune mice. Eur J Immunol 1983; 13: 601-604.
    • (1983) Eur J Immunol , vol.13 , pp. 601-604
    • Santoro, T.J.1
  • 39
    • 0026330837 scopus 로고
    • Functional T cell subpopulations responsible for hyposecretion of IL-2 in patients with systemic lupus erythematosus
    • Hayama T, et al. Functional T cell subpopulations responsible for hyposecretion of IL-2 in patients with systemic lupus erythematosus. Clin Rheumatol 1991; 10: 388-394.
    • (1991) Clin Rheumatol , vol.10 , pp. 388-394
    • Hayama, T.1
  • 40
    • 0023684012 scopus 로고
    • Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate
    • Murakawa Y, Sakane T. Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate. Arthritis Rheum 1988; 31: 826-833.
    • (1988) Arthritis Rheum , vol.31 , pp. 826-833
    • Murakawa, Y.1    Sakane, T.2
  • 42
    • 0021270494 scopus 로고
    • Lymphokines in autoimmunity: Relationship between interleukin-2 and interferon-γ production in systemic lupus erythematosus
    • Sibbitt W, et al. Lymphokines in autoimmunity: relationship between interleukin-2 and interferon-γ production in systemic lupus erythematosus. Clin Immunol Immunopathol 1984; 32: 166-173.
    • (1984) Clin Immunol Immunopathol , vol.32 , pp. 166-173
    • Sibbitt, W.1
  • 43
    • 0025871709 scopus 로고
    • A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus
    • Tada Y, et al. A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1991; 60: 220-231.
    • (1991) Clin Immunol Immunopathol , vol.60 , pp. 220-231
    • Tada, Y.1
  • 44
    • 0029931053 scopus 로고    scopus 로고
    • Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients
    • García-Cózar FJ, et al. Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients. Clin Exp Immunol 1996; 104: 72-79.
    • (1996) Clin Exp Immunol , vol.104 , pp. 72-79
    • García-Cózar, F.J.1
  • 45
    • 0027340338 scopus 로고
    • Molecular regulation of the IL-2 gene: Rheostatic control of the immunc system
    • Umlauf SW, et al. Molecular regulation of the IL-2 gene: Rheostatic control of the immunc system. Immunol Rev 1993; 133: 177-197.
    • (1993) Immunol Rev , vol.133 , pp. 177-197
    • Umlauf, S.W.1
  • 46
    • 0028020329 scopus 로고
    • Effect of CD28 antibody on T cells from patients with systemic lupus erythematosus
    • Alvarado C, et al. Effect of CD28 antibody on T cells from patients with systemic lupus erythematosus. J Autoimmunity 1994; 7: 763-773.
    • (1994) J Autoimmunity , vol.7 , pp. 763-773
    • Alvarado, C.1
  • 47
    • 0028904325 scopus 로고
    • Analysis of proteins that interact with the IL-2 regulatory region in patients with rheumatoid diseases
    • Becker H, Stengl G, Stein M, Federlin K. Analysis of proteins that interact with the IL-2 regulatory region in patients with rheumatoid diseases. Clin Exp Immunol 1995; 99: 325-330.
    • (1995) Clin Exp Immunol , vol.99 , pp. 325-330
    • Becker, H.1    Stengl, G.2    Stein, M.3    Federlin, K.4
  • 48
    • 7144237343 scopus 로고
    • The basis of autoimmunity in MRL-lpr/lpr mice: A role for self Ia-reactive T cells
    • Rosenberg YJ, Steinberg AD, Santoro TJ. The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Ia-reactive T cells. Immunol Today 1984; 5: 64-67.
    • (1984) Immunol Today , vol.5 , pp. 64-67
    • Rosenberg, Y.J.1    Steinberg, A.D.2    Santoro, T.J.3
  • 49
    • 0027358910 scopus 로고
    • Relationship of IL-2, IL-2R (CD25), soluble IL-2R and IL-4 with disease activity in SLE patients
    • Cuadrado MJ, et al. Relationship of IL-2, IL-2R (CD25), soluble IL-2R and IL-4 with disease activity in SLE patients. Lupus 1993; 2: 257-260.
    • (1993) Lupus , vol.2 , pp. 257-260
    • Cuadrado, M.J.1
  • 50
    • 0024323362 scopus 로고
    • Dysregulated lymphokine production in systemic lupus erythematosus (SLE)
    • Linker-Israeli M, Deans R. Dysregulated lymphokine production in systemic lupus erythematosus (SLE). Ann N Y Acad Sci 1989; 557: 567-569.
    • (1989) Ann n y Acad Sci , vol.557 , pp. 567-569
    • Linker-Israeli, M.1    Deans, R.2
  • 51
    • 0028172243 scopus 로고
    • Cytokine gene profile in circulating blood mononuclear cells from patients with systemic lupus erythematosus: Increased interleukin-2 but not interleukin-4 mRNA
    • Horwitz DA, Wang H, Gray JD. Cytokine gene profile in circulating blood mononuclear cells from patients with systemic lupus erythematosus: Increased interleukin-2 but not interleukin-4 mRNA. Lupus 1994; 3: 423-428.
    • (1994) Lupus , vol.3 , pp. 423-428
    • Horwitz, D.A.1    Wang, H.2    Gray, J.D.3
  • 52
    • 0029330109 scopus 로고
    • High levels of Th2 cytokine gene expression in systemic lupus erythematosus
    • Richaud-Patin Y, Alcocer-Varela J, Llorente L. High levels of Th2 cytokine gene expression in systemic lupus erythematosus. Rev Invest Clin 1995, 47: 267-272.
    • (1995) Rev Invest Clin , vol.47 , pp. 267-272
    • Richaud-Patin, Y.1    Alcocer-Varela, J.2    Llorente, L.3
  • 53
    • 0029964272 scopus 로고    scopus 로고
    • In vitro type-1 and type-2 cytokine production in systemic lupus erythematosus. lack of relationship with clinical disease activity
    • Barcellini W, et al. In vitro type-1 and type-2 cytokine production in systemic lupus erythematosus. lack of relationship with clinical disease activity. Lupus 1996; 5: 139-145.
    • (1996) Lupus , vol.5 , pp. 139-145
    • Barcellini, W.1
  • 54
    • 0024524248 scopus 로고
    • Familial occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus
    • Sakane T, et al. Familial occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus. Am J Med 1989; 86: 385-390.
    • (1989) Am J Med , vol.86 , pp. 385-390
    • Sakane, T.1
  • 55
    • 0023683648 scopus 로고
    • Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus
    • Huang Y-P, Perrin LH, Miescher PA, Zubler RH Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus. J Immunol 1988; 141: 827-833.
    • (1988) J Immunol , vol.141 , pp. 827-833
    • Huang, Y.-P.1    Perrin, L.H.2    Miescher, P.A.3    Zubler, R.H.4
  • 56
    • 0029111513 scopus 로고
    • Longitudinal study on the production of and cellular response to interleukin-2 in patients with systemic lupus erythematosus
    • Alcocer-Varela J, Alarcón-Segovia D. Longitudinal study on the production of and cellular response to interleukin-2 in patients with systemic lupus erythematosus. Rheumatol Int 1995; 15: 57-63.
    • (1995) Rheumatol int , vol.15 , pp. 57-63
    • Alcocer-Varela, J.1    Alarcón-Segovia, D.2
  • 57
    • 0026349141 scopus 로고
    • Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2
    • Alcocer-Varela J, et al Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. J Autoimmunity 1991; 4: 935-945.
    • (1991) J Autoimmunity , vol.4 , pp. 935-945
    • Alcocer-Varela, J.1
  • 58
    • 0022533156 scopus 로고
    • Oncogene expression in autoimmune and normal peripheral blood mononuclear cells
    • Klinman DM, et al. Oncogene expression in autoimmune and normal peripheral blood mononuclear cells. J Exp Med 1986; 163: 1292-1307.
    • (1986) J Exp Med , vol.163 , pp. 1292-1307
    • Klinman, D.M.1
  • 59
    • 1842334483 scopus 로고    scopus 로고
    • In vitro apoptosis and expression of apoptosisrelated molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases
    • Lorenz HM, et al. In vitro apoptosis and expression of apoptosisrelated molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases Arthritis Rheum 1997; 40: 306-317.
    • (1997) Arthritis Rheum , vol.40 , pp. 306-317
    • Lorenz, H.M.1
  • 60
    • 0025253570 scopus 로고
    • HLA-DP+ T cells and deficient interleukin-2 production in patients with systemic lupus erythematosus
    • Hishikawa T, et al. HLA-DP+ T cells and deficient interleukin-2 production in patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1990; 55: 285-296.
    • (1990) Clin Immunol Immunopathol , vol.55 , pp. 285-296
    • Hishikawa, T.1
  • 61
    • 0020319043 scopus 로고
    • Interleukin-2 deficiency, genes and systemic lupus erythematosus
    • Talal N, Dauphinee MJ, Wofsy D. Interleukin-2 deficiency, genes and systemic lupus erythematosus. Arthritis Rheum 1982; 25: 838-842.
    • (1982) Arthritis Rheum , vol.25 , pp. 838-842
    • Talal, N.1    Dauphinee, M.J.2    Wofsy, D.3
  • 62
    • 0028962459 scopus 로고
    • Low serum levels of dehydroepiandrosterone may cause deficient IL-2 production by lymphocytes in patients with systemic lupus erythematosus (SLE)
    • Suzuki T, et al. Low serum levels of dehydroepiandrosterone may cause deficient IL-2 production by lymphocytes in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1995; 99: 251-255.
    • (1995) Clin Exp Immunol , vol.99 , pp. 251-255
    • Suzuki, T.1
  • 63
    • 0024672606 scopus 로고
    • Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus
    • Tanaka T, et al. Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus. Arthritis Rheum 1989; 32: 552-559.
    • (1989) Arthritis Rheum , vol.32 , pp. 552-559
    • Tanaka, T.1
  • 64
    • 0025248585 scopus 로고
    • IL-4 inhibits IL-2 receptor expression and IL-2 dependent proliferation of human T cells
    • Martínez OM, Gibbons RS, Garovoy MR, Aronson FR. IL-4 inhibits IL-2 receptor expression and IL-2 dependent proliferation of human T cells J Immunol 1990; 144: 2211-2215.
    • (1990) J Immunol , vol.144 , pp. 2211-2215
    • Martínez, O.M.1    Gibbons, R.S.2    Garovoy, M.R.3    Aronson, F.R.4
  • 65
    • 0026100306 scopus 로고
    • Interleukin-4 regulates the interleukin-2 receptors on human peripheral blood B lymphocytes
    • Tomizawa K, et al. Interleukin-4 regulates the interleukin-2 receptors on human peripheral blood B lymphocytes. Clin Exp Immunol 1991; 83: 492-496.
    • (1991) Clin Exp Immunol , vol.83 , pp. 492-496
    • Tomizawa, K.1
  • 66
    • 0023939718 scopus 로고
    • Interleukin -2 receptor expression in peripheral blood lymphocytes from systemic lupus erythematosus patients: Relationship to clinical activity
    • Wigfall DR, Sakai RS, Wallace DJ, Jordan SC. Interleukin -2 receptor expression in peripheral blood lymphocytes from systemic lupus erythematosus patients: Relationship to clinical activity. Clin Immunol Immunopathol 1988; 47: 354-362.
    • (1988) Clin Immunol Immunopathol , vol.47 , pp. 354-362
    • Wigfall, D.R.1    Sakai, R.S.2    Wallace, D.J.3    Jordan, S.C.4
  • 67
    • 0023273847 scopus 로고
    • Impaired expression of high affinity interleukin 2 receptors on activated lymphocytes from patients with systemic lupus erythematosus
    • Ishida H, et al. Impaired expression of high affinity interleukin 2 receptors on activated lymphocytes from patients with systemic lupus erythematosus. J Immunol 1987; 139: 1070-1074.
    • (1987) J Immunol , vol.139 , pp. 1070-1074
    • Ishida, H.1
  • 68
    • 0025077169 scopus 로고
    • The soluble interleukin-2 receptor, biology, function and clinical application
    • Robin LA, Nelson DL. The soluble interleukin-2 receptor, biology, function and clinical application. Ann Intern Med 1990; 113: 619-627.
    • (1990) Ann Intern Med , vol.113 , pp. 619-627
    • Robin, L.A.1    Nelson, D.L.2
  • 70
    • 0023916644 scopus 로고
    • Soluble interleukin-2 receptors in systemic lupus erythematosus
    • Wolf RE, Brelsford WG. Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum 1988; 31: 729-735.
    • (1988) Arthritis Rheum , vol.31 , pp. 729-735
    • Wolf, R.E.1    Brelsford, W.G.2
  • 71
    • 0030859141 scopus 로고    scopus 로고
    • Cerebrospinal fluid soluble interleukin-2 receptor in cerebral lupus
    • Gilad R, et al. Cerebrospinal fluid soluble interleukin-2 receptor in cerebral lupus. Br J Rheumatol 1997; 36: 190-193.
    • (1997) Br J Rheumatol , vol.36 , pp. 190-193
    • Gilad, R.1
  • 72
    • 0023672638 scopus 로고
    • Serum inhibitors of interleukin-2
    • Kucharz EJ, Goodwin JS. Serum inhibitors of interleukin-2 Life Sci 1988; 42: 1485-1491.
    • (1988) Life Sci , vol.42 , pp. 1485-1491
    • Kucharz, E.J.1    Goodwin, J.S.2
  • 73
    • 0024355835 scopus 로고
    • Two types of antibodies inhibiting interleukin-2 production by normal lymphocytes in patients with systemic lupus erythematosus
    • Miyagi J, et al Two types of antibodies inhibiting interleukin-2 production by normal lymphocytes in patients with systemic lupus erythematosus. Arthritis Rheum 1989; 32: 1356-1364.
    • (1989) Arthritis Rheum , vol.32 , pp. 1356-1364
    • Miyagi, J.1
  • 74
    • 0022559750 scopus 로고
    • Systemic lupus erythematosus sera antilymphocyte reactivity: Detection of antibodies to Tac-antigen positive T cell lines
    • Sano H. el al. Systemic lupus erythematosus sera antilymphocyte reactivity: detection of antibodies to Tac-antigen positive T cell lines. Clin Exp Immunol 1986; 63: 8-16.
    • (1986) Clin Exp Immunol , vol.63 , pp. 8-16
    • Sano, H.1
  • 75
    • 0022402498 scopus 로고
    • Characterization and partial purification of a specific interleukin 2 inhibitor
    • Honda M, Chan C, Shevach EM Characterization and partial purification of a specific interleukin 2 inhibitor. J Immunol 1985; 135: 1834-1839.
    • (1985) J Immunol , vol.135 , pp. 1834-1839
    • Honda, M.1    Chan, C.2    Shevach, E.M.3
  • 76
    • 0022485662 scopus 로고
    • Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders
    • Djeu JY, Kasahara T, Balow JE, Tsokos GC. Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders. Clin Exp Immunol 1986; 65: 279-285.
    • (1986) Clin Exp Immunol , vol.65 , pp. 279-285
    • Djeu, J.Y.1    Kasahara, T.2    Balow, J.E.3    Tsokos, G.C.4
  • 77
    • 0019421331 scopus 로고
    • Interleukin 2, production in the syngeneic mixed lymphocyte reaction
    • Lattime EC, Gillis S, David C, Stutman O. Interleukin 2, production in the syngeneic mixed lymphocyte reaction. Eur J Immunol 1981; 11: 67-69.
    • (1981) Eur J Immunol , vol.11 , pp. 67-69
    • Lattime, E.C.1    Gillis, S.2    David, C.3    Stutman, O.4
  • 78
    • 0020322284 scopus 로고
    • Significance of self-recognition and interleukin-2 for immunoregulation, autoimmunity and cancer
    • Smith JB, Talal N. Significance of self-recognition and interleukin-2 for immunoregulation, autoimmunity and cancer. Scand J Immunol 1982; 16: 269-278.
    • (1982) Scand J Immunol , vol.16 , pp. 269-278
    • Smith, J.B.1    Talal, N.2
  • 79
    • 0021884894 scopus 로고
    • Abnormalities in autologous mixed lymphocyte reaction-activated immunologic processes in systemic lupus erythematosus and their possible correction by interleukin-2
    • Takada S, et al. Abnormalities in autologous mixed lymphocyte reaction-activated immunologic processes in systemic lupus erythematosus and their possible correction by interleukin-2. Eur J Immunol 1985; 15: 262-267.
    • (1985) Eur J Immunol , vol.15 , pp. 262-267
    • Takada, S.1
  • 80
    • 0021051203 scopus 로고
    • Differences in the kinetics of the autologous mixed lymphocyte reaction between the various connective tissue diseases
    • Laffón A, Alcocer-Varela J, Alarcón-Segovia D. Differences in the kinetics of the autologous mixed lymphocyte reaction between the various connective tissue diseases. Rheumatol Int 1983; 3: 117-128.
    • (1983) Rheumatol int , vol.3 , pp. 117-128
    • Laffón, A.1    Alcocer-Varela, J.2    Alarcón-Segovia, D.3
  • 81
    • 0018380803 scopus 로고
    • The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus
    • Kuntz MM, Innes JB, Weksler ME. The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus. J Clin Invest 1979; 63: 151-153.
    • (1979) J Clin Invest , vol.63 , pp. 151-153
    • Kuntz, M.M.1    Innes, J.B.2    Weksler, M.E.3
  • 82
    • 0018174178 scopus 로고
    • Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus
    • Sakane T, Steinberg AD, Green I. Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus. Proc Natl Acad Sci USA 1978; 75: 3464-3468.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 3464-3468
    • Sakane, T.1    Steinberg, A.D.2    Green, I.3
  • 83
    • 0027208746 scopus 로고
    • T cell-antigen-presentmg cell interactions in human systemic lupus erythematosus
    • Via CS, et al. T cell-antigen-presentmg cell interactions in human systemic lupus erythematosus. J Immunol 1993; 151: 3914-3922.
    • (1993) J Immunol , vol.151 , pp. 3914-3922
    • Via, C.S.1
  • 84
    • 0021348974 scopus 로고
    • Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus
    • Alcocer-Varela J, Laffón A, Alarcón-Segovia D. Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol 1983; 54: 125-132
    • (1983) Clin Exp Immunol , vol.54 , pp. 125-132
    • Alcocer-Varela, J.1    Laffón, A.2    Alarcón-Segovia, D.3
  • 85
    • 0029929607 scopus 로고    scopus 로고
    • Defective antigen-presenting cell function in patients with systemic lupus erythematosus. Role of the B7-1 (CD80) costimulatory molecule
    • Tsokos GC, et al. Defective antigen-presenting cell function in patients with systemic lupus erythematosus. Role of the B7-1 (CD80) costimulatory molecule Arthritis Rheum 1996; 39: 600-609.
    • (1996) Arthritis Rheum , vol.39 , pp. 600-609
    • Tsokos, G.C.1
  • 86
    • 0020349835 scopus 로고
    • The mechanism of inhibition of human IL-2 production
    • Chouaib S, Fradelizi D. The mechanism of inhibition of human IL-2 production. J Immunol 1982; 129: 2463-2468.
    • (1982) J Immunol , vol.129 , pp. 2463-2468
    • Chouaib, S.1    Fradelizi, D.2
  • 87
    • 0020335126 scopus 로고
    • 2 effects on human suppressor cell function and on interleukin 2 function
    • 2 effects on human suppressor cell function and on interleukin 2 function. J Immunol 1982; 129: 2469-2473.
    • (1982) J Immunol , vol.129 , pp. 2469-2473
    • Tilden, A.B.1    Balch, C.M.2
  • 88
  • 89
    • 0022506129 scopus 로고
    • Stimulating and differentiation factors for human B lymphocytes in systemic lupus erythematosus
    • Martínez-Cordero E, Alcocer-Varela J, Alarcón-Segovia D. Stimulating and differentiation factors for human B lymphocytes in systemic lupus erythematosus. Clin Exp Immunol 1986; 65: 598-604.
    • (1986) Clin Exp Immunol , vol.65 , pp. 598-604
    • Martínez-Cordero, E.1    Alcocer-Varela, J.2    Alarcón-Segovia, D.3
  • 90
    • 0027787885 scopus 로고
    • Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus
    • Llorente L, el al. Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus. Eur Cytokine Netw 1993; 4: 412-430.
    • (1993) Eur Cytokine Netw , vol.4 , pp. 412-430
    • Llorente, L.1
  • 91
    • 0029867033 scopus 로고    scopus 로고
    • Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-γ-secreting cells in the peripheral blood
    • Hagiwara E, Gourley MF, Lee S, Klinman DM. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-γ-secreting cells in the peripheral blood. Arthritis Rheum 1996; 39: 379-385.
    • (1996) Arthritis Rheum , vol.39 , pp. 379-385
    • Hagiwara, E.1    Gourley, M.F.2    Lee, S.3    Klinman, D.M.4
  • 92
    • 0030924069 scopus 로고    scopus 로고
    • Dysregulation of interleukin 10 prouuction in relatives of patients with systemic lupus erythematosus
    • Llorente L, et al Dysregulation of interleukin 10 prouuction in relatives of patients with systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1429-1435.
    • (1997) Arthritis Rheum , vol.40 , pp. 1429-1435
    • Llorente, L.1
  • 93
    • 0028962115 scopus 로고
    • Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus
    • Llorente L, et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995; 181: 839-844.
    • (1995) J Exp Med , vol.181 , pp. 839-844
    • Llorente, L.1
  • 95
    • 0028070319 scopus 로고
    • Differential effects of IL-10 on proliferation and cytokine production of human γ/δ and α/β T cells
    • Schlaak JF, et al. Differential effects of IL-10 on proliferation and cytokine production of human γ/δ and α/β T cells Scand J Immunol 1994, 39: 209-215.
    • (1994) Scand J Immunol , vol.39 , pp. 209-215
    • Schlaak, J.F.1
  • 96
    • 0027232788 scopus 로고
    • Direct effects of IL-10 on subsets of human CD4-I- T cell clones and resting T cells
    • de Waal Malefyt R, Yssel H, de Vries JE. Direct effects of IL-10 on subsets of human CD4-I- T cell clones and resting T cells. J Immunol 1993, 150: 4754-4765.
    • (1993) J Immunol , vol.150 , pp. 4754-4765
    • De Waal Malefyt, R.1    Yssel, H.2    De Vries, J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.