A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells

Biochemical Pharmacology

Volumn 64, Issue 11, 2002, Pages 1597-1603

  De Haan, Laura H J ^a   Boerboom, Anne Marie J F ^a   Rietjens, Ivonne M C M ^a   Van Capelle, Daniëlla ^a   De Ruijter, Annemieke J M ^a   Jaiswal, Anil K ^b   Aarts, Jac M M J G ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

CHO cells; Cytotoxicity; Dicoumarol; Menadione; NAD(P)H:quinone oxidoreductase; Threshold

Indexed keywords

DICOUMAROL; MENADIONE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE QUINONE OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL PROTECTION; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; CHO CELLS; CRICETINAE; DICUMAROL; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; NAD(P)H DEHYDROGENASE (QUINONE); PROTECTIVE AGENTS; TRANSFECTION; VITAMIN K 3;

EID: 0036890384     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01383-7     Document Type: Article

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