Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast

Nature Communications

Volumn 7, Issue , 2016, Pages

  Scheler, Ulschan ^a   Brandt, Wolfgang ^a   Porzel, Andrea ^a   Rothe, Kathleen ^a   Manzano, David ^b,c   Bozic, Dragana ^d,e   Papaefthimiou, Dimitra ^d   Balcke, Gerd Ulrich ^a   Henning, Anja ^a   Lohse, Swanhild ^a   Marillonnet, Sylvestre ^a   Kanellis, Angelos K ^d   Ferrer, Albert ^b,c   Tissier, Alain ^a  

^a LEIBNIZ INSTITUTE OF PLANT BIOCHEMISTRY   (Germany)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^e UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

11 HYDROXYFERRUGINOL; 11 HYDROXYFERRUGINOL SYNTHASE; ABIETATRIENE; AMINO ACID; CARBON DIOXIDE; CARNOSALDEHYDE; CARNOSIC ACID; CARNOSOL; CYP76AH22 ENZYME; CYP76AH23 ENZYME; CYP76AH24 ENZYME; CYTOCHROME P450; DITERPENE; FERRUGINOL; FERRUGINOL SYNTHASE; HYDROXYFERRUGINOL QUINONE; MILTIRADIEN 20 AL; MILTIRADIENE; OXYGENASE; PISIFERAL; PISIFERIC ACID; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; OXIDIZING AGENT; OXYGEN;

BIOCHEMICAL COMPOSITION; BIOCHEMISTRY; BIOLOGICAL PRODUCTION; ENZYME ACTIVITY; HERB; IMMUNE RESPONSE; ORGANIC ACID; OXIDATION; PHENOLIC COMPOUND; YEAST;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SYNTHESIS; MEDICINAL PLANT; MEMBRANE RECONSTITUTION; METABOLIC ENGINEERING; MOLECULAR MODEL; NONHUMAN; OXIDATION; ROSEMARY; SALVIA; SALVIA FRUTICOSA; SALVIA MILTIORRHIZA; SITE DIRECTED MUTAGENESIS; YEAST; YEAST CELL; BIOSYNTHESIS; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; GENE VECTOR; HUMAN; METABOLISM; MUTAGENESIS; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYLOGENY; ROSMARINUS; SACCHAROMYCES CEREVISIAE;

ROSMARINUS OFFICINALIS; SALVIA FRUTICOSA;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; DITERPENES, ABIETANE; ESCHERICHIA COLI; GENETIC VECTORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDANTS; OXYGEN; PHYLOGENY; ROSMARINUS; SACCHAROMYCES CEREVISIAE; SALVIA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84990924569     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12942     Document Type: Article

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