Transcriptional repression of interleukin-2 in human systemic lupus erythematosus

Autoimmunity Reviews

Volumn 5, Issue 2 SPEC. ISS., 2006, Pages 118-121

  Katsiari, Christina G ^a,c   Tsokos, George C ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^c WRAIR   (United States)

Author keywords

Interleukin 2; Systemic lupus erythematosus; Transcriptional regulation

Indexed keywords

INTERLEUKIN 2;

CONFERENCE PAPER; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; PROTEIN DEFICIENCY; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 31144451804     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2005.08.009     Document Type: Conference Paper

References (14)

1. B.H. Nelson IL-2, regulatory T cells, and tolerance J Immunol 172 7 2004 3983 3988
2. G.C. Tsokos Overview of cellular immune function in systemic lupus erythematosus R.G. Lahita Systemic lupus erythematosus 1999 Academic Press New York 17 54
3. K. Tenbrock, and G.C. Tsokos Transcriptional regulation of the interleukin 2 in SLE T cells Int Rev Immunol 23 2004 333 345
4. J. Jain, C. Loh, and A. Rao Transcriptional regulation of the IL-2 gene Curr Opin Immunol 7 3 1995 333 342
5. K. Tenbrock, Y.T. Juang, M. Tolnay, and G.C. Tsokos The cyclic adenosine 5′-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism J Immunol 170 2003 2971 2976
6. J.A. Lederer, J.S. Liou, M.D. Todd, L.H. Glimcher, and A.H. Lichtman Regulation of cytokine gene expression in T helper cell subsets J Immunol 152 1994 77 86
7. H.K. Wong, G.M. Kammer, G. Dennis, and G.C Tsokos Abnormal NF-kappaB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-relA protein expression J Immunol 163 3 1999 1682 1689
8. T.M. Herndon, Y.T. Juang, E.E. Solomou, S.W. Rothwell, M.F. Gourley, and G.C. Tsokos Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity Clin Immunol 103 2 2002 145 153
9. E.E. Solomou, Y.T. Juang, M.F. Gourley, G.M. Kammer, and G.C. Tsokos Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus J Immunol 166 6 2001 4216 4222
10. V.C. Kyttaris, Y.T. Juang, K. Tenbrock, A. Weinstein, and G.C. Tsokos Cyclic adenosine 5′-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus J Immunol 173 5 2004 3557 3563
11. Y.T. Juang, Y. Wang, E.E. Solomou, Y. Li, C. Mawrin, and K. Tenbrock Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV J Clin Invest 115 4 2005 996 1005
12. C.G. Katsiari, Y.-T. Juang, V.C. Kyttaris, and G.C. Tsokos Overexpression of functional protein phosphatase 2A catalytic subunit C (PP2Ac) in T cells from patients with systemic lupus erythematosus (SLE) Arthritis Rheum 50 9 2005 [Abs No 1598]
13. 2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A Science 280 5367 1998 1258 1261
14. E. Chuang, T.S. Fisher, R.W. Morgan, J.M. Duerr, M.G. Vander Heiden, and J.P. Gardner The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A Immunity 13 3 2000 313 322