Induction of antioxidant enzymes by curcumin and its analogues in human islets: Implications in transplantation

Pancreas

Volumn 38, Issue 4, 2009, Pages 454-460

  Balamurugan, A N ^a   Akhov, Leonid ^b   Selvaraj, Gopalan ^b   Pugazhenthi, Subbiah ^c,d  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Curcumin; Heme oxygenase 1; Human islets; Oxidative stress; Phase 2 enzymes

Indexed keywords

2 NORCURCUMIN; CASPASE 3; CURCUMIN; GLUCOSE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; INSULIN; MESSENGER RNA; NORCURCUMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG; ANTIOXIDANT; DEMETHOXYCURCUMIN; DRUG DERIVATIVE; ENZYME; HMOX1 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN;

ANTIOXIDANT ACTIVITY; ARTICLE; CADAVER DONOR; CELL ISOLATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INSULIN RELEASE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; APOPTOSIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; SECRETION;

ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CURCUMIN; ENZYMES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; NAD(P)H DEHYDROGENASE (QUINONE); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 66149152677     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318196c3e7     Document Type: Article

References (32)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230-238.
2. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355:1318-1330.
3. Bottino R, Balamurugan AN, Tse H, et al. Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes. 2004;53:2559-2568.
4. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various mouse tissues. Free Radic Biol Med. 1996;20:463-466.
5. Avila J, Barbaro B, Gangemi A, et al. Intra-ductal glutamine administration reduces oxidative injury during human pancreatic islet isolation. Am J Transplant. 2005;5:2830-2837.
6. Bottino R, Balamurugan AN, Bertera S, et al. Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes. 2002;51:2561-2567.
7. Kwak MK, Wakabayashi N, Kensler TW. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res. 2004;555:133-148.
8. Pileggi A, Molano RD, Berney T, et al. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes. 2001;50:1983-1991.
9. Wu G, Fang YZ, Yang S, et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489-492.
10. Zafar KS, Inayat-Hussain SH, Siegel D, et al. Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death. Toxicol Lett. 2006;166:261-267.
11. Juurlink BH. Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component. Can J Physiol Pharmacol. 2001;79:266-282.
12. Talalay P. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors. 2000;12:5-11.
13. Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr. 2004;44:97-111.
14. Nirmala C, Puvanakrishnan R. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol Cell Biochem. 1996;159:85-93.
15. Nirmala C, Puvanakrishnan R. Effect of curcumin on certain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats. Biochem Pharmacol. 1996;51:47-51.
16. Pugazhenthi S, Akhov L, Selvaraj G, et al. Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI 3-kinase/Akt-mediated pathway in mouse beta cells. Am J Physiol Endocrinol Metab. 2007;293:E645-E655.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem. 1976;72:248-254.
18. Robertson RP. Oxidative stress and impaired insulin secretion in type 2 diabetes. Curr Opin Pharmacol. 2006;6:615-619.
19. Robertson RP, Harmon JS. Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase. FEBS Lett. 2007;581: 3743-3748.
20. Azevedo-Martins AK, Lortz S, Lenzen S, et al. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. Diabetes. 2003;52:93-101.
21. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006;86:583-650.
22. Sato K, Balla J, Otterbein L, et al. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol. 2001;166:4185-4194.
23. Li Y, Li G, Dong W, et al. Transplantation of rat islets transduced with human heme oxygenase-1 gene using adenovirus vector. Pancreas. 2006;33:280-286.
24. Tran PO, Parker SM, LeRoy E, et al. Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. J Biol Chem. 2004;279:53988-53993.
25. Vasiliou V, Ross D, Nebert DW. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Hum Genomics. 2006;2:329-335.
26. Radjendirane V, Joseph P, Lee YH, et al. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem. 1998;273:7382-7389.
27. Iskander K, Li J, Han S, et al. NQO1 and NQO2 regulation of humoral immunity and autoimmunity. J Biol Chem. 2006;281:30917-30924.
28. Jaiswal AK. Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radic Biol Med. 2000;29:254-262.
29. Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem. 2004;279:42351-42354.
30. Matteucci E, Giampietro O. Oxidative stress in families of type 1 diabetic patients. Diabetes Care. 2000;23:1182-1186.
31. Darville MI, Eizirik DL. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia. 1998;41:1101-1108.
32. Sreejayan, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. 1997;49:105-107.