NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) and cytochrome P450 oxidoreductase (CYP450OR) differentially regulate menadione-mediated alterations in redox status, survival and metabolism in pancreatic β-cells

Toxicology Letters

Volumn 262, Issue , 2016, Pages 1-11

  Gray, Joshua P ^a,b,c   Karandrea, Shpetim ^c   Burgos, Delaine Zayasbazan ^d   Jaiswal, Anil A ^e   Heart, Emma A ^b,c  

^a U S COAST GUARD ACADEMY   (United States)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d UNIVERSITY OF PUERTO RICO AT CAYEY   (Puerto Rico)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

CYP450OR; Menadione; NAD(P)H; NQO1; Pancreatic cell; Redox cycling

Indexed keywords

CYTOCHROME P450 REDUCTASE; DICOUMAROL; HYDROGEN PEROXIDE; MENADIONE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE; XENOBIOTIC AGENT; CYTOCHROME P450; NQO1 PROTEIN, HUMAN; VITAMIN;

ADENOVIRUS INFECTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; LIVER; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION;

CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; HUMANS; HYDROGEN PEROXIDE; INSULIN-SECRETING CELLS; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; VITAMIN K 3; VITAMINS;

EID: 84989360007     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.08.021     Document Type: Article

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