Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA

American Journal of Physiology - Endocrinology and Metabolism

Volumn 310, Issue 6, 2016, Pages E394-E404

  Gray, Joshua P ^a   Burgos, Delaine Zayasbazan ^b   Yuan, Tao ^c   Seeram, Navindra ^c   Rebar, Rebecca ^a   Follmer, Rebecca ^a   Heart, Emma A ^c,d,e  

^a U S COAST GUARD ACADEMY   (United States)

^b UNIVERSITY OF PUERTO RICO AT CAYEY   (Puerto Rico)

^c UNIVERSITY OF RHODE ISLAND   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

Acetyl CoA carboxylase; Insulin secretion; Malonyl CoA; Thymoquinone; cells

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; GLUCOSE; INSULIN; MALONYL COENZYME A; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NIGELLA SATIVA EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THYMOQUINONE; BENZOQUINONE DERIVATIVE; HYDROGEN PEROXIDE; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; CARBOHYDRATE METABOLISM; CELL CLONE; CELL METABOLISM; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME REGULATION; FATTY ACID METABOLISM; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; CELL LINE; CHEMISTRY; DOWN REGULATION; DRUG EFFECTS; METABOLISM; PANCREAS ISLET; RAT; SECRETION (PROCESS);

ACETYL-COA CARBOXYLASE; ANIMALS; BENZOQUINONES; CELL LINE; DOWN-REGULATION; FATTY ACID SYNTHASE, TYPE I; FATTY ACID-BINDING PROTEINS; GLUCOSE; HYDROGEN PEROXIDE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALONYL COENZYME A; MICE; NIGELLA SATIVA; OXIDATION-REDUCTION; PLANT EXTRACTS; RATS;

EID: 84983775195     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00250.2015     Document Type: Article

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