Antisense cyclic adenosine 5′-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus

Journal of Immunology

Volumn 169, Issue 8, 2002, Pages 4147-4152

  Tenbrock, Klaus ^a   Juang, Yuang Taung ^a   Gourley, Mark F ^a   Nambiar, Madhusoodana P ^a   Tsokos, George C ^a  

^a Building 503 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ADULT; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; CYTOKINE PRODUCTION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSCRIPTION REGULATION;

EID: 0037108487     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.8.4147     Document Type: Article

References (38)

1. Refaeli, Y., L. Van Parijs, C. A. London, J. Tschopp, and A. K. Abbas. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8:615.
2. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
3. Powell, J. D., C. G. Lerner, G. R. Ewoldt, and R. H. Schwartz. 1999. The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy. J. Immunol. 163:6631.
4. Rothenberg, E. V., and S. B. Ward. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93:9358.
5. Solomou, E. E., Y. T. Juang, M. F. Gourley, G. M. Kammer, and G. C. Tsokos. 2001. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J. Immunol. 166:4216.
6. Solomou, E. E., Y. T. Juang, and G. C. Tsokos. 2001. Protein kinase C-θ participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. J. Immunol. 166:5665.
7. Barton, K., N. Muthusamy, M. Chanyangam, C. Fischer, C. Clendenin, and J. M. Leiden. 1996. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379:81.
8. Garcia-Cozar, F. J., I. J. Molina, M. J. Cuadrado, M. Marubayashi, J. Pena, and M. Santamaria. 1996. Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients. Clin. Exp. Immunol. 104:72.
9. Via, C. S., G. C. Tsokos, B. Bermas, M. Clerici, and G. M. Shearer. 1993. T cell-APC interactions in human systemic lupus erythematosus: evidence for heterogeneous expression of multiple defects. J. Immunol. 151:3914.
10. Wong, H. K., G. M. Kammer, G. Dennis, and G. C. Tsokos. 1999. Abnormal NF-κB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J. Immunol. 163:1682.
11. Hussain, M. A., P. B. Daniel, and J. F. Habener. 2000. Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic β-cells. Diabetes 49:1681.
12. Foulkes, N. S., G. Duval, and P. Sassone-Corsi. 1996. Adaptive inducibility of CREM as transcriptional memory of circadian rhythms. Nature 381:83.
13. Foulkes, N. S., B. M. Laoide, F. Schlotter, and P. Sassone-Corsi. 1991. Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression. Proc. Natl. Acad. Sci. USA 88:5448.
14. Daniel, P. B., L. Rohrbach, and J. F. Habener. 2000. Novel cyclic adenosine 3′,5′-monophosphate (cAMP) response element modulator θ isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology 141:3923.
15. De Cesare, D., and P. Sassone-Corsi. 2000. Transcriptional regulation by cyclic AMP-responsive factors. Prog. Nucleic Acid Res. Mol. Biol. 64:343.
16. Monaco, L., and P. Sassone-Corsi. 1997. Cross-talk in signal transduction: Ras-dependent induction of cAMP-responsive transcriptional repressor ICER by nerve growth factor. Oncogene 15:2493.
17. Sassone-Corsi, P. 1995. Transcription factors responsive to cAMP. Annu. Rev. Cell Dev. Biol. 11:355.
18. Bodor, J., L. Feigenbaum, J. Bodorova, C. Bare, M. S. Reitz, Jr., and R. E. Gress. 2001. Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukocyte Biol. 69:1053.
19. Bodor, J., J. Bodorova, and R. E. Gress. 2000. Suppression of T cell function: a potential role for transcriptional repressor ICER. J. Leukocyte Biol. 67:774.
20. Bombardier, C., D. D. Gladman, M. B. Urowitz, D. Caron, and C. H. Chang. 1992. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum. 35:630.
21. Foulkes, N. S., E. Borrelli, and P. Sassone-Corsi. 1991. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739.
22. Kammer, G. M., T. M. Haqqi, P. Hasler, and C. J. Malemud. 1993. The effect of circulating serum factors from patients with systemic lupus erythematosus on protein kinase A (PKA) activity and PKA-dependent protein phosphorylation in T lymphocytes. Clin. Immunol. Immunopathol. 67:8.
23. Tsokos, G. C,. H. K. Wong, E. J. Enyedy, and M. P. Nambiar. 2000. Immune cell signaling in lupus. Curr. Opin. Rheumatol. 12:355.
24. Kovacs, B., S. N. Liossis, G. J. Dennis, and G. C. Tsokos. 1997. Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus. Autoimmunity 25:213.
25. Kovacs, B., D. Vassilopoulos, S. A. Vogelgesang, and G. C. Tsokos. 1996. Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-α. Clin. Immunol. Immunopathol. 81:293.
26. Dayal, A. K., and G. M. Kammer. 1996. The T cell enigma in lupus. Arthritis Rheum. 39:23.
27. Burgos, P., C. Metz, P. Bull, R. Pincheira, L. Massardo, C. Errazuriz, M. R. Bono, S. Jacobelli, and A. Gonzalez. 2000. Increased expression of c-rel, from the NF-κB/Rel family, in T cells from patients with systemic lupus erythematosus. J. Rheumatol. 27:116.
28. Takeda, Y., P. Caudell, G. Grady, G. Wang, A. Suwa, G. C. Sharp, W. S. Dynan, and J. A. Hardin. 1999. Human RNA helicase A is a lupus autoantigen that is cleaved during apoptosis. J. Immunol. 163:6269.
29. Horiuchi, T., D. Himeji, H. Tsukamoto, S. Harashima, C. Hashimura, and K. Hayashi. 2000. Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes. Biochem. Biophys. Res. Commun. 272:877.
30. Alvarado-de la Barrera, C., J. Alcocer-Varela, Y. Richaud-Patin, D. Alarcon-Segovia, and L. Llorente. 1998. Differential oncogene and TNF-α mRNA expression in bone marrow cells from systemic lupus erythematosus patients. Scand. J. Immunol. 48:551
31. Khan, I. U., D. Laxminarayana, and G. M. Kammer. 2001. Protein kinase A RI β subunit deficiency in lupus T lymphocytes: bypassing a block in RI β translation reconstitutes protein kinase A activity and augments IL-2 production. J. Immunol. 166:7600.
32. Nathan, P. D., and T. G. Eisen. 2002. The biological treatment of renal-cell carcinoma and melanoma. Lancet Oncol. 3:89.
33. Sule, N. S., R. P. Nerurkar, and S. Kamath. 2001. Interleukin-2 as a therapeutic agent. J. Assoc. Physicians India 49:897.
34. Meyaard, L., H. Schuitemaker, and F. Miedema. 1993. T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function? Immunol. Today 14:161.
35. Mitsuyasu, R. T. 2001. The potential role of interleukin-2 in HIV. AIDS 15(Suppl. 2):S22.
36. Kinter, A., and A. S. Fauci. 1996. Interieukin-2 and human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement. Immunol. Res. 15:1.
37. Krieg, A. M. 2000. Immune effects and mechanisms of action of CpG motifs. Vaccine 19:618.
38. Sin, J. I., and D. B. Weiner. 2000. Improving DNA vaccines targeting viral infection. Intervirology 43:233.