The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: Role of NADH and consequences for insulin secretion

Toxicology and Applied Pharmacology

Volumn 258, Issue 2, 2012, Pages 216-225

  Heart, Emma ^a   Palo, Meridith ^b   Womack, Trayce ^b   Smith, Peter J S ^a,c   Gray, Joshua P ^a,b  

^a MARINE BIOLOGICAL LABORATORY   (United States)

^b U S COAST GUARD ACADEMY   (United States)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Cytosolic oxidoreductase; Insulin secretion; NADH; NQO1; Plasma membrane electron transport (PMET); Redox cycling

Indexed keywords

DICOUMAROL; DIPHENYLIODONIUM SALT; GLUCOSE; HYDROGEN PEROXIDE; INSULIN; MENADIONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE TRANSPORT; CELL METABOLISM; CONCENTRATION (PARAMETERS); DRUG EFFECT; GLYCOLYSIS; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HYDROGEN PEROXIDE; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; ISLETS OF LANGERHANS; MALE; MICE; NAD; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; PANCREATIC NEOPLASMS; RATS; REACTIVE OXYGEN SPECIES; VITAMIN K 3;

RATTUS; RODENTIA;

EID: 84855789983     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.11.002     Document Type: Article

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